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A Muller, M Rochoy
INTRODUCTION: Scuba diving has long been contraindicated for asthmatics. Recommendations are evolving towards authorisation under certain conditions. Our objective was to review the literature on the risks associated with scuba diving among asthmatics and about recommendations on this subject. MATERIALS AND METHODS: We used the MEDLINE and LiSSa databases, until June 2018, in French, English or Spanish language, with the keywords "asthma AND diving" and "asthme plongée" respectively...
November 12, 2018: Revue de Pneumologie Clinique
Clementine Nordon, Lamiae Grimaldi-Bensouda, Celine Pribil, Gaelle Nachbaur, Billy Amzal, Gabriel Thabut, Roger Marthan, Michel Aubier
OBJECTIVE: To describe the clinical and economic burden of severe asthma in France over 12 months. METHODS: Data were retrieved from the observational, prospective "Cohorte Obstruction Bronchique et Asthme" (COBRA) cohort, which has enrolled nearly 1000 asthma patients since 2007 from throughout France. Patients undergoing treatment with GINA step-4 or 5 medications uninterruptedly for 12 months (thus defining "severe asthma") were identified and their clinical data used to describe the clinical burden of asthma (exacerbations, symptoms outside exacerbations, and level of asthma control)...
November 2018: Respiratory Medicine
Itsaso Elizalde-Beiras, Francisco Guillén-Grima, Inés Aguinaga-Ontoso
OBJECTIVES: To determine the factors associated with asthma and asthma-related symptoms in children and adolescents in rural areas of Navarre (Spain). PARTICIPANTS AND METHODS: A cross-sectional study using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, as well as additional variables, was conducted on 797 children and adolescents. These provided prevalence data on asthma symptoms and associated factors without further diagnostic testing...
June 2018: Atencion Primaria
Céline Vernet, Isabelle Pin, Lise Giorgis-Allemand, Claire Philippat, Meriem Benmerad, Joane Quentin, Antonia M Calafat, Xiaoyun Ye, Isabella Annesi-Maesano, Valérie Siroux, Rémy Slama
BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l'Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples...
September 8, 2017: Environmental Health Perspectives
Carole Ober, Anne I Sperling, Erika von Mutius, Donata Vercelli
Children who grow up in traditional farm environments are protected from developing asthma and allergy. This 'farm effect' can be largely explained by the child's early life contact with farm animals, in particular cows, and their microbes. Our studies in Amish and Hutterite school children living on farms in the U.S. have further demonstrated that this protection is mediated through innate immune pathways. Although very similar with respect to ancestry and many lifestyle factors that are associated with asthma risk, Amish and Hutterites follow farming practices that are associated with profound differences in the levels of house dust endotoxin, in the prevalence of asthma and atopy among school children, and in the proportions, phenotypes, and functions of immune cells from these children...
October 2017: Current Opinion in Immunology
Małgorzata Proboszcz, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Katarzyna Górska, Rafał Krenke
BACKGROUND: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a cell-surface receptor presented on neutrophils, macrophages and monocytes. Elevated sTREM-1 levels are a marker of acute microbial infections, and have also been reported in chronic lung diseases. IL-6 and IL-13 are effective markers in distinguishing these diseases. IL-6 has been shown to play an important role in chronic obstructive pulmonary disease (COPD), while IL-13 is described as one of the key mediators of allergic asthma...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Eva Martinez-Moragon, Vicente Plaza, Isabel Torres, Ana Rosado, Isabel Urrutia, Xavier Casas, Belen Hinojosa, Marina Blanco-Aparicio, Julio Delgado, Santiago Quirce, Carles Sabadell, Pilar Cebollero, Ana Muñoz-Fernández
BACKGROUND: Fibromyalgia can affect the control of asthma when both diseases are present in a single patient. OBJECTIVES: To characterize asthma in patients with concomitant fibromyalgia to assess whether fibromyalgia is an independent factor of asthma severity that influences poor asthma control. We also evaluated how dyspnea is perceived by patients in order to demonstrate that alterations in the perception of airway obstruction may be responsible for poor asthma control...
December 2017: Current Medical Research and Opinion
Maithili Deshpande, Kevin A Look
BACKGROUND: Asthma is an expensive chronic lung disease that affects 7% of U.S. adults and results in as many as 1.8 million emergency department (ED) visits each year. Pharmacists play an important role in managing asthma, including assessing control and monitoring disease progression, educating the patient about the disease and associated treatments, and ensuring safe and cost-effective medication use. However, comprehensive studies that account for the complex relationships between factors impacting asthma-related ED visits are lacking in the adult asthma population...
January 2018: Research in Social & Administrative Pharmacy: RSAP
Tamar Sapir, Kathleen F Moreo, Laurence S Greene, Laura C Simone, Jeffrey D Carter, James J L Mateka, Nicola A Hanania
RATIONALE: National quality improvement initiatives emphasize building partnerships between patients and providers by promoting patient engagement through communication, shared decision-making, and self-care skills. Efforts to promote patient engagement are especially important for people with asthma. To cultivate effective partnerships in asthma care, patients and providers may benefit from understanding each other's values and perceptions regarding treatment goals, shared decision-making, as well as barriers to optimal care and outcomes...
May 2017: Annals of the American Thoracic Society
Rohit Divekar, Matthew Rank, Diane Squillace, Hirohito Kita, Devyani Lal
BACKGROUND: Endotyping chronic rhinosinusitis (CRS) through simplified cytokine assays may help direct individualized therapy such as corticosteroids, antibiotics, or biologics. We performed an unsupervised network analysis to endotype CRS and control subjects using a commercially available cytokine-chemokine immunoassay. METHODS: A 41-plex cytokine-chemokine array along with major basic protein (MBP) assay was performed on sinonasal surgical tissue of 32 adults...
April 2017: International Forum of Allergy & Rhinology
Nis Brix, Lonny Stokholm, Fjola Jonsdottir, Kim Kristensen, Niels Jørgen Secher
INTRODUCTION: Caesarean section is thought to be a risk factor for childhood asthma, but this association may be caused by confounding from, for instance, familial factors. To address this problem, we used twin pairs to assess the risk of childhood asthma after emergency caesarean section. METHODS: The study was a register-based nation-wide matched cohort study using twin pairs to minimise residual confounding. Included were twin pairs in which the first twin was delivered vaginally and the second by emergency caesarean section during the study period from January 1997 through December 2012...
January 2017: Danish Medical Journal
Kendra Sih, Ran D Goldman
Un enfant qui fréquente ma clinique s'est récemment fait une entorse à la cheville et il éprouve de la douleur et de la difficulté à supporter son poids sur la jambe affectée. Sa mère lui donne de l'acétaminophène parce qu'on lui a dit de ne jamais utiliser d'anti-inflammatoires non stéroïdiens (AINS) en raison de son asthme contrôlé par pharmacologie. L'asthme chez un enfant est-il une contre-indication à l'administration d'AINS? La maladie respiratoire exacerbée par les AINS existe-t-elle comme entité réelle? RÉPONSE: Les AINS sont des médicaments analgésiques et antipyrétiques efficaces...
August 2016: Canadian Family Physician Médecin de Famille Canadien
Pierre-Olivier Girodet, Benoit Allard, Matthieu Thumerel, Hugues Begueret, Isabelle Dupin, Olga Ousova, Régis Lassalle, Elise Maurat, Annaig Ozier, Thomas Trian, Roger Marthan, Patrick Berger
RATIONALE: Increased bronchial smooth muscle (BSM) mass is a key feature of airway remodeling that classically distinguishes severe from nonsevere asthma. Proliferation of BSM cells involves a specific mitochondria-dependent pathway in individuals with severe asthma. However, BSM remodeling and mitochondrial biogenesis have not been examined in nonsevere asthma. OBJECTIVES: We aimed to assess whether an increase in BSM mass was also implicated in nonsevere asthma and its relationship with mitochondria and clinical outcomes...
March 15, 2016: American Journal of Respiratory and Critical Care Medicine
Fanak Fahimi, Farzad Kobarfard, Jamshid Salamzadeh, Atefeh Fakharian, Pegah Abdolahi, Azita Hajhossein Talasaz, Hamid Mahboobi Pour, Shadi Baniasadi, Mohammadreza Masjedi
PURPOSE: Pressurized metered dose inhalers are commonly used in patients with asthma. However, the need to coordinate inhalation with inhaler actuation means that they are not suitable for use per se. Valved holding chamber devices were developed to overcome some of the problems of pressurized metered dose inhalers. Several types of holding chambers of different sizes are available in Iran. This study was designed to compare the effects of 2 commonly used valved holding chambers (Asthm Yar and Dam Yar) in Iran on bioavailability of salbutamol spray and also spirometric parameters in asthmatic patients...
November 2011: World Allergy Organization Journal
I Tillie-Leblond, P Godard
No abstract text is available yet for this article.
February 2007: Revue des Maladies Respiratoires
D Vervloet, C Rolland
No abstract text is available yet for this article.
April 2005: Revue des Maladies Respiratoires
Gabrielle Pauli, N Emile Birba
PURPOSE OF REVIEW: To describe the latest developments in the field of occupational asthma and occupational rhinitis in 2001 and 2002. RECENT FINDINGS: Several surveillance programs of occupational diseases, such as Observatoire National des Asthmes Professionnels in France, Surveillance of work-related and Occupational Respiratory Diseases in South Africa (SORDSA), Surveillance of Work-related and Occupational Respiratory Diseases (SWORD) in UK, have reported on the frequency of occupational asthma...
April 2003: Current Opinion in Allergy and Clinical Immunology
J Ameille, G Pauli, A Calastreng-Crinquand, D Vervloët, Y Iwatsubo, E Popin, M C Bayeux-Dunglas, M C Kopferschmitt-Kubler et al.
AIMS: To estimate the general and specific incidence of occupational asthma in France in 1996-99; and to describe the distribution of cases by age, sex, suspected causal agents, and occupation. METHODS: New cases of occupational asthma were collected by a national surveillance programme, based on voluntary reporting, named Observatoire National des Asthmes Professionnels (ONAP), involving a network of occupational and chest physicians. For each case, the reporting form included information on age, sex, location of workplace, occupation, suspected causal agent, and methods of diagnosis...
February 2003: Occupational and Environmental Medicine
M C Kopferschmitt-Kubler, J Ameille, E Popin, A Calastreng-Crinquand, D Vervloet, M C Bayeux-Dunglas, G Pauli
Observatoire National des Asthmes Professionnels (ONAP) was created in 1996 by two French professional societies to estimate the incidence of occupational asthma and to promote preventive measures against it. Occupational and chest physicians were asked to report newly diagnosed cases of work-related asthma and reactive airway dysfunction syndrome (RADS), the information collected included age, sex, occupation, suspected causal agents and diagnostic methods. In 1997, 82.3% of 559 cases reported (64% males, mean age 36 +/- 13 yrs) involved occupational asthma, 4...
January 2002: European Respiratory Journal
M L Brandon
Pirbuterol (10mg and 15mg capsules) was found to be an effective bronchodilator on large and small airways in bronchial asthm. Benefit occurred within one hour and it lasted five or more hours. It had no significant effect on ECG, blood pressure or heart rate. Mild nervousness and/or muscle tremor occurred occasionally. Hydroxyzine usually prevented these side effects.
July 1980: Annals of Allergy
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