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Pain And Pressure Or Threshold

Gonzalo Navarro-Fernández, Lucía de-la-Puente-Ranea, Marisa Gandía-González, Alfonso Gil-Martínez
OBJECTIVE: The aim of this paper is to describe the progressive changes of chronic cluster headaches (CHs) in a patient who is being treated by a multimodal approach, using pharmacology, neurostimulation and physiotherapy. SUBJECT: A male patient, 42 years of age was diagnosed with left-sided refractory chronic CH by a neurologist in November 2009. In June 2014, the patient underwent a surgical intervention in which a bilateral occipital nerve neurostimulator was implanted as a treatment for headache...
March 12, 2019: Brain Sciences
Caroline E Phelps, Edita Navratilova, Anthony H Dickenson, Frank Porreca, Kirsty Bannister
Diffuse noxious inhibitory controls (DNIC) is a pain inhibits pain phenomenon demonstrated in humans and animals. DNIC is diminished in many chronic pain states, including neuropathic pain. The efficiency of DNIC has been suggested to prospectively predict both the likelihood of pain chronification and treatment response. Little is known as to why DNIC is dysfunctional in neuropathic pain. Here, we evaluated DNIC in the rat L5/L6 spinal nerve ligation (SNL) model of chronic pain using both behavioral and electrophysiological outcomes...
March 8, 2019: Pain
Stacey M Cornelson, Roberta Sclocco, Norman W Kettner
PURPOSE: Ulnar nerve instability (UNI) in the cubital tunnel is defined as ulnar nerve subluxation or dislocation. It is a common disorder that may be noted in patients with neuropathy or in the asymptomatic. Our prospective, single-site study utilized high-resolution ultrasonography (US) to evaluate the ulnar nerve for cross-sectional area (CSA) and measures of shear-wave elastography (SWE). Mechanical algometry was obtained from the ulnar nerve in the cubital tunnel to assess pressure pain threshold (PPT)...
March 12, 2019: Journal of Ultrasound
Jacques Abboud, Arianne Lessard, Mathieu Piché, Martin Descarreaux
PURPOSE: The aim of this study was to evaluate the effectiveness of an exercise protocol designed to induce delayed-onset muscle soreness (DOMS) in paraspinal muscles and its effects on low back functional capacities. METHODS: Twenty-four healthy participants were asked to perform four series of 25 trunk flexion-extension in a prone position (45° inclined Roman chair). The protocol was performed using loads corresponding to participant's trunk weight plus 10% of their trunk extension maximal voluntary contraction...
March 11, 2019: European Journal of Applied Physiology
David M Klyne, G Lorimer Moseley, Michele Sterling, Mary F Barbe, Paul W Hodges
Central sensitisation is considered to have a pathophysiological role in chronic low back pain (LBP). Whether individuals with increased central sensitisation early in their condition are more likely to develop persistent pain or whether it increases over time is unclear. This study aimed to determine whether sensory profiles during acute LBP differ between individuals who did and did not recover by 6-months and to identify subgroups associated with outcomes. Individuals with acute LBP (<2 weeks of onset, N=99) underwent pain threshold (heat/cold/pressure) and conditioned pain modulation (CPM) testing after completing questionnaires related to pain/disability, sleep, and psychological status...
March 7, 2019: Journal of Pain: Official Journal of the American Pain Society
Duygun Altıntaş Aykan, Tuba Tulay Koca, Selma Yaman, Nadire Eser
BACKGROUND: We hypothesized that renin-angiotensin system and neprilysin (NEP) inhibition can modulate the nociceptive parameters on hypertensive rats. The aim of this study is to assess the preventive and therapeutic effects of ramipril and sacubitril on the pain hypersensitivities, and their interaction mechanisms with high blood pressure. METHODS: Antinociceptive effects of ramipril and sacubitril were compared with those of diclofenac. Threshold of pain assesments were recorded before drugs administration...
December 10, 2018: Pharmacological Reports: PR
Ricardo Ortega-Santiago, Maite Maestre-Lerga, César Fernández-de-Las-Peñas, Joshua A Cleland, Gustavo Plaza-Manzano
OBJECTIVES: The presence of trigger points (MTrPs) and pressure pain sensitivity has been well documented in subjects with neck and back pain; however, it has yet to be examined in people with upper thoracic spine pain. The purpose of this study was to investigate the presence of MTrPs and mechanical pain sensitivity in individuals with upper thoracic spine pain. METHODS: Seventeen subjects with upper thoracic spine pain and 17 pain-free controls without spine pain participated...
March 1, 2019: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Y P Zhao, Y Y Ji, F Y Wang, S L Wang, G K Lai, T Wang, J M Tang
Objective: To investigate the value of fibrinogen to albumin ratio (FAR) at admission on predicting spontaneous recanalization of infarct-related artery (IRA) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: Clinical data from 255 acute STEMI patients ((61.1±11.2) years old, 189 males) who underwent emergency coronary angiography within 12 hours in our hospital from December 2015 to April 2018 were retrospectively analyzed. The acute STEMI patients were divided into non-spontaneous recanalization group (thrombolysis in myocardial infarction (TIMI) flow grade 0-1, 203 cases) and spontaneous recanalization group (TIMI flow grade 2-3, 52 cases)...
February 24, 2019: Zhonghua Xin Xue Guan Bing za Zhi
Ahmad Muhsen, Penny Moss, William Gibson, Bruce Walker, Angela Jacques, Stephan Schug, Anthony Wright
OBJECTIVES: Conditioned Pain Modulation (CPM) and Manipulation Induced Analgesia (MIA) may activate similar neurophysiological mechanisms to mediate their analgesic effects. This study assessed the association between CPM and MIA responses in people with lateral epicondylalgia (LE). METHODS: Seventy participants with LE were assessed for CPM followed by MIA. A single assessor measured pressure pain thresholds (PPT) before, during, and after cold water immersion (10°C) of the asymptomatic hand and contralateral lateral glide (CLG) mobilization of the neck...
February 28, 2019: Clinical Journal of Pain
Maureen E Basha, Susan Kellogg-Spadt, Lara J Burrows, Monique S Ruberu, Andrea S Wallach, Andrea M Nazar, Kristene E Whitmore
Context: Vulvodynia is a chronic pain condition defined as vulvar pain lasting at least 3 months in the absence of gross anatomic or neurologic findings. Provoked, localized vulvodynia (PLV), a subtype of vulvodynia, is characterized by vestibular pain in response to light touch. The cause of PLV remains largely unknown, and triggering events have yet to be determined. Objective: To evaluate vestibular and peripheral experimental pain thresholds in patients with PLV to further define the somatosensory profile of these patients...
March 1, 2019: Journal of the American Osteopathic Association
Abrahão Fontes Baptista, Ana Mércia B L Fernandes, Katia Nunes Sá, Alexandre Hideki Okano, André Russowsky Brunoni, Argelia Lara-Solares, Aziza Jreige Iskandar, Carlos Guerrero, César Amescua-García, Durval Campos Kraychete, Egas Caparelli-Daquer, Elias Atencio, Fabián Piedimonte, Frantz Colimon, Fuad Ahmed Hazime, João Batista S Garcia, John Jairo Hernández-Castro, José Alberto Flores Cantisani, Kátia Karina do Monte-Silva, Luis Claudio Lemos Correia, Manuel Sempértegui Gallegos, Marco Antonio Marcolin, María Antonieta Ricco, María Berenguel Cook, Patricia Bonilla, Pedro Schestatsky, Ricardo Galhardoni, Valquíria Silva, William Delgado Barrera, Wolnei Caumo, Didier Bouhassira, Lucy S Chipchase, Jean-Pascal Lefaucheur, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Introduction: Chronic pain (CP) is highly prevalent and generally undertreated health condition. Noninvasive brain stimulation may contribute to decrease pain intensity and influence other aspects related to CP. Objective: To provide consensus-based recommendations for the use of noninvasive brain stimulation in clinical practice. Methods: Systematic review of the literature searching for randomized clinical trials followed by consensus panel...
January 2019: Pain Reports (Baltimore, Md.)
P S Siebenga, G van Amerongen, P Okkerse, W S Denney, P Dua, R P Butt, J L Hay, G J Groeneveld
BACKGROUND: Although reproducibility is considered essential for any method used in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving human subjects. Here, we studied the reproducibility of a battery of evoked pain models for demonstrating the analgesic effects of two analgesic compounds. METHODS: A total of 81 healthy subjects participated in four studies involving a battery of evoked pain tests in which mechanical, thermal, and electrical stimuli were used to measure pain detection and tolerance thresholds...
February 21, 2019: European Journal of Pain: EJP
Blanca Romero-Moraleda, Jaime González-García, Ángel Cuéllar-Rayo, Carlos Balsalobre-Fernández, Daniel Muñoz-García, Esther Morencos
We aimed to compare the effects between non-vibration foam rolling (NVFR) and vibration foam rolling (VFR) on visual analogic scale (VAS), pressure pain threshold (PPT), oxygen saturation (SmO2), countermovement jump (CMJ) and hip and knee range of movement (ROM) after eliciting muscle damage through eccentric acute exercise using an inertial flywheel. Thirty-eight healthy volunteers (32 men, 6 women; aged 22.2±3.2 years) were randomly assigned in a counter-balanced fashion to either a VFR or NVFR protocol group...
March 2019: Journal of Sports Science & Medicine
Wolnei Caumo, Maria Paz Hidalgo, Andressa Souza, Iraci L S Torres, Luciana C Antunes
Objective: This study compared urinary 6-sulfatoxymelatonin (aMT6s) over 24 hours among fibromyalgia (FM), major depression disorder (MDD), and healthy control (HC) groups, and examined whether rhythm is correlated with depressive symptoms. To answer this question we compared the rhythm of urinary aMT6s secretion among each group in four time series: morning (06:00-12:00 hours), afternoon (12:00-18:00 hours), evening (18:00-24:00 hours), and night (24:00-06:00 hours). In the FM subjects, we assessed if the rhythm of urinary aMT6s secretion is associated with pain severity, sleep quality, number of trigger points (NTPs), and the pain pressure threshold (PPT)...
2019: Journal of Pain Research
Tom Clifford, Matthew Ventress, Dean M Allerton, Sarah Stansfield, Jonathan C Y Tang, William D Fraser, Barbara Vanhoecke, Janne Prawitt, Emma Stevenson
This study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day-1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. Maximal isometric voluntary contractions, countermovement jumps (CMJ), muscle soreness (200 mm visual analogue scale), pressure pain threshold, Brief Assessment of Mood Adapted (BAM +) and a range of blood markers associated with muscle damage, inflammation and bone turnover C-terminal telopeptide of type 1 collagen (β-CTX) and N-terminal propeptides of type 1 pro-collagen (P1NP) were measured before supplementation (baseline; BL), pre, post, 1...
February 19, 2019: Amino Acids
James J Burston, Ana M Valdes, Stephen G Woodhams, Paul I Mapp, Joanne Stocks, David J G Watson, Peter R W Gowler, Luting Xu, Devi R Sagar, Gwen Fernandes, Nadia Frowd, Laura Marshall, Weiya Zhang, Michael Doherty, David A Walsh, Victoria Chapman
Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic treatment strategies. Here, the effect of existing anxiety on future osteoarthritis (OA) pain was investigated, and potential mechanisms were studied in an animal model. Pressure pain detection thresholds, anxiety, and depression were assessed in people with (n = 130) or without (n = 100) painful knee OA...
March 2019: Pain
L Gallo, M Megna, T Cirillo, P Caterino, G Lodi, R Mozzillo, V Dente, A Balato
BACKGROUND/OBJECTIVE: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. METHODS: A real-life 4 weeks prospective, open study on Cal/BD aerosol foam (not compared to vehicle or emollient cream) was performed in adult psoriasis patients attending three Dermatology units located in Campania region, Italy, between March and October 2018...
February 15, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Jan Wilke, Lutz Vogt, Winfried Banzer
Latent myofascial trigger points (MTrP) have been linked to several impairments of muscle function. The present study was conducted in order to examine whether a single bout of self-myofascial release using a foam roller is effective in reducing MTrP sensitivity. Fifty healthy, pain-free subjects (26.8±6 years, 21 men) with latent MTrP in the lateral gastrocnemius muscle were included in the randomized, controlled trial. One week after a familiarization session, they were randomly allocated to three groups: (1) static compression of the most sensitive MTrP using a foam roll, (2) slow dynamic foam rolling of the lateral calf and (3) placebo laser acupuncture of the most sensitive MTrP...
December 2018: Biology of Sport
Ishanka Weerasekara, Peter Grant Osmotherly, Suzanne Jordan Snodgrass, John Tessier, Darren Anthony Rivett
BACKGROUND: Up to 40% of individuals who sprain their ankle develop chronic ankle instability (CAI). One treatment option for this debilitating condition is joint mobilisation. There is preliminary evidence that Mulligan's Mobilisation With Movement (MWM) is effective for treating patients with CAI, but the mechanisms by which it works are unclear, with Mulligan suggesting a repositioning of the fibula. This randomised controlled trial aims to determine the effects of MWM on anatomical and clinical characteristics of CAI...
February 13, 2019: BMC Musculoskeletal Disorders
Dhinu J Jayaseelan, Matthew J Weber, Holly Jonely
STUDY DESIGN: Case report. BACKGROUND: Tendinopathy is a condition often associated with pain, functional and sport performance limitations. While targeted exercise prescriptions are often effective, many patients with tendinopathy develop persistent symptoms. Emerging evidence suggests a possible link between nervous system sensitization and tendinopathy. If so, identifying and treating specific pain mechanisms may improve outcomes. CASE DESCRIPTION: Three patients were seen in physical therapy for complaints of ongoing chronic tendon pain and self-reported disability, despite being treated previously and receiving evidence-informed care...
February 13, 2019: Journal of Orthopaedic and Sports Physical Therapy
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