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https://read.qxmd.com/read/30772922/dynamic-piston-function-of-the-mitral-annulus-to-assess-early-left-ventricular-diastolic-filling-a-proof-of-concept-study
#1
Dagmar F Hernandez-Suarez, Francisco López Menéndez, Angel López-Candales
INTRODUCTION: Early left ventricular (LV) filling has been described as an asymmetric toroidal vortex ring of blood entering the LV upon opening of the mitral valve. This phenomenon is in part responsible for cyclical changes in LV volumes during the cardiac cycle and also contributes to the apical and basal longitudinal displacements of the mitral annulus (MA). Although MA early diastolic (e') velocities have been used to assess early LV filling characteristics, accurate distinction between normal aging and pathological diastolic dysfunction (DD) might be challenging at times...
February 16, 2019: Cardiology and Therapy
https://read.qxmd.com/read/30772704/theoretical-analysis-of-nanoshell-assisted-thermal-treatment-for-subcutaneous-tumor
#2
Jingxuan Ma, Xianfeng Yang, Yuxin Sun, Jialing Yang, Jilin Yu
The hyperthermia is an efficient technique for tumor treatment, in which the tumor is subjected to a heating source, such as laser, supersonic or electromagnetic field. In order to improve the therapeutic efficiency and to protect the surrounding healthy tissues, gold nanoshells are embedded in the tumor as the additive to make it absorb more thermal energy than the healthy tissues. In the present study, a one-dimensional three-layered model is established to investigate the thermal response of the bio-tissue in the hyperthermia treatment for subcutaneous tumor...
February 1, 2019: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/30772581/intense-rainfalls-trigger-nitrite-leaching-in-agricultural-soils-depleted-in-organic-matter
#3
Micòl Mastrocicco, Nicolò Colombani, Elisa Soana, Fabio Vincenzi, Giuseppe Castaldelli
Nitrate and ammonium are common inorganic contaminants of anthropogenic origin in many shallow aquifers around the world, while nitrite is less common, but it is most harmful than nitrate and ammonium due to its high reactivity. This paper presents evidence of nitrite accumulation after intense rainfalls in soil samples collected in an agricultural field characterized by organic matter chronic depletion. Moreover, an intact core from the same site was also collected to perform an unsaturated column experiment (60 cm long and 20 cm outer diameter) mimicking heavy rainfalls (230 mm in 2 days)...
February 2, 2019: Science of the Total Environment
https://read.qxmd.com/read/30772192/reproducibility-of-semi-automated-three-dimensional-volumetric-analysis-using-cardiac-computed-tomography-in-patients-with-left-ventricular-assist-device
#4
Gauravpal S Gill, Gaby Weissman, Yael F Meirovich, Diego Medvedofsky, Selma F Mohammed, Ron Waksman, Hector M Garcia-Garcia
BACKGROUND: Multi-detector gated cardiac computed tomography (CCT) allows three-dimensional (3D) quantification of cardiac chambers and is clinically indicated to assess left ventricular assist device (LVAD) malfunction and complications. Automated volumetric analysis is, however, disrupted by inflow cannula artifact in patients with LVAD. With this study, we evaluated intra-observer variability in semi-automated 3D cardiac volumetric analysis using CCT in patients with LVADs. METHODS: Ten clinically indicated CCTs were studied retrospectively from 9 patients with LVADs...
January 23, 2019: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/30772074/layer-based-visualization-and-biomedical-information-exploration-of-multi-channel-large-histological-data
#5
Qi Zhang, Terry Peters, Aaron Fenster
BACKGROUND AND OBJECTIVE: Modern microscopes can acquire multi-channel large histological data from tissues of human beings or animals, which contain rich biomedical information for disease diagnosis and biological feature analysis. However, due to the large size, fuzzy tissue structure, and complicated multiple elements integrated in the image color space, it is still a challenge for current software systems to effectively calculate histological data, show the inner tissue structures and unveil hidden biomedical information...
February 2, 2019: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://read.qxmd.com/read/30771966/targeted-metabolomics-of-whole-blood-using-volumetric-absorptive-microsampling
#6
Miranda G M Kok, Cindy Nix, Gwenaël Nys, Marianne Fillet
Volumetric absorptive microsampling (VAMS) enables the collection of small and accurate quantities of biological fluids. Therefore, this sampling technique is of great interest for volume-limited samples or serial collection of samples. In this study, we examined the potential of VAMS for targeted mass spectrometry (MS)-based metabolomics. The targeted analysis of 36 major metabolites from only 10 μL of whole blood was optimized. A design of experiments was carried out to maximize the extraction of metabolites...
May 15, 2019: Talanta
https://read.qxmd.com/read/30771783/local-tumor-response-and-survival-outcomes-after-combined-stereotactic-radiosurgery-and-immunotherapy-in-non-small-cell-lung-cancer-with-brain-metastases
#7
Charu Singh, Jack M Qian, James B Yu, Veronica L Chiang
OBJECTIVEConcurrent use of anti-PD-1 therapies with stereotactic radiosurgery (SRS) have been shown to be beneficial for survival and local lesional control in melanoma patients with brain metastases. It is not known, however, if immunotherapy (IT) confers the same outcome advantage in lung cancer patients with brain metastases treated with SRS.METHODSThe authors retrospectively reviewed 85 non-small cell lung cancer (NSCLC) patients with brain metastases who were treated with SRS between January 2006 and December 2016...
February 15, 2019: Journal of Neurosurgery
https://read.qxmd.com/read/30770938/discrimination-of-osteoporosis-related-vertebral-fractures-by-dxa-derived-3d-measurements-a-retrospective-case-control-study
#8
M López Picazo, L Humbert, S Di Gregorio, M A González Ballester, L M Del Río Barquero
A retrospective case-control study assessing the association of DXA-derived 3D measurements with osteoporosis-related vertebral fractures was performed. Trabecular volumetric bone mineral density was the measurement that best discriminates between fracture and control groups. INTRODUCTION: The aim of the present study was to evaluate the association of DXA-derived 3D measurements at the lumbar spine with osteoporosis-related vertebral fractures. METHODS: We retrospectively analyzed a database of 74 postmenopausal women: 37 subjects with incident vertebral fractures and 37 age-matched controls without any type of fracture...
February 15, 2019: Osteoporosis International
https://read.qxmd.com/read/30770890/the-myeloarchitecture-of-impulsivity-premature-responding-in-youth-is-associated-with-decreased-myelination-of-ventral-putamen
#9
Camilla L Nord, Seung-Goo Kim, Mette Buhl Callesen, Timo L Kvamme, Mads Jensen, Mads Uffe Pedersen, Kristine Rømer Thomsen, Valerie Voon
Impulsivity has been suggested as a neurocognitive endophenotype conferring risk across a number of neuropsychiatric conditions, including substance and behavioural addictions, eating disorders, and attention deficit/hyperactivity disorder. We used a paradigm with interspecies translation validity (the four-choice serial reaction time task, 4CSRTT) to assess 'waiting' impulsivity in a youth sample (N = 99, aged 16-26 years). We collected magnetization prepared two rapid acquisition gradient echo (MP2RAGE) scans, which enabled us to measure R1, the longitudinal relaxation rate, a parameter closely related to tissue myelin content, as well as quantify grey matter volume...
February 15, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://read.qxmd.com/read/30770280/periapical-microsurgery-a-4-dimensional-analysis-of-healing-patterns
#10
Daniel Crossen, Thiago Morelli, Don A Tyndall, Peter Z Tawil
INTRODUCTION: Currently, the success of periapical microsurgery is determined by the restoration of the lamina dura and the elimination of symptoms. However, inadequate site preservation may prevent later implant placement. Although not possible before, the advent of cone-beam computed tomographic imaging and computer-aided registration allows for indirect and accurate 3-dimensional analysis of the surgical site over time. This study analyzed the volumetric healing pattern of the buccal plate after periapical microsurgery, with a specific focus on the buccolingual thickness of bone and the regression of the surface contour of the cortical plate...
February 12, 2019: Journal of Endodontics
https://read.qxmd.com/read/30768957/prostate-cancer-treated-with-irreversible-electroporation-mri-based-volumetric-analysis-and-oncological-outcome
#11
Francesco Giganti, Armando Stabile, Simone Giona, José Marenco, Clement Orczyk, Caroline M Moore, Clare Allen, Alex Kirkham, Mark Emberton, Shonit Punwani
BACKGROUND: To assess multiparametric magnetic resonance imaging (mpMRI) characteristics in prostate cancer (PCa) before and after irreversible electroporation (IRE) and to investigate their correlation with the presence of post-operative recurrence of PCa. METHODS: MpMRI was performed in 30 men with PCa prior to treatment, after 10 days and at 6 months. An additional scan at 1 year was available for 18 men. Two radiologists assessed retrospectively the following parameters by planimetry: tumour volume, necrotic volume (early post-treatment scan) and residual fibrosis...
February 12, 2019: Magnetic Resonance Imaging
https://read.qxmd.com/read/30768013/two-photon-psf-engineered-image-scanning-microscopy
#12
Omer Tzang, Dan Feldkhun, Anurag Agrawal, Alexander Jesacher, Rafael Piestun
We present two-photon fluorescence image scanning microscopy (ISM) with engineered excitation and detection point-spread-functions enabling 3D imaging in a single 2D scan. This demonstration combines excitation using a holographic multispot array of focused femtosecond pulses with a high-efficiency single-helix PSF phase mask detection. Camera detection along with a multiview reconstruction algorithm allows volumetric imaging of biological samples over a depth of field spanning more than 1500 nm with an axial resolution of better than 400 nm...
February 15, 2019: Optics Letters
https://read.qxmd.com/read/30767993/axially-shifted-pattern-illumination-for-macroscale-turbidity-suppression-and-virtual-volumetric-confocal-imaging-without-axial-scanning
#13
Shaowei Jiang, Jun Liao, Zichao Bian, Pengming Song, Garrett Soler, Kazunori Hoshino, Guoan Zheng
Structured illumination has been widely used for optical sectioning and 3D surface recovery. In a typical implementation, multiple images under non-uniform pattern illumination are used to recover a single object section. Axial scanning of the sample or the objective lens is needed for acquiring the 3D volumetric data. Here we demonstrate the use of axially shifted pattern illumination for virtual volumetric confocal imaging without axial scanning. In the reported approach, we project illumination patterns at a tilted angle with respect to the detection optics...
February 15, 2019: Optics Letters
https://read.qxmd.com/read/30767383/ethanol-mediated-compaction-and-cross-linking-enhance-mechanical-properties-and-degradation-resistance-while-maintaining-cytocompatibility-of-a-nucleus-pulposus-scaffold
#14
Joshua D Walters, Sanjitpal S Gill, Jeremy J Mercuri
Intervertebral disc degeneration is a complex, cell-mediated process originating in the nucleus pulposus (NP) and is associated with extracellular matrix catabolism leading to disc height loss and impaired spine kinematics. Previously, we developed an acellular bovine NP (ABNP) for NP replacement that emulated human NP matrix composition and supported cell seeding; however, its mechanical properties were lower than those reported for human NP. To address this, we investigated ethanol-mediated compaction and cross-linking to enhance the ABNP's dynamic mechanical properties and degradation resistance while maintaining its cytocompatibility...
February 15, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30767311/beyond-activated-carbon-graphite-cathode-derived-li-ion-pseudocapacitors-with-high-energy-and-high-power-densities
#15
Gang Wang, Steffen Oswald, Markus Löffler, Klaus Müllen, Xinliang Feng
Supercapacitors have aroused considerable attention due to their high power capability, which enables charge storage/output in minutes or even seconds. However, to achieve a high energy density in a supercapacitor has been a long-standing challenge. Here, graphite is reported as a high-energy alternative to the frequently used activated carbon (AC) cathode for supercapacitor application due to its unique Faradaic pseudocapacitive anion intercalation behavior. The graphite cathode manifests both higher gravimetric and volumetric energy density (498 Wh kg-1 and 431...
February 15, 2019: Advanced Materials
https://read.qxmd.com/read/30765763/quantitative-nontumorous-and-tumorous-human-brain-tissue-assessment-using-microstructural-co-and-cross-polarized-optical-coherence-tomography
#16
Konstantin S Yashin, Elena B Kiseleva, Alexander A Moiseev, Sergey S Kuznetsov, Lidia B Timofeeva, Nadezhda P Pavlova, Grigory V Gelikonov, Igor А Medyanik, Leonid Ya Kravets, Elena V Zagaynova, Natalia D Gladkova
Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed...
February 14, 2019: Scientific Reports
https://read.qxmd.com/read/30765196/feasibility-study-of-a-double-resonant-1-h-23-na-abdominal-rf-setup-at-3t
#17
Matthias Malzacher, Jorge Chacon-Caldera, Nadia Paschke, Lothar R Schad
Sodium magnetic resonance imaging (MRI) of the human abdomen is of increasing clinical interest for e.g. kidney, intervertebral disks, prostate and tumor monitoring examinations in the abdomen. To overcome the low MR sensitivity of sodium, optimal radio frequency (RF) structures should be used. A common approach is to combine a volumetric transmit coil for homogeneous excitation with an array of sensitive receive coils adapted to the human shape. Additionally, proton imaging is required to match the physiological sodium images to the morphological proton images...
February 11, 2019: Zeitschrift Für Medizinische Physik
https://read.qxmd.com/read/30764631/effect-of-tumor-size-and-p16-status-on-treatment-outcomes-achievement-of-complete-remission-in-prospectively-followed-patients-with-oropharyngeal-tumors
#18
M Slavik, T Kazda, I Selingerová, J Šána, P Ahmad, D Gurín, M Hermanová, T Novotný, R Červená, R Dymáčková, P Burkoň, O Slabý, P Šlampa
BACKGROUND: Oropharyngeal squamous cell tumors associated with human papillomavirus infection (p16 positive tumors) have better prognosis than p16 negative tumors regardless of the more advanced stage of the disease. Tumor volume (GTVt+n) is generally an important factor affecting treatment results of ionizing radiation. The aim of this prospective non-randomized study is to evaluate the effect of tumor volume on the (chemo)radiation treatment results in a group of patients with p16 negative and p16 positive oropharyngeal tumors...
2019: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://read.qxmd.com/read/30764525/a-laboratory-study-on-non-invasive-soil-water-content-estimation-using-capacitive-based-sensors
#19
Amir Orangi, Guillermo A Narsilio, Dongryeol Ryu
Soil water content is an important parameter in many engineering, agricultural and environmental applications. In practice, there exists a need to measure this parameter rather frequently in both time and space. However, common measurement techniques are typically invasive, time-consuming and labour-intensive, or rely on potentially risky (although highly regulated) nuclear-based methods, making frequent measurements of soil water content impractical. Here we investigate in the laboratory the effectiveness of four new low-cost non-invasive sensors to estimate the soil water content of a range of soil types...
February 5, 2019: Sensors
https://read.qxmd.com/read/30762925/screening-and-optimizing-fermentation-production-of-l-asparaginase-by-aspergillus-terreus-strain-s-18-isolated-from-the-brazilian-caatinga-biome
#20
Wilma Raianny Vieira da Rocha, Tales Alexandre Costa-Silva, Gualberto Segundo Agamez Montalvo, Valker Araújo Feitosa, Suellen Emilliany Feitosa Machado, Gláucia Manoela de Souza Lima, Adalberto Pessoa-Jr, Harley da Silva Alves
AIMS: The aim of this study was to find new eukaryotic sources of the L-asparaginase (L-ASNase), since the prokaryotic sources of the enzyme are well reported as causing allergic hypersensitivity reactions in a significant number of patients. This report describes screening for L-ASNase production by filamentous fungi isolated from the Brazilian Caatinga, and the optimization of fermentation parameters to increase fungal growth and improve yield in the production of L-ASNase. METHODS AND RESULTS: 32 filamentous fungi were investigated in this study...
February 14, 2019: Journal of Applied Microbiology
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