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Dhruv Gohel, Lakshmi Sripada, Paresh Prajapati, Kritarth Singh, Milton Roy, Darshan Kotadia, Flora Tassone, Nicolas Charlet-Berguerand, Rajesh Singh
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by an expansion of 55 to 200 CGG repeats (premutation) in FMR1. These CGG repeats are Repeat Associated non-ATG (RAN) translated into a small and pathogenic protein, FMRpolyG. The cellular and molecular mechanisms of FMRpolyG toxicity are unclear. Various mitochondrial dysfunctions have been observed in FXTAS patients and animal models. However, the causes of these mitochondrial alterations are not well understood...
February 13, 2019: Biochimica et biophysica acta. Molecular basis of disease
Ewerton Zaniboni, Leonardo Bagne, Thaís Camargo, Maria Esméria Corezola do Amaral, Maira Felonato, Thiago Antônio Moretti de Andrade, Gláucia Maria Tech Dos Santos, Guilherme Ferreira Caetano, Marcelo Augusto Marreto Esquisatto, Milton Santamaria, Fernanda Aparecida Sampaio Mendonça
OBJECTIVES: Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent-MC) and low-level laser therapy (LLLT). MATERIAL AND METHODS: One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/corticotomy; (Cort-L) tooth movement/corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/corticotomy and laser/microcurrent alternated...
February 15, 2019: Clinical Oral Investigations
Giacomo Colletti, Federico Biglioli, Tito Poli, Margherita Dessy, Marco Cucurullo, Mario Petrillo, Stavros Tombris, Milton Waner, Enrico Sesenna
Vascular malformations are often found inside the orbit. Isolated venous malformations (frequently misnamed as cavernous hemangiomas) are the most frequent among these. However, also lymphatic and arteriovenous malformations can affect the orbit. The complex anatomy of the orbit and the fact that its content easily suffers from compartmental syndrome explain why treating orbital vascular malformations can be challenging and technically demanding. In this study, two institutions have retrospectively collected their cases, consisting in a total of 69 vascular malformations of the orbit...
September 20, 2018: Journal of Cranio-maxillo-facial Surgery
Sascha Miller, Ben Ainsworth, Lucy Yardley, Alex Milton, Mark Weal, Peter Smith, Leanne Morrison
Trials of digital interventions can yield extensive, in-depth usage data, yet usage analyses tend to focus on broad descriptive summaries of how an intervention has been used by the whole sample. This paper proposes a novel framework to guide systematic, fine-grained usage analyses that better enables understanding of how an intervention works, when, and for whom. The framework comprises three stages to assist in the following: (1) familiarization with the intervention and its relationship to the captured data, (2) identification of meaningful measures of usage and specifying research questions to guide systematic analyses of usage data, and (3) preparation of datasheets and consideration of available analytical methods with which to examine the data...
February 15, 2019: Journal of Medical Internet Research
María Eugenia Mansilla Pareja, Maria Celeste Gaurón, Esteban Robledo, Milton Osmar Aguilera, María Isabel Colombo
Cyclic Adenosine 3',5'-monophosphate (cAMP) is a key second messenger known to directly regulate not only the protein kinase A (PKA) activity but also other important molecules such as the exchange protein activated by cAMP (EPAC), which is as a guanine nucleotide exchange factor (GEF) of the low molecular weight GTPase, Rap2. Coxiella burnetii is a Gram negative bacterium that survives and grows in a large Coxiella replicative vacuole (CRV), which displays lysosomal and autophagic features. In this report, we present evidence that both, EPAC and its downstream effector Rap2b, were recruited to the CRV...
2019: PloS One
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa, Karina Mie Furuzawa, Roger Chammas, Milton Ruiz Alves
PURPOSE: To evaluate the influence of preoperative mitomycin C (MMC) on the proliferative behavior of fibroblasts and fibrovascular tissue derived from the primary pterygium using the immunohistochemical method (Ki67 and CD34). DESIGN: Randomized clinical trial. SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Sixty-five patients with primary pterygium were randomly selected and divided into one of three groups. The control group had 29 patients that were only submitted to pterygium removal...
February 13, 2019: International Ophthalmology
Daniela A B Cervilha, Juliana T Ito, Juliana D Lourenço, Clarice R Olivo, Beatriz M Saraiva-Romanholo, Rildo A Volpini, Manoel C Oliveira-Junior, Thais Mauad, Milton A Martins, Iolanda F L C Tibério, Rodolfo P Vieira, Fernanda D T Q S Lopes
We proposed an experimental model to verify the Th17/Treg cytokine imbalance in COPD exacerbation. Forty C57BL/6 mice were exposed to room air or cigarette smoke (CS) (12 ± 1 cigarettes, twice a day, 30 min/exposure and 5 days/week) and received saline (50 µl) or lipopolysaccharide (LPS) (1 mg/kg in 50 µl of saline) intratracheal instillations. We analyzed the mean linear intercept, epithelial thickness and inflammatory profiles of the bronchoalveolar lavage fluid and lungs. We evaluated macrophages, neutrophils, CD4+ and CD8+ T cells, Treg cells, and IL-10+ and IL-17+ cells, as well as STAT-3, STAT-5, phospho-STAT3 and phospho-STAT5 levels using immunohistochemistry and IL-17, IL-6, IL-10, INF-γ, CXCL1 and CXCL2 levels using ELISA...
February 13, 2019: Scientific Reports
Milton Santos, Jonathan Filippon, Áquilas Mendes, Elias Kondilis
The General Agreement on Trade in Services (GATS), established in 1994, has been a key element of market liberalization of health care services. Brazil had the provision of health care services partially protected from international competition until 2015, when a constitutional change opened the national health care market to international provision. We performed a retrospective and prospective policy analysis based on a systematic policy document review, general literature review, and secondary data analysis mapping, describing and analyzing the international trade agreements signed by Brazil with the World Trade Organization (WTO) and the available legislation relevant to health care services...
February 14, 2019: International Journal of Health Services: Planning, Administration, Evaluation
Dan Aravot, Yaron D Barac, Efrat Krutzwald-Josefson, Aaron M Allen, Dov Flex, Nir Peled, Mordechai R Kramer, Yuri Peysakhovich, Milton Saute
The original article [1] contained an error whereby all authors' names were mistakenly inverted. This error has now been corrected.
February 12, 2019: Journal of Cardiothoracic Surgery
Milton Packer
No abstract text is available yet for this article.
February 7, 2019: European Heart Journal
Thomas J Gampper
No abstract text is available yet for this article.
February 7, 2019: Journal of Craniofacial Surgery
May K Thet, Ma Lourdes F Pelobello, Milton Das, Mohammed M Alhaji, Vui Heng Chong, Muhammad Abdul Mabood Khalil, Terence Chinniah, Jackson Tan
We report a case series of seven patients with nonfermentative Gram-negative bacteria infections in a single dialysis center; four patients with Ralstonia pickettii and three patients with Stenotrophomonas maltophilia. Two of the seven patients were admitted to hospital for intravenous antibiotic treatment, while the rest were treated with oral antibiotics at home. Both the admitted patients had temporary vascular catheter infections from the aforementioned pathogens. We conclude that the outbreak is due to colonization of treated reverse osmosis water, presumably through contamination via polluted filters and compounded by the usage of reprocessed dialysers in the dialysis center...
February 12, 2019: Hemodialysis International
Sandro L Barbosa, Myrlene Ottone, Milton de S Freitas, Camila D Lima, David L Nelson, Giuliano C Clososki, Franco J Caires, Stanlei I Klein, Gabriela R Hurtado
A SiO₂-SO₃H amorphous catalyst containing a small surface area of 115.0 m²g-1 and 1.32 mmol H+ /g was prepared from fine construction sand and sodium carbonate and sulfonated with H₂SO₄. In a 10% (w/w) basis, it is very efficient for catalyzing the esterification of carboxylic acids with phenol. The reaction processes were performed using conventional heating and under microwave irradiation. The yields were higher in the microwave-irradiated esterification. The catalyst could be used for three esterification sequences in both processes...
June 1, 2019: Journal of Nanoscience and Nanotechnology
Pedro Raposo, Tomeu Viver, Luciana Albuquerque, Hugo Froufe, Cristina Barroso, Conceição Egas, Ramon Rosselló-Móra, Milton S da Costa
Chemotaxonomic parameters, phylogenetic analysis of the 16S rRNA gene, phylogenetic analysis of 90 housekeeping genes and 855 core genes, amino acid identity (AAI), average nucleotide identity (ANI) and genomic characteristics were used to examine the 13 species of the genus Meiothermuswith validly published names to reclassify this genus. The results indicate that the species of the genus Meiothermus can be divided into three lineages on the basis of the results of the phylogenetic analysis, AAI, the guanine+cytosine (G+C) mole ratio, the ability to synthesize the red-pigmented carotenoid canthaxanthin and the colony colour, as well as other genomic characteristics...
February 11, 2019: International Journal of Systematic and Evolutionary Microbiology
Orly Vardeny, Brian Claggett, Jessica Kachadourian, Akshay S Desai, Milton Packer, Jean Rouleau, Michael R Zile, Karl Swedberg, Martin Lefkowitz, Victor Shi, John J V McMurray, Scott D Solomon
AIMS: To assess differences in diuretic dose requirements in patients treated with sacubitril/valsartan compared with enalapril in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure (PARADIGM-HF) trial. METHODS AND RESULTS: Overall, 8399 patients with New York Heart Association class II-IV heart failure and reduced LVEF were randomized to sacubitril/valsartan 200 mg bid or enalapril 10 mg twice daily...
February 11, 2019: European Journal of Heart Failure
Adrielle Beatrice do Ó Martins, Samires Moura Malaquias Pinheiro, Lua Morena Leoncio, Milton Santos Cardoso Filho, Guilherme Silva Mesquita, Pedro Ivo de Souza Braga, Antônio Fernando Queiroz, Olívia Maria Cordeiro de Oliveira, Anderson Gomes de Oliveira, Ícaro Thiago Andrade Moreira
Oil exploitation, the basis of the world energy sector, is linked to risks and accidents, causing damage to the affected regions. Oil-suspended particulate matter aggregate (OSA) is a promising technology to mitigate those effects. The present study periodically (February 2016 and July 2016) evaluated the dispersion of oil at 28 points in the São Paulo River's estuary, Todos os Santos Bay, Brazil, analyzing the influence of suspended particulate matter (SPM), particulate organic carbon (POC), ions, and chlorophyll on the formation OSA, targeting the prediction of possible ecotoxicological risks...
February 11, 2019: Environmental Monitoring and Assessment
Inês Paciência, João Cavaleiro Rufo, Diana Silva, Carla Martins, Francisca Mendes, Mariana Farraia, Luís Delgado, Eduardo de Oliveira Fernandes, Patrícia Padrão, Pedro Moreira, Milton Severo, Henrique Barros, André Moreira
BACKGROUND: Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren. METHODS: Data from a cross-sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated...
February 11, 2019: Allergy
Pooja Dewan, Rasmus Rørth, Pardeep S Jhund, Joao Pedro Ferreira, Faiez Zannad, Li Shen, Lars Køber, William T Abraham, Akshay S Desai, Kenneth Dickstein, Milton Packer, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Michael R Zile, John J V McMurray
OBJECTIVES: This study examined the relationship between income inequality and heart failure outcomes. BACKGROUND: The income inequality hypothesis postulates that population health is influenced by income distribution within a society, with greater inequality associated with worse outcomes. METHODS: This study analyzed heart failure outcomes in 2 large trials conducted in 54 countries. Countries were divided by tertiles of Gini coefficients (where 0% represented absolute income equality and 100% represented absolute income inequality), and heart failure outcomes were adjusted for standard prognostic variables, country per capita income, education index, and hospital bed, and health worker density...
February 4, 2019: JACC. Heart Failure
João V A Cerqueira, Joaquim A G Silveira, Fabrício E L Carvalho, Juliana R Cunha, Milton C Lima Neto
Salinity commonly affects photosynthesis and crop production worldwide. Salt stress disrupts the fine balance between photosynthetic electron transport and the Calvin cycle reactions, leading to over-reduction and excess energy within the thylakoids. The excess energy triggers reactive oxygen species (ROS) overproduction that causes photoinhibition in both photosystems (PS) I and II. However, the role of PSI photoinhibition and its physiological mechanisms for photoprotection have not yet been fully elucidated...
February 8, 2019: Physiologia Plantarum
Yue Liu, John Milton, Sue Ann Campbell
We formulate a conductance-based model for a 3-neuron motif associated with Childhood Absence Epilepsy (CAE). The motif consists of neurons from the thalamic relay (TC) and reticular nuclei (RT) and the cortex (CT). We focus on a genetic defect common to the mouse homolog of CAE which is associated with loss of GABAA receptors on the TC neuron, and the fact that myelination of axons as children age can increase the conduction velocity between neurons. We show the combination of low GABAA mediated inhibition of TC neurons and the long corticothalamic loop delay gives rise to a variety of complex dynamics in the motif, including bistability...
February 9, 2019: Journal of Computational Neuroscience
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