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ART, IVF, follicular stimulation, fertility, infertility

Giorgia Gioacchini, Valentina Notarstefano, Elena Sereni, Carlotta Zacà, Giovanni Coticchio, Elisabetta Giorgini, Lisa Vaccari, Oliana Carnevali, Andrea Borini
STUDY QUESTION: Does the molecular and metabolic profile of human mural granulosa cells (GCs) correlate with oocyte fate? SUMMARY ANSWER: A close relation between the metabolic profile of mural GCs and the fate of the corresponding oocyte was revealed by the analysis of selected biomarkers defined by GC Fourier transform infrared microspectroscopy (FTIRM) analysis. WHAT IS KNOWN ALREADY: In ART, oocyte selection is mainly based on the subjective observation of its morphological features; despite recent efforts, the success rate of this practice is still unsatisfactory...
November 1, 2018: Molecular Human Reproduction
Abbas Aflatoonian, Aflatoonian Hosseinisadat, Ramesh Baradaran, Maryam Farid Mojtahedi
BACKGROUND: Management of poor-responding patients is still major challenge in assisted reproductive techniques (ART). Delayed-start GnRH antagonist protocol is recommended to these patients, but little is known in this regards. OBJECTIVE: The goal of this study was assessment of delayed-start GnRH antagonist protocol in poor responders, and in vitro fertilization (IVF) outcomes. MATERIALS AND METHODS: This randomized clinical trial included sixty infertile women with Bologna criteria for ovarian poor responders who were candidate for IVF...
April 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
Khalid Awartani, Rahma Al Ghabshi, Hanan Al Shankiti, Mohamed Al Dossari, Serdar Coskun
BACKGROUND: The association between ABO blood groups and ovarian reserve in infertile patients has been a point of controversy. OBJECTIVES: The aim of this study was to assess the correlation of certain blood groups with ovarian reserve and response to treatment in patients undergoing infertility treatment. DESIGN: Retrospective medical record review. SETTING: Infertility clinic in the assisted reproductive technology (ART) unit at King Faisal Specialist Hospital and Research Center, Riyadh Saudi Arabia...
March 2016: Annals of Saudi Medicine
Laya Farzadi, Homa Khayatzadeh Bidgoli, Morteza Ghojazadeh, Zahra Bahrami, Amir Fattahi, Zeinab Latifi, Vahideh Shahnazi, Mohammad Nouri
BACKGROUND: Vitamin D in complex with its receptor by regulating gene expression, endometrium immune response and stimulation of endometrium decidualization can be involved in implantation. So, it seems that the amount of vitamin D in follicular fluids (FF) may have an association with ART success. OBJECTIVE: First, we intended to investigate the possible association between levels of follicular fluids 25-OH vitamin D with assisted reproductive outcomes. Second, we examined relationship between 25-OH vitamin D levels with number and quality of oocytes...
June 2015: Iranian Journal of Reproductive Medicine
Claus Yding Andersen, Helle Olesen Elbaek, Birgit Alsbjerg, Rita Jakubcionyte Laursen, Betina Boel Povlsen, Lise Thomsen, Peter Humaidan
STUDY QUESTION: Can the luteal phase support be improved in terms of efficacy, hormonal profiles and convenience as compared with today's standard care? SUMMARY ANSWER: Daily low-dose rhCG supplementation in GnRHa triggered IVF cycles can replace the traditional used luteal phase support with exogenous progesterone. WHAT IS KNOWN ALREADY: A bolus of hCG for final maturation of follicles in connection with COS may induce the risk of OHSS and the luteal phase progesterone levels rise very abruptly in the early luteal phase...
October 2015: Human Reproduction
D Spitzer, C Corn, J Stadler, B Wirleitner, M Schuff, P Vanderzwalmen, F Grabher, N H Zech
Introduction: Diminished ovarian reserve (DOR) has been linked to certain subpopulations and distinct gene polymorphisms. It has even been hypothesized that the AB0 blood group system could be linked to ovarian reserve (OR) as reflected by early follicular phase follicle stimulating hormone (FSH) levels. Although estimation of OR is routinely done using levels of anti-Müllerian hormone (AMH), FSH, estradiol or inhibin B, the diagnostic accuracy of these markers is often limited. The aim of this study was to evaluate whether there is any correlation between IVF patients' AB0 blood group system and ART outcome...
October 2014: Geburtshilfe und Frauenheilkunde
Klaus Bühler, Olaf G J Naether, Wilma Bilger
BACKGROUND: Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) both have a role to play in follicular development during the natural menstrual cycle. LH supplementation during controlled ovarian stimulation (COS) for assisted reproductive technology (ART) is used for patients with hypogonadotropic hypogonadism. However, the use of exogenous LH in COS in normogonadotropic women undergoing ART is the subject of debate. The aim of this study was to investigate characteristics of infertile women who received the 2:1 formulation of follitropin alfa and lutropin alfa (indicated for stimulation of follicular development in women with severe LH and FSH deficiency) in German clinical practice...
January 14, 2014: Reproductive Biology and Endocrinology: RB&E
Vittorio Unfer, Emanuela Raffone, Piero Rizzo, Silvia Buffo
BACKGROUND: Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin). AIM: In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality...
November 2011: Gynecological Endocrinology
N Lédée, M Petitbarat, M Rahmati, S Dubanchet, G Chaouat, O Sandra, S Perrier-d'Hauterive, C Munaut, J M Foidart
Identification of biomarkers of optimal uterine receptivity to the implanting embryo as well as biomarkers of oocyte competence would undoubtedly improve the efficiency of assisted reproductive technology (ART). Expression of IL-15 and IL-18 has been shown to be different in patients with failed implantation after IVF/ICSI compared with fertile controls and both correlate with local uNK (CD56+) recruitment and angiogenesis. Tumor necrosis factor weak inducer of apoptosis (TWEAK) has been described in mice as a potent early immune regulator able to protect the conceptus...
March 2011: Journal of Reproductive Immunology
Micah J Hill, Eric D Levens
PURPOSE OF REVIEW: Follicular flushing utilizing double-lumen retrieval needles attempts to increase oocyte yield during transvaginal retrieval. The original work on this topic, now more than 2 decades old, examined its utility in normal-responding assisted reproductive technologies (ART) patients. Newer studies examining its utility have focused on special populations expected to demonstrate benefit: poor responders, natural cycle and minimal stimulation ART, and in-vitro maturation cycles...
June 2010: Current Opinion in Obstetrics & Gynecology
E H Dickerson, L W Cho, S D Maguiness, S L Killick, J Robinson, S L Atkin
BACKGROUND: The dual effects of insulin and androgen on the ovary act to promote early folliculogenesis. In the context of polycystic ovarian syndrome (PCOS), the presence of hyperinsulinaemia, resulting from increased insulin resistance (IR), and hyperandrogenaemia lead to the appearance of multiple antral follicles and frequently a multi-follicular response to gonadotrophin stimulation for assisted reproductive treatments (ARTs). The effect of IR and androgen status in women without PCOS on the follicular outcome of controlled ovarian hyperstimulation (COH) is not known...
February 2010: Human Reproduction
M J Pelinck, H M Knol, N E A Vogel, E G J M Arts, A H M Simons, M J Heineman, A Hoek
BACKGROUND: In modified natural cycle IVF (MNC-IVF), treatment is aimed at using the one follicle that spontaneously develops to dominance, using a GnRH-antagonist together with gonadotrophins in the late follicular phase only. The MNC-IVF is of interest because of its low-risk and patient-friendly profile. The effect of application of MNC-IVF preceding standard IVF with ovarian stimulation on overall results is unknown. METHODS: This single-center cohort study provides follow-up of an earlier study in which nine cycles of MNC-IVF were offered to 268 patients...
August 2008: Human Reproduction
M J Pelinck, N E A Vogel, A Hoek, A H M Simons, E G J M Arts, M H Mochtar, S Beemsterboer, M N Hondelink, M J Heineman
BACKGROUND: In minimal stimulation IVF, treatment is aimed at using the single oocyte that spontaneously develops to dominance. To prevent untimely ovulation, a GnRH antagonist is administered in the late follicular phase of the natural cycle together with recombinant FSH for substitution. Owing to the lack of ovarian stimulation, minimal stimulation IVF is a low-risk and patient-friendly treatment. In this study, effectiveness of minimal stimulation IVF was studied. METHODS: In this prospective multicentre cohort study, minimal stimulation IVF was offered to 350 patients...
September 2006: Human Reproduction
Jason Yen-Ping Ho, Hwa-Fen Guu, Yu-Chiao Yi, Ming-Jer Chen, Esther Shih-Chu Ho
OBJECTIVE: The aim of this study was to investigate the relationship of serum FSH and LH levels at the commencement of stimulation to ovarian follicular development in women undergoing pituitary down-regulation and controlled ovarian hyperstimulation with gonadotropins in IVF or intracytoplasmic sperm injection (ICSI) cycles. DESIGN: Retrospective analysis. SETTING: An IVF program in a tertiary medical center. PATIENT(S): A total of 245 women proven to be pituitary down-regulated by their serum E(2) levels...
April 2005: Fertility and Sterility
M Y Thum, A Gafar, M Wren, R Faris, B Ogunyemi, L Korea, L Scott, H I Abdalla
BACKGROUND: To evaluate the effect of egg-sharing and the outcome of assisted reproductive treatment (ART) in standard IVF/ICSI patients, egg-sharing donors and egg-sharing recipients. METHODS: Descriptive cohort study to evaluate 276 egg-sharing cycles involving 192 egg-sharers, 274 recipient cycles receiving eggs from egg-sharers and 1098 non-egg-sharing standard IVF/ICSI cycles from January 1998 to December 2002. Patients were divided into three groups: group A, egg-sharers; group B, non-egg-sharers, age <36 years, FSH <10 IU/l, BMI <30 kg/m(2); and group C, egg-sharing recipients, all ages...
November 2003: Human Reproduction
K A Miller, G W Patton, J T Queenan
OBJECTIVE: To assess the performance of Fertinex (urofollitropin; Serono Laboratories, Norwell, MA) in stimulating the development of multiple follicles and initiating subsequent pregnancy in patients undergoing controlled ovarian hyperstimulation (COH) for IVF. DESIGN: Prospective observational study. SETTING: Private assisted reproductive technology (ART) center. PATIENT(S): Ninety-three women who underwent an IVF cycle of COH in which Fertinex was used as the sole gonadotropin...
April 1998: Fertility and Sterility
J C Huang, K V Jackson, M D Hornstein, E S Ginsburg
OBJECTIVE: Our purpose was to determine whether elevated progesterone (P) during ovulation induction in IVF-ET cycles is a poor prognostic factor for achieving pregnancy. DESIGN: We retrospectively reviewed 672 consecutive IVF-ET cycles in which ovulation was performed using luteal LA downregulation and hMG. SETTING: The ART program at the Brigham & Women's Hospital, a tertiary care institution, was the study setting. MAIN OUTCOME MEASURES: Patients were divided into groups by serum P levels at baseline, on stimulation day 5, on the day of hCG injection, and, on the day after hCG injection and the following parameters were compared: duration of luteal LA treatment, number of ampoules of hMG used, estradiol (E2) levels, number of follicles > or = 12 mm, number of follicles > or = 15 mm, number of oocytes, number of normal embryos, number of polyspermic embryos, fertilization rate, implantation rate, and clinical and ongoing/live birth pregnancy rates...
September 1996: Journal of Assisted Reproduction and Genetics
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