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JOURNAL ARTICLE
Fabiana Dolovitsch de Oliveira, Rodrigo Carvalho Costa, Emmily Daiane Buarque de Santana Sato, Samira Mohamad Khalil, Gilmara Coelho Meine
BACKGROUND AND AIMS: Monoclonal antibodies (MAbs) have clinical benefits for treating several atopic diseases. However, consensus on its use for eosinophilic esophagitis (EoE) is lacking. The present meta-analysis aimed to compare the efficacy and safety of MAbs versus placebo for treating EoE. METHODS: We searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCTs). The primary outcomes were changes in peak esophageal eosinophils count/high power field (HPF) and mean esophageal eosinophils count/HPF...
May 6, 2024: Digestive Diseases and Sciences
#2
JOURNAL ARTICLE
Sven Ole Sarnoch, Amra Pepić, Lisa Schmitz, Benjamin Becker, Christian Betz, Anna-Sophie Hoffmann
PURPOSE: Since its release, Dupilumab has shown great results in treating severe uncontrolled CRSwNP. However, there is a lack of real-world data beyond 12 months of follow-up, and it is not clear to what extent biomarkers are appropriate for monitoring and predicting the Dupilumab therapy success. Hence, this study aims to analyze biomarkers for monitoring therapy, predicting therapy success and assess the effect of Dupilumab in real-world settings. METHODS: The follow-up was performed with 104 patients retrospectively up to 22 months, assessing SNOT-22, NPS, olfactometry, ACS, FEV-1, and blood biomarkers (total serum IgE, Eosinophils, ECP)...
May 6, 2024: European Archives of Oto-rhino-laryngology
#3
JOURNAL ARTICLE
Shou-Ping Hu, Fei Xiao, Zhuo Zhang, Yan Jiang, Dong-Sheng Mao, Jing-Fei Wang, Xi-Jun He
A 6-year-old male golden retriever presented with swelling of the left upper eyelid of 2 months duration, which did not improve following a course of antibiotics. Routine serum biochemistry, complete blood count and diagnostic imaging identified no clinically significant abnormalities. The mass was surgically excised, and histopathologic examination was performed. Eosinophilic granulocytic sarcoma (GS) was diagnosed based on the results of histopathology and immunohistochemistry. This is the first report of GS affecting the eyelid of a dog...
May 2024: Veterinary Medicine and Science
#4
JOURNAL ARTICLE
Rajesh Kumar Bhola, Christophe Fudaly, Shubham Rastogi
Modern automated laboratory haematology analysers use various methods to measure different haematological parameters. These parameters are useful in the diagnostic and clinical interpretation of patient symptoms. So, it is very important to compare the performance of different analysers measuring the same parameter. Hence, a comparison of complete blood counts analysed by Sysmex XN 3000 and Horiba Yumizen H2500 was performed. Total 296 EDTA anti-coagulated blood samples were processed in both the analysers in duplicate within 4 h of collection...
April 2024: Indian Journal of Hematology & Blood Transfusion
#5
REVIEW
Celia Pinedo Sierra, Elena Curto Sánchez, Rocio Diaz Campos, Tamara Hermida Valverde, Silvia Sánchez-Cuellar, Ana Fernández Tena
Asthma is a chronic inflammatory disease that affects about 5% of the world's population and generates high health and social costs. Proper management of the disease requires a correct diagnosis, based on objective measures of functional impairment, as well as symptom control and assessment of the future risk of exacerbations.It has been estimated that 18% of asthma patients in Western Europe have severe asthma and approximately 50% of them have poor control. The severity of asthma is established based on the minimum maintenance treatment needs to achieve control...
2024: Open Respir Arch
#6
JOURNAL ARTICLE
Robert M Genta, Massimo Rugge
INTRODUCTION: A recent consensus meeting (RE.GA.IN) addressed "host-related, low-prevalence gastritis": eosinophilic (EoG), lymphocytic (Hp-pos_LyG and Hp-neg_LyG), collagenous (CollG), and granulomatous gastritis (GrG). Our study evaluates their clinico-epidemiological characteristics. MATERIALS AND METHODS: We extracted all patients with a diagnosis of EoG, LyG, CollG, and GrG from a clinicopathological database and compared their demographics, clinical and endoscopic characteristics, associated conditions, and clinical awareness to those of all other subjects in the database (controls)...
May 4, 2024: Digestive and Liver Disease
#7
JOURNAL ARTICLE
Joshua E Denny, Md Zahidul Alam, Nontokozo V Mdluli, Jeffrey R Maslanka, Linda A Lieberman, Michael C Abt
Clostridioides difficile infection causes pathology that ranges in severity from diarrhea to pseudomembranous colitis. Toxin A and Toxin B are the two primary virulence factors secreted by C. difficile that drive disease severity. The toxins damage intestinal epithelial cells leading to a loss of barrier integrity and induction of a proinflammatory host response. Monoclonal antibodies (mAbs) that neutralize Toxin A and Toxin B, actoxumab and bezlotoxumab, respectively, significantly reduce disease severity in a murine model of C...
May 1, 2024: Anaerobe
#8
JOURNAL ARTICLE
Avneet Kaur, Ishandeep Singh, Isha Kohli, Sahiljot Singh Bhupal, Jay Patel, Nikki Nikzad, Aalam Sohal, Juliana Yang
Background/Objective: Cannabis, one of the most widely used recreational drug in the United States, has had a significant surge in usage following its legalization in 1996. In recent years, there has been research into the physiological effects of cannabis on the gastrointestinal (GI) system. Our study aims to systematically examine the association between cannabis use and complications of gastroesophageal reflux disease (GERD). Materials and Methods: We queried the 2016-2020 National Inpatient Sample database to identify patient encounters with GERD...
May 3, 2024: Cannabis and Cannabinoid Research
#9
JOURNAL ARTICLE
Xiaoxi Huang, Zheng Liu, Benjamin S Bleier, Yu Song, Dawei Wu
OBJECTIVE: Identifying the biomarkers for uncontrolled chronic rhinosinusitis (CRS) is important for directing treatment decisions. Eosinophilia has been reported to be involved in the poor disease control of CRS and mucus eosinophil-derived neurotoxin (EDN) is potentially a biomarker of intense eosinophil activation. This study aimed to assess the relationship between mucus EDN levels, disease severity, and degree of CRS control. METHODS: A total of 150 adult patients with CRS and 25 healthy controls were prospectively enrolled...
May 3, 2024: European Archives of Oto-rhino-laryngology
#10
REVIEW
Elham Behrangi, Farzan Moodi, Alireza Jafarzadeh, Azadeh Goodarzi
INTRODUCTION: Due to the increasing prevalence of immune-mediated diseases such as psoriasis, lichen planus, rheumatoid arthritis and inflammatory bowel disease, dermatologists have turned to new biologic drugs known as DMARDs (disease-modifying anti-rheumatic drugs) in recent years. AREAS COVERED: In this study, we evaluate the immune-mediated dermatological side effects of DMARDS by reviewing and analyzing previous peer-reviewed research on the effects of TNF-α inhibitors in the treatment of skin diseases, as well as adverse effects of these drugs and some of the main causes of these effects...
May 2024: Skin Research and Technology
#11
JOURNAL ARTICLE
Ajay Babu, Huliraj Narayanswamy, Archana Baburao
BACKGROUND: Asthma COPD overlap (ACO) is a consensus-based phenotype having characteristics of both COPD and asthma. Distinguishing ACO from other diseases is even more important as it is related to low health-related quality of life, augmented exacerbation rate and hospital admission, a rapid deterioration in lung function, and increased morbidity and mortality. But it cannot be diagnosed explicitly based on spirometry tests, patient demographics, radiology, or by-sputum cytology. There is an unmet need to develop biomarkers...
September 2023: Journal of the Association of Physicians of India
#12
JOURNAL ARTICLE
Andrea Segreti, Sara Mastroberardino, Lorenzo Frau, Alessandro Appetecchia, Luca D'Antonio, Danilo Ricciardi, Gian Paolo Ussia, Francesco Grigioni
We describe the case of a 45-year-old female affected by asthma and nasal polyposis who presented to the emergency department because of worsening dyspnea and paresthesia of the left lower limb. Comprehensive instrumental examinations revealed the presence of severe left ventricle dysfunction, intra-cardiac thrombus, deep vein thrombosis, pulmonary embolism, lung infiltrates, polyserositis, and neurological involvements. Finally, the patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome, a rare vasculitis of small-medium blood vessels with several organ involvements...
May 2, 2024: Monaldi Archives for Chest Disease
#13
JOURNAL ARTICLE
Robert S Zeiger, Michael Schatz, Magdalena E Pomichowski, Qiaowu Li, Jeff M Slezak, Hendrik Nolte, Harpreet S Takhar
BACKGROUND: Sublingual immunotherapy (SLIT) with 12 SQ house dust mile SLIT-tablet (HDM SLIT-tablet) for dust mite-induced perennial allergic rhinitis is reported as effective and safe. Although serious allergic reactions (SARs) and eosinophilic esophagitis (EoE) have infrequently occurred under trial conditions, the safety of HDM SLIT-tablet challenge under real-world conditions is unknown. OBJECTIVE: Our aim was to estimate the incidence of SARs and EoE due to HDM SLIT-tablet challenge...
August 2024: J Allergy Clin Immunol Glob
#14
COMPARATIVE STUDY
Anna Drynda, Agnieszka Padjas, Krzysztof Wójcik, Radosław Dziedzic, Grzegorz Biedroń, Katarzyna Wawrzycka-Adamczyk, Anna Włudarczyk, Joanna Wilańska, Jacek Musiał, Zbigniew Zdrojewski, Zenobia Czuszyńska, Anna Masiak, Maria Majdan, Radosław Jeleniewicz, Hanna Augustyniak-Bartosik, Katarzyna Jakuszko, Magdalena Krajewska, Alicja Dębska-Ślizień, Hanna Storoniak, Barbara Bułło-Piontecka, Witold Tłustochowicz, Joanna Kur-Zalewska, Małgorzata Wisłowska, Piotr Głuszko, Marta Madej, Ewa Jassem, Iwona Damps-Konstańska, Eugeniusz Kucharz, Marek Brzosko, Marcin Milchert, Anna Hawrot-Kawecka, Joanna Miłkowska-Dymanowska, Paweł Górski, Anna Lewandowska-Polak, Joanna Makowska, Joanna Zalewska, Lech Zaręba, Stanisława Bazan-Socha
OBJECTIVE: To characterize the eosinophilic granulomatosis with polyangiitis (EGPA) population from the POLVAS registry depending on ANCA status and diagnosis onset, including their comparison with the granulomatosis with polyangiitis (GPA) subset with elevated blood eosinophilia (min. 400/ μ l) (GPA HE) to develop a differentiating strategy. METHODS: A retrospective analysis of the POLVAS registry. RESULTS: The EGPA group comprised 111 patients...
2024: Journal of Immunology Research
#15
Clelia Di Mari, Elena Pozzi, Cecilia Mantegazza, Francesca Destro, Milena Meroni, Marina Coletta, Andrea Sorge, Gloria Pelizzo, Gian Vincenzo Zuccotti
Eosinophilic gastrointestinal diseases (EGIDs) are rare, chronic inflammatory disorders characterized by eosinophilic infiltration of the gastrointestinal tract. Symptoms and clinical presentations vary depending on the site and layer of the gastrointestinal wall infiltrated by eosinophils. Gastrointestinal obstruction is a serious, though uncommon, presentation. Management can be extremely challenging because of the rarity of the condition and the lack of robust scientific evidence. Current treatment approaches for EGIDs mainly focus on elimination diets, proton pump inhibitors and corticosteroids, which present high refractoriness rates...
2024: Frontiers in Pediatrics
#16
JOURNAL ARTICLE
Ezekiel J Haugen, Andrea K Locke, Hernán Correa, Justin S Baba, Anita Mahadevan-Jansen, Girish Hiremath
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by an intense infiltration of eosinophils into the esophageal epithelium. When not adequately controlled, eosinophilic inflammation can lead to changes in components of the extracellular matrix (ECM) of the lamina propria. Particularly, alterations to the collagen fiber matrix can lead to lamina propria fibrosis (LPF), which plays an important role in the fibrostenotic complications of EoE. Current approaches to assess LPF in EoE are prone to inter-observer inconsistencies and provide limited insight into the structural remodeling of the ECM...
2024: Translational medicine communications
#17
JOURNAL ARTICLE
Youmna Abdelghany, Danielle Renee Glick, Todd Cutler
Acute eosinophilic pneumonia (AEP) is a rare cause of acute respiratory failure. Clinical presentations can range from dyspnoea, fever and cough, to rapidly progressive and potentially fulminant respiratory failure. While its exact cause is often unknown, associations with inhalational injuries and exposures to new medications have been described.We report a case of a middle-aged, non-smoking man with a history of alcohol use disorder. He presented with 4 days of shortness of breath that started hours after taking injectable naltrexone (Vivitrol)...
May 2, 2024: BMJ Case Reports
#18
REVIEW
Emma Guttman-Yassky, Lila Bahadori, Laura Brooks, Ken L Clark, Hanna Grindebacke, Calvin N Ho, Rohit Katial, Tuyet-Hang Pham, Claire Walton, Catherine J Datto
WHAT IS THIS SUMMARY ABOUT?: Atopic dermatitis (AD) is a chronic (long-lasting) skin disease that leads to dry, itchy, and swollen red spots, which can also be painful and flare up at any time. Some people with AD have a high number of eosinophils, a type of white blood cell, which are associated with worse disease. Medicated creams and lotions, prescribed by health care providers, are meant to reduce the symptoms of AD. For some people, these creams and lotions do not work. Benralizumab injection is a medication that reduces and removes eosinophils...
May 2, 2024: Immunotherapy
#19
JOURNAL ARTICLE
Inge Jacobs, Bo-Jun Ke, Matthias Ceulemans, Jonathan Cremer, André D'Hoore, Gabriele Bislenghi, Gianluca Matteoli, Gert De Hertogh, João Sabino, Marc Ferrante, Séverine Vermeire, Christine Breynaert, Tim Vanuytsel, Bram Verstockt
INTRODUCTION: Approximately 50% of Crohn's disease (CD) patients develop intestinal strictures necessitating surgery. The immune cell distribution in these strictures remains uncharacterized. We aimed to identify the immune cells in intestinal strictures of CD patients. METHODS: During ileocolonic resections, transmural sections of terminal ileum were sampled from 25 CD patients and 10 non-inflammatory bowel disease (IBD) controls. Macroscopically, unaffected, fibrostenotic and inflamed ileum was collected and analysed for immune cell distribution (flow cytometry) and protein expression...
May 1, 2024: Clinical and Translational Gastroenterology
#20
Reem Al Saadi, Sarah AlQassimi, Mohamed Abuzakouk, Ahmed Alduaij
This report describes a 48-year-old man who presented with a month history of weakness and paraesthesia associated with severe pain of all four limbs. Initially diagnosed and treated as Guillain Barre syndrome due to the severity of his extremity weakness, it was later discovered to be eosinophilic granulomatous polyangiitis (EGPA). Mononeuritis multiplex should not be underestimated or overlooked in the setting of diagnosing EGPA and requires prompt treatment with biologics to limit the permanent consequences on patient's quality of life with regard to developing limb weakness and pain...
March 2024: Curēus
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