keyword
https://read.qxmd.com/read/37197898/benchmarking-enrichment-efforts-in-the-us-canada-across-species-and-enrichment-categories
#21
JOURNAL ARTICLE
Megan R LaFollette, Sylvie Cloutier, Colleen M Brady, Marguerite E O'Haire, Brianna N Gaskill
Enrichment is important for animal welfare and data quality. Provision of enrichment opportunities varies between species and enrichment category. However, data benchmarking these differences does not exist. Our objective was to characterize enrichment provision and associated factors across species in the US and Canada. Personnel who work with research animals ( n = 1098) in the US and Canada voluntarily responded to online promotions and completed a survey about enrichment used for the species they worked with most, their control of and wish for more enrichment, stress or pain in the animals they worked the most with, and demographics...
May 17, 2023: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/37153117/clinical-characteristics-of-long-term-complications-of-severe-rat-lung-worm-disease-in-hawai-i-a-survey-of-4-cases
#22
JOURNAL ARTICLE
Sittichai Khamsai, Kathleen Howe, Kittisak Sawanyawisuth
Rat lung worm disease (RLWD) is endemic to Hawai'i, and cases of severe RLWD with long-term sequelae have been reported in Hawai'i. However, there are limited data on clinical features of the RLWD survivors with the long-term sequelae. The authors conducted a survey to report on clinical characteristics of RLWD survivors with the long-term sequelae. Four RLWD survivors had severe RLWD with persistent, neurological symptoms for years after RLWD. In conclusion, long-term sequelae of severe RLWD exist. The most common long-term consequence among participants was severe skin pain, which may relate to damage of the nerves or spinal cord...
May 2023: Hawai'i journal of health & social welfare
https://read.qxmd.com/read/37150042/nanobiotechnological-approaches-in-antinociceptive-therapy-animal-based-evidence-for-analgesic-nanotherapeutics-of-bioengineered-silver-and-gold-nanomaterials
#23
REVIEW
Hamed Barabadi, Kiana Mobaraki, Fatemeh Ashouri, Hesam Noqani, Kamyar Jounaki, Ebrahim Mostafavi
Pain management is a major challenge in healthcare systems worldwide. Owing to undesirable side effects of current analgesic medications, there is an exceeding need to develop the effective alternative therapeutics. Nowadays, the application of nanomaterials is being highly considered, as their exceptional properties arising from the nanoscale dimensions are undeniable. With the increasing use of metal NPs, more biocompatible and costly methods of synthesis have been developed in which different biological rescores including microorganisms, plants and algae are employed...
May 2, 2023: Advances in Colloid and Interface Science
https://read.qxmd.com/read/37131669/morphine-exposure-during-adolescence-induces-enduring-social-changes-dependent-on-adolescent-stage-of-exposure-sex-and-social-test
#24
David N King'uyu, Erin L Edgar, Christopher Figueroa, J M Kirkland, Ashley M Kopec
Drug exposure during adolescence, when the 'reward' circuitry of the brain is developing, can permanently impact reward-related behavior. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids...
April 22, 2023: bioRxiv
https://read.qxmd.com/read/37113211/characterization-of-pain-anxiety-and-cognition-related-behaviors-in-the-complete-freund-s-adjuvant-model-of-chronic-inflammatory-pain-in-wistar-kyoto-rats
#25
JOURNAL ARTICLE
Mehnaz I Ferdousi, Patricia Calcagno, Connie Sanchez, Karen L Smith, John P Kelly, Michelle Roche, David P Finn
INTRODUCTION: Chronic pain is often associated with comorbid anxiety and cognitive dysfunction, negatively affecting therapeutic outcomes. The influence of genetic background on such interactions is poorly understood. The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain, which models aspects of anxiety and depression, displays enhanced sensitivity to noxious stimuli and impaired cognitive function, compared with Sprague-Dawley (SD) counterparts. However, pain- and anxiety-related behaviors and cognitive impairment following induction of a persistent inflammatory state have not been investigated simultaneously in the WKY rats...
2023: Front Pain Res (Lausanne)
https://read.qxmd.com/read/37094615/chronic-corticosterone-exposure-evokes-itch-hypersensitivity-and-sexual-dysfunction-in-male-rats-relationship-between-the-two-distinct-gastrin-releasing-peptide-systems-in-the-spinal-cord
#26
JOURNAL ARTICLE
Keiko Takanami, Makoto Morishita, Tatsuya Sakamoto, Hirotaka Sakamoto
In today's society, people are subjected to many social stressors, and excessive chronic stress causes functional disruption of the neuroendocrine system and many diseases. Although the exacerbation of atopic dermatitis with symptoms of itching and erectile dysfunction is induced by chronic stress, the details of the mechanisms are unknown. Here, we examined the effects of chronic stress on itch sensation and male sexual function at the behavioral and molecular levels, focusing on two distinct gastrin-releasing peptide (GRP) systems that independently regulate itch transmission, i...
April 22, 2023: General and Comparative Endocrinology
https://read.qxmd.com/read/37078817/bilateral-subdiaphragmatic-vagotomy-modulates-the-peripheral-met%C3%A2-enkephalin-and-striatal-monoamine-responses-to-peripheral-inflammation-in-rat
#27
JOURNAL ARTICLE
Anna Teresa Kobrzycka, Adrian Mateusz Stankiewicz, Paweł Napora, Krystyna Pierzchała-Koziec, Marek Wieczorek
In the central nervous system, long‑term effects of a vagotomy include disturbance of monoaminergic activity of the limbic system. Since low vagal activity is observed in major depression and autism spectrum disorder, the study aimed to determine whether animals fully recovered after subdiaphragmatic vagotomy demonstrates neurochemical indicators of altered well‑being and social component of sickness behavior. Bilateral vagotomy or sham surgery was performed in adult rats. After one month of recovery, rats were challenged with lipopolysaccharide or vehicle to determine the role of central signaling upon sickness...
2023: Acta Neurobiologiae Experimentalis
https://read.qxmd.com/read/36997094/kratom-m-speciosa-exposure-during-adolescence-caused-long-lasting-cognitive-behavioural-deficits-associated-with-perturbated-brain-metabolism-pathways-in-adult-rats
#28
JOURNAL ARTICLE
Farah Wahida Suhaimi, Aiman Nadhirah Zul Aznal, Nurul Aqmar Mohamad Nor Hazalin, Lay Kek Teh, Zurina Hassan, Mohd Zaki Salleh
Kratom (M. speciosa Korth) is an herbal plant native to Southeast Asia. The leaves have been widely used to alleviate pain and opioid withdrawal symptoms. However, the increasing trend of recreational use of kratom among youth is concerning because substance abuse may render the adolescent brain more susceptible to neuropathological processes, causing dramatic consequences that persist into adulthood. Therefore, the present study aimed to investigate the long-term effects of mitragynine, the main alkaloid and lyophilized kratom decoction (LKD) exposure during adolescence on cognitive behaviours and brain metabolite profiles in adult rats...
March 28, 2023: Behavioural Brain Research
https://read.qxmd.com/read/36944982/stellate-ganglion-block-ameliorated-central-post-stroke-pain-with-comorbid-anxiety-and-depression-through-inhibiting-hif-1%C3%AE-nlrp3-signaling-following-thalamic-hemorrhagic-stroke
#29
JOURNAL ARTICLE
Zhong-Mou Shi, Jun-Jie Jing, Zheng-Jie Xue, Wen-Jun Chen, Yan-Bin Tang, Du-Juan Chen, Xin-Yi Qi, Li Huang, Yi-Qing Zou, Xiao-Zhi Wu, Fei Yang
BACKGROUND: Central post-stroke pain (CPSP) is an intractable and disabling central neuropathic pain that severely affects patients' lives, well-being, and socialization abilities. However, CPSP has been poorly studied mechanistically and its treatment remains challenging. Here, we used a rat model of CPSP induced by thalamic hemorrhage to investigate its underlying mechanisms and the effect of stellate ganglion block (SGB) on CPSP and emotional comorbidities. METHODS: Thalamic hemorrhage was produced by injecting collagenase IV into the ventral-posterolateral nucleus (VPL) of the right thalamus...
March 21, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/36937502/high-cbd-cannabis-vapor-attenuates-opioid-reward-and-partially-modulates-nociception-in-female-rats
#30
JOURNAL ARTICLE
Maria T Rivera-Garcia, Rizelle Mae Rose, Adrianne R Wilson-Poe
Chronic pain patients report analgesic effects when using cannabidiol (CBD), a phytocannabinoid found in whole-plant cannabis extract (WPE). Several studies suggest that cannabis-derived products may serve as an analgesic adjunct or alternative to opioids, and importantly, CBD may also attenuate the abuse potential of opioids. Vaping is a popular route of administration among people who use cannabis, however both the therapeutic and hazardous effects of vaping are poorly characterized. Despite the fact that chronic pain is more prevalent in women, the ability of inhaled high-CBD WPE to relieve pain and reduce opioid reward has not been studied in females...
March 2023: Addict Neurosci
https://read.qxmd.com/read/36921751/the-role-of-the-endocannabinoid-2-arachidonoylglycerol-in-the-in-vivo-spinal-oxytocin-induced-antinociception-in-male-rats
#31
JOURNAL ARTICLE
Ana B Salinas-Abarca, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Abimael González-Hernández
Oxytocin receptor (OTR) activation at the spinal level produces antinociception. Some data suggest that central OTR activation enhances social interaction via an increase of endocannabinoids (eCB), but we do not know if this could occur at the spinal level, modulating pain transmission. Considering that oxytocin via OTR stimulates diacylglycerol formation, a key intermediate in synthesizing 2-arachidonylglycerol (2-AG), an eCB molecule, we sought to test the role of the eCB system on the spinal oxytocin-induced antinociception...
May 2023: Experimental Neurology
https://read.qxmd.com/read/36900357/behavioral-voluntary-and-social-bioassays-enabling-identification-of-complex-and-sex-dependent-pain-related-phenotypes-in-rats-with-bone-cancer
#32
JOURNAL ARTICLE
Daniel Segelcke, Jan Linnemann, Bruno Pradier, Daniel Kronenberg, Richard Stange, S Helene Richter, Dennis Görlich, Nicola Baldini, Gemma Di Pompo, Waldiceu A Verri, Sofia Avnet, Esther M Pogatzki-Zahn
Cancer-induced bone pain (CIBP) is a common and devastating symptom with limited treatment options in patients, significantly affecting their quality of life. The use of rodent models is the most common approach to uncovering the mechanisms underlying CIBP; however, the translation of results to the clinic may be hindered because the assessment of pain-related behavior is often based exclusively on reflexive-based methods, which are only partially indicative of relevant pain in patients. To improve the accuracy and strength of the preclinical, experimental model of CIBP in rodents, we used a battery of multimodal behavioral tests that were also aimed at identifying rodent-specific behavioral components by using a home-cage monitoring assay (HCM)...
March 2, 2023: Cancers
https://read.qxmd.com/read/36899677/naked-mole-rats-demonstrate-profound-tolerance-to-low-oxygen-high-carbon-dioxide-and-chemical-pain
#33
REVIEW
Vince G Amoroso, Aishi Zhao, Isabel Vargas, Thomas J Park
Naked mole-rats ( Heterocephalus glaber ) are very unusual among subterranean mammals in that they live in large colonies and are extremely social, spending large amounts of time gathered together in underground nests more than a meter below the surface. Many respiring individuals resting in deep, poorly ventilated nests deplete the oxygen supply and increase the concentration of carbon dioxide. Consistent with living in that atmosphere, naked mole-rats tolerate levels of low oxygen and high carbon dioxide that are deadly to most surface-dwelling mammals...
February 24, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36841797/maternal-separation-and-tnbs-induced-gut-inflammation-synergistically-alter-the-sexually-differentiated-stress-response-in-rats
#34
JOURNAL ARTICLE
Ryoko Hasegawa, Kumi Saito-Nakaya, Li Gu, Motoyori Kanazawa, Shin Fukudo
BACKGROUND: Neonatal maternal separation (MS) has been used to model long-lasting changes in behavior caused by neuroplastic changes associated with exposure to early-life stress. Earlier studies showed that transient gut inflammation can influence the development of irritable bowel syndrome (IBS). A prevailing paradigm of the etiology of IBS is that transient noxious events lead to long-lasting sensitization of the neural pain circuit, despite complete resolution of the initiating event...
February 25, 2023: BioPsychoSocial Medicine
https://read.qxmd.com/read/36824837/serotonin-modulates-social-responses-to-stressed-conspecifics-via-insular-5-ht-2c-receptors-in-rat
#35
Alexandra J Ng, Lindsay K Vincelette, Jiayi Li, Bridget H Brady, John P Christianson
Social interaction allows for the transfer of affective states among individuals, and the behaviors and expressions associated with pain and fear can evoke anxiety-like states in observers which shape subsequent social interactions. We hypothesized that social reactions to stressed individuals engage the serotonergic dorsal raphe nucleus (DRN) which promotes anxiety-like behavior via postsynaptic action of serotonin at serotonin 2C (5-HT 2C ) receptors in the forebrain. First, we inhibited the DRN by administering an agonist (8-OH-DPAT, 1µg in 0...
February 19, 2023: bioRxiv
https://read.qxmd.com/read/36680692/nine-month-long-social-isolation-changes-the-levels-of-monoamines-in-the-brain-structures-of-rats-a-comparative-study-of-neurochemistry-and-behavior
#36
JOURNAL ARTICLE
Sophie D Shirenova, Nadezhda N Khlebnikova, Viktor B Narkevich, Vladimir S Kudrin, Nataliya A Krupina
Social isolation (SI) is chronic psycho-emotional stress for humans and other socially living species. There are few comparative studies that have measured monoamine levels in brain structures in male and female rats subjected to SI. Existing data is highly controversial. In our recent study, we investigated behavioral effects of SI prolonged up to 9 months on a rather large sample of 69 male and female Wistar rats. In the present study, we measured the levels of monoamines-norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), and DA and 5-HT metabolites-in the brain structures of 40 rats from the same sample...
January 21, 2023: Neurochemical Research
https://read.qxmd.com/read/36439724/long-term-social-isolation-increases-visceral-pain-in-rats
#37
JOURNAL ARTICLE
Xuelong Zhou, Xiaolu Zhou, Chenjing Zhang
Long-term social isolation can alter the sensitivity to somatic pain, however, its impact on visceral pain sensitivity remains unknown. The purpose of this study is to investigate the effect of long-term social isolation on visceral pain sensitivity in rats. 4-week social isolation rearing significantly increased CRD-induced AWR score and decreased pain threshold as compared to group rearing. There was no significant difference in the number of spontaneous visceral pain behaviors between group and isolation rearing rats...
November 2022: Heliyon
https://read.qxmd.com/read/36399470/introduction-of-gloved-hand-to-cage-induces-22-khz-ultrasonic-vocalizations-in-male-albino-rats
#38
JOURNAL ARTICLE
Seo-Kyoung Hwang, Cheryl Tyszkiewicz, Melissa Dragon, Kimberly Navetta, Rebecca Ferreira, Chang-Ning Liu
Rodents emit ultrasonic vocalizations (USVs) above the human hearing threshold of ~ 20 kHz to communicate emotional states and to coordinate their social interactive behavior. Twenty-two kHz USVs emitted by adult rats have been reported in a variety of aversive social and behavioral situations. They occur not only under painful or restraining conditions but can also be evoked by gentle cutaneous touch or airflow. This study aimed to test if placement of a human hand in a cage can evoke 22-kHz USVs. It was found that 36% of the adult male Sprague-Dawley and 13% of the adult male Wistar Han rats emitted 22-kHz USVs when a gloved hand was introduced into the cages...
2022: PloS One
https://read.qxmd.com/read/36394056/effect-of-acute-brief-social-isolation-on-visceral-pain
#39
JOURNAL ARTICLE
Chenjing Zhang, Xiaolu Zhou, Xuelong Zhou
Objective: The sensitivity of somatic pain could be affected by social isolation; however, few studies have examined the impact of social isolation on visceral pain. In the present study, the effect of acute brief social isolation on visceral pain response was investigated. Methods: Adult male rats were either reared individually or grouped for 2 hours or 24 hours. Colorectal distention (CRD)-induced abdominal withdrawal reflex (AWR) score and pain threshold were used to assess visceral pain sensitivity...
2022: Journal of Pain Research
https://read.qxmd.com/read/36287299/article-type-original-article-title-linalyl-acetate-ameliorates-mechanical-hyperalgesia-through-suppressing-inflammation-by-tslp-il-33-signaling
#40
JOURNAL ARTICLE
Ying-Yi Lu, Chun-Ching Lu, Chao-Lan Huang, Hung-Pei Tsai, Wei-Ting Wang, Zi-Hao Zhang, Chieh-Hsin Wu
Neuropathic pain is a debilitating chronic disorder, significantly causing personal and social burdens, in which activated neuroinflammation is one major contributor. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 is important for chronic inflammation. Linalyl acetate (LA) is main component of lavender oil with an anti-inflammatory property through TSLP signaling. The aim of the study is to investigate how LA regulates mechanical hyperalgesia after sciatic nerve injury (SNI). Adult Sprague-Dawley male rats were separated into 3 groups: control group, SNI group and SNI with LA group...
October 26, 2022: Neurochemical Research
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