Marta Sureda-Gómez, Ingram Iaccarino, Anna De Bolòs, Mieke Anna Meyer, Patricia Balsas, Julia Richter, Marta Leonor Rodríguez, Cristina López, Maria Carreras-Caballé, Selina Glaser, Ferran Nadeu, Pedro Jares, Maria Chiara Siciliano, Cristiana Bellan, Salvatore Tornambè, Roberto Boccacci, Guillem Clot, Lorenzo Leoncini, Elías Campo, Reiner Siebert, Virginia Amador, Wolfram Klapper
SRY-related HMG-box gene 11 (SOX11) is a transcription factor overexpressed in mantle cell lymphoma (MCL), a subset of Burkitt lymphomas (BL) and precursor lymphoid cell neoplasms but is absent in normal B-cells and other B-cell lymphomas. SOX11 has an oncogenic role in MCL but its contribution to BL pathogenesis remains uncertain. Here, we observed that the presence of Epstein-Barr virus (EBV) and SOX11 expression were mutually exclusive in BL. SOX11 expression in EBV- BL was associated with an IG∷MYC translocation generated by aberrant class switch recombination, while in EBV-/SOX11- tumors the IG∷MYC translocation was mediated by mistaken somatic hypermutations...
April 15, 2024: Blood