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Guided regeneration

Jake P Newsom, Karin A Payne, Melissa D Krebs
Biopolymer microgels are emerging as a versatile tool for aiding in the regeneration of damaged tissues due to their biocompatible nature, tunable microporous structure, ability to encapsulate bioactive factors, and tailorable properties such as stiffness and composition. These properties of microgels, along with their injectability, have allowed for their utilization in a multitude of different tissue engineering applications. Controlled release of growth factors, antibodies, and other bioactive factors from microgels have demonstrated their capabilities as transporters for essential bioactive molecules necessary for guiding tissue reconstruction...
February 12, 2019: Acta Biomaterialia
Markus Tammia, Ruifa Mi, Valentin M Sluch, Allen Zhu, Tiffany Chung, Daniel Shinn, Donald J Zack, Ahmet Höke, Hai-Quan Mao
Schwann cells are key players in peripheral nerve regeneration, and are uniquely capable of remyelinating axons in this context. Schwann cells orchestrate this process via a set of transcription factors. While it has been shown that overexpression of specific genes, e.g. Egr2, upregulates myelin-related transcripts, it remains unknown if such manipulation can functionalize the cells and enhance their myelination frequency. The ability to do so could have implications in the use of human stem cell-derived Schwann cells, where myelination is hard to achieve...
November 2018: Heliyon
Juliana A Passipieri, Jack Dienes, Joseph Frank, Joshua Glazier, Andrew J Portell, Kausnik P Venkatesh, Jacqueline Margaret Bliley, Damian Grybowsky, Benjamin Schilling, Kacey Marra, George Joseph Christ
Severe peripheral nerve injuries have devastating consequences on quality of life in affected patients, and represent a significant unmet medical need. Destruction of nerve fibers results in denervation of targeted muscles, which subsequently undergo progressive atrophy and loss of function. Timely restoration of neural innervation to muscle fibers is crucial to preservation of muscle homeostasis and function. The goal of this study was to evaluate the impact of addition of adipose stem cells (ASCs) to polycaprolactone (PCL) nerve conduit guides on peripheral nerve repair and functional muscle recovery in the setting of a critical size nerve defect...
February 14, 2019: Tissue Engineering. Part A
P D Parmar, R Dhamija, S Tewari, P Sangwan, A Gupta, J Duhan, S Mittal
AIM: To evaluate the effect of collagen membrane on the healing of through-and-through periapical lesions using 2-dimensional (2D) and 3-dimensional (3D) imaging techniques. METHODOLOGY: Thirty two patients with periapical radiolucencies measuring at least 10mm and with confirmed loss of buccal and lingual cortical plates were randomly divided into GTR and control groups. Periapical surgery was performed in both groups, using a resorbable collagen membrane in GTR group only...
February 13, 2019: International Endodontic Journal
Oliver Blume, Phil Donkiewicz, Michael Back, Teresa Born
OBJECTIVE: Various biomaterials have been successfully applied in alveolar bone regeneration, however, the reconstruction of extensive osseous defects remains challenging and is often unfeasible with granular grafting materials. Several studies have outlined allogenic bone blocks as valid alternative to autologous block grafting. CLINICAL CONSIDERATIONS: In this report, we demonstrate the regeneration of two large osseous defects in the maxilla with allogenic bone blocks made from human donor bone...
February 12, 2019: Journal of Esthetic and Restorative Dentistry
Catarina Geão, Ana R Costa-Pinto, Cassilda Cunha-Reis, Viviana P Ribeiro, Sílvia Vieira, Joaquim M Oliveira, Rui L Reis, Ana L Oliveira
Guided tissue regeneration (GTR) is a surgical procedure applied in the reconstruction of periodontal defects, where an occlusive membrane is used to prevent the fast-growing connective tissue from migrating into the defect. In this work, silk fibroin (SF) membranes were developed for periodontal guided tissue regeneration. Solutions of SF with glycerol (GLY) or polyvinyl alcohol (PVA) where prepared at several weight ratios up to 30%, followed by solvent casting and thermal annealing at 85 °C for periods of 6 and 12 h to produce high flexible and stable membranes...
February 12, 2019: Journal of Materials Science. Materials in Medicine
De Li Li, Shi Ying Li, Zhi Hui Tang, Yu Wei Wu, Liang Zhong Li
A 27-year-old patient with a history of maxillary anterior tooth trauma presented with a maxillary central diastema between tooth- and implant-supported prostheses that had been in use for 5 years. The all-ceramic crowns were placed in 2012 after rigorous occlusal adjustment. Evaluations were carried out at 0, 2, 3, 4 and 5 years post restoration. The central diastema between the natural teeth and the implant-supported prosthesis on teeth 11 and 12 was first observed 2 years after implantation. After 5 years, the distance was found to have increased, with anterior occlusion and esthetic changes having taken place...
2019: Chinese Journal of Dental Research
Shashank Shankar Chetty, Selvarasu Praneetha, Kavitha Govarthanan, Rama Shanker Verma, Arumugam Vadivel Murugan
Acute liver injury is a critical syndrome ascribed to prevalent death of hepatocyte and imperatively requires a liver transplantation. Such methodology is certainly hampered due to deficit of healthy donors. In this regard, stem cells-based regenerative therapies are attractive in repairing injured tissues and organs for medical applications. However, it is crucial to understand the migration, engraftment and regeneration capabilities of transplanted stem cells in the living animal models. For the first time, we demonstrate rapid labeling of umbilical cord-derived mesenchymal stem cells (MSCs) with near-infrared (NIR) fluorescent CuInS2-ZnS nanocrystals (CIZS-NCs) to develop an innovative nano-bioconjugates (MSCs-CIZS-NBCs) that exhibit 98% labeling efficiency...
February 11, 2019: ACS Applied Materials & Interfaces
Christian Mertens, Sebastian Braun, Johannes Krisam, Jürgen Hoffmann
OBJECTIVES: The aim of this preclinical study was to analyze and compare different grafting techniques with respect to volume stability after wound closure. MATERIALS AND METHODS: Four different grafting techniques were evaluated in vitro for volume stability in a one-wall horizontal defect configuration. Group 1: guided bone regeneration (GBR) with collagen membrane, particulated xenograft; group 2: GBR with collagen membrane, particulated xenograft, pins; group 3: GBR with titanium-reinforced membrane, particulated xenograft, pins; group 4: autogenous block graft, particulated xenograft, collagen membrane...
February 11, 2019: Clinical Implant Dentistry and related Research
Xiao-Tao He, Xuan Li, Yu Xia, Yuan Yin, Rui-Xin Wu, Hai-Hua Sun, Fa-Ming Chen
Recently, we found that although high-stiffness matrices stimulated osteogenic differentiation of bone marrow-derived stromal cells (BMSCs), the macrophages (Mφs) in high-stiffness transglutaminase crosslinked gelatins (TG-gels) tended to undergo M1 polarization and hence compromised cell osteogenesis. In this study, we hypothesized that the copresentation of interleukin (IL)-4 and stromal cell-derived factor (SDF)-1α in high-stiffness TG-gels may enhance periodontal regeneration by modulating Mφ polarization and promoting endogenous stem cell recruitment...
February 5, 2019: Acta Biomaterialia
S Titsinides, G Agrogiannis, T Karatzas
Bone deficits of the jaws are often attributed to accidents, surgical removal of benign lesions or malignant neoplasms, congenital abnormalities, periodontal inflammation, tooth abscess or extraction and finally jaw atrophy due to advanced age or general disease. These bone defects require rehabilitation for a variety of reasons, e.g. maintaining the normal anatomic outline, eliminating empty space, aesthetic restoration and placing dental implants. Today, several techniques have been developed to eliminate these bone deformities including bone grafting, guided bone regeneration, distraction osteogenesis, use of growth factors and stem cells...
November 2019: Japanese Dental Science Review
Kaijun Xu, Yanxiang Xiao, Ya Cao, Shuhua Peng, Minmin Fan, Ke Wang
An ionic liquid, 1-allyl-3-methylimidazolium methyl phosphonate (Amim(MeO)PHO2 ), was synthesized and used to dissolve and regenerate cellulose under mild conditions. The dissolution mechanism of cellulose in Amim(MeO)PHO2 was investigated by in situ NMR spectroscopy under different conditions. Inorganic salt Na2 PHO3 with an anion structure similar to that of Amim(MeO)PHO2 was added to form a Na2 PHO3 /Amim(MeO)PHO2 composite system. The effects of the composite system on the cellulose structure were investigated by Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and the measurement of the degree of polymerization...
April 1, 2019: Carbohydrate Polymers
Chiara Rinoldi, Marco Costantini, Ewa Kijeńska-Gawrońska, Stefano Testa, Ersilia Fornetti, Marcin Heljak, Monika Ćwiklińska, Robert Buda, Jacopo Baldi, Stefano Cannata, Jan Guzowski, Cesare Gargioli, Ali Khademhosseini, Wojciech Swieszkowski
Fiber-based approaches hold great promise for tendon tissue engineering enabling the possibility of manufacturing aligned hydrogel filaments that can guide collagen fiber orientation, thereby providing a biomimetic micro-environment for cell attachment, orientation, migration, and proliferation. In this study, a 3D system composed of cell-laden, highly aligned hydrogel yarns is designed and obtained via wet spinning in order to reproduce the morphology and structure of tendon fascicles. A bioink composed of alginate and gelatin methacryloyl (GelMA) is optimized for spinning and loaded with human bone morrow mesenchymal stem cells (hBM-MSCs)...
February 6, 2019: Advanced Healthcare Materials
Hyo-Geun Jeong, Yoon-Soo Han, Kyung-Hye Jung, Young-Jin Kim
To provide adequate conditions for the regeneration of damaged bone, it is necessary to develop piezoelectric porous membranes with antioxidant and anti-inflammatory activities. In this study, composite nanofibers comprising poly(vinylidene fluoride) (PVDF) and a polyhedral oligomeric silsesquioxane⁻epigallocatechin gallate (POSS⁻EGCG) conjugate were fabricated by electrospinning methods. The resulting composite nanofibers showed three-dimensionally interconnected porous structures. Their average diameters, ranging from 936 ± 223 nm to 1094 ± 394 nm, were hardly affected by the addition of the POSS⁻EGCG conjugate...
February 1, 2019: Nanomaterials
W G van Nimwegen, G M Raghoebar, A Vissink, H J A Meijer
Implant treatment for two central incisors in the maxillary aesthetic region is complex due to concerns regarding inter-implant hard and soft tissue stability. A treatment protocol was therefore developed and implemented in a 1-year prospective case series study involving 16 patients with two failing or missing central incisors in the maxillary aesthetic region. The protocol consists of five options depending on whether teeth are still present (options 1-3) or not (options 4 and 5) and on the amount of bone available at the start of treatment: (1) extraction followed by immediate implant placement and provisionalization, (2) extraction followed by immediate implant placement and delayed provisionalization, (3) extraction followed by ridge preservation, delayed implant placement and immediate provisionalization, (4) delayed implant placement and guided bone regeneration with delayed provisionalization, (5) guided bone regeneration (extensive bone augmentation of the alveolar ridge), delayed implant placement, and delayed provisionalization...
January 31, 2019: International Journal of Oral and Maxillofacial Surgery
Jay M Patel, Kamiel S Saleh, Jason A Burdick, Robert L Mauck
Articular cartilage is a remarkable tissue whose sophisticated composition and architecture allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the capacity to self-repair, and injuries often progress to joint wide osteoarthritis (OA) resulting in debilitating pain and loss of mobility. Current palliative and surgical management provides short-term symptom relief, but almost always progresses to further deterioration in the long term. A number of bioactive factors, including drugs, corticosteroids, and growth factors, have been utilized in the clinic, in clinical trials, or in emerging research studies to stabilize the inflamed joint environment or to promote new cartilage tissue formation...
January 31, 2019: Acta Biomaterialia
Qingzheng Zhang, Bo Shi, Jianxun Ding, Lesan Yan, Jayesh P Thawani, Changfeng Fu, Xuesi Chen
During the past decades, improving patient neurological recovery following spinal cord injury (SCI) has remained a challenge. An effective treatment for SCI would not only reduce fractured elements and isolate developing local glial scars to promote axonal regeneration but also ameliorate secondary effects including inflammation, apoptosis, and necrosis. Three-dimensional (3D) scaffolds provide a platform in which these mechanisms can be addressed in a controlled manner. Polymer scaffolds with favorable biocompatibility and appropriate mechanical properties have been engineered to minimize cicatrization, customize drug release, and ensure an unobstructed space to promote cell growth and differentiation...
January 30, 2019: Acta Biomaterialia
A Fuchs, A Youssef, A Seher, G Hochleitner, P D Dalton, S Hartmann, R C Brands, U D A Müller-Richter, C Linz
BACKGROUND: The spectrum of indications for the use of membranes and scaffolds in the field of oral and maxillofacial surgery includes, amongst others, guided bone regeneration (GBR). Currently available membrane systems face certain disadvantages such as difficult clinical handling, inconsistent degradation, undirected cell growth and a lack of stability that often complicate their application. Therefore, new membranes which can overcome these issues are of great interest in this field...
February 1, 2019: BMC Oral Health
Bassam M Kinaia, Shahrdad Kazerani, Samuel Korkis, Omar Mario Masabni, Maanas Shah, Anthony L Neely
INTRODUCTION: Immediate implant placement (IIP) into fresh extraction socket is a favorable treatment option. If successfully managed, it reduces the overall treatment time, and increases patient's satisfaction. Surgical and restorative factors affect IIP success rates. In this systematic review we evaluate the effect of guided bone regeneration (GBR) at the time of IIP on crestal bone level (CBL) changes after at least 12-months of functional loading. METHODS: Reviewers conducted an independent search of the National Center for Biotechnology Information PubMed, Medline, and the Cochrane Collaboration Library from 1966 to January 2017 following the inclusion criteria...
January 14, 2019: Journal of Periodontology
Stefania Scialla, Amilcare Barca, Barbara Palazzo, Ugo D'Amora, Teresa Russo, Antonio Gloria, Roberto De Santis, Tiziano Verri, Alessandro Sannino, Luigi Ambrosio, Francesca Gervaso
Over the past years, fundamentals of magnetism opened a wide research area of interest, in the field of tissue engineering and regenerative medicine. The integration of magnetic nanoarchitectures into synthetic/natural scaffold formulations allowed obtaining "on demand" responsive structures able to guide the regeneration process. The aim of this work was the design and characterization of three-dimensional (3D) chitosan-based scaffolds containing dextran-grafted maghemite nanoarchitectures (DM) and functionalized with L-arginine (L-Arg) amino acid as bioactive agent...
January 30, 2019: Journal of Biomedical Materials Research. Part A
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