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Sarcomas radiotherapy

M Taffurelli, A Pellegrini, I Meattini, L Orzalesi, C Tinterri, M Roncella, D Terribile, F Caruso, G Tazzioli, G Pollini, D Friedman, C Mariotti, E Cianchetti, C Cabula, R Thomas, C Cedolini, F Rovera, M Grassi, G Lucani, A Cappella, M Bortul, G Stacul, F Scarabeo, E Procaccini, V Galimberti
BACKGROUND: Breast angiosarcoma is a malignant mesenchymal neoplasm, which accounts for approximately 2% of all soft tissue sarcomas. Secondary breast angiosarcoma (SBA) may be related to chronic lymphedema after a mastectomy with lymph node dissection (Stewart Treves syndrome) and previous radiotherapy for complications from breast radiation treatment. It is a very rare condition; therefore, diagnosis and management are still a challenge. METHODS: The ANISC collected SBA data by means of a survey sent to all Italian breast centres in the ANISC...
March 7, 2019: Breast: Official Journal of the European Society of Mastology
X X Zhang, L B Xu, S F Xu, Z G Zhao, H Fang, P Q Ma, T Liu, S G Zhang, S J Yu
Objective: To evaluate the efficacy and prognostic factors of comprehensive treatment of undifferentiated high grade pleomorphic sarcoma (UHGPS) in extremities and trunk, including surgery, radiotherapy and chemotherapy. Methods: A retrospective analysis and follow-up of 131 UHGPS cases with clinical stage Ⅱ or Ⅲ in extremities and trunk soft tissue was performed to analyze the prognostic factors. Survival data were collected through follow-up. The survival rate was calculated with life table method and Kaplan-Meier survival curves were drawn...
February 23, 2019: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Gianmaria Miolo, Debora Basile, Andrea Carretta, Davide Adriano Santeufemia, Agostino Steffan, Giuseppe Corona
BACKGROUND: The purpose of this case report is to describe the potential that metabolomics breath analysis may have in cancer disease monitoring. The advances in mass spectrometry instrumentation allow the accurate real-time analysis of volatile metabolites exhaled in the breath. The application of such non-invasive devices may provide innovative and complementary monitoring of the physio-pathological conditions of cancer patients. CASE PRESENTATION: A 59-year-old Caucasian woman with spindle cell malignant mesenchymal sarcoma of the presacral region started a first-line therapy with non-pegylated liposomal doxorubicin and ifosfamide associated with pelvic radiant treatment...
March 11, 2019: International Journal of Biological Markers
Nicholas P Gannon, Matthew H Stemm, David M King, Meena Bedi
PURPOSE: Neoadjuvant radiotherapy ± chemotherapy and wide local excision is an accepted management of localized soft tissue sarcomas (STS). Necrosis is prognostic for survival in osteosarcomas, but the significance for STS is undetermined. This study aimed to determine if percent true necrosis, opposed to a combination of necrosis and fibrosis, leads to improved survival in extremity and trunk STS. METHODS: From 2000 to 2015, 162 patients with STS were treated with neoadjuvant therapy and resection...
March 7, 2019: Journal of Cancer Research and Clinical Oncology
Motohiro Chosokabe, Akira Noguchi, Masahiro Hoshikawa, Mikio Masuzawa, Masayuki Takagi
BACKGROUND/AIM: Angiosarcoma is a rare and aggressive soft tissue sarcoma with poor prognosis. Chemotherapy and radiotherapy do not improve the prognosis. SIRT1, a class III histone deacetylase, is up-regulated in many malignant tumours. This study aimed at exploring the role of SIRTl in angiosarcoma. MATERIALS AND METHODS: The effect of suppressing SIRT1 expression with siRNA on the proliferation and invasion ability of ISO-HAS-B angiosarcoma cells was investigated...
March 2019: Anticancer Research
Cristina Fortuno, Arcadi Cipponi, Mandy L Ballinger, Sean V Tavtigian, Magali Olivier, Vatsal Ruparel, Ygal Haupt, Sue Haupt, International Sarcoma Kindred Study, Kathy Tucker, Amanda B Spurdle, David M Thomas, Paul A James
Germline pathogenic variants in the TP53 gene cause Li-Fraumeni Syndrome, a condition that predisposes individuals to a wide range of cancer types. Identification of individuals carrying a TP53 pathogenic variant is linked to clinical management decisions, such as the avoidance of radiotherapy and use of high intensity screening programs. The aim of this study was to develop an evidence-based quantitative model that integrates independent in silico data (Align-GVGD and BayesDel) and somatic to germline ratio (SGR), to assign pathogenicity to every possible missense variant in the TP53 gene...
March 6, 2019: Human Mutation
Noa de la Fuente, Manuel Rodríguez Blanco, Gemma Cerdán, Antonio Moral, Vicenç Artigas
Background: Venous leiomyosarcoma is a mesenchymal tumour that represents 5-7% of soft tissue sarcomas. It originates in the smooth muscle cells of the vessel wall and is frequently located in the inferior vena cava. Primary leiomyosarcomas of the gonadal vein are rare, with only 10 cases reported in the literature. Case report: We present the case of a 51-year-old woman diagnosed with a right retroperitoneal mass by computed tomography (CT). The differential diagnosis was between a neurogenic tumour and a mesodermic tumour...
2019: Case Reports in Surgery
Viviana Vitolo, Amelia Barcellini, Piero Fossati, Maria Rosaria Fiore, Barbara Vischioni, Alberto Iannalfi, Angelica Facoetti, Maria Bonora, Sara Ronchi, Emma D'Ippolito, Rachele Petrucci, Gisela Viselner, Lorenzo Preda, Mario Ciocca, Francesca Valvo, Roberto Orecchia
BACKGROUND: Liposarcomas are the most common soft-tissue sarcomas in adulthood. Orbital and spermatic cord liposarcomas are uncommon and there is no consensus on their management. The treatment of choice is wide excision, which may be destructive and lead to unacceptable morbidity. When surgery is declined by patients and in recurrent disease, management can be challenging. We report two cases of liposarcoma treated with carbon ion radiotherapy at the National Center for Oncological Hadrontherapy (Fondazione CNAO) in Italy...
March 2019: In Vivo
Brandon S Imber, Suzanne L Wolden, Hilda E Stambuk, Evan Matros, Leonard H Wexler, Alexander S Drew, Evan B Rosen, Ian Ganly, Gil'ad N Cohen, Antonio L Damato
BACKGROUND: Intraoperative radiotherapy (IORT) is an effective strategy for the delivery of high doses of radiotherapy to a residual tumor or resection cavity with relative sparing of nearby healthy tissues. This strategy is an important component of the multimodality management of pediatric soft tissue sarcomas, particularly in cases where patients have received prior courses of external beam radiotherapy. PURPOSE: Tumor beds with significant topographic irregularity remain a therapeutic challenge because existing IORT technologies are typically most reliable with flat surfaces...
February 22, 2019: Brachytherapy
Hideshi Sugiura, Satoshi Tsukushi, Masahiro Yoshida, Yoshihiro Nishida
BACKGROUND: Treatment for patients with locally recurrent soft tissue sarcomas after wide resection is challenging, and few studies have examined the results of treating these patients. In treatment of recurrent tumors, it has been reported that positive margins are correlated to local rerecurrence, but the relationship between surgical margin and survival remains controversial and risk factors for local recurrences after wide resection of soft tissue sarcomas are not well established...
September 2018: Clinical Orthopaedics and related Research
Divya Khosla, Shalini Verma, Rajpal S Punia, Arjun Dass, Kislay Dimri, Gurbir Kaur, Awadhesh K Pandey
Introduction: Extraosseous Ewing's sarcoma (EES) of the head and neck region is a rare occurrence, and Ewing's sarcoma of the parapharyngeal space is even rarer. To the best of our knowledge, only three cases of EES of the parapharyngeal space have been reported in the literature. Case Report: We report a rare case of EES of the parapharyngeal space in an 8-year-old girl. She presented with complaints of earache, difficulty in breathing and swallowing and bleeding from the mouth...
January 2019: Iranian Journal of Otorhinolaryngology
Bishnubrata Patra, Julie Lafontaine, Maeva Bavoux, Karim Zerouali, Audrey Glory, Mohsen Ahanj, Jean-François Carrier, Thomas Gervais, Philip Wong
Radiotherapy (RT) and chemotherapy (CT) are the major therapeutics to treat cancer patients. Conventional in vitro 2D models are insufficient to study the combined effects of RT and CT towards optimized dose selection or drug screening. Soft-tissue sarcomas (STS) are rare cancers with profound social impacts as they affect patients of all ages. We developed a microfluidic device to form and culture STS spheroids to study the combined cytotoxicities of RT and CT. Uniformly-sized spheroids of two different cell lines, STS 93 and STS 117, were formed in the device...
February 18, 2019: Scientific Reports
Pichaya Thanindratarn, Dylan C Dean, Scott D Nelson, Francis J Hornicek, Zhenfeng Duan
Bone sarcomas are a collection of sporadic malignancies of mesenchymal origin. The most common subtypes include osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. Despite the use of aggressive treatment protocols consisting of extensive surgical resection, chemotherapy, and radiotherapy, outcomes have not significantly improved over the past few decades for osteosarcoma or Ewing sarcoma patients. In addition, chondrosarcoma and chordoma are resistant to both chemotherapy and radiation therapy. There is, therefore, an urgent need to elucidate which novel new therapies may affect bone sarcomas...
April 2019: Journal of Bone Oncology
Marie Meurer, A Floquet, I Ray-Coquard, F Bertucci, M Auriche, A Cordoba, S Piperno-Neumann, S Salas, M Delannes, T Chevalier, A Italiano, J Y Blay, Julien Mancini, P Pautier, F Duffaud
OBJECTIVE: High grade endometrial stromal sarcoma and undifferentiated uterine sarcomas are associated with a very poor prognosis. Although large surgical resection is the standard of care, the optimal adjuvant strategy remains unclear. METHODS: A retrospective analysis of patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas (stages I-III) treated in 10 French Sarcoma Group centers was conducted. RESULTS: 39 patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas treated from 2008 to 2016 were included...
February 16, 2019: International Journal of Gynecological Cancer
O D Persa, C Loquai, M Wobser, M Baltaci, S Dengler, A Kreuter, A Volz, M Laimer, M Emberger, M Doerler, C Mauch, D Helbig
BACKGROUND: Pleomorphic dermal sarcomas (PDS) are frequent UV-induced sarcomas of the skin of intermediate grade malignant potential. Despite the fact that PDS have a noteworthy potential to recur (up to 28%) as well as to metastasize (up to 20%), there are no specific clinical guidelines with respect to follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS. OBJECTIVE: The aim of the present study was to identify risk factors to predict relapse in a large multicenter sample cohort of PDS which could aid to optimize personalized treatment recommendations regarding surgical safety margins and adjuvant radiotherapy...
February 14, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Se Hyun Paek, Kyoung Eun Lee, Han Su Kim, Joohyun Woo, Woosung Lim
BACKGROUND Sarcomas can develop de novo or secondary to radiotherapy after or during breast cancer treatment. Diagnosis can be challenging, as such, a sarcoma is often missed on routine follow-up imaging and often presents with dermatologic findings. CASE REPORT Here, we present a case of a 45-year-old female who developed spindle cell sarcoma on her neck, which was mimicking supraclavicular lymph node metastasis of breast cancer. CONCLUSIONS Based on our report, we recommend a tissue biopsy with an immunohistochemistry profile when a mass suspicious for metastasis is found in patients with breast cancer...
February 14, 2019: American Journal of Case Reports
Bonnie B Boudreaux, Susan M LaRue, Nathalie Rademacher, Daniel Neck, Britton Grasperge, Charles Wood, David G Baker
A 10-year-old male captive tiger (Panthera tigris) developed right-sided facial asymmetry and enlargement. Computed tomography revealed a destructive mass of the right maxillary bone with right nasal cavity involvement. Histopathology indicated a spindle cell sarcoma. A single fraction of 22 Gy using stereotactic radiotherapy was prescribed. After treatment, the facial conformation returned to normal and the tiger resumed normal behavior. Diagnostics 4 months later indicated severe metastatic disease. Humane euthanasia and necropsy were performed...
February 12, 2019: Veterinary Radiology & Ultrasound
Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li
BACKGROUND: To compare the survival outcomes and late toxicities of postoperative intensity-modulated radiation therapy (IMRT) with two-dimensional radiotherapy (2D-RT) for patients with soft tissue sarcoma (STS) of extremities and trunk. METHODS: 274 consecutive patients with nonmetastatic STS of extremities and trunk treated with postoperative IMRT (n = 187) and 2D-RT (n = 87) were analyzed. Survival was calculated by using Kaplan-Meier method. Independent prognostic factors were identified using Cox stepwise regression analysis for variables with a P-value <0...
February 10, 2019: Cancer Medicine
Ricarda Rauschenberg, Johannes Bruns, Julia Brütting, Dirk Daubner, Fabian Lohaus, Lisa Zimmer, Andrea Forschner, Daniel Zips, Jessica C Hassel, Carola Berking, Katharina C Kaehler, Jochen Utikal, Ralf Gutzmer, Patrik Terheyden, Frank Meiss, David Rafei-Shamsabadi, Felix Kiecker, Dirk Debus, Evelyn Dabrowski, Andreas Arnold, Marlene Garzarolli, Marvin Kuske, Stefan Beissert, Steffen Löck, Jennifer Linn, Esther G C Troost, Friedegund Meier
BACKGROUND: Combining stereotactic radiosurgery (SRS) and active systemic therapies (STs) achieved favourable survival outcomes in patients with melanoma brain metastases (MBMs) in retrospective analyses. However, several aspects of this treatment strategy remain poorly understood. We report on the overall survival (OS) of patients with MBM treated with a combination of radiotherapy (RT) and ST as well as the impact of the v-Raf murine sarcoma viral oncogene homolog B (BRAF)-V600 mutation (BRAFmut) status, types of RT and ST and their sequence...
February 7, 2019: European Journal of Cancer
Sebastian Scheidt, Cornelius Jacobs, Sebastian Koob, Kristian Welle, Sebastian Walter, Jens Jakob, Michael Kehrer, Jan Schmolders
Soft tissue sarcomas are a heterogeneous group of neoplasias that due to their often clinically silent appearance often remain undetected or experience delayed treatment. Especially soft tissue swelling is often misinterpreted by patients and doctors and trivialized or verified with an incorrect biopsy technique. The hereby evoked complications for the patients are serious and may be reduced by simply following the available guidelines. The treatment of soft tissue sarcomas requires a close interdisciplinary coordination between specialists in tumor orthopedics, oncology, radiology, pathology and radiotherapy...
February 8, 2019: Zeitschrift Für Orthopädie und Unfallchirurgie
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