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"Low Back Pain"

Abdullah M Abunimer, Hussam Abou-Al-Shaar, Timothy G White, Jian Y Li, David J Chalif
BACKGROUND: Metastatic subdural hematoma with dural metastasis in the setting of an underlying malignancy is a rare condition that is difficult to diagnose and associated with a poor prognosis. Knowledge of this rare entity is of a paramount importance to neurosurgeons as its diagnosis may affect the management plan and overall survival. Here, we report a rare case of atraumatic subdural hematoma with dural metastasis in a patient with poorly differentiated adenocarcinoma of unknown origin...
February 16, 2019: World Neurosurgery
Ke Wang, Sunli Hu, Ben Wang, Jianle Wang, Xiangyang Wang, Cong Xu
Oxidative stress has been reported to be closely associated with the development of intervertebral disc degeneration (IDD). IDD is one of the major causes of low back pain. Genistein (GES), one of the main isoflavones of soybean, has been shown to exert multiple biological functions on different diseases. Here, we tested the therapeutic potential of GES for IDD. In vitro experiments, we confirmed GES was nontoxic to rat nucleus pulposus cells (NPCs) within the concentration of 100 μM. Furthermore, GES was able to suppress apoptosis in tert-butyl hydroperoxide (TBHP)-treated NPCs...
February 18, 2019: Journal of Cellular Physiology
Deborah Solomonow-Avnon, Amir Herman, Uriel Giwnewer, Nimrod Rozen, Avi Elbaz, Amit Mor, Alon Wolf
Footwear devices that shift foot center of pressure (COP), thereby impacting lower-limb biomechanics to produce clinical benefit, have been studied regarding degenerative diseases of knee and hip joints, exhibiting evidence of clinical success. Ability to purposefully affect trunk biomechanics has not been investigated for this type of footwear. Fifteen healthy young male subjects underwent gait and electromyography analysis using a biomechanical device that shifts COP via moveable convex elements attached to the shoe sole...
February 12, 2019: Journal of Biomechanics
Nader Tarabeih, Adel Shalata, Svetlana Trofimov, Alexander Kalinkovich, Gregory Livshits
The development of low back pain (LBP) is often associated with obesity and sarcopenia. However, the mechanisms of this association remain unclear. To clarify this, we measured circulating levels of a selected panel of soluble factors, presumably involved in obesity and sarcopenia pathogenesis, and correlated them with several LBP-related characteristics, taking into account body composition and other relevant covariates. In the cross-sectional study of 1078 individuals, we collected data on self-reported LBP, body composition (including fat and skeletal muscle mass) assessed by the bioimpedance method and anthropometrically, and measured plasma levels of several cytokines by ELISA...
February 15, 2019: Cytokine
Joshua Goodwin, Bijon Das
A 23-year-old man with acute lymphoblastic leukemia presented to the emergency department without any history of constitutional symptoms (fatigue, anorexia, or weight loss), dyspnea, bruising, or bleeding. Presentation of acute leukemia solely as musculoskeletal pathology is common in pediatric populations but rare among adult patients. Recognizing this presentation of acute leukemia in adult patients could help prevent delayed diagnoses.
February 2019: Clinical practice and cases in emergency medicine
Steven D Jackson, Bethany A Wiering, Amanda A Herrmann, MacKenna A Hinz, Leah R Hanson
Introduction: Low back pain is a leading disability worldwide; however, it is not often the result of a serious underlying condition such as a tumor. As a result, diagnosis of a serious underlying cause of low back pain may be delayed, such as in this case. Case presentation: We describe a case of a man presenting with low back pain, who was eventually diagnosed with solitary bone plasmacytoma (SBP) causing spinal cord compression from approximately T7-T9. The patient was classified as T8 ASIA C-Incomplete Paraplegia...
2019: Spinal Cord Series and Cases
Sweekriti Sharma, Adrian C Traeger, Shiva Raj Mishra, Saurab Sharma, Chris G Maher
No abstract text is available yet for this article.
June 2019: Journal of Global Health
Carol A Flavell, Laurence G Marshman, Susan J Gordon
Real-time ultrasound imaging (US) to measure abdominal muscle dimensions has aided low back pain rehabilitation and research. Notwithstanding, ultrasound imaging measurement of transversus abdominis muscle activation in chronic low back pain populations has been characterized by variable and generally suboptimal intra-observer reliability. Methodological deficiencies of 'freehand' ultrasound imaging are uncontrolled probe-skin pressure, inclination and roll of the probe. Despite previous attempts to standardize these parameters, intra-observer reliability in chronic low back pain was poor to moderate (0...
February 2019: Ultrasound: Journal of the British Medical Ultrasound Society
Alex Bekker, Carolyn Kloepping, Shemille Collingwood
Oral formulations of meloxicam, a preferential cyclooxygenase-2 (COX-2) inhibitor, have long been used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, as well as various pain syndromes of skeletomuscular origin (e.g., low back pain). However, these preparations are rarely indicated for the treatment of acute pain due to a poor dissolution rate and consequently a slow onset of action. The recent introduction of an intravenous (IV) NanoCrystal Colloidal Dispersion formulation opens up the possibility of using this drug during the perioperative period...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
P Hampel, A Köpnick, S Roch
BACKGROUND: This study investigated the long-term effects (12 months post-rehabilitation) of a standard inpatient multidisciplinary rehabilitation program for patients with chronic low back pain (CLBP), in which a control group (CG) received pain competence training and an intervention group (IG) received combined pain competence and depression prevention training. METHODS: In this prospective control group study with cluster-block randomization, a total of n = 583 patients were included into per protocol analyses...
February 15, 2019: BMC Psychology
Brigitte Wirth, Fabienne Riner, Cynthia Peterson, Barry Kim Humphreys, Mazda Farshad, Susanne Becker, Petra Schweinhardt
Background: A close collaboration between surgeons and non-surgical spine experts is crucial for optimal care of low back pain (LBP) patients. The affiliation of a chiropractic teaching clinic to a university hospital with a large spine division in Zurich, Switzerland, enables such collaboration. The aim of this study was to describe the trajectories and outcomes of patients with chronic LBP referred from the spine surgery division to the chiropractic teaching clinic. Methods: The patients filled in an 11-point numeric rating scale (NRS) for pain intensity and the Bournemouth Questionnaire (BQ) (bio-psycho-social measure) at baseline and after 1 week, 1, 3, 6 and 12 months...
2019: Chiropractic & Manual Therapies
Azadeh Nazari, Shahram Naderi Mazjin, Mansour Shamsipour
Tramadol abuse is a critical and growing health concern in Asia. In Iran, tramadol abuse arises most commonly as a result of self-medicating that leads to tramadol dependence. Buprenorphine, a partial agonist of mu opioid receptors approved for the treatment of tramadol dependence, is administered sublingually due to its extensive first-pass metabolism and resulting low oral bioavailability. A 50-year-old man presenting with tramadol dependence after self-medicating for chronic low back pain experienced adverse reactions to a minimal dosage (0...
2019: Current Therapeutic Research, Clinical and Experimental
Joe Iwanaga, Emily Simonds, Maia Schumacher, Emre Yilmaz, Juan Altafulla, R Shane Tubbs
Superior cluneal nerve entrapment neuropathy is one cause of low back pain often referred to as "pseudosciatica." Studies have found that the superior cluneal nerve can arise variably from the T11 to L5. The osteofibrous tunnels formed by a groove on the iliac crest might compress the superior cluneal nerve. Therefore, the purpose of this study was to investigate the origin of the superior cluneal nerve and its course through such bony grooves. Twenty sides from ten fresh frozen Caucasian cadavers were used in this study...
February 11, 2019: World Neurosurgery
Marc Parisien, Alexander Samoshkin, Shannon N Tansley, Marjo H Piltonen, Loren J Martin, Nehme El-Hachem, Concetta Dagostino, Massimo Allegri, Jeffrey S Mogil, Arkady Khoutorsky, Luda Diatchenko
Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. In the current study, we identify molecular pathways contributing to chronic pain states through the analysis of global changes in the transcriptome of dorsal root ganglia, spinal cord, brain, and blood in mouse assays of nerve injury- and inflammation-induced pain...
January 3, 2019: Pain
Mamiko Noguchi, Michal Glinka, Graham R Mayberry, Kimihiro Noguchi, Jack P Callaghan
Potential alternatives for conventional sitting and standing postures are hybrid sit-stand postures (i.e., perching). The purposes of this study were i) to identify where lumbopelvic and pelvic angles deviate from sitting and standing and ii) to use these breakpoints to define three distinct postural phases: sitting, perching, and standing, in order to examine differences in muscle activations and ground reaction forces between phases. Twenty-four participants completed 19 one-minute static trials, from sitting (90°) to standing (180°), sequentially in 5°trunk-thigh angle increments...
February 14, 2019: Ergonomics
Michael Seth Smith, Jairo Olivas, Kristy Smith
Manipulative therapies include osteopathic manipulative treatment and many other forms of manual therapies used to manage a variety of conditions in adults and children. Spinal manipulative therapy may provide short-term improvement in patients with acute or chronic low back pain, comparable with other standard treatments. When compared with oral analgesics, cervical manipulation and/or mobilization appears to provide better short-term pain relief and improved function in patients with neck pain. Manipulative therapies may be as effective as amitriptyline for treating migraine headaches and can reduce the frequency and intensity of pain...
February 15, 2019: American Family Physician
Kangwu Chen, Hao Chen, Kai Zhang, Peng Yang, Jiajia Sun, Jianqiang Mo, Feng Zhou, Huilin Yang, Haiqing Mao
STUDY DESIGN: This is a retrospective study. OBJECTIVE: The purpose of this study is to compare the clinical outcomes between O-arm navigation combined with microscope-assisted minimally invasive transforaminal lumbar interbody fusion (novel MIS-TLIF) and open-TLIF for the treatment of 1-level lumbar degenerative disease. SUMMARY OF BACKGROUND DATA: MIS-TLIF is becoming increasingly popular; however, the limited visualization may increase various surgical complications...
February 12, 2019: Clinical Spine Surgery
Wei Wei, Hua-Yu Tang, Yu-Zhi Li, Tian-Shu Wang
BACKGROUND: Previous clinical trials have reported that extracorporeal shock wave (EPSW) can be used to treat low back pain (LBP), and have achieved satisfied effect. However, its effectiveness is still inconclusive. Thus, this systematic review will aim to assess the effectiveness and safety of EPSW for patients with LBP. METHODS: In this systematic review, the electronic databases of Cochrane Central Register of Controlled Trials, EMBASE, PUBMED, Cumulative Index to Nursing and Allied Health Literature, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and Wanfang Data will be searched from inception to January 1, 2019...
February 2019: Medicine (Baltimore)
Yunlong Zou, Ye Li, Jingchen Liu, Boyin Zhang, Rui Gu
RATIONALE: Gout occurs mainly in joints, but rarely in the spine. In the spine, urate crystals can cause intervertebral space instability but rarely lead to retrolisthesis. Here, we present an extremely rare disease with gout invaded the intervertebral disc with lumbar retrolisthesis. PATIENT CONCERNS: A 61-years male patient with gout history has suffered from severe low back pain and intermittent claudication. Physical examination showed the level of muscle strength of his left first toe was 3/5...
February 2019: Medicine (Baltimore)
Ayşegül Ceylan, İbrahim Aşık, Güngör Enver Özgencil, Burak Erken
Background/aim: We aimed to compare the results of the treatment of the patients with failed back surgery syndrome (FBSS) by mechanical lysis and steroid hylase injection via epiduroscopy due to their stabilization status and to detect the effect of pathological diagnostic markers on prognosis and ongoing treatment protocol. Materials and methods: Eighty-two patients with FBSS symptoms were included. Two groups were composed as group I (stabilized) and group II (nonstabilized)...
February 11, 2019: Turkish Journal of Medical Sciences
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