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https://read.qxmd.com/read/30771212/understanding-skin-screening-practices-among-children-at-elevated-risk-for-melanoma-to-inform-interventions-for-melanoma-prevention-and-control
#1
Bridget G Parsons, Jennifer L Hay, Lisa G Aspinwall, Kelsey Zaugg, Angela Zhu, Ryan H Mooney, Stephanie Z Klein, Douglas Grossman, Sancy A Leachman, Yelena P Wu
Melanoma is the deadliest form of skin cancer. Screening can aid in early disease detection, when treatment is more effective. Although there are currently no consensus guidelines regarding skin screening for pediatric populations with elevated familial risk for melanoma, at-risk children with the help of their parents and healthcare providers may implement skin self-exams. Healthcare providers may also recommend screening practices for these children. The goal of the current study was to describe current screening behaviors and provider recommendation for screening among children of melanoma survivors...
February 15, 2019: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://read.qxmd.com/read/30771043/update-on-the-diagnosis-and-management-of-gastric-intestinal-metaplasia-in-the-usa
#2
REVIEW
Judy A Trieu, Mohammad Bilal, Hamzeh Saraireh, Andrew Y Wang
Gastric intestinal metaplasia (GIM) is a premalignant condition that can lead to intestinal-type gastric adenocarcinoma. It is characterized by a change in the gastric mucosa to a small-intestinal phenotype. Infection with Helicobacter pylori is the most common factor associated with GIM. Although GIM is typically a histologic diagnosis, various techniques have been developed to enable the endoscopic identification of GIM. There are presently no widely accepted guidelines on screening and surveillance strategies in patients with GIM in the USA...
February 15, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30770485/provable-data-integrity-in-the-pharmaceutical-industry-based-on-version-control-systems-and-the-blockchain
#3
Valentin Steinwandter, Christoph Herwig
In the pharmaceutical industry, process validation tasks are based on the generated process raw and derived analytical results. Risks to fail in process validation, affect both, the patient's safety as well as the economic success of the manufacturing company. Hence, data integrity is highly critical in this area. Regulatory agencies, such as the FDA, reacted to past data integrity breaches, by publishing new guidelines on data integrity for the correct handling of data in the pharmaceutical context. In this contribution, we want to show how data integrity can be improved on a technological level, removing the need for trusted third parties and centralized systems for this task...
February 15, 2019: PDA Journal of Pharmaceutical Science and Technology
https://read.qxmd.com/read/30768988/validation-of-baveno-vi-criteria-for-screening-and-surveillance-of-esophageal-varices-in-patients-with-compensated-cirrhosis-and-a-sustained-response-to-antiviral-therapy
#4
Dominique Thabut, Christophe Bureau, Richard Layese, Valérie Bourcier, Maryam Hammouche, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Odile Goria, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle-Bladou, Thông Dao, Christophe Pilette, Christine Silvain, Christos Christidis, Dominique Capron, Brigitte Bernard-Chabert, Sophie Hillaire, Vincent Di Martino, Angela Sutton, Etienne Audureau, Françoise Roudot-Thoraval, Pierre Nahon, Pierre Nahon, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Hélène Fontaine, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Vincent Leroy, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Sebastien Dharancy, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Dominique Capron, Gérard Thiefin, Sophie Hillaire, Vincent Di Martino
BACKGROUND & AIMS: Management of patients with cirrhosis includes endoscopic screening and surveillance to detect esophageal varices (EV) and prevent bleeding. However, the Baveno VI guidelines recommend avoiding endoscopies for patients with liver stiffness measurements below 20 kPa and platelet counts above 150,000 (favorable Baveno VI status) and endoscopic assessment of patients with higher levels of liver stiffness and platelet counts (unfavorable Baveno VI status). We aimed to validate the Baveno VI guidelines, evaluating outcomes of patients in the ANRS-CO12 CirVir cohort with compensated cirrhosis associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, with or without a sustained response to antiviral therapy...
February 12, 2019: Gastroenterology
https://read.qxmd.com/read/30767062/-assessment-of-individualized-treatment-of-rectal-carcinoma
#5
REVIEW
F Aigner, A Lorenz, D Öfner, J Pratschke
Individualized and tailored treatment plays a crucial role in the rating of special operation techniques or certain treatment strategies following defined quality criteria and indicators. Deviations from clearly defined recommendations in guidelines must therefore be justified, documented and evaluated as precisely as possible. The aim of this leading article is to examine the individualized treatment of rectal cancer based on existing evidence and to discuss its role in the light of routinely used treatment algorithms...
February 14, 2019: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://read.qxmd.com/read/30767029/-diagnosis-and-treatment-of-acute-myeloid-leukemia-the-updated-2018-onkopedia-guideline
#6
Christoph Röllig
In April 2018, an updated version of the previously published guidelines on acute myeloid leukemia (AML) from 2010 and 2017 was released. A revision was necessary because of two positive aspects: First, new data and insights on risk stratification and monitoring, and second, the clinical development and approval of new agents. The modified genetic risk classification allows a more precise distinction of different diagnostic groups and consequently a better matched post-remission treatment. The availability of new targeted drugs such as inhibitors turns genetic analyses from a mere prognostic tool into an instrument for treatment decisions...
February 14, 2019: Der Internist
https://read.qxmd.com/read/30765024/long-term-oxygen-therapy
#7
Andreas Rembert Koczulla, Tessa Schneeberger, Inga Jarosch, Klaus Kenn, Rainer Gloeckl
BACKGROUND: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic hypoxemia. Its scientific basis is derived mainly from two trials from the early 1980s that showed a survival advantage for patients with chronic obstructive pulmonary disease (COPD) treated with LTOT. Robust data are not available for other diseases associated with hypoxemia. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed...
December 24, 2018: Deutsches Ärzteblatt International
https://read.qxmd.com/read/30765023/the-diagnosis-and-treatment-of-carbon-monoxide-poisoning
#8
Lars Eichhorn, Marcus Thudium, Björn Jüttner
BACKGROUND: The symptoms of carbon monoxide (CO) poisoning are nonspecific, ranging from dizziness and headache to unconsciousness and death. A German national guideline on the diagnosis and treatment of this condition is lacking at present. METHODS: This review is based on a selective literature search in the PubMed and Cochrane databases, as well as on existing guidelines from abroad and expert recommendations on diagnosis and treatment. RESULTS: The initiation of 100% oxygen breathing as early as possible is the most important treatment for carbon monoxide poisoning...
December 24, 2018: Deutsches Ärzteblatt International
https://read.qxmd.com/read/30763523/the-importance-of-early-peanut-ingestion-in-the-prevention-of-peanut-allergy
#9
Amanda Agyemang, Scott Sicherer
Peanut allergy appears to have increased in prevalence, is often severe and is typically life-long. Therefore, reducing its incidence through a primary prevention strategy is a priority. Guidelines on peanut introduction have evolved with time and given evidence of peanut allergy risk reduction with early infant ingestion exposure, the current US advice promotes early introduction for infants, particularly targeting those at highest risk. Areas covered: This article describes the evolution of peanut introduction guidelines in infants in the US, as shaped by key research over the last 20-30 years and culminates in the landmark LEAP study It also compares and contrasts current iterations of peanut introduction guidelines in infants globally...
February 14, 2019: Expert Review of Clinical Immunology
https://read.qxmd.com/read/30763325/a-prescription-support-tool-for-chronic-management-of-oral-antithrombotic-combinations-in-adults-based-on-a-systematic-review-of-international-guidelines
#10
Lorene Zerah, René-Sosata Bun, Sylvie Guillo, Jean-Philippe Collet, Dominique Bonnet-Zamponi, Florence Tubach
BACKGROUND: Oral antithrombotic (AT) drugs, which include antiplatelet and anticoagulant therapies, are widely implicated in serious preventable bleeding events. Avoiding inappropriate oral AT combinations is a major concern. Numerous practical guidelines have been released; a document to enhance prescriptions of oral AT combinations for adults would be of great help. OBJECTIVE: To synthesize guidelines on the prescription of oral AT combinations in adults and to create a prescription support-tool for clinicians about chronic management (≥ one month) of oral AT combinations...
2019: PloS One
https://read.qxmd.com/read/30762614/blood-pressure-targets-and-kidney-and-cardiovascular-disease-same-data-but-discordant-guidelines
#11
Bethany Roehm, Daniel E Weiner
PURPOSE OF REVIEW: Hypertension is highly prevalent in the United States and a major risk factor for the development of cardiovascular disease. Hypertension is common in chronic kidney disease (CKD), and likely contributes to the association between CKD and cardiovascular disease. The ideal systolic BP to reduce cardiovascular disease risk in individuals with CKD is controversial. RECENT FINDINGS: Several societies have released guidelines on the treatment of hypertension in the past year, each differing in important aspects, including BP targets...
February 12, 2019: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/30762387/apa-multicultural-guidelines-executive-summary-ecological-approach-to-context-identity-and-intersectionality
#12
Caroline S Clauss-Ehlers, David A Chiriboga, Scott J Hunter, Gargi Roysircar, Pratyusha Tummala-Narra
The initial version of the Multicultural Guidelines, titled Guidelines on Multicultural Education, Training, Research, Practice, and Organizational Change for Psychologists, was published in 2002. Since then, there has been significant growth in research and theory regarding multicultural contexts. The revised Multicultural Guidelines are conceptualized to reconsider diversity and multicultural practice within professional psychology at this period in time, with intersectionality as its primary purview. Psychologists are encouraged to incorporate developmental and contextual antecedents of identity and consider how they can be acknowledged, addressed, and embraced to generate more effective models of professional engagement...
February 2019: American Psychologist
https://read.qxmd.com/read/30760474/methicillin-resistant-staphylococcus-aureus-prosthetic-valve-endocarditis-pathophysiology-epidemiology-clinical-presentation-diagnosis-and-management
#13
REVIEW
Alicia Galar, Ana A Weil, David M Dudzinski, Patricia Muñoz, Mark J Siedner
SUMMARY Staphylococcus aureus prosthetic valve endocarditis (PVE) remains among the most morbid bacterial infections, with mortality estimates ranging from 40% to 80%. The proportion of PVE cases due to methicillin-resistant Staphylococcus aureus (MRSA) has grown in recent decades, to account for more than 15% of cases of S. aureus PVE and 6% of all cases of PVE. Because no large studies or clinical trials for PVE have been published, most guidelines on the diagnosis and management of MRSA PVE rely upon expert opinion and data from animal models or related conditions (e...
March 20, 2019: Clinical Microbiology Reviews
https://read.qxmd.com/read/30760415/2019-canadian-cardiovascular-society-canadian-association-of-interventional-cardiology-guidelines-on-the-acute-management-of-st-elevation-myocardial-infarction-focused-update-on-regionalization-and-reperfusion
#14
Graham C Wong, Michelle Welsford, Craig Ainsworth, Wael Abuzeid, Christopher B Fordyce, Jennifer Greene, Thao Huynh, Laurie Lambert, Michel Le May, Sohrab Lutchmedial, Shamir R Mehta, Madhu Natarajan, Colleen M Norris, Christopher B Overgaard, Michele Perry Arnesen, Ata Quraishi, Jean François Tanguay, Mouheiddin Traboulsi, Sean van Diepen, Robert Welsh, David A Wood, Warren J Cantor
Rapid reperfusion of the infarct-related artery is the cornerstone of therapy for the management of acute ST-elevation myocardial infarction (STEMI). Canada's geography presents unique challenges for timely delivery of reperfusion therapy for STEMI patients. The Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology STEMI guideline was developed to provide advice regarding the optimal acute management of STEMI patients irrespective of where they are initially identified: in the field, at a non-percutaneous coronary intervention-capable centre or at a percutaneous coronary intervention-capable centre...
February 2019: Canadian Journal of Cardiology
https://read.qxmd.com/read/30760260/adherence-to-standard-nursing-protocols-on-nasogastric-tube-feeding-in-a-secondary-referral-hospital-in-ghana-comparing-self-ratings-by-professional-and-auxiliary-nurses
#15
Robert Kaba Alhassan, Richard Tsikata, Richard Naatu Tizaawaw, Prince Asante Tannor, Perpetual Praba Quaw, Cecilia Aba Ata Awortwi, Martin Amogre Ayanore, Agani Afaya, Solomon Mohammed Salia, Japiong Milipaak, Prudence Portia Mwini-Nyaledzigbor
BACKGROUND: Data on nurses' adherence to standard protocol on nasogastric (NG) tube feeding remain scanty in Ghana even though patients in critical medical conditions are routinely managed using this procedure. This study explored self-rated adherence to standard protocols on NG tube feeding among professional and auxiliary nurses and the perceived barriers impeding compliance to these standard protocols. METHODS: This is a descriptive analytical cross-sectional study among professional (n = 89) and auxiliary (n = 24) nurses in a major referral hospital in one of the ten administrative regions in Ghana...
February 13, 2019: BMC Health Services Research
https://read.qxmd.com/read/30760248/equiptt-the-evaluation-of-the-quipp-app-for-triage-and-transfer-protocol-for-a-cluster-randomised-trial-to-evaluate-the-impact-of-the-quipp-app-on-inappropriate-management-for-threatened-preterm-labour
#16
Helena A Watson, Naomi Carlisle, Katy Kuhrt, Rachel M Tribe, Jenny Carter, Paul Seed, Andrew H Shennan
BACKGROUND: Accurate diagnosis of preterm labour is needed to ensure correct management of those most at risk of preterm birth and to prevent the maternal and fetal risks incurred by unnecessary interventions given to the large majority of women, who do not deliver within a week of presentation. Intervention "just-in-case" results in many avoidable admissions, women being transferred out of their local hospital unnecessarily and most women receiving unwarranted drugs, such as steroids and tocolytics...
February 13, 2019: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/30758767/beyond-the-equivalence-thesis-how-to-think-about-the-ethics-of-withdrawing-and-withholding-life-saving-medical-treatment
#17
Nathan Emmerich, Bert Gordijn
With few exceptions, the literature on withdrawing and withholding life-saving treatment considers the bare fact of withdrawing or withholding to lack any ethical significance. If anything, the professional guidelines on this matter are even more uniform. However, while no small degree of progress has been made toward persuading healthcare professionals to withhold treatments that are unlikely to provide significant benefit, it is clear that a certain level of ambivalence remains with regard to withdrawing treatment...
February 13, 2019: Theoretical Medicine and Bioethics
https://read.qxmd.com/read/30756154/-s3-guidelines-on-the-diagnosis-and-treatment-of-carcinoma-of-the-endometrium-requirements-for-pathology
#18
REVIEW
L-C Horn, G Emons, S Aretz, N Bock, M Follmann, S Lax, M Nothacker, E Steiner, D Mayr
The present article summarises the relevant aspects of the S3 guidelines on endometrioid carcinomas. The recommendations include the processing rules of fractional currettings as well as for hysterectomy specimens and lymph node resections (including sentinel lymph nodes). Besides practical aspects, the guidelines consider the needs of the clinicians for appropriate surgical and radiotherapeutic treatment of the patients. Carcinosarcomas are assigned to the endometrial carcinoma as a special variant. For the first time, an algorithmic approach for evaluation of the tumour tissue for Lynch syndrome is given...
February 2019: Der Pathologe
https://read.qxmd.com/read/30747760/one-hour-high-sensitivity-troponin-testing-a-safe-and-effective-triage-tool-for-the-emergency-department
#19
Asad Shabbir, Lampson Fan, Gregory Fraser, Mark Philip Cassar, Jon Swinburn
The latest European Society of Cardiology guideline on the management of acute coronary syndromes without persistent ST-elevation stipulates several acceptable pathways through which patients presenting with chest pain can be assessed for unstable coronary disease. This article reviews the data behind the "rule-in and rule-out algorithm," which can exclude acute myocardial infarction within 1 hour of presentation through the use of fifth generation high-sensitivity troponin assays.
March 2019: Critical Pathways in Cardiology
https://read.qxmd.com/read/30747443/beyond-inference-by-eye-statistical-and-graphing-practices-in-jeab-1992-2017
#20
Elizabeth G E Kyonka, Suzanne H Mitchell, Lewis A Bizo
Debates about the utility of p values and correct ways to analyze data have inspired new guidelines on statistical inference by the American Psychological Association (APA) and changes in the way results are reported in other scientific journals, but their impact on the Journal of the Experimental Analysis of Behavior (JEAB) has not previously been evaluated. A content analysis of empirical articles published in JEAB between 1992 and 2017 investigated whether statistical and graphing practices changed during that time period...
February 12, 2019: Journal of the Experimental Analysis of Behavior
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