Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group...
February 7, 2024: Molecular Psychiatry