keyword
https://read.qxmd.com/read/38535247/active-and-passive-mineralization-of-bio-gide-%C3%A2-membranes-in-rat-calvaria-defects
#1
JOURNAL ARTICLE
Karol Ali Apaza Alccayhuaman, Patrick Heimel, Stefan Tangl, Stefan Lettner, Carina Kampleitner, Layla Panahipour, Ulrike Kuchler, Reinhard Gruber
Bio-Gide® is a collagen membrane routinely used in guided bone regeneration. Recent studies have shown that this collagen membrane has osteoconductive properties, meaning that it can support the growth of new bone. However, it has also been observed that the collagen membrane has areas of mineralized fibers which can occur spontaneously and independently of osteoblasts. To better understand how this works, we established a model using minced collagen membranes to reduce the active mineralization of intact collagen membranes in favor of passive mineralization...
February 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534964/bioprinting-of-a-liposomal-oxygen-releasing-scaffold-for-ovary-tissue-engineering
#2
JOURNAL ARTICLE
Arezoo Dadashzadeh, Saeid Moghassemi, Christiani Amorim
This study addresses a critical challenge in bioprinting for regenerative medicine, specifically the issue of hypoxia compromising cell viability in engineered tissues. To overcome this hurdle, a novel approach utilizing a microfluidic bioprinter is employed to create a two-layer structure resembling the human ovary. This structure incorporates a liposomal oxygen-releasing system to enhance cell viability. The bioprinting technique enables the simultaneous extrusion of two distinct bioinks, namely bioink A (comprising alginate 1% and 5mg/ml PEGylated fibrinogen in a 20:1 molar ratio) and bioink B (containing alginate 0...
March 27, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38534963/acrylated-hyaluronic-acid-based-hydrogel-for-the-treatment-of-craniofacial-volumetric-muscle-loss
#3
JOURNAL ARTICLE
Lucas Rohrer, Shinji Kato, Shane Browne, Katharine Striedinger, Kevin E Healy, Jason H Pomerantz
Current treatment options for craniofacial volumetric muscle loss (VML) have disadvantages and cannot fully restore normal function. Bio-inspired semi-synthetic acrylated hyaluronic acid (AcHyA) hydrogel, which fills irregularly shaped defects, resembles an extracellular matrix, and induces a minimal inflammatory response, has shown promise in experimental studies of extremity VML. We therefore sought to evaluate the efficacy of AcHyA hydrogel in the treatment of craniofacial VML. For this, we used a novel model of masseter VML in the rat...
March 27, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38534878/the-effects-of-negative-pressure-therapy-on-hair-growth-of-mouse-models
#4
JOURNAL ARTICLE
Chun-Yu Cheng, Ming-Huei Cheng, Chin-Yu Yang, Cheng-Han Wang, Joshua Lim, Wei Huang, Chih-Hsin Lin
Negative pressure therapy (NPT) has been shown to facilitate wound healing and promote hair growth in a porcine model. However, there is a paucity of research on the impact of negative pressure on hair growth in murine models. Despite the ability of nude mice to develop hair follicles, the hair they produce is often flawed due to genetically induced keratin disorders, rendering them a pertinent animal model for assessing hair regeneration. Therefore, this study aims to investigate the effects of negative pressure on hair follicle growth in a nude mouse model...
March 27, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38534838/recent-advances-in-scaffolds-for-guided-bone-regeneration
#5
REVIEW
Theodoros-Filippos Valamvanos, Xanthippi Dereka, Hector Katifelis, Maria Gazouli, Nefeli Lagopati
The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534276/simultaneous-implant-and-guided-bone-regeneration-using-bovine-derived-xenograft-and-acellular-dermal-matrix-in-aesthetic-zone
#6
Anggun Alfreda Devina, Felita Clarissa Halim, Benso Sulijaya, Patricia Rinanti Sumaringsih, Ratna Sari Dewi
INTRODUCTION: Implant placement in the maxillary anterior area requires sufficient quantity and quality of both soft and hard tissue. In cases where soft and hard tissues are insufficient, additional regeneration using biomaterials is recommended. Treatment using bovine-derived xenograft and acellular dermal matrix (ADM) may increase bone volume and soft tissue thickness. Case and management: A 65-year-old woman sought help for discomfort and aesthetic issues with her denture, reporting missing teeth (11, 12, 13, 14, and 21) and bone volume shrinkage due to disuse atrophy...
February 26, 2024: Dentistry Journal
https://read.qxmd.com/read/38534262/anti-adhesion-biomaterials-in-tendon-repair-application-status-and-future-prospect
#7
JOURNAL ARTICLE
Peilin Zhang, Jiacheng Hu, Xiaonan Liu, Yanhao Li, Sa Pang, Shen Liu
The healing process after tendon injury is often accompanied by the formation of peritendinous adhesion, contributing to limb dysfunction and exerting detrimental effects on the individuals, as well as the development of society and economy. With the continuous development of material science, as well as the augmented understanding of tendon healing and the mechanism of peritendinous adhesion formation, materials employed for the fabrication of barrier membranes against peritendinous adhesion emerge in endlessly...
March 27, 2024: Tissue Engineering. Part B, Reviews
https://read.qxmd.com/read/38534037/profilometric-esthetic-and-patient-reported-outcomes-of-the-l-shape-technique-combined-with-delayed-connective-tissue-grafting-in-the-maxillary-anterior-region-a-3-year-case-series-study
#8
JOURNAL ARTICLE
Yeon-Tae Kim, Jae-Hong Lee
OBJECTIVE: To evaluate the profilometric, esthetic, and patient-reported outcomes of peri-implant tissues in the maxillary anterior esthetic zone following guided bone regeneration (GBR) using the L-shape technique combined with delayed connective tissue grafting (CTG). MATERIALS AND METHODS: Profilometric and pink esthetic score (PES) measurements were performed at the time of implant surgery with GBR (T0) and at the 1- (T1), 2- (T2), and 3-year (T3) follow-up...
March 27, 2024: Journal of Esthetic and Restorative Dentistry
https://read.qxmd.com/read/38528350/the-biomechanical-investigation-of-osseointegration-levels-in-titanium-implants-simultaniously-placed-with-different-bone-grafts
#9
JOURNAL ARTICLE
R Guler, S Dundar, A Bozoglan, E C Ozcan, M F Ozupek, I Acikan, N Gunes, M B Bingul
BACKGROUND: Dental implant-supported prostheses have been scientifically accepted and have been a common treatment choice in the case reconstructing of partial or total tooth loss. In additon, bone grafts (alloplast, xsenograft, allograft) are frequently used in implant and sinus lift surgical procedures. AIM: The aim of this study is to investigate the bone-implant osseointegration levels of titanium implants simultaniously placed with different bone grafts. MATERIALS AND METHODS: In the study, 32 female S...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38526390/restoration-of-pregnancy-function-using-gt-pcl-biofilm-in-a-rabbit-model-of-uterine-injury
#10
JOURNAL ARTICLE
Di Huang, Jing Liu, Jie Yang, Junhui Liang, Jing Zhang, Qinyu Han, Jianlong Yu, Tingting Yang, Qi Meng, Thorsten Steinberg, Zhongle Chang, Changzhong Li
Biomaterial scaffolds have been used successfully to promote the regenerative repair of small endometrial lesions in small rodents, providing partial restoration of gestational function. The use of rabbits in this study allowed us to investigate a larger endometrial tissue defect and myometrial-injury model. A gelatin/polycaprolactone (GT/PCL) gradient-layer biofilm was sutured at the defect to guide the reconstruction of the original tissue structure. 28 days post-implantation, the uterine cavity had been restored its original morphology; endometrial growth was accompanied by the formation of glands and blood vessels, and the fragmented myofibers of the uterine smooth muscle had begun to resemble the normal structure of the lagomorph uterine cavity, arranging in a circular luminal pattern and a longitudinal serosal pattern...
March 25, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38526353/biological-processes-in-gingival-tissue-integration-around-dental-implants
#11
JOURNAL ARTICLE
Bart van Oirschot, Jing Han, Sander C G Leeuwenburgh, John A Jansen, Fang Yang
Peri-implant gingival tissue integration (GTI) is pivotal in determining the long-term success and functionality of dental implants. To enhance GTI, researchers have increasingly focused during the past decade on unravelling the response of gingival tissues to implant surfaces. This increased focus on soft instead of hard tissue integration has led to the development of various models, including in vitro cell culture systems and in vivo animal models, designed to predict and assess GTI around dental implants...
March 25, 2024: Tissue Engineering. Part B, Reviews
https://read.qxmd.com/read/38526280/emerging-strategies-for-nerve-repair-and-regeneration-in-ischemic-stroke-neural-stem-cell-therapy
#12
JOURNAL ARTICLE
Siji Wang, Qianyan He, Yang Qu, Wenjing Yin, Ruoyu Zhao, Xuyutian Wang, Yi Yang, Zhen-Ni Guo
Ischemic stroke is a major cause of mortality and disability worldwide, with limited treatment options available in clinical practice. The emergence of stem cell therapy has provided new hope to the field of stroke treatment via the restoration of brain neuron function. Exogenous neural stem cells are beneficial not only in cell replacement but also through the bystander effect. Neural stem cells regulate multiple physiological responses, including nerve repair, endogenous regeneration, immune function, and blood-brain barrier permeability, through the secretion of bioactive substances, including extracellular vesicles/exosomes...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38525327/mri-guided-photothermal-photodynamic-immune-activation-combined-with-pd-1-inhibitor-for-the-multimodal-combination-therapy-of-melanoma-and-metastases
#13
JOURNAL ARTICLE
Changqiang Wu, Wei Chen, Shuang Yan, Jie Zhong, Liang Du, Chenwu Yang, Yu Pu, Yang Li, Jiafu Lin, Mei Zeng, Xiaoming Zhang
Non-invasive image-guided precise photothermal/photodynamic therapy (PTT/PDT) has been proven to be an effective local treatment modality but incompetent against metastases. Hence, the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor eradication. Herein, a magnetic resonance imaging (MRI)-visualized PTT/PDT agent (SIDP NMs) was constructed, and the efficacy of its multimodal combination with a programmed cell death 1 (PD-1) inhibitor in the treatment of melanoma and metastases was studied...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38525183/the-use-of-guided-tissue-regeneration-in-endodontic-microsurgery-setting-a-threshold
#14
JOURNAL ARTICLE
Fatemah A Alkandari, Mazen K Alotaibi, Sami Al-Qahtani, Samhan Alajmi
AIM: We aimed to compare the radiographic outcomes of conventional and regenerative approaches in endodontic microsurgery (EMS) and set a critical defect size for healing in conventional and regenerative therapies. METHODOLOGY: The study evaluated 53 root canal-treated teeth (33 patients) with periapical lesions. Among them, 19 teeth (35.8 %) were treated with regenerative treatment, whereas 34 teeth (64.1 %) were managed with the conventional approach...
March 2024: Saudi Dental Journal
https://read.qxmd.com/read/38525180/demineralized-dentin-matrix-for-bone-regeneration-in-dentistry-a-critical-update
#15
REVIEW
Zohaib Khurshid, Necdet Adanir, Jithendra Ratnayake, George Dias, Paul R Cooper
Over the last few decades, several new materials and techniques have been developed for bone regeneration. Scaffolds based on demineralized dentin matrix (DDM) present an attractive option due to their availability and several animal and human studies have been conducted to ascertain their utility in regenerative dentistry. The aim of this review was to summarize the recent studies conducted on DDM and used for bone grafts. PubMed, Web of Science, and Scopus were used to search for studies published within the last 10 years...
March 2024: Saudi Dental Journal
https://read.qxmd.com/read/38524520/microsurgical-management-of-radicular-cyst-using-guided-tissue-regeneration-technique-a-case-report
#16
Juan Carlos Gómez Mireles, Eugenia Karina Martínez Carrillo, Katia Alcalá Barbosa, Evangelina Gutiérrez Cortés, Javier González Ramos, Luis Antonio González Gómez, Rubén Alberto Bayardo González, Sarah Monserrat Lomelí Martínez
BACKGROUND: Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic pulps. The therapeutic management of radicular cysts is controversial. There is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy, but without the use of the guided tissue regeneration (GTR) technique in the same surgical procedure...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38523703/effects-of-mgo-nanoparticle-addition-on-the-mechanical-properties-degradation-properties-antibacterial-properties-and-in-vitro-and-in-vivo-biological-properties-of-3d-printed-zn-scaffolds
#17
JOURNAL ARTICLE
Leiting Yu, Fengdong Sun, Yuanyuan Wang, Wei Li, Yufeng Zheng, Guangxin Shen, Yao Wang, Minfang Chen
Bone tissue engineering is the main method for repairing large segment bone defects. In this study, a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders, which allowed the MgO nanoparticles to be incorporated into 3D-printed Zn matrix and improved the biodegradation and biocompatibility of the Zn matrix. The results showed that porous pure Zn scaffolds and Zn/MgO scaffolds with skeletal-gyroid (G) model structure were successfully prepared by selective laser melting (SLM)...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38522018/biodegradable-poly-caprolactone-fumarate-3d-printed-scaffolds-for-segmental-bone-defects-within-the-masquelet-technique
#18
JOURNAL ARTICLE
Maria D Astudillo Potes, Indranath Mitra, Kari Hanson, Emily T Camilleri, Bipin Gaihre, Mahnoor Shafi, Abdelrahman Hamouda, Lichun Lu, Benjamin D Elder
Segmental bone defects, often clinically treated with nondegradable poly(methylmethacrylate) (PMMA) in multistage surgeries, present a significant clinical challenge. Our study investigated the efficacy of 3D printed biodegradable polycaprolactone fumarate (PCLF)/PCL spacers in a one-stage surgical intervention for these defects, focusing on early bone regeneration influenced by spacer porosities. We compared nonporous PCLF/PCL and PMMA spacers, conventionally molded into cylinders, with porous PCLF/PCL spacers, 3D printed to structurally mimic segmental defects in rat femurs for a 4-week implantation study...
March 24, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38517315/research-advancements-on-nerve-guide-conduits-for-nerve-injury-repair
#19
REVIEW
Shoushuai Wang, Xinggui Wen, Zheyuan Fan, Xiangdong Ding, Qianqian Wang, Zhongling Liu, Wei Yu
Peripheral nerve injury (PNI) is one of the most serious causes of disability and loss of work capacity of younger individuals. Although PNS has a certain degree of regeneration, there are still challenges like disordered growth, neuroma formation, and incomplete regeneration. Regarding the management of PNI, conventional methods such as surgery, pharmacotherapy, and rehabilitative therapy. Treatment strategies vary depending on the severity of the injury. While for the long nerve defect, autologous nerve grafting is commonly recognized as the preferred surgical approach...
March 25, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38517098/amino-acid-uptake-limitations-during-human-mesenchymal-stem-cell-based-chondrogenesis
#20
JOURNAL ARTICLE
Yi Zhong, Bo Zhang, Rodrigo A Somoza, Arnold I Caplan, Jean F Welter, Harihara Baskaran
Amino acids are the essential building block for collagen and proteoglycan, which are the main constituents for cartilage extracellular matrix (ECM). Synthesis of ECM proteins require uptake of various essential/non-essential amino acids. Analyzing amino acids metabolism during chondrogenesis can help to relate tissue quality to amino acids metabolism under different conditions. In our study, we studied amino acids uptake/secretion using hMSC-based aggregate chondrogenesis in a serum-free induction medium with a defined chemical formulation...
March 22, 2024: Tissue Engineering. Part A
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