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https://read.qxmd.com/read/30763634/core-matched-nanoassemblies-for-targeted-co-delivery-of-chemotherapy-and-photosensitizer-to-treat-drug-resistant-cancer
#1
Di Jiang, Minjun Xu, Yuanyuan Pei, Yukun Huang, Yu Chen, Fenfen Ma, Huiping Lu, Jun Chen
Emergence of drug resistance in tumors causes therapeutic failure or tumor relapse. Combination of chemotherapy and photodynamic therapy holds significant promise to treat drug-resistant tumors. However, stubborn hydrophobicity of photosensitizer (PS), low encapsulation efficiency and leaking problem of PS in organic carrier, and disparate physicochemical properties of PS and chemotherapeutics make the combination unachievable. Thus how to efficiently co-deliver the two functional agents to enable photo-chemotherapy seems to be one of the key challenges...
February 11, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30763330/a-chronic-bioluminescent-model-of-experimental-visceral-leishmaniasis-for-accelerating-drug-discovery
#2
Raquel Álvarez-Velilla, Maria Del Camino Gutiérrez-Corbo, Carmen Punzón, Maria Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Manuel Fresno, Rosa María Reguera
BACKGROUND: Visceral leishmaniasis is a neglected parasitic disease with no vaccine available and its pharmacological treatment is reduced to a limited number of unsafe drugs. The scarce readiness of new antileishmanial drugs is even more alarming when relapses appear or the occurrence of hard-to-treat resistant strains is detected. In addition, there is a gap between the initial and late stages of drug development, which greatly delays the selection of leads for subsequent studies. METHODOLOGY/PRINCIPAL FINDINGS: In order to address these issues, we have generated a red-shifted luminescent Leishmania infantum strain that enables long-term monitoring of parasite burden in individual animals with an in vivo limit of detection of 106 intracellular amastigotes 48 h postinfection...
February 14, 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30762762/aggravation-of-atrial-arrhythmia-by-amiodarone-during-the-perinatal-period-a-case-report
#3
Fanhao Ye, Wenbing Jiang, Yi Wang, Wei Lin, Hao Chen, Binglin Pan
RATIONALE: Amiodarone, a broad-spectrum antiarrhythmic drug, is widely used for the clinical treatment of tachyarrhythmias because of its safety and efficacy. PATIENT CONCERNS: A 30-year-old woman presented with known paroxysmal atrial tachycardia and severe preeclampsia. Two days before admission, she had given birth to twins. She described her symptoms as a sudden palpitation at 10:20 accompanied by chest tightness and shortness of breath. DIAGNOSIS: Cardiac arrhythmia and acute left heart failure...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30762454/symptom-burden-and-end-of-life-palliative-treatments-during-the-last-two-weeks-of-life-in-patients-with-advanced-musculoskeletal-sarcoma
#4
Hiroyuki Kawashima, Takashi Ariizumi, Tetsuro Yamagishi, Akira Ogose, Miho Ikoma, Tetsuo Hotta, Naoto Endo
BACKGROUND: Musculoskeletal sarcomas (MSSs) are rare cancers and often aggressive tumors that originate from mesenchymal tissue. Patients with advanced MSS often report difficulties with symptom burden, which can reduce their health-related quality-of-life. OBJECTIVE: The aim of this study was to describe the patterns of the physical symptoms of MSS patients in the palliative setting and to detail the palliative treatment used in the last two weeks of life. DESIGN: Retrospective study using the electronic patient records from a single institution...
February 14, 2019: Journal of Palliative Medicine
https://read.qxmd.com/read/30761557/pharmacokinetics-of-vitacoxib-in-rabbits-after-intravenous-and-oral-administration
#5
Jianzhong Wang, Jiao Xue, Lu Zhang, Suxia Zhang, Jing Li, Xingyuan Cao
This study describes the pharmacokinetics of vitacoxib in healthy rabbits following administration of 10 mg/kg intravenous (i.v.) and 10 mg/kg oral. Twelve New Zealand white rabbits were randomly allocated to two equally sized treatment groups. Blood samples were collected at predetermined times from 0 to 36 hr after treatment. Plasma drug concentrations were determined using UPLC-MS/MS. Pharmacokinetic analysis was completed using noncompartmental methods via WinNonlin™ 6.4 software. The mean concentration area under curve (AUClast ) for vitacoxib was determined to be 11...
February 13, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/30761235/bilateral-compartment-syndrome-in-intravenous-drug-abuse
#6
Justin Loloi, Alex T Burton, Leonard T Walsh, Nitasa Sahu, Rohit Jain
Compartment syndrome is an orthopedic emergency in which the neurovasculature of the extremity is compromised. Typically, it presents unilaterally and is the consequence of major trauma to the extremity in the form of fracture. However, more uncommon etiologies of compartment syndrome have been reported, which includes reperfusion injury, burns, and congenital or acquired bleeding disorders. We present an extremely rare case of bilateral posterior thigh compartment syndrome thought to be due to intravenous drug abuse (IVDA) causing prolonged ischemia with subsequent reperfusion...
December 4, 2018: Curēus
https://read.qxmd.com/read/30760702/baicalin-ameliorates-lupus-autoimmunity-by-inhibiting-differentiation-of-tfh-cells-and-inducing-expansion-of-tfr-cells
#7
Ji Yang, Xue Yang, Jie Yang, Ming Li
Baicalin is a natural compound isolated from Chinese herb, which has been reported as an anti-inflammatory drug. Here, we demonstrated that Baicalin treatment could reduce urine protein, inhibit anti-ds-DNA antibody titers, and ameliorate lupus nephritis in MRL/lpr lupus-prone mice. Baicalin inhibited Tfh cell differentiation and IL-21 production, but promoted Foxp3+ regulatory T cell differentiation including part of follicular regulatory T (Tfr) cells. Intravenous injection of Baicalin-induced Foxp3+ regulatory T cells could relieve nephritis, inhibit Tfh cell differentiation and IL-21 production...
February 13, 2019: Cell Death & Disease
https://read.qxmd.com/read/30759154/quantitative-systems-pharmacology-of-interferon-alpha-administration-a-multi-scale-approach
#8
Priyata Kalra, Julian Brandl, Thomas Gaub, Christoph Niederalt, Jörg Lippert, Sven Sahle, Lars Küpfer, Ursula Kummer
The therapeutic effect of a drug is governed by its pharmacokinetics which determine the downstream pharmacodynamic response within the cellular network. A complete understanding of the drug-effect relationship therefore requires multi-scale models which integrate the properties of the different physiological scales. Computational modelling of these individual scales has been successfully established in the past. However, coupling of the scales remains challenging, although it will provide a unique possibility of mechanistic and holistic analyses of therapeutic outcomes for varied treatment scenarios...
2019: PloS One
https://read.qxmd.com/read/30758221/intravenous-olanzapine-for-the-management-of-agitation-review-of-the-literature
#9
Farah Khorassani, Maha Saad
OBJECTIVE: The purpose of this review is to summarize the current evidence of the off-label use of intravenous (IV) olanzapine and discuss its risks versus benefits for the management of agitation. DATA SOURCES: A literature search was conducted to gather relevant data regarding IV use of olanzapine for the management of acute agitation. PubMed, EMBASE, MEDLINE, and IPA were searched using the keywords and MESH terms: olanzapine, intravenous, IV, off-label, and agitation...
February 13, 2019: Annals of Pharmacotherapy
https://read.qxmd.com/read/30756115/utilization-of-observational-data-as-a-proxy-cohort-for-comparison-purposes-with-open-label-study-results-an-example-from-alzheimer-s-disease
#10
C Reed, M Happich, J Raskin, A Tockhorn-Heidenreich, M Belger
BACKGROUND: Randomized placebo-controlled trials in the development of disease-modifying treatments for Alzheimer's disease are typically of short duration (12-18 months), and health economic modeling requires extrapolation of treatment effects beyond the trial period. OBJECTIVES: To investigate whether observational data can be used to extrapolate data from open-label trials, we compared outcomes (cognition, function, behavior) over 36 months for patients with mild Alzheimer's disease dementia in the GERAS observational study (proxy for placebo control) with those of the mild Alzheimer's disease population on active treatment (solanezumab) in two 18-month randomized placebo-controlled trials (EXPEDITION and EXPEDITION2) and the additional 18-month open-label extension study (EXPEDITION-EXT)...
2019: Journal of Prevention of Alzheimer's Disease
https://read.qxmd.com/read/30755804/the-full-spectrum-of-infective-endocarditis-case-report-and-review
#11
Aniket S Rali, Mejalli Al-Kofahi, Nilay Patel, Benjamin Wiele, Zubair Shah, Jayant Nath
Over the past five decades, the incidence of intravenous drug use- (IVDU-) associated infective endocarditis (IE) has been on the rise in North America. Classically, IVDU has been thought to affect right-sided valves. However, in recent times a more variable presentation of IVDU-associated IE has been reported. Here, we report a case of a patient with a known history of IVDU who presented with clinical symptoms concerning for right- as well as left-sided endocarditis. In addition, we also discuss what should be considered adequate evaluation for patients with suspected endocarditis, and more specifically, what should be the role of transesophageal echocardiography in patients with IE noted on transthoracic echocardiography...
2019: Case Reports in Cardiology
https://read.qxmd.com/read/30755574/a-randomized-controlled-trial-to-study-the-effect-of-intravenous-clonidine-and-intravenous-fentanyl-on-perioperative-hemodynamics-during-laparoscopic-cholecyctetomy
#12
V Gupta, A Jain, A Gupta, N Hayaran
Peritoneal insufflation and laryngoscopy & intubation cause alteration of hemodynamics to a certain extent. The aim of this double blind, randomized controlled trial was to know and compare the effect of I.V. clonidine and I.V. fentanyl on hemodynamics during laparoscopic cholecystectomy in the department of Anaesthesia, Lady Hardinge Medical College, Delhi University, Delhi, India from November 2011 to April 2013. Eighty (80) patients (ASA I or II) posted for elective laparoscopic cholecystectomy were randomly allocated to two groups...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30753743/adjunctive-intravenous-diclofenac-decreases-opioid-consumption-and-increases-satisfaction-in-the-primary-total-hip-arthroplasty-population
#13
Nicole E George, Cheryle Gurk-Turner, Iciar M Dávila Castrodad, Jennifer I Etcheson, Nequesha S Mohamed, Chukwuweike U Gwam, Alexandra N Passarrello, Chiemena U Ohanale, Ronald E Delanois
Despite the success of total hip arthroplasty (THA), postoperative pain management remains a concern. Although the nonsteroidal anti-inflammatory drug (NSAID) intravenous (IV) diclofenac is a promising addition, its impact on THA outcomes has not been investigated. This study evaluates the effects of adjunctive IV diclofenac on: 1) postoperative pain intensity; 2) opioid consumption; 3) discharge destination; 4) length of stay; and 5) patient satisfaction in primary THA patients. A retrospective study was performed for patients who underwent primary THA by a single surgeon between May 1 and September 31, 2017...
February 11, 2019: Surgical Technology International
https://read.qxmd.com/read/30747341/in-use-stability-of-the-rituximab-biosimilar-ct-p10-truxima-%C3%A2-following-preparation-for-intravenous-infusion-and-storage
#14
Su Jung Kim, Kwang Woo Kim, Yeon Kyeong Shin, Ji Woong Kwon, Hye Young Kang, Yoon A Park, Ji Young Shin, So Young Kim, Won Yong Han
BACKGROUND: CT-P10 is the first biosimilar of the anti-CD20 monoclonal antibody, rituximab. CT-P10 is currently available in over 51 countries worldwide, where it is approved in the same indications as its reference product rituximab. In-use stability studies are conducted for biologics to determine how conditions (e.g., temperature, light, humidity, length of time stored) affect drug quality following dilution and storage in infusion bags. OBJECTIVE: We evaluated the in-use stability of CT-P10 for intravenous infusion stored diluted in infusion bags over longer periods than currently recommended by manufacturer guidelines...
February 11, 2019: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://read.qxmd.com/read/30746017/potential-cost-savings-with-once-daily-aminomethylcycline-antibiotic-versus-vancomycin-in-hospitalized-patients-with-acute-bacterial-skin-and-skin-structure-infections
#15
Ken LaPensee, Thomas Lodise
Background: Omadacycline is an oral and intravenous (IV) once-daily aminomethylcycline antibiotic that was recently approved by the US Food and Drug Administration for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI). In 2 phase 3 clinical trials, IV-to-oral switch and oral-only administration of omadacycline achieved the primary end points of noninferiority compared with linezolid in treating patients with ABSSSI. Objective: To estimate the potential cost-savings with bioequivalent IV-to-oral antibiotics, such as omadacycline, compared with the standard of care with IV vancomycin by avoiding hospitalizations and reducing hospital stays in patients presenting from the emergency department for ABSSSI treatment...
December 2018: American Health & Drug Benefits
https://read.qxmd.com/read/30745090/tisotumab-vedotin-in-patients-with-advanced-or-metastatic-solid-tumours-innovatv-201-a-first-in-human-multicentre-phase-1-2-trial
#16
Johann S de Bono, Nicole Concin, David S Hong, Fiona C Thistlethwaite, Jean-Pascal Machiels, Hendrik-Tobias Arkenau, Ruth Plummer, Robert Hugh Jones, Dorte Nielsen, Kristian Windfeld, Srinivas Ghatta, Brian M Slomovitz, James F Spicer, Jeffrey Yachnin, Joo Ern Ang, Paul Morten Mau-Sørensen, Martin David Forster, Dearbhaile Collins, Emma Dean, Reshma A Rangwala, Ulrik Lassen
BACKGROUND: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor. METHODS: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe...
February 7, 2019: Lancet Oncology
https://read.qxmd.com/read/30744481/prediction-of-human-pharmacokinetics-of-long-half-life-compounds-using-chimeric-mice-with-humanised-liver
#17
Maki Miyamoto, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano, Yohei Kosugi, Hideki Hirabayashi
1. The prediction of human pharmacokinetic (PK) parameters is an important theme to select drug candidates from preclinical studies. It is essential to improve the prediction accuracy of compound half-life (t1/2 ) in humans. In this study, the predictability of t1/2 in humans using PXB mice®, chimeric mice with humanised liver, was assessed using 14 compounds showing long t1/2 in humans. 2. After intravenous administration of the compounds to PXB mice, the plasma concentration-time profiles were fitted using one- or two-compartment models and the human clearance (CLt ) and distribution volume (Vdss ) were predicted from single-species scaling...
February 12, 2019: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://read.qxmd.com/read/30744451/intranasal-administration-of-erythropoietin-rescues-the-photoreceptors-in-degenerative-retina-a-noninvasive-method-to-deliver-drugs-to-the-eye
#18
Ye Tao, Chong Li, Anhui Yao, Yingxin Qu, Limin Qin, Zuojun Xiong, Jianbin Zhang, Weiwen Wang
Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue. The present study is designed to deliver the erythropoietin (EPO) into the N-methyl-N-nitrosourea (MNU) induced mice, a pharmacological retinopathy model via intranasal or intravenous route. The mice were then subjected to bioavailability assay and therapeutic effects evaluation. Our results showed that the intranasal delivery of EPO is effective to alleviate the morphological disruptions in the MNU induced mice...
December 2019: Drug Delivery
https://read.qxmd.com/read/30744432/enhanze-%C3%A2-drug-delivery-technology-a-novel-approach-to-subcutaneous-administration-using-recombinant-human-hyaluronidase-20
#19
Kenneth W Locke, Daniel C Maneval, Michael J LaBarre
ENHANZE® drug delivery technology is based on the proprietary recombinant human hyaluronidase PH20 enzyme (rHuPH20; Halozyme Therapeutics, Inc.) that facilitates the subcutaneous (SC) delivery of co-administered therapeutics. rHuPH20 works by degrading the glycosaminoglycan hyaluronan (HA), which plays a role in resistance to bulk fluid flow in the SC space, limiting large volume SC drug delivery, dispersion, and absorption. Co-administration of rHuPH20 with partner therapies can overcome administration time and volume barriers associated with existing SC therapeutic formulations, and has been shown to reduce the burden on patients and healthcare providers compared with intravenous formulations...
December 2019: Drug Delivery
https://read.qxmd.com/read/30744025/development-of-solid-lipid-nanoparticles-by-cold-dilution-of-microemulsions-curcumin-loading-preliminary-in-vitro-studies-and-biodistribution
#20
Daniela Chirio, Elena Peira, Chiara Dianzani, Elisabetta Muntoni, Casimiro Luca Gigliotti, Benedetta Ferrara, Simona Sapino, Giulia Chindamo, Marina Gallarate
Background : Solid lipid nanoparticles (SLNs) are attractive drug delivery systems for lipophilic molecules like curcumin (CURC) with low chemical stability. Methods : A simple, innovative, and cold-operating method, named "cold dilution of microemulsion" is developed by the authors to produce SLNs. An oil-in-water microemulsion (µE), whose disperse phase consisted of a solution of trilaurin in a partially water-miscible solvent, was prepared after mutually saturating solvent and water. Trilaurin SLNs precipitated following solvent removal upon water dilution of the µE...
February 8, 2019: Nanomaterials
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