keyword
https://read.qxmd.com/read/38539331/proton-pump-inhibitors-in-pediatric-gastroesophageal-reflux-disease-a-systematic-review-of-randomized-controlled-trials
#1
REVIEW
Sara María Fernández-González, Ana Moreno-Álvarez, Alfonso Solar-Boga
This systematic review was conducted with the objective of understanding the efficacy and safety of proton pump inhibitors (PPIs) in the pediatric population. We used PubMed to identify randomized controlled trials (RCTs) published between 1 June 2010 and 30 June 2023, performed in patients from birth to 18 years old with gastroesophageal reflux disease (GERD) who received treatment with any PPI. This literature search yielded 76 articles and 13 of these met the inclusion criteria. For infants, PPIs were equal to placebos in reducing GERD symptoms in four articles...
March 1, 2024: Children
https://read.qxmd.com/read/38509613/level-and-correlates-of-physical-activity-among-children-and-adolescents-with-juvenile-idiopathic-arthritis-compared-to-controls-results-from-a-german-nationwide-prospective-observational-cohort-study
#2
JOURNAL ARTICLE
Florian Milatz, Sandra Hansmann, Jens Klotsche, Martina Niewerth, Tilmann Kallinich, Frank Dressler, Johannes-Peter Haas, Rainer Berendes, Gerd Horneff, Markus Hufnagel, Frank Weller-Heinemann, Daniel Windschall, Ralf Trauzeddel, Moritz Klaas, Hermann Girschick, Prasad T Oommen, Ivan Foeldvari, Serdar Mustafa Cantez, Annette F Jansson, Matthias Hartmann, Joachim Peitz-Kornbrust, Kirsten Minden
BACKGROUND: Physical active lifestyles are essential throughout growth and maturation and may offer potential preventive and therapeutic benefit in patients with juvenile idiopathic arthritis (JIA). Insufficient physical activity (PA), in contrast, can lead to aggravation of disease-related symptoms. This study aimed to i) examine PA levels in children and adolescents with JIA compared to general population controls and ii) investigate correlates of pronounced physical inactivity in order to identify risk groups for sedentary behaviour...
March 20, 2024: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/38428330/position-paper-of-diagnosis-and-treatment-of-post-extubation-laryngitis-in-a-multidisciplinary-expert-based-opinion
#3
JOURNAL ARTICLE
Débora Bressan Pazinatto, Rebecca Maunsell, Melissa Ameloti Gomes Avelino, Jose Faibes Lubianca Neto, Cláudia Schweiger, Jamil Pedro de Siqueira Caldas, Marcelo Barciela Brandão, Paula Pires de Souza, Fernanda Aparecida de Oliveira Peixoto, Claudia Pires Ricachinevsky, Rita C Silveira, Cinara Andreolio, Carolina Sponchiado Miura, Daniele da Silva Jordan Volpe, Walusa Assad Gonçalves Ferri, Fabiano Bleggi Gavazzoni, Paulo Ramos David João, Silmara Aparecida Possas, Carlos Takahiro Chone
OBJECTIVES: To make recommendations on the diagnosis and treatment of post-extubation laryngitis (PEL) in children with or without other comorbidities. METHODS: A three-iterative modified Delphi method was applied. Specialists were recruited representing pediatric otolaryngologists, pediatric and neonatal intensivists. Questions and statements approached topics encompassing definition, diagnosis, endoscopic airway evaluation, risk factors, comorbidities, management, and follow-up...
February 22, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38414706/differential-diagnosis-and-interdisciplinary-workup-of-a-pediatric-patient-with-an-unknown-immune-condition-chronic-respiratory-distress-secondary-to-viral-illness-and-developmental-consequences
#4
Camryn Daidone, Sheyenne Carper
We present a case of a three-year-old African American male, born at term, who initially presented with bronchiolitis at six months and has since experienced recurrent episodes of respiratory distress and hospitalizations. The patient also has severe eczema, developmental delays, and recurrent viral illnesses. Despite thorough evaluations from various specialists, such as pulmonology, allergy, and gastroenterology, the underlying cause remained elusive. The differential diagnosis for this case is as follows: severe persistent asthma with a possible link to genetic mutations such as CDHR3, hyper-IgE syndrome, atypical presentation of Wiskott-Aldrich syndrome, and severe gastroesophageal reflux disease (GERD) with aspiration pneumonitis...
January 2024: Curēus
https://read.qxmd.com/read/38410833/prevalence-of-adolescents-meeting-criteria-for-metabolic-and-bariatric-surgery
#5
JOURNAL ARTICLE
Warren L Shapiro, Poornima Kunani, Margo A Sidell, Xia Li, Sabina R Anderson, Jeffrey M Slezak, Corinna Koebnick, Jeffrey B Schwimmer
BACKGROUND AND OBJECTIVES: The American Academy of Pediatrics endorses metabolic and bariatric surgery (MBS) as a safe and effective treatment of severe obesity in children with class 3 obesity or with class 2 obesity and qualifying comorbidities. The study objective was to determine eligibility and characteristics of adolescents who qualify for MBS based on American Academy of Pediatrics guidelines. METHODS: This retrospective cohort study analyzed electronic health record data of 603 051 adolescents aged 13 to 17 years between January 1, 2018, and December 31, 2021...
March 1, 2024: Pediatrics
https://read.qxmd.com/read/38397357/recurrent-respiratory-infections-in-children-with-down-syndrome-a-review
#6
REVIEW
Michele Ghezzi, Nicolò Garancini, Raffaella De Santis, Laura Gianolio, Salvatore Zirpoli, Anna Mandelli, Andrea Farolfi, Enza D'Auria, Gian Vincenzo Zuccotti
Down Syndrome (DS) is the most common chromosomal abnormality compatible with life. The life of patients suffering from DS can be strongly impacted by Recurrent Respiratory tract Infections (RRIs), leading to an increased rate of hospitalisation, a higher need for intensive care and fatality. With a literature review, we summarise here the main etiological factors for RRI in this category of patients, particularly focusing on airway malformations such as tracheomalacia, tracheal bronchus and bronchomalacia, comorbidities associated with the syndrome, like congenital heart diseases, dysphagia, gastroesophageal reflux, musculoskeletal involvement and obesity, and immunologic impairments, involving both innate and adaptive immunity...
February 15, 2024: Children
https://read.qxmd.com/read/38385686/the-role-of-high-resolution-impedance-manometry-to-identify-rumination-syndrome-in-children-with-unexplained-foregut-symptoms
#7
JOURNAL ARTICLE
Maria Giovanna Puoti, Mark Safe, Nikhil Thapar, Teresa Di Chio, Elena Sofia Pieri, Kornilia Nikaki, Keith Lindley, Anna Rybak, Osvaldo Borrelli
OBJECTIVES: Diagnosis of rumination syndrome (RS) relies on Rome IV criteria. Oesophageal high-resolution impedance manometry (HRIM) can objectively demonstrate the episodes of rumination, but its role in the diagnostic pathway is not yet established. We aimed to demonstrate the clinical contribution of this tool for the timely diagnosis of RS and diagnostic work-up of children with unexplained foregut symptoms deemed to be due to other conditions. METHODS: HRIMs performed between 2012 and 2021 were searched to retrieve all diagnoses of RS...
February 22, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38364547/characteristics-and-outcomes-of-interventions-for-pediatric-laryngomalacia-a-systematic-review-with-meta-analysis
#8
JOURNAL ARTICLE
John F Mills, Neil P Monaghan, Shaun A Nguyen, Christopher L Nguyen, Clarice S Clemmens, William W Carroll, Phayvanh P Pecha, David R White
OBJECTIVES: To analyze characteristics of children treated for laryngomalacia to determine predictive factors and provide an updated meta-analysis on outcomes. METHODS: A systematic review was conducted according to PRISMA guidelines from inception to May 2, 2023, using CINAHL, PubMed, and Scopus databases. Study screening, data extraction, quality rating, and risk of bias assessment were performed by 2 independent reviewers. Data were meta-analyzed using fixed-/random-effects model to derive continuous measures (mean), proportions (%), and mean difference (Δ) with 95% confidence interval (CI)...
February 12, 2024: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38326559/white-matter-diffusion-estimates-in-obsessive-compulsive-disorder-across-1653-individuals-machine-learning-findings-from-the-enigma-ocd-working-group
#9
JOURNAL ARTICLE
Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group...
February 7, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38317336/gastrointestinal-complications-in-pediatric-lung-transplant-recipients-incidence-risk-factors-and-effects-on-patient-outcomes
#10
JOURNAL ARTICLE
Timothy Klouda, Morgan Ryan E, Jessica Brie Leonard, Dawn Freiberger, Levent Midyat, Suzanne Dahlberg, Rachel Rosen, Gary Visner
BACKGROUND: Gastrointestinal (GI) complications in lung transplant recipients can occur any time during the post-operative period, leading to prolonged morbidity and mortality. Despite the negative association between GI complications and patient outcomes, little is known about their incidence and risk factors for their development in pediatric lung transplant recipients. METHODS: We performed a retrospective chart review at one pediatric tertiary center to describe the frequency of GI complications in lung transplant recipients...
February 2024: Pediatric Transplantation
https://read.qxmd.com/read/38290114/challenging-case-a-multidisciplinary-approach-to-demystifying-chronic-sleep-impairment-in-an-infant-with-a-complex-medical-and-behavioral-profile
#11
JOURNAL ARTICLE
Erica Gleason, Kristina Malik, Elise Sannar, Dana Kamara, Verenea Serrano, Marilyn Augustyn
X is a 22-month-old White male infant with a complex medical history, including diagnoses of FBXO11 mutation, hypotonia, restrictive lung disease and mild intermittent asthma, laryngotracheomalacia, obstructive sleep apnea (OSA), feeding difficulties with a history of aspiration, gastroesophageal reflux disease (GERD), and developmental delays. X's medical presentation has resulted in multiple prior medical admissions for respiratory failure due to acute illnesses, procedures and treatments including gastrojejunostomy (GJ) tube dependence, supraglottoplasty to reshape tissues of the upper larynx, and the use of biphasic positive airway pressure (BiPAP) at night and room air during the day when he is at baseline...
January 30, 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
https://read.qxmd.com/read/38262739/proton-pump-inhibitors-in-esophageal-atresia-a-systematic-review-and-meta-analysis
#12
REVIEW
Georges Dimitrov, Madeleine Aumar, Alain Duhamel, Mathilde Wanneveich, Frédéric Gottrand
Gastroesophageal reflux disease (GERD) is frequent and prolonged in esophageal atresia (EA) pediatric patients requiring routine use of proton pump inhibitors (PPIs). However, there are still controversies on the prophylactic use of PPIs and the efficacy of PPIs on GERD and EA complications in this special condition. The aim of the study is to assess the prophylactic use of PPIs in pediatric patients with EA and its complications. We, therefore, performed a systematic review including all reports on the subject from 1980 to 2022...
January 23, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38255425/robotic-assisted-nissen-fundoplication-in-pediatric-patients-a-matched-cohort-study
#13
JOURNAL ARTICLE
Rianne E M Killaars, Omar Mollema, Hamit Cakir, Ruben G J Visschers, Wim G van Gemert
BACKGROUND: Nissen Fundoplication (NF) is a frequently performed procedure in children. Robotic-assisted Nissen Fundoplication (RNF), with the utilization of the Senhance® Surgical System (SSS® ) (Asensus Surgical® Inc., Durham, NC, USA) featuring 3 mm instruments, aims to improve precision and safety in pediatric surgery. This matched cohort study assesses the safety and feasibility of RNF in children using the SSS® , comparing it with Laparoscopic Nissen Fundoplication (LNF)...
January 17, 2024: Children
https://read.qxmd.com/read/38204176/longitudinal-brain-perfusion-and-symptom-presentation-following-pediatric-concussion-a-pediatric-concussion-assessment-of-rest-and-exertion-mri-pedcare-mri-substudy
#14
JOURNAL ARTICLE
Veronik Sicard, Zhuo Fang, Rachel Kardish, Katherine Healey, Andra M Smith, Sarah Reid, Greg O Cron, Gerd Melkus, Nishard Abdeen, Keith Owen Yeates, Gary Goldfield, Nick Reed, Roger Zemek, Andrée-Anne Ledoux
Emerging evidence suggests that advanced neuroimaging modalities such as arterial spin labelling (ASL) might have prognostic utility for pediatric concussion. This study aimed to: 1) examine group differences in global and regional brain perfusion in youth with concussion or orthopedic injury (OI) at 72 h and 4 weeks post-injury; 2) examine patterns of abnormal brain perfusion within both groups and their recovery; 3) investigate the association between perfusion and symptom burden within concussed and OI youths at both time-points; and 4) explore perfusion between symptomatic and asymptomatic concussed and OI youths...
January 30, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38157011/-pediatric-chronic-rhinosinusitis
#15
REVIEW
Ingo Baumann, Miray-Su Yılmaz Topçuoğlu, Stephan Hackenberg, Olaf Sommerburg
Pediatric chronic rhinosinusitis (PCRS) differs from adult chronic rhinosinusitis (CRS) in several aspects. The confrontation with the environment takes place in the growing sinus system, and the immune system is also developing. The inflammatory mechanisms differ to some extent from those of adult CRS patients. The adenoid vegetations play an important role, particularly during the first 6 years of life. Other pathogenetic aspects are important (e.g., asthma, gastroesophageal reflux disease, immunodeficiency)...
December 29, 2023: HNO
https://read.qxmd.com/read/38136038/-multisystem-inflammatory-syndrome-in-children-like-disease-after-covid-19-vaccination-mis-v-with-potential-significance-of-functional-active-autoantibodies-targeting-g-protein-coupled-receptors-gpcr-faab-for-pathophysiology-and-therapy
#16
Marius Schmidt, Steven Hébert, Gerd Wallukat, Rolf Ponader, Tobias Krickau, Matthias Galiano, Heiko Reutter, Joachim Woelfle, Abbas Agaimy, Christian Mardin, André Hoerning, Bettina Hohberger
BACKGROUND: An infection with SARS-CoV-2 can trigger a systemic disorder by pathological autoimmune processes. A certain type of this dysregulation is known as Multisystemic inflammatory syndrome in children (MIS-C). However, similar symptoms may occur and have been described as Multisystemic inflammatory syndrome after SARS-CoV-2 Vaccination (MIS-V) following vaccination against SARS-CoV-2. We report the case of a 12-year-old boy who was identified with MIS-C symptoms without previous SARS-CoV-2 infection after receiving two doses of the Pfizer-BioNTech COVID-19 vaccine approximately one month prior to the onset of symptoms...
November 22, 2023: Children
https://read.qxmd.com/read/38134318/pediatric-patients-with-tracheostomies-and-its-multifacet-association-with-lower-airway-infections-an-8-year-retrospective-study-in-a-large-tertiary-center
#17
JOURNAL ARTICLE
Khanh Lai, Yaron Fireizen, Tricia Morphew, Inderpal Randhawa
Background: Lower respiratory tract infections frequently complicate the care of children with chronic tracheostomies. Pediatric patients have significantly more risk to have tracheostomy infections than adults. Better understanding of modifiable risk factors for pulmonary exacerbations may improve the care of technology-dependent children. Methods: A retrospective single-center cohort study conducted on children with tracheostomy and chronic home ventilator to determine the incidence of pulmonary exacerbations leading to hospitalizations, emergency room (ER) visits, and antibiotic prescriptions...
December 2023: Pediatric Allergy, Immunology, and Pulmonology
https://read.qxmd.com/read/38116947/infant-gastroesophageal-reflux-disease-management-consensus
#18
REVIEW
Yvan Vandenplas, Marina Orsi, Marc Benninga, Felizardo Gatcheco, Rachel Rosen, Mike Thomson
AIM: Infant gastroesophageal reflux is mostly benign; however, when associated with complications like failure to thrive, it may be indicative of gastroesophageal reflux disease. There are currently several unmet needs pertaining to the management of infant gastroesophageal reflux (disease). Reflux in infants is mostly composed of breast milk or formula, so this population is significantly different to older children and adults. The objective of this Delphi consensus was to establish recommendations based on published literature and the experience of clinical experts in paediatric gastroenterology in the context of infant gastroesophageal reflux (disease)...
December 20, 2023: Acta Paediatrica
https://read.qxmd.com/read/38088201/an-8-year-old-boy-with-scimitar-syndrome-presentation-with-gastroesophageal-reflux-symptoms-and-concurrent-associations-including-ectopic-herniated-liver
#19
JOURNAL ARTICLE
Kadir Han Alver, Zozan Ayaz, Muhammed Tekinhatun
No abstract text is available yet for this article.
December 13, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/38057499/neurogastroenterology-and-motility-disorders-of-the-gastrointestinal-tract-in-cystic-fibrosis
#20
REVIEW
Dhiren Patel, Folashade Jose, Jason Baker, Baha Moshiree
PURPOSE OF REVIEW: To discuss all the various motility disorders impacting people with Cystic Fibrosis (PwCF) and provide diagnostic and management approaches from a group of pediatric and adult CF and motility experts and physiologists with experience in the management of this disease. RECENT FINDINGS: Gastrointestinal (GI) symptoms coexist with pulmonary symptoms in PwCF regardless of age and sex. The GI manifestations include gastroesophageal reflux disease, esophageal dysmotility gastroparesis, small bowel dysmotility, small intestinal bacterial overgrowth syndrome, distal idiopathic obstruction syndrome, constipation, and pelvic floor disorders...
December 7, 2023: Current Gastroenterology Reports
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