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Cold injury

Ming-Xiang Cheng, Jin-Zheng Li, Yong Chen, Ding Cao, Jian-Ping Gong, Bing Tu
BACKGROUND: Vascular endothelial growth factor receptor-3 (VEGFR-3) / vascular endothelial growth factor -c (VEGF-C) signaling is reported to negatively regulate TLR4-triggered inflammation of macrophages. This study aims to clarify whether the VEGFR-3/VEGF-C signaling can suppress Kupffer cells (KCs) activation and attenuate hepatic ischemia-reperfusion injury (IRI) after liver transplantation. METHODS: A rat model of liver transplantation was performed. Donor livers were perfused with VEGF-C injection via portal vein during cold preservation, and controls were perfused with UW solution...
February 13, 2019: Transplant Immunology
Michael F Bath, Sarah A Hosgood, Michael L Nicholson
BACKGROUND: The effects of renal allograft ischemic injury on vascular endothelial function have not been clearly established. The aim of this study was to examine vascular reactivity to acetylcholine (ACh) in kidneys subjected to ischemic injury and reperfusion. METHODS: Porcine kidneys were exposed to different combinations of warm ischemic time (WIT) and cold ischemic time (CIT) as follows: 15 min (n = 7), 60 min (n = 6), 90 min (n = 6), or 120 min (n = 4) WIT + 2 h CIT or 15 min WIT + 16 h CIT (n = 8)...
February 12, 2019: Journal of Surgical Research
Jenna M Crowe-Riddell, Bruno F Simões, Julian C Partridge, David M Hunt, Steven Delean, Julian G Schwerdt, James Breen, Alastair Ludington, David J Gower, Kate L Sanders
Dermal phototaxis has been reported in a few aquatic vertebrate lineages spanning fish, amphibians and reptiles. These taxa respond to light on the skin of their elongate hind-bodies and tails by withdrawing under cover to avoid detection by predators. Here, we investigated tail phototaxis in sea snakes (Hydrophiinae), the only reptiles reported to exhibit this sensory behaviour. We conducted behavioural tests in 17 wild-caught sea snakes of eight species by illuminating the dorsal surface of the tail and midbody skin using cold white, violet, blue, green and red light...
February 15, 2019: Molecular Ecology
Gregory Scott Troutman, Jason Salamon, Matthew Scharf, Jeremy A Mazurek
Osborn waves, or J waves, initially described by John Osborn in 1953 in hypothermic dog experiments, are highly sensitive and specific for hypothermia. Initially thought to be secondary to a hypothermia-induced "injury current," they have more recently been attributed to a voltage differential between epicardial and endocardial potassium (Ito ) currents. While the exact conditions required to induce such waves have been debated, numerous clinical scenarios of environmental and iatrogenic hypothermia have been described...
2019: Case Reports in Cardiology
Abhinandan S Patil, Dalia Maurer, Oleg Feygenberg, Noam Alkan
Mango quarantine is based mainly on heat treatment, with a possible deterioration of fruit quality. We studied the effects of cold quarantine (19 days storage at 2 °C) on fruit quality of commercial mango cvs. Keitt and Shelly for three consecutive years. Chilling injury (CI) occurs in mango fruit stored at temperatures lower than 12 °C. By reanalysing our previous transcriptome, we found that under sub-optimal temperature storage (5 °C), the fruit increases its ethylene biosynthesis and osmolarity by activating sugar metabolism, thereby probably reducing its freezing point...
February 13, 2019: Scientific Reports
Stefanie Hardt, Caroline Fischer, Alexandra Vogel, Annett Wilken-Schmitz, Irmgard Tegeder
Inflammation or injuries of the trigeminal nerve are often associated with persistent facial pain and its sequelae. A number of models have been described to study trigeminal pain in rodents, but the long-lasting behavioral consequences are unknown. The present study characterizes the impact of a distal infraorbital nerve injury, called DIONI, which consists of ligature and transection of distal fibers of the infraorbital nerve. We assessed nociception using a conflict paradigm and optogenetics, and a set of reward, aversion, spatial, temporal and competition tasks in the IntelliCage to study multiple aspects of cognition, circadian rhythms and social interactions in groups of mice in home cage environments...
February 8, 2019: Pain
Guiping Cheng, Dandan Ke, Meng Rao, Shifu Hu, Yingying Wang, Fang Zhou, Heyu Liu, Changhong Zhu, Wei Xia
Cold-inducible RNA-binding protein (CIRBP) is reduced by scrotal hyperthermia in cryptorchidism, varicocoele and heat treatment, but there is no direct evidence clarifying the relationship between CIRBP and spermatogenesis. The aim of this study was to investigate the expression of CIRBP in GC2-spd cells (a mouse spermatocyte cell line) before and after heat treatment, and to determine the effects of the downregulation or overexpression of CIRBP on spermatocyte cell proliferation and apoptosis. GC2-spd cells overexpressing CIRBP and GC2-spd cells in CIRBP was knocked down were constructed to investigate the function of CIRBP in cell proliferation and apoptosis using a cell counting kit-8 and flow cytometry respectively...
February 12, 2019: Reproduction, Fertility, and Development
Xingan Wang, Michael Emmet O'Brien, Junyi Yu, Liangfang Fu, Qiang Zhang, Songjian Lu, Xiaojing An, John F McDyer, Rama K Mallampalli
Primary graft dysfunction (PGD), a major cause of morbidity after lung transplantation, is linked to ischemia-reperfusion injury (IRI). Other factors such as preceding brain death (BD), hemorrhagic shock (HS), and pre-engraftment lung management are also important. We hypothesized that a multi-hit isogenic mouse model of lung transplantation is more closely linked to PGD than IRI alone. Left lung transplants were performed between inbred mice. A one-hit model of IRI was established by inducing cold ischemia (CI) to the donor lung at 0°C for 1h, 72h or 96h...
February 11, 2019: American Journal of Respiratory Cell and Molecular Biology
D Dondossola, C Lonati, A Zanella, M Maggioni, B Antonelli, P Reggiani, S Gatti, G Rossi
BACKGROUND: Machine perfusion is increasingly utilized in liver transplantation to face the detrimental consequences of the use of extended-criteria donors. Hypothermic oxygenated machine perfusion (HOPE) appears to be more protective relative to static cold storage. Conversely, normothermic machine perfusion (NMP) allows a better graft evaluation. We describe a pilot prospective study on machine perfusion in selected grafts. METHODS: HOPE was executed for all the grafts procured from donors after cardiac death (DCDs) and for livers from donors after brain death (DBDs) requiring prolonged preservation time...
January 2019: Transplantation Proceedings
Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, Shintaro Hashimoto, Masataka Sakisaka, Yasuko Narita, Daiki Yoshii, Lin Zhong, Yoshihiro Komohara, Xiao-Kang Li, Yukihiro Inomata, Taizo Hibi
BACKGROUND: Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts and graft loss. Some reports have found that molecular-hydrogen showed antioxidant and anti-inflammatory effects in preventing IRI in some non-hepatic transplant models...
February 8, 2019: BMC Gastroenterology
Jing Zhou, Nan Yao, Shuxia Wang, Dongchen An, Kangna Cao, Jiali Wei, Ning Li, Di Zhao, Lirui Wang, Xijing Chen, Yang Lu
ETHNOPHARMACOLOGICAL RELEVANCE: Fructus Gardenia (FG) is a widely used bitter and cold herb for clearing heat and detoxicating. Currently, toxicity of FG and its relative formula has been reported in many clinical and animal studies. However, no systematic research has been carried out on FG-related gastrointestinal (GI) injury which has been emphasized in China since the Ming Dynasty. AIM OF THE STUDY: The purpose of this article is to investigate whether FG could damage GI and explore the mechanisms involved...
February 5, 2019: Journal of Ethnopharmacology
Uwe Scheuermann, Minghua Zhu, Mingqing Song, John Yerxa, Qimeng Gao, Robert P Davis, Min Zhang, William Parker, Matthew G Hartwig, Jean Kwun, Todd V Brennan, Jaewoo Lee, Andrew S Barbas
INTRODUCTION: Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP. We hypothesized that there is a metabolism-dependent accumulation of damage-associated molecular patterns (DAMPs) and inflammatory cytokines during MP, and that these molecules provoke inflammation in the graft. METHODS: To stratify groups by metabolic rate, MP was performed on rat livers from standard donors at three different temperatures: room temperature, subnormothermic (30°C), and normothermic (37°C)...
February 7, 2019: Liver Transplantation
Martin Smith, B Dominguez-Gil, D M Greer, A R Manara, M J Souter
The continuing shortage of deceased donor organs for transplantation, and the limited number of potential donors after brain death, has led to a resurgence of interest in donation after circulatory death (DCD). The processes of warm and cold ischemia threaten the viability of DCD organs, but these can be minimized by well-organized DCD pathways and new techniques of in situ organ preservation and ex situ resuscitation and repair post-explantation. Transplantation survival after DCD is comparable to donation after brain death despite higher rates of primary non-function and delayed graft function...
February 6, 2019: Intensive Care Medicine
B P Mohan, R Krishnamoorthi, S Ponnada, M Shakhatreh, M Jayaraj, R Garg, J Law, M Larsen, S Irani, A Ross, D G Adler
Radiofrequency ablation (RFA) is the preferred treatment option for Barrett's esophagus (BE) to achieve complete eradication (CE) of dysplasia (D), and intestinal metaplasia (IM). Cryotherapy, using liquid nitrogen (LNC), is a cold-induced tissue-injury technique option for the ablation of BE. We conducted a systematic review and meta-analysis to assess the overall efficacy and safety of LNC in the treatment of BE.We conducted a search of multiple electronic databases and conference proceedings from inception through June 2018...
January 31, 2019: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Micaela Pagliari, Carlo Raimondo Menna, Avraam Christodoulidis, Michele Soldà, Marco Molinari
BACKGROUND AND AIM OF THE WORK: Hypothenar Hammer Syndrome is a relatively rare disease process caused by repetitive stress or injury to the hypothenar eminence leading to chronic injury to the ulnar artery. Our study reports an unusual case. METHODS: A 57 years old Plumber presented in April 2016 with a history of constant pain and recurrent paresthesia involving the fingers of the right hand for several months, over the previous 1 year, his hand had become more intolerant of exposure to cold temperatures...
December 20, 2018: Acta Bio-medica: Atenei Parmensis
Geoffrey K Dube, Corey Brennan, S Ali Husain, R John Crew, Mariana C Chiles, David J Cohen, Sumit Mohan
While deceased donor renal transplants (DDRT) from donors with either acute kidney injury (AKI) or long cold ischemia time (CIT) are associated with increased risk of delayed graft function (DGF), recipients of these kidneys have good patient and allograft survival. There are limited data on whether kidneys with both AKI and long CIT have outcomes similar to kidneys with only one of these insults. Using data from the Scientific Registry of Transplant Recipients, we analyzed transplant outcomes in patients (2005-2015) receiving kidneys with AKI (terminal creatinine ≥2...
February 3, 2019: Transplant International: Official Journal of the European Society for Organ Transplantation
James Papworth, L Osborne, M A Shimmings, C C S Roberts
INTRODUCTION: In April 2017, 22% of Army Full-time Trade Trained Strength was downgraded, reducing fully deployable strength to 60 546, against a target of 82 000. In June 2017, Commander 20 Armoured Infantry Brigade (20 AI Bde) initiated a study to look at the principal conditions causing medical downgrading, as a stepping stone to finding ways of reducing injury, enhancing rehabilitation and improving deployability. METHOD: The Defence Medical Information Capability Programme medical records for every downgraded soldier in 20 AI Bde and supporting units were scrutinised to identify their Medical Deployment Standard and the primary condition causing downgrading...
February 2, 2019: Journal of the Royal Army Medical Corps
Tim van Smaalen, Shane R Ellis, Nadine E Mascini, Tiffany Porta, Berta Cillero-Pastor, Lisa M Hillen, L W Ernest van Heurn, Carine J Peutz-Kootstra, Ron M A Heeren
The increasing analytical speed of mass spectrometry imaging (MSI) has led to growing interest in the medical field. Acute kidney injury is a severe disease with high morbidity and mortality. No reliable cut-offs are known to estimate the severity of acute kidney injury. Thus, there is a need for new tools to rapidly and accurately assess acute ischemic, which is of clinical importance in the intensive care and in kidney transplantation. We investigated the value of MSI to assess acute ischemic kidney tissue in a porcine model...
January 31, 2019: Analytical Chemistry
Tanya Onushko, Gordhan Mahtani, Gabrielle Brazg, T George Hornby, Brian D Schmit
The purpose of this study was to understand how high and low intensity locomotor training (LT) affects sympathetic-somatomotor coupling in people with incomplete spinal cord injury (SCI). Proper coupling between sympathetic and somatomotor systems allows controlled regulation of cardiovascular responses to exercise. In people with SCI, altered connectivity between descending pathways and spinal segments impairs sympathetic and somatomotor coordination, which may have deleterious effects during exercise and limit rehabilitation outcomes...
January 30, 2019: Journal of Neurotrauma
Naomi-Liza Denning, Weng-Lang Yang, Laura Hansen, Jose Prince, Ping Wang
INTRODUCTION: Neonatal sepsis remains a leading cause of infant mortality. Cold-inducible RNA binding protein (CIRP) is an inflammatory mediator that induces TNF-α production in macrophages. C23 is a CIRP-derived peptide that blocks CIRP from binding its receptor. We therefore hypothesized that treatment with C23 reduces systemic inflammation and protects the lungs in neonatal sepsis. METHODS: Sepsis was induced in C56BL/6 mouse pups (5-7 days) by intraperitoneal injection of adult cecal slurry (0...
January 4, 2019: Journal of Pediatric Surgery
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