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Z D Shen, H M Yu, J T Wang, G Y Shi, Y Sun
Objective: To modify Western Ontario and McMaster University Osteoarthritis Index (WOMAC) for more accurate evaluation of patients with knee osteoarthritis in China,and its reliability and validity were measured. Methods: The WOMAC was modified through reviewing relevant literatures and practical survey.Total of 120 patients were enrolled in this study. The subjects completed the WOMAC,the modified WOMAC and Medical Outcomes Study 36-item Short Form(SF-36), and 113 of the questionnaires were valid for analysis [27 males (23...
February 19, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Carla Rohrer Bley, Valeria S Meier, Juergen Besserer, Uwe Schneider
Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. In spite of this framework, however, in implementing IMRT, we have identified different "interpretations" of the extended prescription and reporting recommendations of the International Commission on Radiation Units and Measurements (ICRU 83), even within our small team...
February 20, 2019: Veterinary Radiology & Ultrasound
Leyna Leite Santos, Jamilly Leite Santos, Luciano Timbó Barbosa, Ivan do Nascimento da Silva, Célio Fernando de Sousa-Rodrigues, Fabiano Timbó Barbosa
Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. The objective of the present study was to determine the effectiveness of insulin analogs compared with human insulin in the treatment of pregnant women with diabetes through a systematic review with meta-analysis. The search comprised the period since the inception of each database until July 2017, and the following databases were used: MEDLINE, CINAHL, EMBASE, ISI Web of Science, LILACS, Scopus, SIGLE and Google Scholar...
February 2019: Revista Brasileira de Ginecologia e Obstetrícia
Volker J Schmidt, Ulrich Kneser
The present refresher article highlights the current role of pedicled flaps in the reconstruction of complex wounds at the lower extremity. Due to the increasing standardization and ongoing improvements in microsurgery and in view of the fact that local tissue limitation and elevated rates of wound healing disorders reduced the attraction of pedicled flaps to the lower extremity, free flaps became a serious alternative. However, in consideration of the individual patient demand pedicled flaps to the lower extremity still have their eligibility and can be superior to free flaps in selected cases...
February 2019: Zeitschrift Für Orthopädie und Unfallchirurgie
Kenyu Hayashi, Yu Hasegawa, Yushin Takemoto, Cheng Cao, Hiroto Takeya, Yoshihiro Komohara, Akitake Mukasa, Shokei Kim-Mitsuyama
Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. In this study, we investigated whether brain exposure of Pg-LPS induced systemic organ dysfunction in a model of AD mouse...
February 17, 2019: Experimental Gerontology
Robert M Glaeser
Impressive though the achievements of single-particle cryo-electron microscopy are today, a substantial gap still remains between what is currently accomplished and what is theoretically possible. As is reviewed here, twofold or more improvements are possible as regards ( a) the detective quantum efficiency of cameras at high resolution, ( b) converting phase modulations to intensity modulations in the image, and ( c) recovering the full amount of high-resolution signal in the presence of beam-induced motion of the specimen...
February 20, 2019: Annual Review of Biophysics
Kinam Park, Andrew Otte
Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes. Even though formulations with varying abuse-deterrent technologies have been approved, questions remain about their effectiveness...
February 20, 2019: Annual Review of Biomedical Engineering
Pengfei Yang, Zhepeng Zhang, Mengxing Sun, Feng Lin, Ting Cheng, Jianping Shi, Chunyu Xie, Yuping Shi, Shaolong Jiang, Yahuan Huan, Porun Liu, Feng Ding, Chunyang Xiong, Dan Xie, Yanfeng Zhang
Atomically thin transition metal dichalcogenides (TMDCs) have received substantial interests due to their unique thickness-dependent optical and electronic properties, and related applications in optoelectronics. However, the large-scale, thickness tunable growth of such materials are still challenging. Herein, we report a fast growth of thickness tunable wedding-cake like MoS2 flakes on 6-inch soda-lime glass, by using NaCl-coated Mo foils as metal-precursors. The MoS2 thicknesses are tuned from one layer (1L) to ˃20L by controlling the concentrations of NaCl promoter...
February 20, 2019: ACS Nano
Yi Jiang, Xingqiao Wu, Yucong Yan, Sai Luo, Xiao Li, Jingbo Huang, Hui Zhang, Deren Yang
Developing an efficient electrocatalyst for the hydrogen evolution reaction (HER) working in both acidic and alkaline solutions is highly desirable, but still remains challenging. Here, Ptx Ni ultrathin nanowires (NWs) with tunable compositions (x = 1.42, 3.21, 5.67) are in situ grown on MXenes (Ti3 C2 nanosheets), serving as electrocatalysts toward HER. Such Ptx Ni@Ti3 C2 electrocatalysts exhibit excellent HER performance in both acidic and alkaline solutions, with the Pt3.21 Ni@Ti3 C2 being the best one. Specifically, Pt3...
February 20, 2019: Small
Hans-Jörg Himmel
Electron-deficient small boron rings are unique in their formation of sigma- and pi-delocalized electron systems, and the avoidance of "classical" structures in terms of two-center-two-electron (2c,2e) bonds. These rings are tolerant to several skeletal electron numbers, making their redox-chemistry highly interesting. In the past decades, the synthesis of a range of stable compounds with varying electron numbers in the B3 and B4 cores was achieved. In alliance with quantum-chemical calculations the electronic structures were evaluated...
February 20, 2019: Angewandte Chemie
Nobuko Makino, Yosikazu Nakamura, Mayumi Yashiro, Koki Kosami, Yuri Matsubara, Ryusuke Ae, Yasuko Aoyama, Hiroshi Yanagawa
BACKGROUND: Approximately 50 years have passed since Kawasaki disease (KD) was first reported. The Kawasaki disease nationwide survey began in 1970. Although more than 360,000 patients have already been reported in Japan, the cause is still unknown. In Japan, the number of patients and incidence rate of KD has continued to increase. It is necessary to exam the trend of the occurrence of patients in the surveillance of KD. METHODS: The nationwide survey of patient incidence in 2015 and 2016 was conducted in 2017, as the 24th nationwide survey of KD...
February 20, 2019: Pediatrics International: Official Journal of the Japan Pediatric Society
Lung-Yi Mak, Michael Ko, Elvis To, Danny Ka-Ho Wong, Justin Hei-Chun Ma, Teresa Lok-Yee Hui, Wai-Kay Seto, James Fung, Ching-Lung Lai, Man-Fung Yuen
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) can still develop in chronic hepatitis B (CHB) patients receiving antiviral treatment. Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel marker for liver fibrosis. We investigated its role on incidence of HCC in entecavir (ETV)-treated CHB patients. METHODS: We identified HCC cases diagnosed at ≥1 year of ETV treatment. CHB patients without HCC (matched for age, gender, baseline HBV DNA, and duration of ETV treatment) were identified in approximately 1:2 ratio (HCC: non-HCC) for comparison...
February 20, 2019: Journal of Gastroenterology and Hepatology
Samuel M Goldman, Kenneth Marek, Ruth Ottman, Cheryl Meng, Kathleen Comyns, Piu Chan, Jinghong Ma, Connie Marras, J William Langston, G Webster Ross, Caroline M Tanner
During the 1990s we estimated the genetic contribution to Parkinson's disease risk in a large population-based twin registry. Because many unaffected twins were still alive, prior concordance estimates were based on incomplete information. 95% of twins are now deceased. Here we update concordance and heritability through 2015 using National Death Index data. In total, we identified 30 concordant and 193 discordant pairs. Probandwise concordance was 0.20 in monozygotic and 0.13 in dizygotic pairs. Heritability was 0...
February 20, 2019: Annals of Neurology
Sofia Galanou, Giorgos Chouliaras, Panagiotis Girginoudis, Chryssanthi Mengreli, Amalia Sertedaki, Maria Dracopoulou, Ioanna Farakla, Dimitris Platis, Alexandra Iliadi, George P Chrousos, Catherine Dacou-Voutetakis, Emanuil Zoumakis, Alexandra-Maria Magiakou, Christina Kanaka-Gantenbein, Antonis Voutetakis
CONTEXT: The adrenal gland undergoes significant remodeling during the neonatal period, an essential developmental process that still remains incompletely understood. With respect to control over the remodeling process and, specifically, the role of thyroid hormones (TH), no human studies have been published. The effect of both hypo- and hyper-thyroidism has only been evaluated in adults, focusing on the mature adrenal. Recently, Huang et al identified expression of the TH receptor β1 in the mouse adrenal X-zone and demonstrated that TH administration could alter the postnatal adrenal remodeling process...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
Marcos Zurita
The aim of this paper is to discuss about some key issues concerning psychiatry. What really does a psychiatrist nowadays? What kind of disorder does he treat? Why psychiatry keeps itself apart from other specialties and within its own autonomous field? Having in mind the differences between the mental disorders, can we consider that the same semiological elements are appropriate for all of them or do we need to resume an individual analysis from each of those disorders? Can we go through the sparse spectrum of neurotic disorders ignoring the market forces or the dualistic interpretation? In this context, there is still room for questioning: is there an undiscovered explanation regarding the psychiatry disorders or are we trying to find a whole rationale explanation to study non-agroupable objects, lacking of that aforementioned common nuclear logic? And finally, could it be that the constant variables which we assume as the constitutive elements of psychiatric objects are barely the shifting boundaries that change as the time and the culture does?...
September 2018: Vertex: Revista Argentina de Psiquiatriá
Stefano Bedini, Guido Flamini, Francesca Cosci, Roberta Ascrizzi, Maria C Echeverria, Evelin V Gomez, Lucia Guidi, Marco Landi, Andrea Lucchi, Barbara Conti
Cutaneous myiasis is a severe worldwide medical and veterinary issue. In this trial the essential oil (EO) of the Andean medicinal plant species Clinopodium nubigenum (Kunth) Kuntze was evaluated for its bioactivity against the myiasis-inducing blowfly Lucilia sericata (Meigen) (Diptera Calliphoridae) and compared with that of the well-known medicinal plant species Lavandula angustifolia Mill. The EOs were analysed and tested in laboratory for their oviposition deterrence and toxicity against L. sericata adults...
2019: PloS One
Shintaro Sagami, Taku Kobayashi, Nao Kikkawa, Satoko Umeda, Masaru Nakano, Takahiko Toyonaga, Shinji Okabayashi, Ryo Ozaki, Toshifumi Hibi
BACKGROUND/AIMS: The small bowel is affected in more than half of patients with Crohn's disease (CD) at the time of diagnosis, and small bowel involvement has a negative impact on the long-term outcome. Many patients reportedly have active lesions in the small intestine even in patients in clinical remission. This study was performed to compare findings of magnetic resonance enterography (MRE) and ileocolonoscopy. METHODS: A single-center retrospective study was conducted in 50 patients (60 imaging series) with CD, for whom MRE was additionally performed during the bowel preparation for subsequent ileocolonoscopy...
2019: PloS One
Max Cardoso Langer, Blair Wayne McPhee, Júlio César de Almeida Marsola, Lúcio Roberto-da-Silva, Sérgio Furtado Cabreira
Sauropodomorphs are the most abundant and diverse clade of Triassic dinosaurs, but the taxonomy of their earliest (Carnian) representatives is still poorly understood. One such taxon is Pampadromaeus barberenai, represented by a nearly complete disarticulated skeleton recovered from the upper part of the Santa Maria Formation of Rio Grande do Sul, Brazil. Here, the osteology of Pam. barberenai is fully described for the first time. Detailed comparisons with other Carnian sauropodomorphs reveal a unique anatomy, corroborating its status as a valid species...
2019: PloS One
Sung-Hee Han, Joowon Yi, Ji-Hoon Kim, SangWon Lee, Hee-Won Moon
Data concerning the human microbiota composition during Clostridioides (Clostridium) difficile infection (CDI) using next-generation sequencing are still limited. We aimed to confirm key features indicating tcdB positive patients and compare the microbiota composition between subgroups based on toxin gene load (tcdB gene) and presence of significant diarrhea. Ninety-nine fecal samples from 79 tcdB positive patients and 20 controls were analyzed using 16S rRNA gene sequencing. Chao1 index for alpha diversity were calculated and principal coordinate analysis was performed for beta diversity using Quantitative Insights into Microbial Ecology (QIIME) pipeline...
2019: PloS One
Arnolfo Petruzziello, Rocco Sabatino, Giovanna Loquercio, Annunziata Guzzo, Lucia Di Capua, Francesco Labonia, Anna Cozzolino, Rosa Azzaro, Gerardo Botti
INTRODUCTION: It has been greatly described that different hepatitis C virus (HCV) genotypes are strictly correlated to various evolution, prognosis and response to therapy during the chronic liver disease. Aim of this study was to outline the changes in the epidemiology of Hepatitis C genotypes in Southern Italy regions from 2006 to 2014. MATERIAL/METHODS: Prevalence of HCV genotypes was analyzed in 535 HCV-RNA positive patients with chronic Hepatitis C infection, selected during the period 2012-2014, and compared with our previous data, referred to periods 2006-2008 and 2009-2011...
2019: PloS One
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