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https://read.qxmd.com/read/30762563/a-magnetoencephalography-study-of-pediatric-interictal-neuromagnetic-activity-changes-and-brain-network-alterations-caused-by-epilepsy-in-the-high-frequency-80-1000hz
#1
Lu Meng
More and more studies propose that high frequency brain signals are promising biomarkers of epileptogenic zone. In this study, our aim is to investigate the neuromagnetic changes and brain network topological alterations during an interictal period at high frequency ranges (80-1000Hz) between healthy controls and epileptic patients with Magnetoencephalography (MEG). We analyzed neuromagnetic activities with accumulated source imaging, and constructed brain network based on graph theory. Neuromagnetic activity changes and brain network alterations between two groups were analyzed in three frequency bands: ripple (80-250Hz), fast ripples (FRs, 250-500Hz), and very high frequency oscillations (VHFO, 500-1000Hz)...
February 12, 2019: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/30742861/delayed-creatine-supplementation-counteracts-reduction-of-gabaergic-function-and-protects-against-seizures-susceptibility-after-traumatic-brain-injury-in-rats
#2
Rogerio R Gerbatin, Luiz Fernando Almeida Silva, Maurício S Hoffmann, Iuri D Della-Pace, Patricia Severo do Nascimento, Aline Kegler, Viviane Nogueira de Zorzi, Jane Marçal Cunha, Priscilla Botelho, João Bento Torres Neto, Ana Flavia Furian, Mauro Schneider Oliveira, Michele R Fighera, Luiz Fernando Freire Royes
Traumatic brain injury (TBI) is a devastating disease frequently followed by behavioral disabilities including post-traumatic epilepsy (PTE). Although reasonable progress in understanding its pathophysiology has been made, treatment of PTE is still limited. Several studies have shown the neuroprotective effect of creatine in different models of brain pathology, but its effects on PTE is not elucidated. Thus, we decided to investigate the impact of delayed and chronic creatine supplementation on susceptibility to epileptic seizures evoked by pentylenetetrazol (PTZ) after TBI...
February 8, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/30733144/medial-septal-stimulation-increases-seizure-threshold-and-improves-cognition-in-epileptic-rats
#3
Ali Izadi, Aleksandr Pevzner, Darrin J Lee, Arne D Ekstrom, Kiarash Shahlaie, Gene G Gurkoff
BACKGROUND: Temporal lobe epilepsy is most prevalent among focal epilepsies, and nearly one-third of patients are refractory to pharmacological intervention. Persistent cognitive and neurobehavioral comorbidities also occur due to the recurrent nature of seizures and medication-related side effects. HYPOTHESIS: Electrical neuromodulation is an effective strategy to reduce seizures both in animal models and clinically, but its efficacy to modulate cognition remains unclear...
January 17, 2019: Brain Stimulation
https://read.qxmd.com/read/30712997/strong-relationship-between-nrem-sleep-epilepsy-and-plastic-functions-a-conceptual-review-on-the-neurophysiology-background
#4
REVIEW
Péter Halász, Róbert Bódizs, Przemysla Péter Ujma, Dániel Fabó, Anna Szűcs
The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. The interictal epileptic discharges associate with different sleep constituents (sleep slow waves, spindling and high frequency oscillations); known to play essential role in memory and learning...
January 31, 2019: Epilepsy Research
https://read.qxmd.com/read/30685321/preface-practical-and-theoretical-considerations-for-performing-a-multi-center-preclinical-biomarker-discovery-study-of-post-traumatic-epileptogenesis-lessons-learned-from-the-epibios4rx-consortium
#5
Asla Pitkänen, Terence J O'Brien, Richard Staba
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a NINDS funded Center-Without-Walls international study aimed at preventing epileptogenesis after traumatic brain injury (TBI). One objective of EpiBioS4Rx relates to preclinical biomarker discovery for post-traumatic epilepsy. In order to perform a statistically appropriately powered biomarker discovery study, EpiBioS4Rx has made a rigorous attempt to harmonize the preclinical procedures performed at the three EpiBioS4Rx centers, located in Finland, Australia, and the USA...
January 18, 2019: Epilepsy Research
https://read.qxmd.com/read/30629979/chronobiology-of-limbic-seizures-potential-mechanisms-and-prospects-of-chronotherapy-for-mesial-temporal-lobe-epilepsy
#6
REVIEW
Daniel Leite Góes Gitai, Tiago Gomes de Andrade, Ygor Daniel Ramos Dos Santos, Sahithi Attaluri, Ashok K Shetty
Mesial Temporal Lobe Epilepsy (mTLE) characterized by progressive development of complex partial seizures originating from the hippocampus is the most prevalent and refractory type of epilepsy. One of the remarkable features of mTLE is the rhythmic pattern of occurrence of spontaneous seizures, implying a dependence on the endogenous clock system for seizure threshold. Conversely, circadian rhythms are affected by epilepsy too. Comprehending how the circadian system and seizures interact with each other is essential for understanding the pathophysiology of epilepsy as well as for developing innovative therapies that are efficacious for better seizure control...
January 7, 2019: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/30589767/interictal-slow-and-high-frequency-oscillations-is-it-an-epileptic-slow-or-red-slow
#7
Takeshi Inoue, Morito Inouchi, Masao Matsuhashi, Riki Matsumoto, Takefumi Hitomi, Masako Daifu-Kobayashi, Katsuya Kobayashi, Mitsuyoshi Nakatani, Kyoko Kanazawa, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
PURPOSE: We reported the presence of interictal slow and high-frequency oscillations (HFOs) (IIS + HFO) and its temporal change so as to elucidate its clinical usefulness as a surrogate marker of epileptogenic zone in a patient with intractable focal epilepsy. METHODS: We focused on one of the core electrodes of epileptogenicity, and investigated IIS + HFO in the pre- and post-segment of 30 minutes to all the 6 seizures. We adopted interictal slow in duration of 0...
December 26, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://read.qxmd.com/read/30579026/magnetoencephalography-as-a-prognostic-method-in-patients-with-medically-intractable-temporal-lobe-epilepsy
#8
Chang Kyu Park, Su Jeong Hwang, Na Young Jung, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
OBJECTIVE: Most surgical treatments for medically intractable temporal lobe epilepsy are favorable. However, when a patient has persistent symptoms after surgery, there are no tests that can accurately predict whether a patient will have remnant epileptic foci. The purpose of this study was to evaluate the usefulness of magnetoencephalography (MEG) as a prognostic method in patients with temporal lobe epilepsy METHODS: From July 2012 to July 2016, a total of 21 patients underwent pre- and postoperative MEG at our center...
December 19, 2018: World Neurosurgery
https://read.qxmd.com/read/30564779/clinically-indicated-electrical-stimulation-strategies-to-treat-patients-with-medically-refractory-epilepsy
#9
Ali Izadi, Katelynn Ondek, Amber Schedlbauer, Inna Keselman, Kiarash Shahlaie, Gene Gurkoff
Focal epilepsies represent approximately half of all diagnoses, and more than one-third of these patients are refractory to pharmacologic treatment. Although resection can result in seizure freedom, many patients do not meet surgical criteria, as seizures may be multifocal in origin or have a focus in an eloquent region of the brain. For these individuals, several U.S. Food and Drug Administration (FDA)-approved electrical stimulation paradigms serve as alternative options, including vagus nerve stimulation, responsive neurostimulation, and stimulation of the anterior nucleus of the thalamus...
December 2018: Epilepsia open
https://read.qxmd.com/read/30564771/interrater-reliability-in-visual-identification-of-interictal-high-frequency-oscillations-on-electrocorticography-and-scalp-eeg
#10
Hiroki Nariai, Joyce Y Wu, Danilo Bernardo, Aria Fallah, Raman Sankar, Shaun A Hussain
High-frequency oscillations (HFOs), including ripples (Rs) and fast ripples (FRs), are promising biomarkers of epileptogenesis, but their clinical utility is limited by the lack of a standardized approach to identification. We set out to determine whether electroencephalographers experienced in HFO analysis can reliably identify and quantify interictal HFOs. Two blinded raters independently reviewed 10 intraoperative electrocorticography (ECoG) samples from epilepsy surgery cases, and 10 scalp EEG samples from epilepsy monitoring unit evaluations...
December 2018: Epilepsia Open
https://read.qxmd.com/read/30564770/nonictal-eeg-biomarkers-for-diagnosis-and-treatment
#11
Jerome Engel, Anatol Bragin, Richard Staba
There are no reliable nonictal biomarkers for epilepsy, electroencephalography (EEG) or otherwise, but efforts to identify biomarkers that would predict the development of epilepsy after a potential epileptogenic insult, diagnose the existence of epilepsy, or assess the effects of antiseizure or antiepileptogenic interventions are relying heavily on electrophysiology. The most promising EEG biomarkers to date are pathologic high-frequency oscillations (pHFOs), brief EEG events in the range of 100 to 600 Hz, which are believed to reflect summated action potentials from synchronously bursting neurons...
December 2018: Epilepsia Open
https://read.qxmd.com/read/30548850/sensory-coding-is-impaired-in-rat-absence-epilepsy
#12
Florian Studer, Emel Laghouati, Guillaume Jarre, Olivier David, Benoît Pouyatos, Antoine Depaulis
KEY POINTS: Absence epilepsy is characterized by the occurrence of spike-and-wave discharges concomitant with an alteration of consciousness and associated with cognitive comorbidities. In a genetic model of absence epilepsy in the rat, the GAERS, we showed that spike-and-wave discharges are initiated in the barrel field primary somatosensory cortex that codes whisker-related information therefore playing an essential role in rodents' interactions with their environment. Sensory-information processing is impaired in the epileptic barrel field primary somatosensory cortex of GAERS with a delayed sensory-evoked potential and a duplicated neuronal response to whisker-stimulation in in vivo extracellular recordings...
December 13, 2018: Journal of Physiology
https://read.qxmd.com/read/30544358/ictal-networks-of-temporal-lobe-epilepsy-views-from-high-frequency-oscillations-in-stereoelectroencephalography
#13
(no author information available yet)
OBJECTIVEIn this study, the authors investigated high-frequency oscillation (HFO) networks during seizures in order to determine how HFOs spread from the focal cerebral cortex and become synchronized across various areas of the brain.METHODSAll data were obtained from stereoelectroencephalography (SEEG) signals in patients with drug-resistant temporal lobe epilepsy (TLE). The authors calculated intercontact cross-coefficients between all pairs of contacts to construct HFO networks in 20 seizures that occurred in 5 patients...
November 1, 2018: Journal of Neurosurgery
https://read.qxmd.com/read/30542266/astroglial-ca-2-dependent-hyperexcitability-requires-p2y-1-purinergic-receptors-and-pannexin-1-channel-activation-in-a-chronic-model-of-epilepsy
#14
Mario Wellmann, Carla Álvarez-Ferradas, Carola J Maturana, Juan C Sáez, Christian Bonansco
Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. The above suggests that alterations in astroglial Ca2+ -dependent excitability observed in the epileptic tissue could arise from changes in astrocyte-to-astrocyte signaling, which is mainly mediated by purines in physiological and pathological conditions...
2018: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/30542259/imbalance-of-functional-connectivity-and-temporal-entropy-in-resting-state-networks-in-autism-spectrum-disorder-a-machine-learning-approach
#15
Robert X Smith, Kay Jann, Mirella Dapretto, Danny J J Wang
Background: Two approaches to understanding the etiology of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) involve network level functional connectivity (FC) and the dynamics of neuronal signaling. The former approach has revealed both increased and decreased FC in individuals with ASD. The latter approach has found high frequency EEG oscillations and higher levels of epilepsy in children with ASD. Together, these findings have led to the hypothesis that atypical excitatory-inhibitory neural signaling may lead to imbalanced association pathways...
2018: Frontiers in Neuroscience
https://read.qxmd.com/read/30529399/tonic-thermonociceptive-stimulation-selectively-modulates-ongoing-neural-oscillations-in-the-human-posterior-insula-evidence-from-intracerebral-eeg
#16
Giulia Liberati, Maxime Algoet, Susana Ferrao Santos, Jose Geraldo Ribeiro-Vaz, Christian Raftopoulos, André Mouraux
The human insula is an important target for spinothalamic input, but there is still no consensus on its role in pain perception and nociception. In this study, we show that the human insula exhibits activity preferential for sustained thermonociception. Using intracerebral EEG recorded from the insula of 8 patients (2 females) undergoing a presurgical evaluation of focal epilepsy (53 contacts: 27 anterior, 26 posterior), we "frequency-tagged" the insular activity elicited by sustained thermonociceptive and vibrotactile stimuli, by periodically modulating stimulation intensity at a fixed frequency of 0...
December 5, 2018: NeuroImage
https://read.qxmd.com/read/30499503/-neurotrauma-as-a-factor-of-epileptogenesis
#17
A K Shishmanidi, S M Karpov, I A Vyshlova, A S Karpov, E M Bahadova
The presented article deals with traumatic brain injury, which can cause convulsive seizures with the subsequent development of epilepsy, which is especially characteristic of young people. The problems of classification of posttraumatic epileptic seizures, development of their mechanisms, characteristics of diagnosis, as well as the stages of epileptogenesis leading to the development of traumatic epilepsy are considered. The variants of therapy are given in view of traumatic brain injury. It is noted that the use of electrical stimulation during individual phases of paroxysmal oscillations can be an effective method in preventing the development of homeostatic plasticity that is involved in the development of epileptogenesis...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/30497180/modulation-of-neural-oscillations-by-vagus-nerve-stimulation-in-posttraumatic-multifocal-epilepsy-case-report
#18
(no author information available yet)
The putative mechanism of vagus nerve stimulation (VNS) for medically refractory epilepsy is desynchronization of hippocampal and thalamocortical circuitry; however, the nature of the dose-response relationship and temporal dynamics is poorly understood. For greater elucidation, a study in a nonepileptic rat model was previously conducted and showed that rapid-cycle (RC) VNS achieved superior desynchrony compared to standard-cycle (SC) VNS. Here, the authors report on the first in-human analysis of the neuromodulatory dose-response effects of VNS in a patient with posttraumatic, independent, bilateral mesial temporal lobe epilepsy refractory to medications and SC-VNS who was referred as a potential candidate for a responsive neurostimulation device...
November 1, 2018: Journal of Neurosurgery
https://read.qxmd.com/read/30483204/determining-the-quantitative-threshold-of-high-frequency-oscillation-distribution-to-delineate-the-epileptogenic-zone-by-automated-detection
#19
Chenxi Jiang, Xiaonan Li, Jiaqing Yan, Tao Yu, Xueyuan Wang, Zhiwei Ren, Donghong Li, Chang Liu, Wei Du, Xiaoxia Zhou, Yue Xing, Guoping Ren, Guojun Zhang, Xiaofeng Yang
Objective: We proposed an improved automated high frequency oscillations (HFOs) detector that could not only be applied to various intracranial electrodes, but also automatically remove false HFOs caused by high-pass filtering. We proposed a continuous resection ratio of high order HFO channels and compared this ratio with each patient's post-surgical outcome, to determine the quantitative threshold of HFO distribution to delineate the epileptogenic zone (EZ). Methods: We enrolled a total of 43 patients diagnosed with refractory epilepsy...
2018: Frontiers in Neurology
https://read.qxmd.com/read/30472273/partial-restoration-of-physiological-up-state-activity-by-gaba-pathway-modulation-in-an-acute-brain-slice-model-of-epilepsy
#20
Anna-Lucia Koerling, Tanja Fuchsberger, Ole Paulsen, Y Audrey Hay
In addition to reducing seizures, anti-epileptic treatments should preserve physiological network activity. Here, we used a thalamocortical slice preparation displaying physiological slow oscillations to investigate the effects of anticonvulsant drugs on physiological activity and epileptiform activity in two pharmacological epilepsy models. Thus, we compared the effects of GABA pharmacology on spontaneous physiological and pathological events in slices of the mouse barrel cortex. We show that both reducing inhibition using GABAA R blockers and enhancing excitation by lowering Mg2+ concentration allow for the transition from physiological slow oscillations to epileptiform activity...
November 22, 2018: Neuropharmacology
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