keyword
https://read.qxmd.com/read/38537866/the-smoker-s-paradox-in-transjugular-intrahepatic-portosystemic-shunt-procedure-a-national-inpatient-sample-analysis-from-2015-to-2020
#21
JOURNAL ARTICLE
Renxi Li, Shawn Sarin
OBJECTIVES: Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure used to alleviate patients with chronic liver cirrhosis and portal hypertension. Smoking can adversely impact liver function and has been shown to influence liver-related outcomes. This study aimed to examine the impact of smoking on the immediate outcomes of TIPS procedure. MATERIALS AND METHOD: The study compared smokers and non-smokers who underwent TIPS procedures in the National Inpatient Sample (NIS) database from the last quarter of 2015 to 2020...
March 26, 2024: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/38537676/a-phase-ii-randomized-controlled-trial-evaluated-antithrombotic-treatment-with-fesomersen-in-patients-with-kidney-failure-on-hemodialysis
#22
JOURNAL ARTICLE
Wolfgang C Winkelmayer, Anthonie W A Lensing, Ravi I Thadhani, Kenneth W Mahaffey, Michael Walsh, Ákos F Pap, Stefan Willmann, Kirstin Thelen, Sophie Hodge, Alexander Solms, Sheila J M Ingham, John Eikelboom
Patients with kidney failure on hemodialysis (KF-HD) are at high risk for both atherothrombotic events and bleeding. This Phase IIb study evaluated the dose-response of fesomersen, an inhibitor of hepatic Factor XI expression, versus placebo, for bleeding and atherothrombosis in patients with KF-HD. Patients were randomized to receive fesomersen 40, 80, or 120 mg once-monthly, or matching placebo, for up to 12 months. The primary safety endpoint was a composite of major bleeding and clinically relevant non-major bleeding (MB/CRNMB)...
March 25, 2024: Kidney International
https://read.qxmd.com/read/38537579/bet-inhibitor-nanotherapy-halts-kidney-damage-and-reduces-chronic-kidney-disease-progression-after-ischemia-reperfusion-injury
#23
JOURNAL ARTICLE
Maria Laura Saiz, Laura Lozano-Chamizo, Aida Bernardo Florez, Marzia Marciello, Paula Diaz-Bulnes, Viviana Corte-Iglesias, Cristian Ruiz Bernet, Raul R Rodrigues-Diez, Cristina Martin-Martin, Mar Rodriguez-Santamaria, Ivan Fernandez-Vega, Ramon M Rodriguez, Carmen Diaz-Corte, Beatriz Suarez-Alvarez, Marco Filice, Carlos Lopez-Larrea
Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown promise in preclinical models of acute kidney injury (AKI) and chronic kidney disease (CKD). However, its clinical translation faces challenges due to issues with poor pharmacokinetics and side effects. Here, we developed engineered liposomes loaded with JQ1 with the aim of enhancing kidney drug delivery and reducing the required minimum effective dose by leveraging cargo protection...
March 26, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38537372/unilateral-nephrectomy-in-dogs-is-associated-with-a-high-rate-of-intraoperative-and-postoperative-complications
#24
JOURNAL ARTICLE
Carley Johnson, Hunter Piegols, Janis Lapsley, Laura E Selmic
OBJECTIVE: To determine the incidence of complications in the intraoperative and postoperative period for dogs undergoing nephrectomy for renal disease. ANIMALS: 69 dogs. METHODS: Medical records of dogs undergoing nephrectomies for renal disease were reviewed for signalment, date of surgery, results of blood analyses, and intra- and postoperative complications. Long-term follow-up was obtained via client telephone interview or referring veterinarian medical records...
March 27, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38537129/the-association-between-mean-arterial-pressure-and-acute-kidney-injury-reversal-among-decompensated-cirrhosis-patients
#25
JOURNAL ARTICLE
Giuseppe Cullaro, Andrew S Allegretti, Cynthia Fenton, Jin Ge, Kavish R Patidar, Jessica Rubin, Arjun Sharma, Jennifer C Lai
BACKGROUND: This study informs how mean arterial pressure (MAP) impacts AKI recovery among all patients hospitalized with cirrhosis, regardless of etiology. METHODS: We identified incident AKI episodes among subjects in our cohort of decompensated cirrhosis patients. AKI was defined as a ≥50% increase in creatinine (sCr) from an outpatient baseline (≥7 days prior) that required hospitalization. Linear mixed-effects models were completed to determine the impact between AKI recovery, MAP, and time...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#26
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537069/controversies-in-terlipressin-and-transplantation-in-the-united-states-how-do-we-meld-the-two
#27
JOURNAL ARTICLE
Eric M Przybyszewski, Robert M Wilechansky, Paige McLean Diaz, Andrew S Allegretti, Lisa B VanWagner, Giuseppe Cullaro, Josh Levitsky, Pere Ginès, Salvatore Piano, Sumeet K Asrani, Kavish R Patidar
Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a severe complication of cirrhosis that carries a poor prognosis. The recent Food and Drug Administration approval of terlipressin has substantial implications for managing HRS-AKI and liver allocation in the United States (US). Terlipressin has been available in Europe for over a decade, and several countries have adapted policy changes such as Model for End-Stage Liver Disease (MELD) score "lock" for HRS-AKI. In this article, we outline the European experience with terlipressin use and explore the question of whether terlipressin treatment for HRS-AKI should qualify for MELD score "lock" in the US in those who respond to therapy...
March 28, 2024: Liver Transplantation
https://read.qxmd.com/read/38536893/urinary-proteomics-reveals-biological-processes-related-to-acute-kidney-injury-in-bothrops-atrox-envenomings
#28
JOURNAL ARTICLE
Lisele Maria Brasileiro-Martins, Sofia Angiole Cavalcante, Thaís Pinto Nascimento, Alexandre Vilhena Silva-Neto, Marlon Dias Mariano Santos, Amanda C Camillo-Andrade, Juliana de Saldanha da Gama Fischer, Caroline Coelho Ferreira, Lucas Barbosa Oliveira, Marco Aurelio Sartim, Allyson Guimarães Costa, Manuela B Pucca, Fan Hui Wen, Ana Maria Moura-da-Silva, Jacqueline Sachett, Paulo Costa Carvalho, Priscila Ferreira de Aquino, Wuelton M Monteiro
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536864/sex-related-differences-in-pre-dialysis-trajectories-and-dialysis-initiation-a-french-nationwide-retrospective-study
#29
JOURNAL ARTICLE
Maxime Raffray, Louise Bourasseau, Cécile Vigneau, Cécile Couchoud, Clémence Béchade, François Glowacki, Sahar Bayat
BACKGROUND: In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. METHODS: Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry...
2024: PloS One
https://read.qxmd.com/read/38536621/triglyceride-glucose-index-predicts-major-adverse-cardiovascular-events-in-patients-with-chronic-kidney-disease
#30
JOURNAL ARTICLE
Kangbo Li, Qiqi Hou, Xinyi Li, Liying Tian, Liyan Wang, Shouling Wu, Quanle Han
BACKGROUND AND PURPOSE: Triglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD). METHODS/PATIENTS: 13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index...
March 27, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#31
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38533944/risk-score-for-prediction-of-dialysis-after-transcatheter-aortic-valve-replacement
#32
JOURNAL ARTICLE
Vincenzo Pasceri, Francesco Pelliccia, Roxana Mehran, George Dangas, Italo Porto, Francesco Radico, Fausto Biancari, Fabrizio D'Ascenzo, Francesco Saia, Giampaolo Luzi, Francesco Bedogni, Ignacio J Amat Santos, Vincenzo De Marzo, Arnaldo Dimagli, Timo Mäkikallio, Eugenio Stabile, Sara Blasco-Turrión, Luca Testa, Marco Barbanti, Corrado Tamburino, Franco Fabiocchi, Ahmed Chilmeran, Federico Conrotto, Giuliano Costa, Giulio Stefanini, Carmen Spaccarotella, Andrea Macchione, Michele La Torre, Francesco Bendandi, Tatu Juvonen, Wojciech Wańha, Wojtek Wojakowski, Umberto Benedetto, Ciro Indolfi, David Hildick-Smith, Marco Zimarino
BACKGROUND: Dialysis is a rare but serious complication after transcatheter aortic valve replacement. We analyzed the large multicenter TRITAVI (transfusion requirements in transcatheter aortic valve implantation) registry in order to develop and validate a clinical score assessing this risk. METHODS AND RESULTS: A total of 10 071 consecutive patients were enrolled in 19 European centers. Patients were randomly assigned (2:1) to a derivation and validation cohort...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533295/hemodynamic-determinants-of-cardiac-surgery-associated-acute-kidney-injury
#33
JOURNAL ARTICLE
Sevag Demirjian, Faisal Bakaeen, W H Wilson Tang, Chase Donaldson, Jon Taliercio, Anne Huml, Crystal A Gadegbeku, A Marc Gillinov, Steven Insler
OBJECTIVES: Examine the: 1) relative role of hemodynamic determinants of acute kidney injury (AKI) obtained in the immediate postcardiac surgery setting compared with established risk factors, 2) their predictive value, and 3) extent mediation via central venous pressure (CVP) and mean arterial pressure (MAP). DESIGN: Retrospective observational study. The main outcome of the study was moderate to severe AKI, per kidney disease: improving global outcomes, within 14 days of surgery...
April 2024: Critical care explorations
https://read.qxmd.com/read/38533056/molecular-identification-of-different-toxinogenic-strains-of-clostridium-perfringens-and-histo-pathological-observations-of-camels-died-of-per-acute-entero-toxaemia
#34
JOURNAL ARTICLE
Hafiz Muhammad Ali, Shujaat Hussain, Muhammad Zishan Ahmad, Abu Baker Siddique, Sultan Ali, Mudassar Mohiuddin, Muhammad Ehsan, Muhammad Nadeem, Abdul Qayyum, Riaz Hussain, Iahtasham Khan, Dunia A Al Farraj, Enshad Alzaidi
Enterotoxaemia is a severe disease caused by Clostridium perfringens and render high mortality and huge economic losses in livestock. However, scanty information and only few cases are reported about the presence and patho-physiology of enterotoxaemia in camels. The bacterium induces per-acute death in animals due to rapid production of different lethal toxins. The necropsy of camels (per-acute = 15, acute = 3) was conducted at 18 outbreaks of enterotoxaemia in camels in the desert area of Bahawalpur region...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532810/letter-to-the-editor-comment-on-association-between-premorbid-renin-angiotensin-aldosteron-system-blockade-and-the-risk-of-acute-kidney-injury-in-critically-ill-patients
#35
JOURNAL ARTICLE
https://read.qxmd.com/read/38532333/early-and-mid-term-outcomes-of-open-thoracoabdominal-aortic-aneurysm-repair-after-thoracic-endovascular-aortic-repair
#36
JOURNAL ARTICLE
Ji Lin, Wei Liu, Cheng-Wei Yang, Kaitao Jian, Yu Xia, Hao Peng, Bin You, Li-Zhong Sun
OBJECTIVE: To evaluate the early and mid-term outcomes of open repair in patients with thoracoabdominal aortic aneurysm (TAAA) after thoracic endovascular aortic repair (TEVAR). METHODS: This was a retrospective single center study. Data were retrospectively collected and analyzed for consecutive patients undergoing open TAAA repair (TAAAR) after TEVAR from November 2016 to June 2021. Indications for TAAAR included aneurysm progression due to endoleak, persisted false lumen perfusion, proximal/distal disease progression, and aorta rupture...
March 26, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38531708/in-hospital-outcomes-and-trends-of-patients-with-autoimmune-diseases-undergoing-percutaneous-coronary-intervention-a-nationwide-analysis
#37
JOURNAL ARTICLE
Akanimo Antia, Kessiena Aomreore, Ndausung Udongwo, Sharika Menon, Uzoma Ibebuogu
BACKGROUND: The risk of coronary artery disease is exaggerated in patients with autoimmune diseases (AID). A higher risk of complications has been reported during and after percutaneous coronary intervention (PCI) in these patients. We aimed to analyze the in-hospital outcomes and trends of patients with AID, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) undergoing PCI. METHOD: We identified all PCI procedures using the National In-patient Sample database from 2016 to 2020...
March 9, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38531564/investigation-of-renal-perfusion-and-pathological-changes-in-patients-with-acute-kidney-disease-and-tubulointerstitial-nephritis-using-intravoxel-incoherent-motion-and-arterial-spin-labelling-mri-a-prospective-observational-study-protocol
#38
JOURNAL ARTICLE
Jiajia Liu, Rui Wang, Jianxing Qiu, Tao Su
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38530069/adjusting-current-hemoglobin-thresholds-a-way-to-improve-outcome-in-women-undergoing-major-surgery
#39
JOURNAL ARTICLE
Alina Netz, Lotta Hof, Florian Rumpf, Lea Valeska Blum, Vanessa Neef, Anja Kerner, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil
Background/Objective: In the perioperative setting, a suboptimal total hemoglobin (Hb) mass puts women and men at an unreasonable disadvantage. Anemia is an independent risk factor for transfusion, postoperative complications, and mortality. The Hb cut-off value for women was set at <12.0 g/dL by the World Health Organization (WHO) and has been rigorously debated for decades. The aim of this study was to elucidate the risk for postoperative complications in female patients with Hb levels < 12...
March 26, 2024: Journal of Women's Health
https://read.qxmd.com/read/38529931/acute-kidney-injury-in-children-with-lymphoma
#40
JOURNAL ARTICLE
Hejia Zhang, Yanlong Duan, Xiaoxue Li, Zhi Chen, Xiaorong Liu
OBJECTIVE: To analyze the epidemiology of acute kidney injury (AKI) in children with lymphoma and to assess the incidence, risk profile of AKI, and effects on renal function in children with lymphoma during their first 30 days of hospitalization. MATERIALS AND METHODS: This was a retrospective screen of electronic hospital and laboratory databases to select hospitalized children who were first diagnosed and treated for lymphoma at Beijing Children's Hospital between 2020 and 2021...
March 26, 2024: Clinical Nephrology
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