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Garrett S Bullock, Mallory S Faherty, Leila Ledbetter, Charles A Thigpen, Timothy C Sell
OBJECTIVE: Arm injuries in baseball players are a common problem. The identification of modifiable risk factors, including range of motion (ROM), is essential for injury prevention. The purpose of this review was to assess the methodologic quality and level of evidence in the literature and to investigate the relationship between shoulder ROM and the risk of arm injuries in baseball players. DATA SOURCES: Relevant studies in PubMed, CINAHL, Embase, and SPORTDiscus published from inception to August 1, 2017...
December 7, 2018: Journal of Athletic Training
Lori A Michener, Jeffrey S Abrams, Kellie C Huxel Bliven, Sue Falsone, Kevin G Laudner, Edward G McFarland, James E Tibone, Charles A Thigpen, Timothy L Uhl
OBJECTIVE:   To present recommendations for the diagnosis, management, outcomes, and return to play of athletes with superior labral anterior-posterior (SLAP) injuries. BACKGROUND:   In overhead athletes, SLAP tears are common as either acute or chronic injuries. The clinical guidelines presented here were developed based on a systematic review of the current evidence and the consensus of the writing panel. Clinicians can use these guidelines to inform decision making regarding the diagnosis, acute and long-term conservative and surgical treatment, and expected outcomes of and return-to-play guidelines for athletes with SLAP injuries...
March 2018: Journal of Athletic Training
Kyung-Won Min, Richard W Zealy, Sylvia Davila, Mikhail Fomin, James C Cummings, Daniel Makowsky, Catherine H Mcdowell, Haley Thigpen, Markus Hafner, Sang-Ho Kwon, Constantin Georgescu, Jonathan D Wren, Je-Hyun Yoon
Gene expression is dynamically regulated in a variety of mammalian physiologies. During mammalian aging, there are changes that occur in protein expression that are highly controlled by the regulatory steps in transcription, post-transcription, and post-translation. Although there are global profiles of human transcripts during the aging processes available, the mechanism(s) by which transcripts are differentially expressed between young and old cohorts remains unclear. Here, we report on N6-methyladenosine (m6A) RNA modification profiles of human peripheral blood mononuclear cells (PBMCs) from young and old cohorts...
June 2018: Aging Cell
Richard W Zealy, Mikhail Fomin, Sylvia Davila, Daniel Makowsky, Haley Thigpen, Catherine H McDowell, James C Cummings, Edward S Lee, Sang-Ho Kwon, Kyung-Won Min, Je-Hyun Yoon
Eukaryotic mRNA metabolism regulates its stability, localization, and translation using complementarity with counter-part RNAs. To modulate their stability, small and long noncoding RNAs can establish complementarity with their target mRNAs. Although complementarity of small interfering RNAs and microRNAs with target mRNAs has been studied thoroughly, partial complementarity of long noncoding RNAs (lncRNAs) with their target mRNAs has not been investigated clearly. To address that research gap, our lab investigated whether the sequence complementarity of two lncRNAs, lincRNA-p21 and OIP5-AS1, influenced the quantity of target RNA expression...
March 2018: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
Catherine Godfrey, Michael C Thigpen, Keith W Crawford, Patrick Jean-Phillippe, Deenan Pillay, Deborah Persaud, Daniel R Kuritzkes, Mark Wainberg, Elliot Raizes, Joseph Fitzgibbon
No abstract text is available yet for this article.
December 1, 2017: Journal of Infectious Diseases
Leandra Desjardins, Jennifer C Thigpen, Molly Kobritz, Alexandra H Bettis, Meredith A Gruhn, Megan Ichinose, Kristen Hoskinson, Claire Fraley, Allison Vreeland, Colleen McNally, Bruce E Compas
Neurocognitive problems in childhood survivors of brain tumors are well documented. Further, research has shown that problems in cognitive functioning may be associated with impairment in the use of complex strategies needed to cope with stress, including secondary control coping strategies (e.g., acceptance and cognitive reappraisal) which have been associated with fewer adjustment problems. The present study measured cognitive function, coping strategies, and adjustment in children ages 6-16 years at the time of brain tumor diagnosis and at two follow-up time-points up to 1 year post-diagnosis...
October 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Bruce E Compas, Sarah S Jaser, Alexandra H Bettis, Kelly H Watson, Meredith A Gruhn, Jennifer P Dunbar, Ellen Williams, Jennifer C Thigpen
In this meta-analytic and narrative review, we examine several overarching issues related to the study of coping, emotion regulation, and internalizing and externalizing symptoms of psychopathology in childhood and adolescence, including the conceptualization and measurement of these constructs. We report a quantitative meta-analysis of 212 studies (N = 80,850 participants) that measured the associations between coping and emotion regulation with symptoms of internalizing and externalizing psychopathology. Within the meta-analysis we address the association of broad domains of coping and emotion regulation (e...
September 2017: Psychological Bulletin
Richard E Haaland, Angela Holder, Chou-Pong Pau, Alison Swaims-Kohlmeier, Carolyn Dawson, Dawn K Smith, Tebogo M Segolodi, Michael C Thigpen, Lynn A Paxton, Teresa L Parsons, Craig W Hendrix, Clyde E Hart
No abstract text is available yet for this article.
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Jennifer C Thigpen, Matthew Pearson, Kristen E Robinson, Charissa Andreotti, Jennifer P Dunbar, Kelly H Watson, Leandra Dejardins, Lindsay Holmes, Rebecca Byram, Claire Fraley, Bruce E Compas
BACKGROUND: Establishing a presurgical baseline of neurocognitive functioning for pediatric brain tumor patients is a high priority to identify level of functioning prior to medical interventions. However, few studies have obtained adequate samples of presurgery assessments. METHODS: This study examines the feasibility of completing tests to assess pre-surgical neurocognitive functioning in 59 identified pediatric brain tumor patients. RESULTS: Eighty-five percent of patients ( n = 50) were referred by the neurosurgery team before surgery and 83% of patients ( n = 49) enrolled in the study...
December 2016: Neuro-oncology Practice
Nicole Lafko Breslend, Justin Parent, Rex Forehand, Bruce E Compas, Jennifer C Thigpen, Emily Hardcastle
The current investigation examined if interparental conflict (IPC), including psychological and physical violence, moderated the relationship between parental depressive symptoms and youth internalizing and externalizing problems, respectively, in a sample of youth with a parent with a history of Major Depressive Disorder (MDD). One hundred and eighty families with a parent with a history of MDD (Mage = 41.96; 88.9% mothers) and a youth in the target age range of 9-to-15 years (49.4% females; Mage = 11.46) participated...
October 2016: Journal of Family Violence
Ellen Hillegass, Michael Puthoff, Ethel M Frese, Mary Thigpen, Dennis C Sobush, Beth Auten
The American Physical Therapy Association (APTA), in conjunction with the Cardiovascular & Pulmonary and Acute Care sections of APTA, have developed this clinical practice guideline to assist physical therapists in their decision-making process when treating patients at risk for venous thromboembolism (VTE) or diagnosed with a lower extremity deep vein thrombosis (LE DVT). No matter the practice setting, physical therapists work with patients who are at risk for or have a history of VTE. This document will guide physical therapist practice in the prevention of, screening for, and treatment of patients at risk for or diagnosed with LE DVT...
February 2016: Physical Therapy
Peter C Panus, David W Stewart, Nicholas E Hagemeier, Jim C Thigpen, Lauren Brooks
OBJECTIVE: To determine if the frequency of self-testing of course material prior to actual examination improves examination scores, regardless of the actual scores on the self-testing. METHODS: Practice quizzes were randomly generated from a total of 1342 multiple-choice questions in pathophysiology and made available online for student self-testing. Intercorrelations, 2-way repeated measures ANOVA with post hoc tests, and 2-group comparisons following rank ordering, were conducted...
November 15, 2014: American Journal of Pharmaceutical Education
Clare L Cutland, Stephanie J Schrag, Michael C Thigpen, Sithembiso C Velaphi, Jeannette Wadula, Peter V Adrian, Locadiah Kuwanda, Michelle J Groome, Eckhart Buchmann, Shabir A Madhi
Although group B Streptococcus (GBS) is a leading cause of severe invasive disease in young infants worldwide, epidemiologic data and knowledge about risk factors for the disease are lacking from low- to middle-income countries. To determine the epidemiology of invasive GBS disease among young infants in a setting with high maternal HIV infection, we conducted hospital-based surveillance during 2004-2008 in Soweto, South Africa. Overall GBS incidence was 2.72 cases/1,000 live births (1.50 and 1.22, respectively, among infants with early-onset disease [EOD] and late-onset [LOD] disease)...
April 2015: Emerging Infectious Diseases
Brett Alan Davis, Lauren Kellet Thigpen, Jared Heath Hornsby, James Matthew Green, Thomas Elliot Coates, Eric Kyle O'Neal
Current American College of Sports Medicine (ACSM) guidelines recommend replacing 150% of sweat losses between training bouts separated by ≤12 hours, but little evidence exists concerning the implications of this strategy for runners. Participants (n = 13) in this study replaced 75% (1637 ± 372 mL) or 150% (3099 ± 850 mL) of sweat losses following an outdoor evening run (∼75 minutes; Wet-bulb-globe temperature (WBGT) = ∼27°C) and consumed a standardised evening meal and breakfast before completing an outdoor (WBGT = ∼23°C) 10-km time-trial the following morning...
2014: European Journal of Sport Science
Michael Kasonde, Richard W Niska, Charles Rose, Faith L Henderson, Tebogo M Segolodi, Kyle Turner, Dawn K Smith, Michael C Thigpen, Lynn A Paxton
BACKGROUND: Tenofovir-emtricitabine (TDF-FTC) pre-exposure prophylaxis (PrEP) has been found to be effective for prevention of HIV infection in several clinical trials. Two studies of TDF PrEP among men who have sex with men showed slight bone mineral density (BMD) loss. We investigated the effect of TDF and the interaction of TDF and hormonal contraception on BMD among HIV-uninfected African men and women. METHOD: We evaluated the effects on BMD of using daily oral TDF-FTC compared to placebo among heterosexual men and women aged 18-29 years enrolled in the Botswana TDF2 PrEP study...
2014: PloS One
Eric K O'Neal, Christina R Caufield, Jordan B Lowe, Mary C Stevenson, Brett A Davis, Lauren K Thigpen
This study examined 24-h post-run hydration status and sweat loss estimation accuracy in college age runners (men=12, women=8) after completing a 1-h self-paced outdoor run (wet bulb globe temperature=19.9±3.0 °C). Sweat losses (1353±422 mL; 1.9%±0.5% of body mass) were significantly greater (p<0.001) than perceived losses (686±586 mL). Cumulative fluid consumption equaled 3876±1133 mL (218±178 mL during) with 37% of fluid ingested lost through urine voids (1450±678 mL). Fluid balance based on intake and urine production equaled +554±669 mL at 12 h and +1186±735 mL at 24 h...
December 19, 2013: Nutrients
Lovemore I Chirwa, Jeffrey A Johnson, Richard W Niska, Tebogo M Segolodi, Faith L Henderson, Charles E Rose, Jin-Fen Li, Michael C Thigpen, Onkabetse Matlhaba, Lynn A Paxton, John T Brooks
We examined CD4 cell count and plasma viral load patterns among Botswana TDF/FTC Oral HIV Prophylaxis Trial (TDF2 study) participants who seroconverted, comparing participants assigned to receive tenofovir/emtricitabine with participants assigned to receive placebo. We also evaluated for antiretroviral drug resistance among the breakthrough HIV infections. Among nine seroconverters assigned to tenofovir/emtricitabine and 24 to placebo, there were no significant differences in their CD4 cell count or viral load profiles over time...
January 14, 2014: AIDS
Jordan T Morrison, Ralph A Lugo, Jim C Thigpen, Stacy D Brown
OBJECTIVE: The purpose of this study was to examine the stability of a generic lansoprazole product in a 3 mg/mL sodium bicarbonate suspension under room temperature and refrigerated conditions. METHODS: Lansoprazole suspensions (3 mg/mL) were prepared in triplicate using an 8.4% sodium bicarbonate vehicle for each storage condition (room temperature and refrigerated). During 1 month, samples from each replicate were periodically removed and analyzed for lansoprazole concentration by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
April 2013: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Eric K O'Neal, Brett A Davis, Lauren K Thigpen, Christina R Caufield, Anthony D Horton, Joyce R McIntosh
The purpose of this study was to determine how accurately runners estimate their sweat losses. Male (n = 19) and female (n = 20) runners (41 ± 10 yr, VO2max 57 ± 9 ml · kg(-1) · min(-1) from the southeastern U.S. completed an ~1-hr run during late summer on a challenging outdoor road course (wet bulb globe temperature 24.1 ± 1.5 °C). Runs began at ~6:45 a.m. or p.m. Before and after running, participants filled race-aid-station paper cups with a volume of fluid they felt would be equivalent to their sweat losses...
October 2012: International Journal of Sport Nutrition and Exercise Metabolism
Frederick B Stehman, Mark F Brady, J Tate Thigpen, Emma C Rossi, Robert A Burger
BACKGROUND: Granulocyte colony stimulating factor (G-CSF) and erythropoietin stimulating agents (ESA) may be used to support patients during chemotherapy. We assessed whether G-CSF or ESA were associated with progression or death in patients with ovarian cancer. METHODS: Patients with ovarian cancer following surgery, were on a protocol to evaluate bevacizumab with chemotherapy. Guidelines for administering G-CSF and ESA were specified in the protocol. Overall survival (OS) was analyzed with landmark procedures and multivariate, time-dependent hazard models...
December 2012: Gynecologic Oncology
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