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https://read.qxmd.com/read/30774380/the-expression-of-special-at-rich-binding-protein-1-in-cervical-cancer-and-its-clinical-significance
#1
Lijie Zhao, Yuhua Zheng, Yong Ji, Xiaoying Zhang
Background: The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer patients. Methods: A total of 33 cervical cancer patients treated in our hospital from September 2012 to December 2015 were included. The mRNA expression level of STAB1 in cervical cancer tissue was determined by real-time PCR, and the patients were divided into dichotomous groups based on their SATB1 expression level...
2019: OncoTargets and Therapy
https://read.qxmd.com/read/30771995/frequency-and-risk-factors-of-thoracic-metastases-and-optimisation-of-the-use-of-cross-sectional-chest-imaging-in-follow-up-patients-with-cervical-cancer
#2
K K Nakao, A Kido, T Imai, K Abiko, K Fujimoto, A Horie, S Minamiguchi, S Tanaka, M Mandai, K Togashi
AIM: To optimise cross-sectional chest imaging usage by identifying frequency and risk factors associated with thoracic metastases in cervical cancer patients after initial definitive treatment. MATERIALS AND METHODS: This study, conducted during 2004-2015, examined 361 consecutive patients with histopathologically proven cervical carcinoma with at least 1 year of follow-up. Electronic medical records and all available imaging modes were used to record and assess patient and tumour characteristics and timing of thoracic metastases...
February 13, 2019: Clinical Radiology
https://read.qxmd.com/read/30720106/prostaglandin-d2-expression-is-prognostic-in-high%C3%A2-grade-serous-ovarian-cancer
#3
Mariana Rezende Alves, Nayra Soares Do Amaral, Fabio Albuquerque Marchi, Felipe Ilelis De Barros Silva, Alexandre André Balieiro Anastácio Da Costa, Kátia Cândido Carvalho, Glauco Baiocchi, Fernando Augusto Soares, Louise De Brot, Rafael Malagoli Rocha
To identify biomarkers that could predict response or lack of response to conventional chemotherapy at the time of diagnosis of high‑grade serous ovarian carcinoma (HGSOC), the present study compared large‑scale gene expression from patients with short or long disease‑free survival times, according to the last cycle of chemotherapy, and validated these findings using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and conventional immunohistochemical (IHC) analysis. Samples were selected for microarray evaluation, at the time of diagnosis, using the following criteria: Identical debulking primary surgery, International Federation of Gynaecology and Obstetrics staging, histological subtype and grade...
January 28, 2019: Oncology Reports
https://read.qxmd.com/read/30712336/do-barbed-sutures-with-different-surface-textures-have-different-effects-on-adhesion-formation-and-histological-features-an-experimental-blinded-study-in-an-animal-model
#4
Tolga Karacan, Eser Ozyurek, Lale Susan Türkgeldi, Hüseyin Kıyak, Simge Pesen, Merve Yasti, Taner Usta
BACKGROUND: The obstetrics and gynecology literature has expanded in recent years to include clinical trials assessing the use of barbed sutures. The difficulty of intracorporeal suturing continues to be a barrier to a wider use of laparoscopy. Although the use of barbed sutures has been shown to ease the process of laparoscopic suturing considerably, concerns have been raised regarding a potentially increased risk of adhesions or inflammation as a result of their use. OBJECTIVES: The aim of this study was to determine whether differences in surface textures, resulting from the variations in the geometric configurations of barbs, lead to differences in intra-abdominal adhesion formation...
January 30, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30700285/abundance-of-mitochondrial-superoxide-dismutase-is-a-negative-predictive-biomarker-for-endometriosis-associated-ovarian-cancers
#5
Tsukuru Amano, Tokuhiro Chano, Takahiro Isono, Fuminori Kimura, Ryoji Kushima, Takashi Murakami
BACKGROUND: Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance. METHODS: To clarify the clinical significance of SOD2 in EAOC, SOD2 expression was semi-quantitatively investigated by immunohistochemical analysis in 61 primary EAOC cases, and the correlations between SOD2 expression and clinicopathological data and survival were analyzed...
January 30, 2019: World Journal of Surgical Oncology
https://read.qxmd.com/read/30695901/-relationship-between-various-histological-status-of-margins-of-leep-and-residual-hsil-or-worse-at-hysterectomy-following-conization
#6
Y P Xiao, X Tao, C Y Zhao, Y Q Qu, F Xie, Y Ning
Objective: To investigate the relationship between various loop electrosurgical excision procedure (LEEP) margin status and residual high grade squamous intraepithelial lesion (HSIL) or worse at hysterectomy following conization. Methods: The relevant clinicopathological data were collected in the Obstetrics and Gynecology Hospital, Fudan University from Jan. 2014 to Dec. 2015, including 947 cases who underwent hysterectomy within 6 months of LEEP. The residual HSIL or worse at hysterectomy were analyzed among the groups...
January 25, 2019: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/30684972/rrbp1-overexpression-is-associated-with-progression-and-prognosis-in-endometrial-endometrioid-adenocarcinoma
#7
Shuang Liu, Mu Lin, Hongying Ji, Jing Ding, Jiaqi Zhu, Rong Ma, Fanling Meng
BACKGROUND: Currently, ribosome-binding protein 1 (RRBP1) is considered to be a novel oncogene that is overexpressed in colorectal cancer, lung cancer, mammary cancer, esophageal cancer and other carcinomas. However, the relationship between RRBP1 and endometrioid-type endometrial carcinoma (EC) remains unknown. Our purpose is to explore the function of RRBP1 in endometrioid-type endometrial carcinoma. METHODS: We investigated the expression of RRBP1 protein by immunohistochemistry on paraffin-embedded surgical specimens from one hundred thirty patients with endometrioid-type endometrial carcinoma...
January 26, 2019: Diagnostic Pathology
https://read.qxmd.com/read/30648088/placenta-and-umbilical-cord-cause-in-antepartum-deaths
#8
Xenofon Mantakas, Ioannis Dalivigkas, Leon Aravantinos, Nikos Goutas, Christina Goudeli, Nikos Vlahos
Stillbirth is a sudden and painful event for parents and obstetrical specialists as well. It is, therefore, of greatest importance to be able to give answers for the cause in order to plan a subsequent pregnancy. The aim of this retrospective study is to estimate the placental and umbilical cord cause of intrauterine death in relation to different gestational ages. The study took place on the Medical Birth Registry of Aretaieio Hospital, National and Kapodistrian University, Athens, Greece. We include a total of 19,283 pregnancies from 1998 to 2012...
November 7, 2018: Curēus
https://read.qxmd.com/read/30646153/effect-of-positron-emission-tomography-imaging-in-women-with-locally-advanced-cervical-cancer-a-randomized-clinical-trial
#9
Lorraine M Elit, Anthony W Fyles, Chu-Shu Gu, Gregory R Pond, David D'Souza, Rajiv Samant, Margaret Anthes, Gillian Thomas, Marc Filion, Julie Arsenault, Ian Dayes, Timothy J Whelan, Karen Y Gulenchyn, Ur Metser, Kavita Dhamanaskar, Mark N Levine
Importance: In women with locally advanced cancer of the cervix (LACC), staging defines disease extent and guides therapy. Currently, undetected disease outside the radiation field can result in undertreatment or, if disease is disseminated, overtreatment. Objective: To determine whether adding fludeoxyglucose F 18 positron emission tomography-computed tomography (PET-CT) to conventional staging with CT of the abdomen and pelvis affects therapy received in women with LACC...
September 7, 2018: JAMA network open
https://read.qxmd.com/read/30640684/adipose-only-sentinel-lymph-nodes-a-finding-during-the-adaptation-of-a-sentinel-lymph-node-mapping-algorithm-with-indocyanine-green-in-women-with-endometrial-cancer
#10
J A Harold, D Uyar, J S Rader, E Bishop, M Nugent, P Simpson, W H Bradley
OBJECTIVE: To identify factors that affect successful adaptation of sentinel lymph node mapping and those that lead to unintended adipose-only sentinel lymph node identification. METHODS: Surgical and pathological data were prospectively collected on patients with endometrial cancer who underwent sentinel lymph node mapping with indocyanine green with or without pelvic and/or para-aortic lymph node dissection between November 2013 and April 2017. All mapping cases were performed with the robotic system...
January 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30638462/clinical-significance-of-c-met-and-phospho-c-met-tyr1234-1235-in-ovarian-cancer
#11
Ling Lim, Chao-Chih Wu, Yun-Ting Hsu, Fang-Ju Sun, Chih-Long Chang
OBJECTIVE: c-Met is expressed in human ovarian cancer tissues, and its phosphorylation activates signaling cascades that might affect the behavior of cancer cells. In this study, we evaluated the association of c-Met and phosphorylated c-Met (phospho-c-Met) expressions with the clinical outcomes of ovarian cancer patients. MATERIALS AND METHODS: Archived tissue from surgical specimens of 269 ovarian cancer patients who underwent a debulking operation in MacKay Memorial Hospital between 2004 and 2012 were collected...
January 2019: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/30636711/dna-ploidy-status-s-phase-fraction-and-p53-are-not-independent-prognostic-factors-for-survival-in-endometrioid-endometrial-carcinoma-figo-stage-i-iii
#12
Teresia Svanvik, Ulf Strömberg, Erik Holmberg, Janusz Marcickiewicz, Karin Sundfeldt
OBJECTIVES: To assess the effects on relative survival of established and new prognostic factors in stage I-III grade 1-3 endometrioid endometrial carcinoma and in the subgroup of stage I grade 1-2. METHODS: This was a population-based, retrospective study including all women (n=1113) in the western Swedish healthcare region diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I-III grade 1-3 endometrioid endometrial carcinoma in 2006-2011...
January 13, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30630889/pre-operative-assessment-of-intra-abdominal-disease-spread-in-epithelial-ovarian-cancer-a-comparative-study-between-ultrasound-and-computed-tomography
#13
Juan Luis Alcázar, María Caparros, Maria Arraiza, José Ángel Mínguez, Stefano Guerriero, Luis Chiva, Matías Jurado
OBJECTIVE: To compare the diagnostic performance of ultrasound and computed tomography (CT) for detecting pelvic and abdominal tumor spread in women with epithelial ovarian cancer. METHODS: An observational cohort study of 93 patients (mean age 57.6 years) with an ultrasound diagnosis of adnexal mass suspected of malignancy and confirmed histologically as epithelial ovarian cancer was undertaken. In all cases, transvaginal and transabdominal ultrasound as well as CT scans were performed to assess the extent of the disease within the pelvis and abdomen prior to surgery...
January 10, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30615540/hes1-protein-modulates-human-papillomavirus-mediated-carcinoma-of-the-uterine-cervix
#14
Richa Tripathi, Gayatri Rath, Vishwas Sharma, Showket Hussain, Shashi Sharma, Mausumi Bharadwaj, Ravi Mehrotra
PURPOSE: Cervical cancer (CC) is the most common cancer affecting women worldwide. Human papillomavirus (HPV) infection is a major contributing factor for the development of CC. The development of CC occurs progressively from precancer stages to cancerous stages (ie, invasive squamous cell carcinoma [ISCC] and adenocarcinoma [ADC]). ADC is a rare form of CC that develops from the mucinous endocervical epithelium. It is believed that the downstream targets of Notch signaling contribute to the etiology of CC...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30596194/invasive-cervical-cancer-in-ibadan-socio-sexual-characteristics-clinical-stage-at-presentation-histopathology-distributions-and-hiv-status
#15
Olutosin A Awolude, Sunday O Oyerinde
Background: Human Papillomavirus (HPV) infection persistence is the necessary but not sufficient cause of invasive cervical cancer (ICC). The effects of Human Immunodeficiency Virus (HIV) co-infection have been well documented. The purpose of this study was to describe our experience on the clinico-pathological characteristics of patients with cervical cancer and HIV status at a tertiary Hospital in Nigeria. Materials and Methods: This was a descriptive study among ICC patients presenting for clinical staging and biopsy for histological diagnosis at the Obstetrics and Gynaecology outpatient theatre of our hospital between January 2009 and February 2011...
2019: African Journal of Infectious Diseases
https://read.qxmd.com/read/30584683/sono-histological-findings-of-the-placenta-accreta-spectrum
#16
Junichi Hasegawa, Akiko Kurasaki, Toshiyuki Hata, Chika Honma, Ayako Miura, Haruhiro Kondo, Nao Suzuki
Placenta accreta spectrum (PAS) is a complex obstetric complication associated with high maternal morbidity. Several prenatal ultrasound signs of PAS were reported: mainly the disappearance of the normal uteroplacental interface (clear zone), extreme thinning of the underlying myometrium, and vascular changes within the placenta (lacunae) and placental bed (hypervascularity).1, 2 The ability of the ultrasound to detect PAS is dependent upon several factors, such as operator experience, gestational age at assessment, number of abnormal ultrasound findings, and actual degree of placental invasion...
December 24, 2018: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/30580366/fatal-spontaneous-rupture-of-splenic-artery-aneurysm-in-third-trimester-pregnancy
#17
P N Samberkar, T K Chow, S P Samberkar
INTRODUCTION: Unforeseen emergency in late pregnancy can be catastrophic and cause unexpected maternal and foetal demise. Moreover, lack of awareness and failure of prompt treatment raise mortality rate. Such fatalities warrant a forensic autopsy as it may raise redundant medico-legal concerns. CASE REPORT: We report a case that revealed significant intra-abdominal haemorrhage at autopsy. The source of haemorrhage was at the spleen hilum and histology established rupture of splenic artery aneurysm...
December 2018: Malaysian Journal of Pathology
https://read.qxmd.com/read/30538552/pretreatment-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-as-predictive-factors-for-the-survival-of-cervical-adenocarcinoma-patients
#18
Joanna Jonska-Gmyrek, Leszek Gmyrek, Agnieszka Zolciak-Siwinska, Maria Kowalska, Malgorzata Fuksiewicz, Beata Kotowicz
Objective: Our study assessed the clinical utility and prognostic value of pretreatment hematological parameters and calculated coefficients including the platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to lymphocyte ratio (MLR) in patients with cervical adenocarcinoma (CA). Materials and methods: Among 738 cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stages IA-IV treated at our institution, 96 (13%) presented with CA histology...
2018: Cancer Management and Research
https://read.qxmd.com/read/30505342/prevalence-of-human-papillomavirus-among-wenzhou-women-diagnosed-with-cervical-intraepithelial-neoplasia-and-cervical-cancer
#19
Chanqiong Zhang, Chongan Huang, Xiang Zheng, Dan Pan
Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Methods: We undertook a retrospective analysis including 2612 women who were treated in the Department of Gynecology and Obstetrics from Jan 2016 to Nov 2017...
2018: Infectious Agents and Cancer
https://read.qxmd.com/read/30451574/fetal-anthropometric-features-a-postmortem-study-of-fetuses-after-the-termination-of-pregnancy-for-psychosocial-reasons-between-12-and-20-gestational-weeks
#20
Anne-Claude Muller Brochut, Patrick Taffe, Romain Piaget-Rossel, Laurence de Leval, Anne-Laure Rougemont
INTRODUCTION: Reference ranges in fetal postmortem anthropometric data derive from heterogeneous studies and rely on data obtained after intrauterine fetal death and abortion, which may introduce bias in the reported fetal growth parameters. We report anthropometric findings in fetuses with the least variation due to cause of death or developmental anomalies. METHODS: We analyzed fetuses after the termination of pregnancy for psychosocial reasons. The external measurements, X-ray dimensions, and body and organ weights were recorded as well as the placenta weight...
November 19, 2018: Pediatric and Developmental Pathology
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