keyword
https://read.qxmd.com/read/38529380/a-dynamic-study-of-vegf-a-sidox-evs-trafficking-through-the-in-vitro-insert-co-culture-blood-brain-barrier-model-by-digital-holographic-microscopy
#1
JOURNAL ARTICLE
Parisa Shamshiripour, Mehrana Rahnama, Mehdi Nikoobakht, Fahimeh Hajiahmadi, Ali-Reza Moradi, Davoud Ahmadvand
INTRODUCTION: Modeling the blood-brain barrier has long been a challenge for pharmacological studies. Up to the present, numerous attempts have been devoted to recapitulating the endothelial barrier in vitro to assess drug delivery vehicles' efficiency for brain disorders. In the current work, we presented a new approach for analyzing the morphometric parameters of the cells of an insert co-culture blood-brain barrier model using rat brain astrocytes, rat brain microvascular endothelial cells, and rat brain pericytes...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38509074/dmrta2-supports-glioma-stem-cell-mediated-neovascularization-in-glioblastoma
#2
JOURNAL ARTICLE
Marta Maleszewska, Kamil Wojnicki, Jakub Mieczkowski, Sylwia K Król, Karol Jacek, Magdalena Śmiech, Marta Kocyk, Iwona A Ciechomska, Mateusz Bujko, Janusz Siedlecki, Katarzyna Kotulska, Wiesława Grajkowska, Małgorzata Zawadzka, Bozena Kaminska
Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance survival times are less than two years for patients with IDH-wildtype GBM. GBM is noted for the considerable cellular heterogeneity, high stemness indices and abundance of the glioma stem-like cells known to support tumor progression, therapeutic resistance and recurrence. Doublesex- and mab-3-related transcription factor a2 (DMRTA2) is involved in maintaining neural progenitor cells (NPC) in the cell cycle and its overexpression suppresses NPC differentiation...
March 20, 2024: Cell Death & Disease
https://read.qxmd.com/read/38493151/gli1-mediated-tumor-cell-derived-bfgf-promotes-tumor-angiogenesis-and-pericyte-coverage-in-non-small-cell-lung-cancer
#3
JOURNAL ARTICLE
Xueping Lei, Zhan Li, Manting Huang, Lijuan Huang, Yong Huang, Sha Lv, Weisong Zhang, Zhuowen Chen, Yuanyu Ke, Songpei Li, Jingfei Chen, Xiangyu Yang, Qiudi Deng, Junshan Liu, Xiyong Yu
BACKGROUND: Tumor angiogenesis inhibitors have been applied for non-small cell lung cancer (NSCLC) therapy. However, the drug resistance hinders their further development. Intercellular crosstalk between lung cancer cells and vascular cells was crucial for anti-angiogenenic resistance (AAD). However, the understanding of this crosstalk is still rudimentary. Our previous study showed that Glioma-associated oncogene 1 (Gli1) is a driver of NSCLC metastasis, but its role in lung cancer cell-vascular cell crosstalk remains unclear...
March 16, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38455669/blocking-tgf-%C3%AE-and-epithelial-to-mesenchymal-transition-emt-mediated-activation-of-vessel-associated-mural-cells-in-glioblastoma-impacts-tumor-angiogenesis
#4
JOURNAL ARTICLE
Luisa Merk, Katja Regel, Hermann Eckhardt, Marietheres Evers, Ali El-Ayoubi, Michel Mittelbronn, Marcel Krüger, Jean-Jacques Gérardy, Andreas F Mack, Ulrike Naumann
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. GBM displays excessive and unfunctional vascularization which may, among others, be a reason for its devastating prognosis. Pericytes have been identified as the major component of the irregular vessel structure in GBM. In vitro data suggest an epithelial-to-mesenchymal transition (EMT)-like activation of glioma-associated pericytes, stimulated by GBM-secreted TGF-β, to be involved in the formation of a chaotic and dysfunctional tumor vasculature...
January 2024: Free neuropathology
https://read.qxmd.com/read/37752585/tumor-microenvironment-in-a-minipig-model-of-spinal-cord-glioma
#5
JOURNAL ARTICLE
Muhibullah S Tora, Stewart G Neill, Yuliya Lakhina, Hemza Assed, Michelle Zhang, Purva P Nagarajan, Thais Federici, Juanmarco Gutierrez, Kimberly B Hoang, Yuhong Du, Kecheng Lei, Nicholas M Boulis
BACKGROUND: Spinal cord glioma (SCG) is considered an orphan disease that lacks effective treatment options with margins that are surgically inaccessible and an overall paucity of literature on the topic. The tumor microenvironment is a critical factor to consider in treatment and modeling design, especially with respect to the unresectable tumor edge. Recently, our group developed a high-grade spinal cord glioma (SCG) model in Göttingen minipigs. METHODS: Immunofluorescence and ELISA were performed to explore the microenvironmental features and inflammation cytokines in this minipig SCG model...
September 27, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37710025/intratumoral-thrombosis-as-a-histological-biomarker-for-predicting-epidermal-growth-factor-receptor-alteration-and-poor-prognosis-in-patients-with-glioblastomas
#6
JOURNAL ARTICLE
Takuya Furuta, Tetsuya Negoto, Hiroaki Miyoshi, Mayuko Moritsubo, Hideo Nakamura, Motohiro Morioka, Jun Akiba, Koichi Ohshima, Yasuo Sugita
PURPOSE: Intratumoral thrombosis is a specific finding in glioblastomas and considered the origin of palisading necrosis. Its distribution and contribution to the glioblastoma pathophysiology and systemic thrombosis are obscure, although deep vein thrombosis is a common complication in glioblastoma cases. METHODS: Clinicopathological and genetic analyses were performed on 97 glioblastoma tissue specimens to elucidate the role of thrombotic events and associated molecular abnormalities...
September 14, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/37403213/documented-growth-of-an-intracranial-capillary-hemangioma-a-case-report
#7
Abigale D MacLellan, Alexander S Easton, Rufus Alubankudi, Gwynedd E Pickett
Intracranial capillary hemangiomas in adults are rare, and diagnosis can be challenging. Hemangiomas, in general (and particularly in the skin), are more often noted in the pediatric population. Due to the lack of imaging undertaken in the presymptomatic phase, the literature provides few clues on the rate of growth of these unusual tumors. Therefore, we report a case of a 64-year-old man with a medical history of Lyme disease who presented with exhaustion and confusion. Imaging demonstrated an intra-axial lesion with vascularity in the posterior right temporal lobe, raising the possibility of a glioma...
July 4, 2023: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://read.qxmd.com/read/37355636/on-the-origin-and-development-of-glioblastoma-multifaceted-role-of-perivascular-mesenchymal-stromal-cells
#8
REVIEW
F Ah-Pine, M Khettab, Y Bedoui, Y Slama, M Daniel, B Doray, P Gasque
Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. The exact mechanisms of glioblastoma oncogenesis, including the identification of the glioma-initiating cell, are yet to be discovered. Recent studies have led to the hypothesis that glioblastoma arises from neural stem cells and glial precursor cells and that cell lineage constitutes a key determinant of the glioblastoma molecular subtype. These findings brought significant advancement to the comprehension of gliomagenesis...
June 24, 2023: Acta Neuropathologica Communications
https://read.qxmd.com/read/37315748/glioma-derived-small-extracellular-vesicles-induce-pericyte-phenotype-transition-of-glioma-stem-cells-under-hypoxic-conditions
#9
JOURNAL ARTICLE
Yue Cheng, Shijie Li, Yongying Hou, Weijun Wang, Ke Wang, Shihui Fu, Ye Yuan, Kaidi Yang, Xiufeng Ye
BACKGROUND: Glioblastoma (GBM) is the most common and lethal primary brain tumor characterized by extensive vascularization. Anti-angiogenic therapy for this cancer offers the possibility of universal efficacy. However, preclinical and clinical studies suggest that anti-VEGF drug such as Bevacizumab actively promotes tumor invasion, which ultimately leads to a therapy-resistant and recurrent phenotype of GBMs. Whether Bevacizumab can improve survival over chemotherapy alone remains debated...
June 12, 2023: Cellular Signalling
https://read.qxmd.com/read/37144386/astrocytoma-and-glioblastoma-idh1-wildtype-cells-colonize-tumor-vessels-and-deploy-vascular-mimicry
#10
JOURNAL ARTICLE
Haitham H Maraqah, Mones S Abu-Asab, Han Sung Lee, Orwa Aboud
Gliomas are the most prevalent type of malignant brain tumors with a very dismal prognosis. Angiogenesis in glioma has recently gotten more attention and its molecular aspects have been published; however, these were not complemented with ultrastructural evidence. Our ultrastructural examination of glioma vessels reveals several unique and critical features related to their mechanisms of progression and metastasis strategy. The detailed ultrastructural survey of 18 isocitrate dehydrogenase-wildtype (IDH1-wt) glioblastomas and 12 isocitrate dehydrogenase-mutant (IDH1-mt) High-grade gliomas indicated that tumor vessels of both types had undergone deformities such as the thickening of the vessel wall (VW) and proliferation of the basement membrane, contour distortions, abnormal and discontinuous basal lamina, tumor cells' invasion and colonization of VW, disappearance of endothelial cells (ECs), pericytes, and smooth muscle cells, as well as the formation of a continuous ring of tumor cells attached to the luminal side of VW in numerous cases...
May 5, 2023: Ultrastructural Pathology
https://read.qxmd.com/read/37029364/ancient-ubiquitous-protein-1-aup1-is-a-prognostic-biomarker-connected-with-tp53-mutation-and-the-inflamed-microenvironments-in-glioma
#11
JOURNAL ARTICLE
Pei-Chi Chang, Yu-Chieh Lin, Hui-Ju Yen, Dueng-Yuan Hueng, Shih-Ming Huang, Yao-Feng Li
INTRODUCTION: Glioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and chemotherapy, Temozolomide (TMZ). However, tumors tend to develop TMZ resistance which leads to therapeutic failure. Ancient ubiquitous protein 1 (AUP1) is a protein associated with lipid metabolism, which is widely expressed on the surface of ER and Lipid droplets, involved in the degradation of misfolded proteins through autophagy. It has recently been described as a prognostic marker in renal tumors...
April 7, 2023: Cancer Cell International
https://read.qxmd.com/read/36712042/astrocytoma-and-idh1-wildtype-glioblastoma-gbm-cells-colonize-tumor-vessels-and-deploy-vascular-mimicry
#12
Haitham H Maraqah, Mones S Abu-Asab, Han Sung Lee, Orwa Aboud
Gliomas are the most prevalent type of malignant brain tumors with a very dismal prognosis. Angiogenesis in glioma has recently gotten more attention and its molecular aspects have been published; however, these were not complemented with ultrastructural evidence. Our ultrastructural examination of glioma vessels reveals several unique and critical features related to their mechanisms of progression and metastasis strategy. The detailed ultrastructural survey of 18 IDH1 -wildtype glioblastomas (GBM) and 12 IDH1 -mutant High-grade gliomas indicated that tumor vessels of both types had undergone deformities such as the thickening of the vessel wall (VW) and proliferation of the basement membrane, contour distortions, abnormal and discontinuous basal lamina, tumor cells' invasion and colonization of VW, disappearance of endothelial cells (ECs), pericytes, and smooth muscle cells, as well as the formation of a continuous ring of tumor cells attached to the luminal side of VW in numerous cases...
January 17, 2023: Research Square
https://read.qxmd.com/read/36623589/heterogeneity-of-cgmp-signalling-in-tumour-cells-and-the-tumour-microenvironment-challenges-and-chances-for-cancer-pharmacology-and-therapeutics
#13
REVIEW
Daniel Stehle, Mariagiovanna Barresi, Jennifer Schulz, Robert Feil
The second messenger cyclic guanosine monophosphate (cGMP) is an important regulator of human (patho-)physiology and has emerged as an attractive drug target. Currently, cGMP-elevating drugs are mainly used to treat cardiovascular diseases, but there is also increasing interest in exploring their potential for cancer prevention and therapy. In this review article, we summarise recent findings in cancer-related cGMP research, with a focus on melanoma, breast cancer, colorectal cancer, prostate cancer, glioma, and ovarian cancer...
January 6, 2023: Pharmacology & Therapeutics
https://read.qxmd.com/read/36261421/p300-promotes-tumor-recurrence-by-regulating-radiation-induced-conversion-of-glioma-stem-cells-to-vascular-like-cells
#14
JOURNAL ARTICLE
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G Alvarado, Michael C Condro, Fuying Gao, Raymond Gau, Maria G Castro, Pedro R Lowenstein, Arjun Deb, Jason D Hinman, Frank Pajonk, Terry C Burns, Steven A Goldman, Daniel H Geschwind, Harley I Kornblum
Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and whole transcriptomic analyses to uncover that radiation induces a dynamic shift in functional states of glioma cells allowing for acquisition of vascular endothelial-like and pericyte-like cell phenotypes. These vascular-like cells provide trophic support to promote proliferation of tumor cells, and their selective depletion results in reduced tumor growth post-treatment in vivo...
October 19, 2022: Nature Communications
https://read.qxmd.com/read/36261010/a-molecular-interactome-of-the-glioblastoma-perivascular-niche-reveals-integrin-binding-sialoprotein-as-a-mediator-of-tumor-cell-migration
#15
JOURNAL ARTICLE
Yasmin Ghochani, Sree Deepthi Muthukrishnan, Alireza Sohrabi, Riki Kawaguchi, Michael C Condro, Soniya Bastola, Fuying Gao, Yue Qin, Jack Mottahedeh, M Luisa Iruela-Arispe, Nagesh Rao, Dan R Laks, Linda M Liau, Gary W Mathern, Steven A Goldman, S Thomas Carmichael, Ichiro Nakano, Giovanni Coppola, Stephanie K Seidlits, Harley I Kornblum
Glioblastoma (GBM) is characterized by extensive microvascular hyperproliferation. In addition to supplying blood to the tumor, GBM vessels also provide trophic support to glioma cells and serve as conduits for migration into the surrounding brain, promoting recurrence. Here, we enrich CD31-expressing glioma vascular cells (GVCs) and A2B5-expressing glioma tumor cells (GTCs) from primary GBM and use RNA sequencing to create a comprehensive molecular interaction map of the secreted and extracellular factors elaborated by GVCs that can interact with receptors and membrane molecules on GTCs...
October 18, 2022: Cell Reports
https://read.qxmd.com/read/36233730/glioma-shapes-blood-brain-barrier-integrity-and-remodels-the-tumor-microenvironment-links-with-clinical-features-and-prognosis
#16
JOURNAL ARTICLE
Xiaokai Li, Lei Li, Ke Zhou, Huixiang Zhang, Ali Abdi Maalim, Xingyu Chen, Ximiao He, Xinmin Ding, Chuanrui Xu, Yonghong Wang
BACKGROUND: The presence of the blood-brain barrier (BBB) uniquely distinguishes the brain from other organs, and various brain pathologies, including cancer, can disrupt or breach the BBB. The specific implications of BBB alterations in glioma have not been sufficiently clarified. METHODS: In this study, statistical analysis of the TCGA pan-glioma dataset and four other validation cohorts was used to investigate the infiltration of BBB constituent cells (endothelial cells, pericytes and astrocytes) in the glioma tumor microenvironment (TME)...
October 4, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36201955/construction-of-a-novel-blood-brain-barrier-glioma-microfluidic-chip-model-applications-in-the-evaluation-of-permeability-and-anti-glioma-activity-of-traditional-chinese-medicine-components
#17
JOURNAL ARTICLE
Yiwei Shi, Xiaoli He, Hui Wang, Jianying Dai, Jiahao Fang, Yuzhen He, Xiaofei Chen, Zhanying Hong, Yifeng Chai
Since most anti-glioma drug candidates hardly permeate through the blood-brain barrier (BBB), preclinical models that can integrate the complexity of the tumor microenvironment and the structure and function of the BBB is urgently needed for the treatment of glioma. Herein, we constructed an in vitro BBB-glioma microfluidic chip model lined by primary human brain microvascular endothelial cells, pericytes, astrocytes and glioma cells, which could recapitulate the high level of barrier function of the in vivo human BBB and glioma microenvironment...
September 29, 2022: Talanta
https://read.qxmd.com/read/36200383/vascular-adhesion-protein-1-vap-1-in-vascular-inflammatory-diseases
#18
REVIEW
Marianna Danielli, Roisin Clare Thomas, Lauren Marie Quinn, Bee Kang Tan
<b/>Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes...
November 2022: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/36118697/identification-of-a-6-rbp-gene-signature-for-a-comprehensive-analysis-of-glioma-and-ischemic-stroke-cognitive-impairment-and-aging-related-hypoxic-stress
#19
JOURNAL ARTICLE
Weiwei Lin, Qiangwei Wang, Yisheng Chen, Ning Wang, Qingbin Ni, Chunhua Qi, Qian Wang, Yongjian Zhu
There is mounting evidence that ischemic cerebral infarction contributes to vascular cognitive impairment and dementia in elderly. Ischemic stroke and glioma are two majorly fatal diseases worldwide, which promote each other's development based on some common underlying mechanisms. As a post-transcriptional regulatory protein, RNA-binding protein is important in the development of a tumor and ischemic stroke (IS). The purpose of this study was to search for a group of RNA-binding protein (RBP) gene markers related to the prognosis of glioma and the occurrence of IS, and elucidate their underlying mechanisms in glioma and IS...
2022: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/35871725/-latest-research-findings-on-the-role-of-non-tumor-cells-in-glioma-microenvironment
#20
REVIEW
Ming-Rong Zuo, Yan-Hui Liu
As the tumor cell-centered treatment strategies cannot curb the malignant progression of glioblastoma effectively, the therapeutic effect of glioblastoma is still not satisfactory. In addition to glioma cells, glioma microenvironment (GME) comprises massive numbers of non-tumor cells and soluble cytokines. The non-tumor cells include endothelial cells, pericytes, microglia/macrophages, mesenchymal cells, astrocytes, neurons, etc. These non-tumor cell components, together with glioma cells, form one organism which regulates the progression of glioma...
July 2022: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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