Daniel Segelcke, Jan Linnemann, Bruno Pradier, Daniel Kronenberg, Richard Stange, S Helene Richter, Dennis Görlich, Nicola Baldini, Gemma Di Pompo, Waldiceu A Verri, Sofia Avnet, Esther M Pogatzki-Zahn
Cancer-induced bone pain (CIBP) is a common and devastating symptom with limited treatment options in patients, significantly affecting their quality of life. The use of rodent models is the most common approach to uncovering the mechanisms underlying CIBP; however, the translation of results to the clinic may be hindered because the assessment of pain-related behavior is often based exclusively on reflexive-based methods, which are only partially indicative of relevant pain in patients. To improve the accuracy and strength of the preclinical, experimental model of CIBP in rodents, we used a battery of multimodal behavioral tests that were also aimed at identifying rodent-specific behavioral components by using a home-cage monitoring assay (HCM)...
March 2, 2023: Cancers