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https://read.qxmd.com/read/30742700/micrornas-new-biomarkers-and-promising-therapeutic-targets-for-diabetic-kidney-disease
#1
Linicene Rosa do Nascimento, Caroline Pereira Domingueti
Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus associated with significant morbidity and mortality regarded as a global health issue. MicroRNAs - small RNA molecules responsible for the post-transcriptional regulation of gene expression by degradation of messenger RNA or translational repression of protein synthesis - rank among the factors linked to the development and progression of DKD. This study aimed to offer a narrative review on investigations around the use of microRNAs in the diagnosis, monitoring, and treatment of DKD...
February 7, 2019: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://read.qxmd.com/read/30740171/predictors-of-renal-dysfunction-in-adults-with-childhood-vesicoureteral-reflux-after-long-term-follow-up
#2
Smiljana Bundovska-Kocev, Dafina Kuzmanovska, Gjulsen Selim, Ljubica Georgievska-Ismail
BACKGROUND: Triad of childhood vesicoureteral reflux (VUR), urinary infection (UTI) and renal scarring might initiate potentially serious consequences that lead to renal dysfunction manifested at the second or third decade of life. AIM: To identify the risk factors predictive for renal dysfunction in adults with primary VUR after long-term follow-up. METHODS: We evaluated the records of 101 children (94.1% female, 5.9% male) at a median age of 5...
January 15, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30717885/usefulness-of-left-ventricular-strain-by-cardiac-magnetic-resonance-feature-tracking-to-predict-cardiovascular-events-in-patients-with-and-without-heart-failure
#3
Mayank Sardana, Prasad Konda, Zeba Hashmath, Garrett Oldland, Swetha Gaddam, Rachana Miller, Vaibhav Satija, Bilal Ansari, Jonathan Lee, Anique Mustafa, Scott R Akers, Julio A Chirinos
There is controversy regarding the utility of left ventricular (LV) mechanics assessed by feature-tracking steady-state free-precession (FT-SSFP), a readily implementable technique in clinical practice. In particular, whether LV mechanics assessed by FT-SSFP predicts outcomes in subjects with heart failure (HF) with reduced ejection fraction (HFrEF), with preserved ejection fraction (HFpEF), or without HF is unknown. We aimed to assess whether LV mechanics measured with FT-SSFP cine magnetic resonance imaging (MRI) predicts adverse outcomes...
January 25, 2019: American Journal of Cardiology
https://read.qxmd.com/read/30680271/diagnostic-value-of-gauze-filtration-technique-a-comparison-with-conventional-methods-in-a-diagnostic-laboratory-in-pakistan
#4
Naima Maqsood, Aymen Shakeel, Najia K Ghanchi, Ahmed Raheem, Feroz Zaheruddin, Ghazala Jabeen, Afsheen Raza, Mohammad A Beg
Background Intestinal parasites cause significant morbidity and impact human development with an enormous global burden. Diagnosis of intestinal parasites by conventional methods has several limitations. The gauze filtration technique is a relatively simple method that has been shown to identify intestinal parasites with a high sensitivity and specificity. The aim of this study was to determine the diagnostic value of this technique as compared to more conventional methods in a large acclaimed laboratory within Pakistan...
November 19, 2018: Curēus
https://read.qxmd.com/read/30679704/the-association-between-intraoperative-urine-output-and-postoperative-acute-kidney-injury-differs-between-partial-and-radical-nephrectomy
#5
Min Hur, Sun-Kyung Park, Seokha Yoo, Sheung-Nyoung Choi, Chang Wook Jeong, Won Ho Kim, Jin-Tae Kim, Cheol Kwak, Jae-Hyon Bahk
We sought to investigate the association between intraoperative urine output and postoperative acute kidney injury (AKI) in patients undergoing radical and partial nephrectomy. We retrospectively reviewed data of 742 patients. Postoperative AKI was defined by the Kidney Disease: Improving Global Outcomes criteria. The relationship between intraoperative urine output and the risk of AKI was evaluated by multivariable logistic regression analysis in radical and partial nephrectomy, separately. Minimum P-value approach was used to find the optimal threshold of intraoperative oliguria associated with the risk of AKI...
January 24, 2019: Scientific Reports
https://read.qxmd.com/read/30655133/long-term-glomerular-filtration-rate-and-kidney-disease-improving-global-outcomes-stage-stability-after-conversion-to-once-daily-tacrolimus-in-kidney-transplant-recipients
#6
F Tinti, I Umbro, L Poli, A Cappoli, M Garofalo, A Bachetoni, M D D'Alessandro, S Lai, P B Berloco, A P Mitterhofer
Close monitoring of estimated glomerular filtration rate (eGFR) is important for early recognition of worsening renal function to prevent further deterioration. Safe conversion from twice-daily tacrolimus (TD-Tac) to once-daily tacrolimus (OD-Tac) has been reported, but the effects on eGFR are contrasting. The aim of our study is to evaluate long-term stability of eGFR after 1:1 conversion from TD-Tac to OD-Tac and the effects on serum cytokine blood levels. Forty-six consecutive kidney transplant recipients treated with TD-Tac 3 to 5 years post-transplant, with stable renal function, were enrolled in the study (2009-2011)...
January 2019: Transplantation Proceedings
https://read.qxmd.com/read/30647177/osteopontin-and-disease-activity-in-patients-with-recent-onset-systemic-lupus-erythematosus-results-from-the-slicc-inception-cohort
#7
Lina Wirestam, Helena Enocsson, Thomas Skogh, Leonid Padyukov, Andreas Jönsen, Murray B Urowitz, Dafna D Gladman, Juanita Romero-Diaz, Sang-Cheol Bae, Paul R Fortin, Jorge Sanchez-Guerrero, Ann E Clarke, Sasha Bernatsky, Caroline Gordon, John G Hanly, Daniel Wallace, David A Isenberg, Anisur Rahman, Joan Merrill, Ellen Ginzler, Graciela S Alarcón, W Winn Chatham, Michelle Petri, Munther Khamashta, Cynthia Aranow, Meggan Mackay, Mary Anne Dooley, Susan Manzi, Rosalind Ramsey-Goldman, Ola Nived, Kristjan Steinsson, Asad Zoma, Guillermo Ruiz-Irastorza, Sam Lim, Ken Kalunian, Murat Inanc, Ronald van Vollenhoven, Manuel Ramos-Casals, Diane L Kamen, Søren Jacobsen, Christine Peschken, Anca Askanase, Thomas Stoll, Ian N Bruce, Jonas Wetterö, Christopher Sjöwall
OBJECTIVE: In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. METHODS: We included 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who had 5 years of followup data available...
January 15, 2019: Journal of Rheumatology
https://read.qxmd.com/read/30631159/association-between-early-stage-chronic-kidney-disease-and-reduced-choroidal-thickness-in-essential-hypertensive-patients
#8
Giuseppe Mulè, Maria Vadalà, Tiziana La Blasca, Rossella Gaetani, Giuseppe Virone, Marco Guarneri, Massimo Castellucci, Giulia Guarrasi, Micol Terrasi, Santina Cottone
The introduction in the past few years of advanced optical coherence tomography (OCT) techniques has greatly increased our understanding of the choroid, which is the most important vascular layer of the eye. Our study aimed to assess choroidal thickness by using swept-source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without early-stage chronic kidney disease (CKD). We enrolled 100 EHs, of whom 65 were without kidney damage, and 35 had stage 1-3 CKD. In all of the participants, SS-OCT and a routine biochemical workup were performed...
January 10, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/30630856/adiposity-and-risk-of-decline-in-glomerular-filtration-rate-meta-analysis-of-individual-participant-data-in-a-global-consortium
#9
Alex R Chang, Morgan E Grams, Shoshana H Ballew, Henk Bilo, Adolfo Correa, Marie Evans, Orlando M Gutierrez, Farhad Hosseinpanah, Kunitoshi Iseki, Timothy Kenealy, Barbara Klein, Florian Kronenberg, Brian J Lee, Yuanying Li, Katsuyuki Miura, Sankar D Navaneethan, Paul J Roderick, Jose M Valdivielso, Frank L J Visseren, Luxia Zhang, Ron T Gansevoort, Stein I Hallan, Andrew S Levey, Kunihiro Matsushita, Varda Shalev, Mark Woodward
OBJECTIVE: To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality. DESIGN: Individual participant data meta-analysis. SETTING: Cohorts from 40 countries with data collected between 1970 and 2017. PARTICIPANTS: Adults in 39 general population cohorts (n=5 459 014), of which 21 (n=594 496) had data on waist circumference; six cohorts with high cardiovascular risk (n=84 417); and 18 cohorts with chronic kidney disease (n=91 607)...
January 10, 2019: BMJ: British Medical Journal
https://read.qxmd.com/read/30628047/old-age-is-a-positive-modifier-of-renal-outcome-in-taiwanese-patients-with-stages-3-5-chronic-kidney-disease
#10
Yu-Hsiang Chou, Chung-Jen Yen, Tai-Shuan Lai, Yung-Ming Chen
BACKGROUND: The incidence of end-stage renal disease (ESRD) is increasing in elderly patients with chronic kidney disease (CKD). This contradicts the general notion that elderly people are more likely to die than to ever reach ESRD. And racial disparity in relation to age on kidney disease outcomes has always been a subject of research interest. AIMS: We investigated the effect of age on outcome in a cohort with stages 3-5 CKD patients by age category. METHODS: A total of 430 patients with a mean age of 65...
January 9, 2019: Aging Clinical and Experimental Research
https://read.qxmd.com/read/30625463/cardiovascular-outcomes-in-african-americans-with-sickle-cell-trait-and-chronic-kidney-disease
#11
Kabir O Olaniran, Nwamaka D Eneanya, Andrew S Allegretti, Sophia H Zhao, Maureen M Achebe, Ravi I Thadhani
BACKGROUND: Sickle cell trait (SCT) is common among African Americans and has been historically considered to be benign. Recently, SCT has been associated with an increased risk for chronic kidney disease (CKD) and cardiovascular disease in the general population. Our understanding of SCT has been extrapolated largely from data of patients with sickle cell disease (SCD). Notably, in SCD, the outcomes differ by sex. The effect of SCT on cardiovascular risk in the African American CKD population is unknown, and the interaction between SCT and sex on cardiovascular risk has not been investigated...
2019: American Journal of Nephrology
https://read.qxmd.com/read/30604766/trans-ethnic-kidney-function-association-study-reveals-putative-causal-genes-and-effects-on-kidney-specific-disease-aetiologies
#12
Andrew P Morris, Thu H Le, Haojia Wu, Artur Akbarov, Peter J van der Most, Gibran Hemani, George Davey Smith, Anubha Mahajan, Kyle J Gaulton, Girish N Nadkarni, Adan Valladares-Salgado, Niels Wacher-Rodarte, Josyf C Mychaleckyj, Nicole D Dueker, Xiuqing Guo, Yang Hai, Jeffrey Haessler, Yoichiro Kamatani, Adrienne M Stilp, Gu Zhu, James P Cook, Johan Ärnlöv, Susan H Blanton, Martin H de Borst, Erwin P Bottinger, Thomas A Buchanan, Sylvia Cechova, Fadi J Charchar, Pei-Lun Chu, Jeffrey Damman, James Eales, Ali G Gharavi, Vilmantas Giedraitis, Andrew C Heath, Eli Ipp, Krzysztof Kiryluk, Holly J Kramer, Michiaki Kubo, Anders Larsson, Cecilia M Lindgren, Yingchang Lu, Pamela A F Madden, Grant W Montgomery, George J Papanicolaou, Leslie J Raffel, Ralph L Sacco, Elena Sanchez, Holger Stark, Johan Sundstrom, Kent D Taylor, Anny H Xiang, Aleksandra Zivkovic, Lars Lind, Erik Ingelsson, Nicholas G Martin, John B Whitfield, Jianwen Cai, Cathy C Laurie, Yukinori Okada, Koichi Matsuda, Charles Kooperberg, Yii-Der Ida Chen, Tatjana Rundek, Stephen S Rich, Ruth J F Loos, Esteban J Parra, Miguel Cruz, Jerome I Rotter, Harold Snieder, Maciej Tomaszewski, Benjamin D Humphreys, Nora Franceschini
Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and enrichment in genomic annotations including kidney-specific histone modifications. Fine-mapping reveals 40 high-confidence variants driving eGFR associations and highlights putative causal genes with cell-type specific expression in glomerulus, and in proximal and distal nephron...
January 3, 2019: Nature Communications
https://read.qxmd.com/read/30581790/sulfur-mustard-induced-changes-in-blood-urea-nitrogen-uric-acid-and-creatinine-levels-of-civilian-victims-and-their-correlation-with-spirometric-values
#13
Ensieh Sadat Mirsharif, Fatemeh Heidary, Mohammad Reza Vaez Mahdavi, Reza Gharebaghi, Shahriar Pourfarzam, Tooba Ghazanfari
Background: The aim of this study was assessment of the chronic effects of sulfur mustard (SM) among victims. Methods: In this cohort study, 355 SM-exposed subjects from Sardasht, and 123 controls from Rabat, both from West Azerbaijan Province, Iran were included. The spirometric evaluation and the global initiative for chronic obstructive lung disease (GOLD) classification were applied for all. Serum levels of urea, creatinine (Cr), and uric acid (UA) and glomerular filtration rate (GFR) were assessed...
November 2018: Iranian Journal of Public Health
https://read.qxmd.com/read/30579025/study-on-acute-kidney-injury-in-patients-with-spontaneous-intracranial-hemorrhage-an-overview-from-a-tertiary-care-hospital-in-south-india
#14
Marzieh Ansaritoroghi, Shankar Prasad Nagaraju, Rajesh Parameshwaran Nair, Vinod Kumar, Lakshman I Kongwad, Ravindra Prabhu Attur, Girish Menon Ramachandran, Ajay Hegde
INTRODUCTION: Acute kidney injury (AKI) is an independent risk factor for adverse clinical outcomes in patients with haemorrhagic stroke.There is limited data regarding the occurrence and impact of AKI in the setting of spontaneous intracerebral hemorrhage (SICH). Herewith, we sought to determine the incidence and risk factors for AKI in patients with SICH and to determine the role of AKI on SICH mortality in our population. MATERIALS AND METHODS: A retrospective analysis of the data recorded in the stroke registry maintained by the department of neurosurgery, Kasturba hospital, Kasturba Medical College, MAHE after ethical committee clearance...
December 19, 2018: World Neurosurgery
https://read.qxmd.com/read/30576390/temperature-driven-response-reversibility-and-short-term-quasi-acclimation-of-daphnia-magna
#15
Mara F Müller, Jordi Colomer, Teresa Serra
Analysing the effect water temperature has on Daphnia magna is essential in anticipating the impact climate change will have on this freshwater zooplanktonic keystone species. While many authors have followed this line of research, few have covered an extensive temperature range or complex temperature change scenarios. Global warming is mostly associated with increased extreme temperature events, such as heat waves, as well as earlier and more intense thermal stratification. Both of these events may directly influence D...
2018: PloS One
https://read.qxmd.com/read/30515657/left-ventricular-strain-and-relaxation-are-independently-associated-with-renal-cortical-perfusion-in-hypertensive-patients
#16
Arkadiusz Lubas, Robert Ryczek, Artur Maliborski, Przemysław Dyrla, Longin Niemczyk, Stanisław Niemczyk
Renal perfusion, which depends on cardiac function, is a factor conditioning the work of kidneys. The objective of the study was to assess the influence of cardiac function, including left ventricular contractility and relaxation, on renal cortical perfusion in patients with hypertension and chronic kidney disease treated pharmacologically. There were 63 patients (7 F and 56 M; aged 56 ± 14) with hypertension and stable chronic kidney disease enrolled into the study. Serum cystatin C, with estimated glomerular filtration rate (eGFR), ambulatory blood pressure monitoring, carotid intima-media thickness (cIMT), echocardiography with speckle tracking imaging and the calculation of global longitudinal strain (GLS), diameter of vena cava inferior (VCI), and an ultrasound dynamic tissue perfusion measurement of the renal cortex were performed...
December 4, 2018: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30506283/personalized-177-lu-octreotate-peptide-receptor-radionuclide-therapy-of-neuroendocrine-tumours-initial-results-from-the-p-prrt-trial
#17
Michela Del Prete, François-Alexandre Buteau, Frédéric Arsenault, Nassim Saighi, Louis-Olivier Bouchard, Alexis Beaulieu, Jean-Mathieu Beauregard
PURPOSE: Peptide receptor radionuclide therapy (PRRT) is mostly administered using a fixed injected activity (IA) per cycle. This empiric regime results in highly variable absorbed doses to the critical organs and undertreatment of the majority of patients. We conceived a personalized PRRT protocol in which the IA is adjusted to deliver a prescribed absorbed dose to the kidney, with the aim to safely increase tumour irradiation. We herein report on the initial results of our prospective study of personalized PRRT, the P-PRRT Trial (NCT02754297)...
November 30, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30503478/microplastic-fiber-uptake-ingestion-and-egestion-rates-in-the-blue-mussel-mytilus-edulis
#18
Madelyn N Woods, Margaret E Stack, David M Fields, Susan D Shaw, Patricia A Matrai
Microplastic fibers (MPF) are a ubiquitous marine contaminant, making up to 90% of global microplastic concentrations. Imaging flow cytometry was used to measure uptake and ingestion rates of MPF by blue mussels (Mytilus edulis). Mussels were fed a diet of Rhodomonas salina and MPF concentrations up to 30 MPF mL-1 , or 0.374% of available seston. Filtration rates were greatly reduced in mussels exposed to MPF. Uptake of MPF followed a Holling's Type II functional response with 95% of the maximum rate (5227 MPF h- 1 ) occurring at 13 MPF mL-1 ...
December 2018: Marine Pollution Bulletin
https://read.qxmd.com/read/30476257/towards-a-personalized-treatment-for-iga-nephropathy-considering-pathology-and-pathogenesis
#19
Rosanna Coppo
The search of personalized treatment for a subject with immunoglobulin A nephropathy (IgAN) is appealing since the individual long-term outcome is highly variable in spite of common mild clinical signs such as microscopic haematuria, moderate proteinuria and slightly reduced glomerular filtration rate (GFR). The only risk factor considered by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to target corticosteroid/immunosuppressive treatment in IgAN is proteinuria persistently >1 g/day despite 3-6 months of optimized supportive care...
November 26, 2018: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30450461/impact-of-acute-kidney-injury-and-ckd-on-adverse-outcomes-in-critically-ill-septic-patients
#20
Javier A Neyra, Federica Mescia, Xilong Li, Beverley Adams-Huet, Lenar Yessayan, Jerry Yee, Robert D Toto, Orson W Moe
Introduction: Chronic kidney disease (CKD) and acute kidney injury (AKI) are strongly associated with excess morbidity and mortality and frequently co-occur in critically ill septic patients, but how their interplay affects clinical outcomes is not well elucidated. Methods: We conducted a single-center, retrospective cohort study of 2632 adult patients admitted to the intensive care unit (ICU) with severe sepsis or septic shock. Subjects were classified into 6 groups according to baseline CKD (no-CKD: estimated glomerular filtration rate [eGFR] ≥60; CKD: eGFR 15-59 ml/min per 1...
November 2018: KI Reports
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