Eduardo Boiteux Uchôa Cavalcanti, Rita de Cássia Carvalho Leal, Wilson Marques Junior, Osvaldo José Moreira do Nascimento
Hereditary motor and sensory neuropathy, also known as Charcot-Marie-Tooth disease (CMT), traditionally refers to a group of genetic disorders in which neuropathy is the main or sole feature. Its prevalence varies according to different populations studied, with an estimate between 1:2,500 to 1:10,000. Since the identification of PMP22 gene duplication on chromosome 17 by Vance et al., in 1989, more than 100 genes have been related to this group of disorders, and we have seen advances in the care of patients, with identification of associated conditions and better supportive treatments, including clinical and surgical interventions...
August 23, 2023: Arquivos de Neuro-psiquiatria