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Borderline personality disorder cortical thickness

David L Perez, Nassim Matin, Benjamin Williams, Kaloyan Tanev, Nikos Makris, W Curt LaFrance, Bradford C Dickerson
BACKGROUND: Links between dissociation and functional neurological disorder (FND)/conversion disorder are well-established, yet the pathophysiology of dissociation remains poorly understood. This MRI study investigated structural alterations associated with somatoform and psychological dissociation in FND. We hypothesized that multimodal, paralimbic cingulo-insular regions would relate to the severity of somatoform dissociation in patients with FND. METHODS: FreeSurfer cortical thickness and subcortical volumetric analyses were performed in 26 patients with motor FND and 27 matched healthy controls...
January 2018: Human Brain Mapping
Q Zhou, M Zhong, S Yao, X Jin, Y Liu, C Tan, X Zhu, J Yi
OBJECTIVE: Although the frontolimbic cortex has been implicated in borderline personality disorder (BPD), information about possible asymmetries in this region in patients with BPD is limited. This study aimed to examine whether frontolimbic cortex asymmetries differ between patients with BPD and healthy individuals. METHODS: The brains of 30 young adult patients with BPD and 32 healthy control subjects were scanned with magnetic resonance imaging (MRI). The participants completed self-report scales assessing impulsivity, affect intensity and other psychological variables...
December 2017: Acta Psychiatrica Scandinavica
Doris E Payer, Min Tae M Park, Stephen J Kish, Nathan J Kolla, Jason P Lerch, Isabelle Boileau, M M Chakravarty
Personality disorder symptomatology (PD-Sx) can result in personal distress and impaired interpersonal functioning, even in the absence of a clinical diagnosis, and is frequently comorbid with psychiatric disorders such as substance use, mood, and anxiety disorders; however, they often remain untreated, and are not taken into account in clinical studies. To investigate brain morphological correlates of PD-Sx, we measured subcortical volume and shape, and cortical thickness/surface area, based on structural magnetic resonance images...
2015: Frontiers in Human Neuroscience
Gerardo Maria de Araujo Filho, Chadi Abdallah, João Ricardo Sato, Thabata Bueno de Araujo, Cláudio Mauricio Lisondo, Álvaro Ancona de Faria, Katia Lin, Ivaldo Silva, Rodrigo Affonsecca Bressan, Julieta Freitas Ramalho da Silva, Jeremy Coplan, Andrea Parolin Jackowski
Functional imaging studies have implicated the orbitofrontal cortex (OFC) in the pathophysiology of borderline personality disorder (BPD). To date, however, volume-based magnetic resonance imaging (MRI) studies have yielded mixed results. We used a surface-based processing approach that allowed us to measure five morphometric cortical features of the OFC, including volumetric (cortical thickness and surface area) and geometric (mean curvature, depth of sulcus, and metric distortion - three indicators of cortical folding) parameters...
August 30, 2014: Psychiatry Research
E Bøen, L T Westlye, T Elvsåshagen, B Hummelen, P K Hol, B Boye, S Andersson, S Karterud, U F Malt
OBJECTIVE: We investigated cerebral cortical thickness and its relation to measurements of difficulties with identifying and describing emotions in patients with borderline personality disorder (BPD). METHOD: Eighteen SCID-II-diagnosed female patients with BPD and 21 healthy female controls underwent magnetic resonance imaging and completed the Toronto Alexithymia Scale (TAS). First, regional cortical thickness across the cerebral surface was compared between patients and healthy controls...
September 2014: Acta Psychiatrica Scandinavica
Julia Richter, Romuald Brunner, Peter Parzer, Franz Resch, Bram Stieltjes, Romy Henze
Volumetric alterations in limbic structures have been detected in adults, but not in adolescents with borderline personality disorder (BPD). We examined adolescents in the early stages of BPD to provide a unique opportunity to investigate which parts of the brain are initially affected by the disorder before confounding factors such as long-term medication or chronicity can mask them. A group of 60 right-handed female adolescents between 14 and 18 years of age (20 patients with BPD, 20 clinical controls, and 20 healthy controls) underwent magnetic resonance imaging (MRI)...
March 30, 2014: Psychiatry Research
Hannah Bruehl, Sandra Preißler, Isabella Heuser, Hauke R Heekeren, Stefan Roepke, Isabel Dziobek
Previous studies suggest that amygdala, insula and prefrontal cortex (PFC) disintegrity play a crucial role in the failure to adequately regulate emotions in Borderline Personality Disorder (BPD). However, prior results are confounded by the high rate of comorbidity with Posttraumatic Stress Disorder (PTSD), which itself has been associated with changes in frontolimbic circuitry. We thus scrutinized the link between PFC, amygdala, insula, and the ability to regulate emotions, contrasting 17 women with BPD without comorbid PTSD to 27 non-clinical control women and in addition to those with BPD and PTSD (n = 14)...
2013: PloS One
João Ricardo Sato, Gerardo Maria de Araujo Filho, Thabata Bueno de Araujo, Rodrigo Affonsecca Bressan, Pedro Paulo de Oliveira, Andrea Parolin Jackowski
Several recent studies in literature have identified brain morphological alterations associated to Borderline Personality Disorder (BPD) patients. These findings are reported by studies based on voxel-based-morphometry analysis of structural MRI data, comparing mean gray-matter concentration between groups of BPD patients and healthy controls. On the other hand, mean differences between groups are not informative about the discriminative value of neuroimaging data to predict the group of individual subjects...
September 2012: Journal of Psychiatric Research
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