Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G Alvarado, Michael C Condro, Fuying Gao, Raymond Gau, Maria G Castro, Pedro R Lowenstein, Arjun Deb, Jason D Hinman, Frank Pajonk, Terry C Burns, Steven A Goldman, Daniel H Geschwind, Harley I Kornblum
Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and whole transcriptomic analyses to uncover that radiation induces a dynamic shift in functional states of glioma cells allowing for acquisition of vascular endothelial-like and pericyte-like cell phenotypes. These vascular-like cells provide trophic support to promote proliferation of tumor cells, and their selective depletion results in reduced tumor growth post-treatment in vivo...
October 19, 2022: Nature Communications