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Botulinum cosmetic

Ines Verner, Hadas Prag Naveh, Dario Bertossi
An increasing number of minimally invasive cosmetic procedures, such as filler or botulinum toxin injections, are performed annually. These procedures are associated with a high risk of post-procedure bruising or ecchymosis. Ecchymoses arise following hemorrhage and extravasation of red blood cells into the subcutaneous tissue, leading to local skin discoloration. Although ecchymoses generally resolve within 14 days, their appearance is cosmetically bothersome, and they may be painful and cause major distress to patients...
February 13, 2019: Dermatologic Therapy
Brin Freund, Aruna Rao
BACKGROUND: Botulinum toxin is approved to treat chronic migraine and has shown significant benefit in refractory cases. Due to its effect on pain by sensory modulation there may also be efficacy in its use in chronic tension-type headaches (CTTH). METHODS: A systematic review of the literature was performed using our predefined inclusion and exclusion criteria. We targeted prospective trials, randomized or non-randomized, studying botulinum toxin in tension-type headaches in adults...
February 11, 2019: Pain Practice: the Official Journal of World Institute of Pain
Liu Shuo, Yang Ting, Wu KeLun, Zhao Rui, Zhao Rui, Wang Hang
BACKGROUND: Oily skin is one of the most common dermatological complaints. Oily skin may be accompanied by enlarged pores, acne, and seborrheic dermatitis. Moreover, oily skin has negative effects on self-perception. Most therapeutic approaches used to treat oily skin have had varying degrees of efficacy and include topical treatments, such as photodynamic therapy and lasers. However, certain of these therapies for oily skin may lead to severe side effects. With the expanding use and high safety profile of botulinum toxin type A (BoNT-A), its use in the treatment of oily skin has caused significant concerns; moreover, relevant reports have gradually accumulated to address the efficacy of BoNT-A and explore its mechanisms of action...
January 29, 2019: Journal of Cosmetic Dermatology
Martina Kerscher, Rungsima Wanitphakdeedecha, Ada Trindade de Almeida, Corey Maas, Jürgen Frevert
Aesthetic dermatologic applications of botulinum neurotoxin (BoNT), including treatment of glabellar lines, horizontal forehead lines, and crow’s feet, were the most common non-surgical cosmetic procedures in the US in 2017, with high levels of subject satisfaction. Since the first BoNT type A (BoNT-A) formulation was approved in 1989, the number of formulations available on the world’s commercial markets has increased and new approvals are expected. BoNT is produced by Clostridium botulinum in nature as part of a large protein complex...
January 1, 2019: Journal of Drugs in Dermatology: JDD
Marilyn S Kwolek, Jon E Block
Background: Although freehand injection of botulinum toxin remains the status quo, it is an inaccurate technique for delivering precise amounts of neurotoxin at multiple injection sites with expediency. We developed an inexpensive, ergonomic, single-use, disposable exostructure device that rapidly converts a standard syringe into a highly accurate injection instrument. Materials and methods: Based on the results of two independent injectors, we determined the comparative delivery dose accuracy, precision, and amount of product waste associated with a standard syringe using the freehand injection technique vs a prototype injection assist device...
2019: Clinical, Cosmetic and Investigational Dermatology
Gaoussou Touré, Minh-Kim Tran de Fremicourt, Tahiry Randriamanantena, Sandrine Vlavonou, Virginia Priano, Christian Vacher
BACKGROUND: The marginal mandibular nerve (MMN) is the branch of the facial nerve that is injured most frequently during corrective and cosmetic surgery. Recent or emerging techniques such as the injection of filler materials, botulinum toxin, allotransplantation of composite tissues of the face, placement of chin implants, and submental cryolipolysis require in-depth knowledge of the anatomy of the MMN. The studies to date are not in agreement regarding the number of branches of the MMN and its relationship with the vasculature and other nerves...
December 27, 2018: Plastic and Reconstructive Surgery
Stanley Evander Emeltan Tjoa, Yoanes Maria Vianney, Sulistyo Emantoko Dwi Putra
Botulinum toxin serotype A is a prominent therapeutic enzyme, for both clinical and cosmetic use. Since this protein is produced by bacteria, it exhibits an allergenic effect when subjected to human therapy. Protein mutagenesis is one method to improve the characteristics of protein. However, in-silico study is needed to give suggestion which amino acid should be mutated. Hence, a lot of money and time can be saved. This study initially screened which residue of the Botulinum toxin serotype A is B-cell epitopes both linearly and conformationally...
December 17, 2018: Journal of Biomolecular Structure & Dynamics
Alireza Mohebbipour Loron, Azra Ghaffari, Negin Poursafargholi
Objective: Body dysmorphic disorder, narcissistic personality disorder, and histrionic personality disorders are the most frequent personality disorders in patients seeking cosmetic interventions. Botulinum toxin type A (BoNTA) injection for cosmetic purpose is the most popular among non-surgical cosmetic procedures and is also the second common aesthetic treatment in Iran. The current study aimed to assess personality disorders in people who were referred for BoNTA injection in Ardabil, Iran...
October 2018: Eurasian Journal of Medicine
Steve G Yoelin, Sunil S Dhawan, Domenico Vitarella, Wajdie Ahmad, Fauad Hasan, Susan Abushakra
BACKGROUND: Botulinum neurotoxins, which are widely used commercially for therapeutic and cosmetic applications, have historically belonged to serotypes A and B. Serotype E has a distinct profile with a faster onset and shorter duration of effect. EB-001 is a proprietary formulation of serotype E in development for aesthetic (cosmetic) and therapeutic uses. METHODS: This first-in-human, randomized, double-blinded, placebo-controlled, ascending-dose cohort study enrolled 42 subjects who received EB-001 (n = 35) or placebo (n = 7)...
December 2018: Plastic and Reconstructive Surgery
Ge-Fei Li, Shiyu Ban, Mengxing Wang, Jilei Zhang, Haifeng Lu, Yan-Hui Shi, Xin-Wei He, Yi-Lan Wu, Peng Peng, Yi-Sheng Liu, Mei-Ting Zhuang, Rong Zhao, Xiao-Lei Shen, Qiang Li, Jian-Ren Liu, Xiaoxia Du
BACKGROUND: Botulinum toxin type A (BoNT-A) is generally considered safe and is widely used to treat a variety of clinical conditions involving muscle hyperactivity and for cosmetic purposes. However, the effects of BoNT-A poisoning (botulism) on brain function are poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Herein, we investigated brain functions in 9 patients who received illegal cosmetic injections of botulinum and 18 matched controls by combining the analysis methods of regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) based on resting-state fMRI...
2018: PloS One
Michelle M De Souza, Andrea D Jewell, Samuel N Grief, Belinda A Vail
Plastic surgery is a broad field, including maxillofacial surgery, reconstruction after injuries, hand surgery, and skin flaps and grafts, but the most common procedures for women are liposuction and body contouring, breast surgery, and facial cosmetic procedures. Techniques of face and brow lifts, blepharoplasty, and rhinoplasty are discussed as well as botulinum toxin and filler injections, and laser and pulsed light techniques that may delay or eliminate the need for surgery. Comparison of the surgeries for breast reconstruction, reduction, augmentation, and mastopexy is discussed...
December 2018: Primary Care
Zhencheng Li, Lui Näslund-Koch, Carlos Henriquez-Olguin, Jonas R Knudsen, Jingwen Li, Agnete B Madsen, Satoru Ato, Jacob Wienecke, Riki Ogasawara, Jens B Nielsen, Thomas E Jensen
Botulinum toxin A (botox) is a toxin used for spasticity treatment and cosmetic purposes. Botox blocks the excitation of skeletal muscle fibers by preventing the release of acetylcholine from motor nerves, a process termed chemical denervation. Surgical denervation is associated with increased expression of the canonical insulin-activated kinase Akt, lower expression of glucose handling proteins GLUT4 and hexokinase II (HKII) and insulin resistant glucose uptake, but it is not known if botox has a similar effect...
October 21, 2018: Cellular Signalling
Bahram Eshraghi, Hadi Ghadimi, Mojgan Nikdel, Fazl Hajizadeh
BACKGROUND: Synkinesis is a recognized complication following peripheral facial nerve paralysis. Different types of synkinesis have been described, with oral-ocular and ocular-oral synkinesis being the most common. Ocular-nasal synkinesis has been reported in two patients following cosmetic rhinoplasty. However, synkinesis between the orbicularis oculi and procerus muscles has not been reported by now. METHODS: This is an interventional case report. RESULTS: Two women, aged 42 and 37 years, presented with unilateral contraction of the medial eyebrow muscles (procerus) with spontaneous or voluntary blinking, 4 and 5 months after cosmetic rhinoplasty, respectively...
October 16, 2018: Aesthetic Plastic Surgery
Matteo Caleo, Matteo Spinelli, Francesca Colosimo, Ivica Matak, Ornella Rossetto, Zdravko Lackovic, Laura Restani
Botulinum neurotoxin Type A (BoNT/A) is an effective treatment for several movement disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) at the neuromuscular junction, thus blocking synaptic transmission and weakening overactive muscles. However, not all the therapeutic benefits of the neurotoxin are explained by peripheral neuroparalysis, suggesting an action of BoNT/A on central circuits. Currently, the specific targets of BoNT/A central activity remain unclear...
November 28, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Michael B Lewis
Botulinum toxin (BTX) injections reduce muscle mobility and are commonly used to treat the appearance of glabellar frown lines. Research shows that this cosmetic treatment leads to a reduction in depression. This reduction is consistent with the theory of embodied emotions because patients have a reduced ability to frown and so receive less negative feedback associated with this action. The current research explored this effect and three further hypotheses for the effects of cosmetic BTX injections based on embodied emotions...
October 3, 2018: Scientific Reports
Joris R de Groot
No abstract text is available yet for this article.
September 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Akash Dhawan, Sunil Dhawan, Domenico Vitarella
Botulinum toxins have been utilized in a number of cosmetic and therapeutic applications. One of the more novel uses of botulinum toxin involves its use to mitigate the effects of superficial cutaneous scarring. This is accomplished by decreasing the dynamic tension of a wound by denervating the underlying muscle. Studies have indicated that botulinum toxin serotypes A and B have a positive effect on wound healing and scar appearance. However, larger prospective, blinded, randomized, placebo-controlled clinical trials are required to refine this concept and target optimum toxin dose placement, timing, and concentration...
September 1, 2018: Journal of Drugs in Dermatology: JDD
Mi-Sun Hur, Kwan Hyun Youn, Hee-Jin Kim
The present study aimed to determine the arrangement and terminal attachments of the zygomaticus minor (Zmi) muscle fibers connecting the orbital and mouth regions. The Zmi was examined in 32 specimens of embalmed Korean adult cadavers. The Zmi was present in all 32 specimens (100%). In 31 of the specimens (96.9%), the Zmi that inserted into the upper lip was formed by muscle fibers that arose from the zygomatic bone and muscle fibers that extended from the orbicularis oculi (OOc) muscle. In 14 of the specimens (43...
September 8, 2018: Clinical Anatomy
Lili Bai, Xiaobo Peng, Yanqing Liu, Yawei Sun, Xin Wang, Xingwang Wang, Guodong Lin, Peng Zhang, Kun Wan, Zewu Qiu
This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection of botulinum toxin (BoNT).A total of 86 botulism patients caused by cosmetic injection of BoNT were enrolled in our study. All of the patients were diagnosed according to their history of cosmetic BoNT injection, clinical symptoms and signs, and other auxiliary examinations (including those on renal and liver functions, blood index detection, and chest X-ray)...
August 2018: Medicine (Baltimore)
Roy Kazan, Mirko S Gilardino
No abstract text is available yet for this article.
August 22, 2018: Aesthetic Surgery Journal
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