Mengyang Chu, Shengxian Shen, Zhenlai Zhu, Zhiguo Li, Yaxing Bai, Jingyi Ma, Junfeng Hao, Lei Wang, Meng Fu, Erle Dang, Gang Wang, Shuai Shao
Psoriasis is a chronic, refractory inflammatory skin disease, with a high prevalence of psychiatric comorbidities, including depression, anxiety, and even suicidality, which may in turn initiate or exacerbate skin inflammation. However, the causal relationships between these comorbidities remain unclear. To investigate the cause-effect relationships between psoriasis and mental disorders including depression, anxiety, and suicidality, we conducted a bidirectional two-sample Mendelian randomization (MR) study utilizing summary statistics from the most comprehensive genome-wide association studies of psoriasis (n = 306 123), broad depression (n = 500 199), major depressive disorder (n = 173 005), anxiety (n = 17 310), and suicide attempts (n = 50 264)...
September 12, 2023: Journal of Dermatology