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Pediatric GERD

Marine Juzaud, Marie-Dominique Lamblin, Alexandre Fabre, Marine Alessandrini, Karine Baumstarck, Camille Bazin, Clothilde Esteve, Nolwenn Laborde, Lindsay Osei, Laurent Michaud, Frederic Gottrand, Veronique Vitton
OBJECTIVES: High-resolution manometry (HRM) is the gold standard for diagnosis of esophageal motility disorders. However, clinical signs associated with these disorders are non-specific, and it is difficult to correlate clinical signs with HRM data. The main objective of our study was to assess the positive predictive value (PPV) and negative predictive value (NPV) of each clinical sign, as well as their sensitivity and specificity in the diagnosis of esophageal motility disorders. METHODS: This is a bicentric retrospective cohort study based on HRM data collected between May 2012 and May 2016...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
Maartje M J Singendonk, Robyn Rexwinkel, Nina F Steutel, Frederic Gottrand, Lisa McCall, Danielle K Orsagh-Yentis, Rachel Rosen, Caterina Strisciuglio, Nikhil Thapar, Yvan Vandenplas, Marc A Benninga, Merit M Tabbers
OBJECTIVE: In therapeutic trials for infant gastroesophageal reflux disease (GERD), ways to define GERD and measure and report study outcomes vary widely. The aim of this study was to develop a core outcome set (COS) for infant GERD. METHODS: The COS was developed using the Delphi technique, adhering to the OMERACT 2.0 recommendations. Healthcare professionals (HCPs) (predominantly pediatric gastroenterologists and general pediatricians) and parents of infants (age 0-12 months) with GERD, listed up to five primary goals of therapy from their perspective and up to five persistent signs or symptoms that would signify inadequate treatment...
December 27, 2018: Journal of Pediatric Gastroenterology and Nutrition
Elizabeth D Allen, Tricia Montgomery, Gloria Ayres, Jennifer Cooper, Joshua Gillespie, Sean P Gleeson, Judith Groner, Stephen Hersey, Gerd McGwire, Courtney Rowe, Dane Snyder, David Stukus, Kristin S Stukus, Christopher Timan, Neal Wegener, Richard J Brilli
OBJECTIVE(S): This study evaluates the impact of a coordinated effort by an urban pediatric hospital and its associated accountable care organization (ACO) to reduce asthma-related emergency department (ED) and inpatient (IP) utilization by a large, county-wide Medicaid patient population. METHODS: Multiple evidence-based interventions targeting general pediatric asthma care as well as high healthcare utilizers were implemented using standardized quality improvement (QI) methodologies...
December 28, 2018: Academic Pediatrics
Sukgi Choi, Claire Lawlor, Reza Rahbar, Russell Jennings
Importance: Tracheobronchomalacia (TBM) describes an increased collapsibility of the trachea and bronchi that is greatest on forced expiration. A broad term, TBM encompasses intrinsic tracheal weakness, some forms of tracheal deformation, and extrinsic compression. Tracheobronchomalacia is the most common congenital tracheal anomaly, affecting 1 in 2100 children. Tracheobronchomalacia is often associated with recurrent and prolonged respiratory tract infections, can lead to chronic lung disease, and can be fatal in its most severe form...
December 27, 2018: JAMA Otolaryngology—Head & Neck Surgery
Lyudmila Boyanova, Petyo Hadzhiyski, Rumyana Markovska, Penka Yaneva, Daniel Yordanov, Galina Gergova, Ivan Mitov
Helicobacter pylori positivity was assessed among 656 symptomatic children in 2010-2017. Overall infection prevalence was 24.5% and a significantly higher rate was detected in girls (28.5%) compared to boys (20.0%). Moreover, in children with duodenal ulcer, H. pylori prevalence was higher (47.4%) compared with the rest (23.9%). On the contrary, the infection was detected 1.9-fold less frequently in patients with GERD (14.5%) compared with the other (27.0%) patients and 2.1-fold less often in the presence of duodenogastric reflux (bile) reflux (13...
December 26, 2018: Acta Microbiologica et Immunologica Hungarica
Jayanthy Pavithran, Indu Vadakke Puthiyottil, Mythili Narayan, Sivakumar Vidhyadharan, Jayakumar R Menon, Subramania Iyer
OBJECTIVES: The clinical variables that are predictive of aspiration pneumonia are not clear in the pediatric population. This study was conducted in order to identify the demographic, clinical, and radiological risk factors for the development of aspiration pneumonia in children referred to the dysphagia clinic. METHODS: A retrospective analysis of medical records of 88 children referred to the dysphagia clinic who had undergone videofluroscopic swallow study (VFSS)...
December 24, 2018: Laryngoscope
Silvia Iuliano, Roberta Minelli, Francesca Vincenzi, Federica Gaiani, Claudio Ruberto, Gioacchino Leandro, Barbara Bizzarri, Antonio Nouvenne, Francesco Di Mario, Gian Luigi De'Angelis
Eosinophilic esophagitis (EoE) is a chronic immune-mediated relapsing disease caused by eosinophilic infiltration of the esophageal mucosa which is normally lacking these cells. EoE belongs to the group of the so called Eosinophilic Gastrointestinal Disorders (EGIDs). From a rare and unusual disease, EoE has become an emerging entity and in recent years its incidence and prevalence have increased all over the world, also in children. The pathogenesis is very complex and still not completely clear. Esophageal disfunction symptoms (e...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
Timur M Yildirim, Gerd U Auffarth, Hyeck-Soo Son, Christian Huber, Flemming Beisse, Ramin Khoramnia
Purpose: To present the case of a 9-year-old child with bilateral posterior subcapsular cataract developed through steroid treatment for acute lymphoblastic leukemia. Cataract surgery with trifocal intraocular lens implantation was performed in both eyes. Observations: Uncorrected distance visual acuity increased from +0.3 and + 0.4 logMAR preoperatively to 0.00 and + 0.04 logMAR after surgery. Binocular uncorrected values for intermediate and near visual acuity were -0...
March 2019: American Journal of Ophthalmology Case Reports
Conor McCann, Paul S Cullis, Amanda J McCabe, Fraser D Munro
AIM OF THE STUDY: The aim of the study was to identify major gastrointestinal complications associated with direct jejunal feeding. We hypothesized that jejunal feeding may cause life-threatening surgical complications in a minority of patients. METHODS: All patients undergoing jejunal feeding between 1/2008 and 1/2018 at a pediatric surgical unit were identified retrospectively. Data sought from records included demographics, comorbidities, indications, feeding strategies, adverse events, and follow-up...
November 6, 2018: Journal of Pediatric Surgery
Marc Bardou, Kyle J Fortinsky, Nicolas Chapelle, Maxime Luu, Alan Barkun
Gastroesophageal reflux (GER), and its complicated form gastroesophageal reflux disease (GERD) is a common condition in infants and children. As GERD is often considered to cause extra-oesophageal symptoms in children and in the absence of standardized diagnostic and treatment algorithm, many children are inappropriately exposed to empirical anti-reflux treatments, with Acid-Suppressive Medications (ASM); mostly proton pump inhibitors (PPIs). Areas covered: The authors summarize the pharmacological management of pediatric GERD and discuss the efficacy of PPIs as randomized controlled trials have failed to demonstrate their clinical efficacy in the pediatric population...
November 29, 2018: Expert Opinion on Pharmacotherapy
Doyeon Kim, Eun Kyung Lee, Ji Seon Jeong, Nam-Su Gil, Tae Soo Hahm, Young Hee Shin
BACKGROUND: It is often difficult for the pediatric patient to cooperate or to remain immobile during MR scans. Therefore, sedation is usually needed for children. PURPOSE: To evaluate the incidence and contributing factors of unanticipated intubation during sedation for MRI scan in children. STUDY TYPE: Retrospective observational study. POPULATION/SUBJECTS: In all, 1165 charts were reviewed retrospectively of patients who had been sedated by anesthesiologists at a single institution from May 2015 to June 2016...
October 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
Matea Kovačić, Josipa Unić, Zrinjka Mišak, Oleg Jadrešin, Vlatka Konjik, Sanja Kolaček, Iva Hojsak
BACKGROUND AND AIMS: Despite rising incidence of eosinophilic esophagitis (EoE), data on the follow-up and treatment outcomes in pediatric patients are scarce. Therefore, the aim of this study was to present data on the treatment outcomes in children diagnosed with EoE who were treated in a tertiary medical center. PATIENTS AND METHODS: A retrospective study involving patients younger than 18 years who were diagnosed with EoE in our center between January 2011 and June 2017...
October 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Masoumeh Asgarshirazi, Monir Farokhzadeh-Soltani, Zarrintaj Keihanidost, Mamak Shariat
Objective: This cross sectional study aims to survey developing feeding disorders and nutritional deficiencies disorders in children with neurodevelopmental disorders such as cerebral palsy. Materials and methods: A total of 50 children (28 boys and 22 girls) with cerebral palsy and symptoms suggesting gastrointestinal problems such as choking, recurrent pneumonia and poor weight gain, who referred to the Pediatric department of Vali-asr Hospital, Imam Khomeini hospital complex between 1 October 2012 and 30 October 2013, were checked...
December 2017: Journal of Family & Reproductive Health
Gabor Kovacs, Daniel Dumitrescu, Andreas Barner, Sebastian Greiner, Ekkehard Grünig, Alfred Hager, Thomas Köhler, Rainer Kozlik-Feldmann, Irmtraut Kruck, Astrid E Lammers, Derliz Mereles, Andreas Meyer, Joachim Meyer, Stefan Pabst, Hans-Jürgen Seyfarth, Christoph Sinning, Stephan Sorichter, Gerd Stähler, Heinrike Wilkens, Matthias Held
In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH). These recommendations were built on the 2015 European Pulmonary Hypertension guidelines, aiming at their practical implementation, considering country-specific issues, and including new evidence, where available...
August 27, 2018: International Journal of Cardiology
Vasile Valeriu Lupu, Marin Burlea, Nicolai Nistor, Violeta Streanga, Magdalena Iuliana Starcea, Gabriela Paduraru, Dragos Catalin Ghica, Elena Cristina Mitrofan, Mihaela Moscalu, Ancuta Ignat
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy.72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix-Ochoa score), which also underwent the upper digestive endoscopy...
September 2018: Medicine (Baltimore)
Paul E Beaulé, George Grammatopoulos, Andrew Speirs, K C Geoffrey Ng, Sasha Carsen, Hanspeter Frei, Gerd Melkus, Kawan Rakhra, Mario Lamontagne
This article reviews a body of work performed by the investigators over 9 years that has addressed the significance of cam morphology in the development of hip osteoarthritis (OA). Early hip joint degeneration is a common clinical presentation and preexisting abnormal joint morphology is a risk factor for its development. Interrogating Hill's criteria, we tested whether cam-type femoroacetabular impingement leads to hip OA. Strength of association was identified between cam morphology, reduced range-of-movement, hip pain, and cartilage degeneration...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Daisuke Masui, Suguru Fukahori, Shinji Ishii, Naoki Hashizume, Nobuyuki Saikusa, Motomu Yoshida, Naruki Higashidate, Saki Sakamoto, Shiori Tsuruhisa, Hirotomo Nakahara, Yoshiaki Tanaka, Minoru Yagi
BACKGROUND: The present study aimed to evaluate whether the detailed observation of pH/MII waveforms and the analysis of baseline impedance (BI) values could detect esophageal dysmotility in pediatric patients with esophageal disorders. PATIENTS AND METHODS: Eleven patients with congenital esophageal disorder in whom pH/MII was conducted from April 2011 to June 2015, were enrolled in this study. The diagnoses of the patients were as follows: postoperative esophageal atresia (EA), n = 6; esophageal achalasia (EAch), n = 4; and congenital esophageal stenosis (CES), n = 1...
August 25, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Daniel P Fox, Julina Ongkasuwan
Acute croup is a common admitting diagnosis for pediatric patients. If a patient is not responding to medical management for presumed croup, the otolaryngology team is occasionally consulted for direct laryngoscopy and bronchoscopy (DLB) to rule out tracheitis or another airway pathology. We conducted a study to determine if inpatient DLB in acute croup is safe and efficacious and to correlate preoperative vital signs with intraoperative findings. We reviewed the charts of 521 patients with an admitting diagnosis of acute tracheitis, acute laryngotracheitis, or croup...
August 2018: Ear, Nose, & Throat Journal
Molly Crenshaw, Molly Gribbin, Saba Qasmieh, Jessica Heil, Caitlin Ward, Steven Kariya, Jeremy Kern
INTRODUCTION: George Washington Students for Haiti conducts mobile clinics in the Central Plateau of Haiti. Baseline health data for specific rural areas of Haiti are needed. METHODS: Medical teams conducted mobile clinics in rural locations of Haiti's Central Plateau. Diagnoses, blood pressure, growth parameters, medications prescribed, and referrals were recorded. RESULTS: Analyses included 865 patients. The leading pediatric diagnoses were acute respiratory infection, dermatitis, and abdominal pain...
2018: Journal of Health Care for the Poor and Underserved
Stephanie Posten, Tonya Adamiak, Melissa Jensen
Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal inflammatory disease that is becoming more widely recognized as a cause of feeding difficulties in infants and young children, as well as gastroesophageal reflux disease (GERD)-like symptoms, dysphagia, and food impaction in children and adolescents. The diagnosis of EoE is clinicopathologic, based on endoscopic, histologic, and clinical findings. Patients with suspected eosinophilic esophagitis require an endoscopy with biopsies. The diagnosis requires the presence of 15 or more intraepithelial eosinophils/HPF in at least one endoscopic esophageal mucosal biopsy...
August 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
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