Xiaomin Yang, Erika Porcel, Laurent Marichal, Cesar Gonzalez Vargas, Amine Khitous, Daniela Salado-Leza, Xue Li, Jean-Philippe Renault, Serge Pin, Hynd Remita, Frank Wien, Sandrine Lacombe
Noble metal materials, especially platinum nanoparticles (Pt NPs), have immense potential in nanomedicine as therapeutic agents on account of their high electron density and their high surface area. Intravenous injection is proposed as the best mode to deliver the product to patients. However, our understanding of the reaction of nanoparticles with blood components, especially proteins, is far behind the explosive development of these agents. Using synchrotron radiation circular dichroism (SRCD), we investigated the structural and stability changes of human serum albumin (HSA) upon interaction with PEG-OH coated Pt NPs at nanomolar concentrations, conditions potentially encountered for intravenous injection...
February 7, 2024: Journal of Pharmaceutical Sciences