Kyong-Oh Shin, Debra A Crumrine, Sungeun Kim, Yerin Lee, Bogyeong Kim, Katrina Abuabara, Chaehyeong Park, Yoshikazu Uchida, Joan S Wakefield, Jason M Meyer, Sekyoo Jeong, Byeong Deog Park, Kyungho Park, Peter M Elias
BACKGROUND: Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are associated with atopic dermatitis (AD). Moreover, ASD prevalence increases further as AD severity worsens, though these disorders share no common causative mutations. We assessed here the link between these two disorders in the standard, valproic acid mouse model of ASD. In prior studies, there was no evidence of skin involvement, but we hypothesized that cutaneous involvement could be detected in experiments conducted in BALB/c mice...
June 22, 2021: BMC Neuroscience