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Victoria S Chang, Stephen G Schwartz, Janet L Davis, Harry W Flynn
Purpose: To describe an immunosuppressed patient who developed acute-onset postoperative endophthalmitis caused by a moxifloxacin-resistant strain of Staphylococcus epidermidis after cataract surgery despite the use of intracameral moxifloxacin. Observations: A 76-year old woman with a history of birdshot chorioretinopathy controlled on systemic immunosuppression underwent uneventful cataract surgery in her right eye. Compounded intracameral moxifloxacin 0.2 cc of 1mg/0...
March 2019: American Journal of Ophthalmology Case Reports
Ivan E Castro, David A Larsen, Bryce Hruska, Patrick J Parsons, Christopher D Palmer, Brooks B Gump
BACKGROUND: Heightened blood lead levels (BLL) are associated with cognitive deficiencies and adverse behavioral outcomes. Lead-contaminated house dust is the primary source of exposure in U.S. children, and evidence suggests that even background (low-level) exposure has negative consequences. Identifying sources of background exposure is of great public health significance because of the larger number of children that can be affected. METHODS: Blood lead was assessed in a bi-racial sample of children from Syracuse, NY, aged 9-11, using established biomonitoring methods...
January 6, 2019: Environmental Research
Alyssa L Norris, Larry K Brown, Ralph J DiClemente, Robert F Valois, Daniel Romer, Peter A Vanable, Michael P Carey
PURPOSE: To better understand sexual health disparities among African-American sexual minority adolescents. METHODS: African-American adolescents (N = 1120; mean age = 15.24 years) were recruited from 4 cities (Columbia, SC; Macon, GA; Providence, RI; Syracuse, NY) to a larger trial. The current analyses used data from the 18-month follow-up when adolescents reported on their sexual partnerships, condom use knowledge, self-efficacy and outcome expectancies for condom use, sexual risk behavior, and STI testing history...
December 1, 2018: Journal of the National Medical Association
Dessa Bergen-Cico, Sandra D Lane, Robert H Keefe, David A Larsen, Anthony Panasci, Najah Salaam, Timothy Jennings-Bey, Robert A Rubinstein
The association of indirect exposure to firearm-related violence and standardized test scores among third grade elementary school children were analyzed using geospatial mapping of police department data for all gunshots in Syracuse, NY (n = 2, 127) and state standardized test scores from 2009-2015. Confirmed gunshots were geocoded and mapped across the city and neighborhood school catchment areas. Third grade standardized New York State test scores for English Language Arts (ELA) and math were coded as dichotomous variables of proficient and below proficient scores...
November 14, 2018: Social Work in Public Health
Carmela Dell'Aversano, Luciana Tartaglione, Giuseppe Polito, Karl Dean, Mariagrazia Giacobbe, Silvia Casabianca, Samuela Capellacci, Antonella Penna, Andrew D Turner
Paralytic shellfish toxins (PST) and tetrodotoxin (TTX) are naturally-occurring toxins that may contaminate the food chain, inducing similar neurological symptoms in humans. They are co-extracted under the same conditions and thus their combined detection is desirable. Whilst PST are regulated and officially monitored in Europe, more data on TTX occurrence in bivalves and gastropods are needed before meaningful regulations can be established. In this study, we used three separate analytical methods - pre-column oxidation with liquid chromatography and fluorescence detection, ultrahigh performance hydrophilic interaction liquid chromatography (HILIC) tandem mass spectrometry (MS/MS) and HILIC high resolution (HR) MS/MS - to investigate the presence of PST and TTX in seawater and shellfish (mussels, clams) collected in spring summer 2015 to 2017 in the Mediterranean Sea...
January 2019: Chemosphere
Heather L M Dacus, Victoria L Wagner, Elisè A Collins, Jacqueline M Matson, Margaret Gates, Sonja Hoover, Florence K L Tangka, Teri Larkins, Sujha Subramanian
BACKGROUND: The objective of this study was to evaluate an ongoing initiative to improve colorectal cancer (CRC) screening uptake in the New York State (NYS) Medicaid managed care population. METHODS: Patients aged 50 to 75 years who were not up to date with CRC screening and resided in 2 NYS regions were randomly assigned to 1 of 3 cohorts: no mailed reminder, mailed reminder, and mailed reminder + incentive (in the form of a $25 cash card). Screening prevalence and the costs of the intervention were summarized...
November 1, 2018: Cancer
Zhen Zhen, Qianqian Cao, Liyang Shao, Lianjun Zhang
Objective : The purpose of this study was to explore the full distribution of children's lead poisoning and identify "high risk" locations or areas in the neighborhood of the inner city of Syracuse (NY, USA), using quantile regression models. Methods : Global quantile regression (QR) and geographically weighted quantile regression (GWQR) were applied to model the relationships between children's lead poisoning and three environmental factors at different quantiles (25th, 50th, 75th, and 90th). The response variable was the incident rate of children's blood lead level ≥ 5 µg/dL in each census block, and the three predictor variables included building year, town taxable values, and soil lead concentration...
October 19, 2018: International Journal of Environmental Research and Public Health
Zulma Tovar-Spinoza, Robert Ziechmann, Stephanie Zyck
OBJECTIVE Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive treatment for the surgical treatment of epilepsy. In this paper, the authors report on clinical outcomes for a series of pediatric patients with tuberous sclerosis complex (TSC) and medication-refractory epileptogenic cortical tubers. METHODS A retrospective chart review was performed at SUNY Upstate Golisano Children's Hospital in Syracuse, New York. The authors included all cases involving pediatric patients (< 18 years) who underwent MRgLITT for ablation of epileptogenic cortical tubers between February 2013 and November 2015...
September 2018: Neurosurgical Focus
Zhen Zhen, Liyang Shao, Lianjun Zhang
Objective The purpose of this study is to identify the high-risk areas of children's lead poisoning in Syracuse, NY, USA, using spatial modeling techniques. The relationships between the number of children's lead poisoning cases and three socio-economic and environmental factors (i.e., building year and town taxable value of houses, and soil lead concentration) were investigated. Methods Spatial generalized linear models (including Poisson, negative binomial, Poisson Hurdle, and negative binomial Hurdle models) were used to model the number of children's lead poisoning cases using the three predictor variables at the census block level in the inner city of Syracuse...
August 21, 2018: International Journal of Environmental Research and Public Health
Michael H Cynamon, Ernest N Damianopoulos
To model the ART (antiretroviral therapeutic) drug interaction with the HIV-1 virus, a two-domain model is proposed that separates HIV-1 into a stable non-proliferating domain where the virus is integrated into the host resting memory CD4+ t cells; and, a second domain where the virus is in the blood in a rapidly reproductive state. ART inhibits blood HIV-1 reproduction levels sufficient to prevent progression to the AIDS end-stage, the principal goal of ART. There are 25 FDA approved antiretroviral drugs toward this goal grouped into 6 classes: NRTIs (nucleoside/nucleotide inhibitors), NNRTIs (non-nucleoside/nucleotide inhibitors), PIs (protease inhibitors), FIs (fusion inhibitors), CCR5s (chemokine cell receptor 5 antagonists), and INSTIs (integrase inhibitors)...
August 3, 2018: AIDS Research and Human Retroviruses
Shan Zhou, Cora J Young, Trevor C VandenBoer, Shawn F Kowal, Tara F Kahan
Indoor oxidizing capacity in occupied residences is poorly understood. We made simultaneous continuous time-resolved measurements of ozone (O3 ), nitric oxide (NO), nitrogen dioxide (NO2 ), and nitrous acid (HONO) for two months in an occupied detached home with gas appliances in Syracuse, NY. Indoor NO and HONO mixing ratios were higher than those outdoors, whereas O3 was much lower (sub-ppbv) indoors. Cooking led to peak NO, NO2 , and HONO levels 20-100 times greater than background levels; HONO mixing ratios of up to 50 ppbv were measured...
August 7, 2018: Environmental Science & Technology
Emily Ap Haigh, Olivia E Bogucki, Peter J Dearborn, Michael A Robbins, Merrill F Elias
A recent meta-analysis identified a prospective association between depression and cardiovascular disease; however, there was no association for studies with long-term follow-up periods. The literature has primarily focused on baseline depression status or symptoms, which may not capture the chronic nature of depression. This study examined the prospective relationship between depressive symptoms and cardiovascular disease up to 15 years later in 274 cardiovascular disease-free older adults. Depressive and anxiety symptoms, mean arterial pressure, and cardiovascular disease status were assessed...
June 1, 2018: Journal of Health Psychology
Peter J Dearborn, Merrill F Elias, Kevin J Sullivan, Cara E Sullivan, Michael A Robbins
OBJECTIVES: Prior studies have found associations between visual acuity (VA) and cognitive function. However, these studies used a limited range of cognitive measures and did not control for cardiovascular disease risk factors (CVD-RFs) and baseline function. The primary objective of this study was to analyze the associations of VA and cognitive performance using a thorough neuropsychological test battery. METHODS: This study used community-dwelling sample data across the sixth (2001-2006) and seventh (2006-2010) waves of the Maine-Syracuse Longitudinal Study (n=655)...
August 2018: Journal of the International Neuropsychological Society: JINS
Rishi Prasad, Stephan Kpoti Gunn, Clarence Alan Rotz, Heather Karsten, Greg Roth, Anthony Buda, Anne M K Stoner
Corn has been a pillar of American agriculture for decades and continues to receive much attention from the scientific community for its potential to meet the food, feed and fuel needs of a growing human population in a changing climate. By midcentury, global temperature increase is expected to exceed 2°C where local effects on heat, cold and precipitation extremes will vary. The Northeast United States is a major dairy producer, corn consumer, and is cited as the fastest warming region in the contiguous U...
2018: PloS One
Simone Arvisais-Anhalt, Matthew MacDougall, Michael Rosenthal, Peter Congelosi, Daniel F Farrell, Paula Rosenbaum
Free clinics provide healthcare to underserved patient populations, playing a critical role in the medical safety-net. Syracuse, New York has notable racial, socioeconomic, and educational disparities and is home to four free clinics. Little is known about these clinics' patient population. This study attempts to better define this population and the barriers they face accessing traditional care. We developed a 27-question survey investigating patient demographics, barriers to traditional healthcare, and experience at local free clinics...
December 2018: Journal of Community Health
Merrill F Elias, Georgina E Crichton, Peter J Dearborn, Michael A Robbins, Walter P Abhayaratna
Background: The aim of this study was to investigate prospective associations between type 2 diabetes mellitus status and the gold standard non-invasive method for ascertaining arterial stiffness, carotid femoral pulse wave velocity. Methods: The prospective analysis employed 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study. Pulse wave velocity at wave 7 (2006-2010) was compared between those with type 2 diabetes mellitus at wave 6 (2001-2006) ( n = 52) and non-diabetics at wave 6 ( n = 456), with adjustment for demographic factors, cardiovascular risk factors and lifestyle- and pulse wave velocity-related factors...
March 2018: Pulse (Basel, Switzerland)
Zhi-Wei Lai, Ryan Kelly, Thomas Winans, Ivan Marchena, Ashwini Shadakshari, Julie Yu, Maha Dawood, Ricardo Garcia, Hajra Tily, Lisa Francis, Stephen V Faraone, Paul E Phillips, Andras Perl
BACKGROUND: Patients with systemic lupus erythematosus have T-cell dysfunction that has been attributed to the activation of the mammalian target of rapamycin (mTOR). Rapamycin inhibits antigen-induced T-cell proliferation and has been developed as a medication under the generic designation of sirolimus. We assessed safety, tolerance, and efficacy of sirolimus in a prospective, biomarker-driven, open-label clinical trial. METHODS: We did a single-arm, open-label, phase 1/2 trial of sirolimus in patients with active systemic lupus erythematosus disease unresponsive to, or intolerant of, conventional medications at the State University of New York Upstate Medical University (Syracuse, NY, USA)...
March 24, 2018: Lancet
Robert Bifulco, Ross Rubenstein, Hosung Sohn
BACKGROUND: "Place-based" scholarships seek to improve student outcomes in urban school districts and promote urban revitalization in economically challenged cities. Say Yes to Education is a unique district-wide school reform effort adopted in Syracuse, NY, in 2008. It includes full-tuition scholarships for public and private universities, coupled with extensive wraparound support services in schools. OBJECTIVES: This study uses synthetic control methods to evaluate the effect of Say Yes on district enrollment and graduation rates...
December 2017: Evaluation Review
Rachael V Torres, Merrill F Elias, Georgina E Crichton, Gregory A Dore, Adam Davey
The aim of the present study was to examine the relationship between orthostatic changes in blood pressure (BP) and cognition, with consideration given to cardiovascular risk factors and lifestyle variables. The cross-sectional analysis included 961 community-dwelling participants of the Maine-Syracuse Longitudinal Study, for whom BP clinic measures (five sitting, five recumbent, and five standing) were obtained. Eighteen percent of participants had orthostatic hypotension (fall in systolic BP ≥20 mm Hg or diastolic BP ≥10 mm Hg upon standing) and 6% had orthostatic hypertension (rise in systolic BP ≥20 mm Hg)...
December 2017: Journal of Clinical Hypertension
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