keyword
https://read.qxmd.com/read/38536044/acetazolamide-as-an-effective-treatment-for-pilomotor-seizures-in-autoimmune-encephalitis
#1
JOURNAL ARTICLE
Kia Gilani, Apameh Tarazi, Richard Wennberg
Pilomotor seizures are strongly associated with autoimmune encephalitis (AE), particularly anti-LGI1 encephalitis. The carbonic anhydrase inhibitor acetazolamide may have special efficacy for treating AE-associated pilomotor seizures. Six patients with AE (five anti-LGI1, one seronegative) and temporal lobe pilomotor seizures (five with seizures inducible by hyperventilation) were treated with acetazolamide, administered in a cycling (2-days-ON, 4-days-OFF) regimen to offset tolerance. Seizures were assessed during epilepsy monitoring unit (EMU) recordings in four inpatients (one of whom also maintained an outpatient seizure diary chronicling 1203 seizures over 1079 days); two outpatients self-reported seizure frequencies...
March 27, 2024: Epilepsia
https://read.qxmd.com/read/38534498/measurement-of-the-mapping-between-intracranial-eeg-and-fmri-recordings-in-the-human-brain
#2
JOURNAL ARTICLE
David W Carmichael, Serge Vulliemoz, Teresa Murta, Umair Chaudhary, Suejen Perani, Roman Rodionov, Maria Joao Rosa, Karl J Friston, Louis Lemieux
There are considerable gaps in our understanding of the relationship between human brain activity measured at different temporal and spatial scales. Here, electrocorticography (ECoG) measures were used to predict functional MRI changes in the sensorimotor cortex in two brain states: at rest and during motor performance. The specificity of this relationship to spatial co-localisation of the two signals was also investigated. We acquired simultaneous ECoG-fMRI in the sensorimotor cortex of three patients with epilepsy...
February 27, 2024: Bioengineering
https://read.qxmd.com/read/38533170/keto-clarity-a-comprehensive-systematic-review-exploring-the-efficacy-safety-and-mechanisms-of-ketogenic-diet-in-pediatric-epilepsy
#3
REVIEW
Youmna Faheem, Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Ann Kashmer Yu
Epilepsy, a widespread neurological disorder characterized by recurrent seizures, affects millions globally, with a significant impact on the pediatric population. Antiepileptic drugs (AEDs) constitute the primary treatment; however, drug-resistant epilepsy (DRE), especially in children, poses a therapeutic challenge. Alternative interventions, such as surgery, vagus nerve stimulation, and the ketogenic diet (KD), have been explored. This systematic review aims to investigate various types of KDs, their distinctions, their effectiveness, and their safety concerning the reduction of seizure frequency, achieving seizure freedom, and the occurrence of adverse events...
February 2024: Curēus
https://read.qxmd.com/read/38531502/low-frequency-stimulation-for-seizure-suppression-identification-of-optimal-targets-in-the-entorhinal-hippocampal-circuit
#4
JOURNAL ARTICLE
Piret Kleis, Enya Paschen, Ute Häussler, Carola A Haas
BACKGROUND: Mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) is a common form of drug-resistant focal epilepsy in adults. Treatment for pharmacoresistant patients remains a challenge, with deep brain stimulation (DBS) showing promise for alleviating intractable seizures. This study explores the efficacy of low-frequency stimulation (LFS) on specific neuronal targets within the entorhinal-hippocampal circuit in a mouse model of MTLE. OBJECTIVE: /Hypothesis: Our previous research demonstrated that LFS of the medial perforant path (MPP) fibers in the sclerotic hippocampus reduced seizures in epileptic mice...
March 24, 2024: Brain Stimulation
https://read.qxmd.com/read/38530712/feasibility-study-for-a-high-frequency-flexible-ultrasonic-cuff-for-high-precision-vagus-nerve-ultrasound-neuromodulation
#5
JOURNAL ARTICLE
Cornelis Van Damme, Gandhika K Wardhana, Andrada Iulia Velea, Vasiliki Giagka, Tiago L Costa
In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to reduce side effects, as well as to increase the effectiveness of the delivered therapy, sub-fascicle stimulation specificity is required. In the electrical domain, increasing spatial selectivity can only be achieved using invasive and potentially damaging approaches like compressive forces or nerve penetration...
March 26, 2024: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://read.qxmd.com/read/38529699/radiprodil-a-selective-glun2b-negative-allosteric-modulator-rescues-audiogenic-seizures-in-mice-carrying-the-glun2a-n615s-mutation
#6
JOURNAL ARTICLE
Ilaria Bertocchi, Lorenzo Cifarelli, Alessandra Oberto, Carola Eugenia Eva, Rolf Sprengel, Naheed Rohman Mirza, Pierandrea Muglia
BACKGROUND AND PURPOSE: GRIN-related disorders are neurodevelopmental disorders caused by mutations in N-methyl-D-aspartate receptor (NMDAR) subunit genes. A large fraction of these mutations lead to a 'gain of function' (GoF) of the NMDAR. Patients present with a range of symptoms including epilepsy, intellectual disability, behavioural and motor. Controlling seizures is a significant unmet medical need in most patients with GRIN-related disorders. Although several hundred GRIN mutations have been identified in humans, until recently none of the mouse models carrying Grin mutations/deletions showed an epileptic phenotype...
March 26, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38528770/yield-and-utility-of-routine-epilepsy-panel-genetic-testing-among-young-patients-with-seizures
#7
JOURNAL ARTICLE
Emily Grew, Mayuri Reddy, Hayley Reichner, Jinsoo Kim, Misbah Salam, Anjum Hashim
Objective: We examined the yield of routine epilepsy panel genetic testing in pediatric patients. Methods: We retrospectively reviewed epilepsy genetic panel results routinely performed in the hospital or clinic on patients <8 years old from July 2021 to July 2023. We evaluated demographics, family history, seizure type, severity, and frequency, development, tone and movement abnormalities, dysmorphism, and electroencephalography (EEG) or magnetic resonance imaging (MRI) results as predictors of results...
March 25, 2024: Journal of Child Neurology
https://read.qxmd.com/read/38524275/affiliate-stigma-and-caregiver-burden-in-parents-of-children-with-epilepsy
#8
JOURNAL ARTICLE
Xingyanan Wang, Jinghua Ye, Xiaoqin Tian, Fangping Wang, Xiaocui Guo
OBJECTIVE: This study aimed to investigate the current status of affiliated stigma and caregiver burden among parents of children with epilepsy, analyze their correlation, and identify factors influencing affiliated stigma. METHODS: A cross-sectional survey was conducted among 194 parents of children with epilepsy who met the inclusion and exclusion criteria in Shenzhen City, Guangdong Province, China. Data were collected through questionnaires, including a demographic information sheet, an affiliated stigma scale, and a caregiver burden scale...
May 2024: Preventive Medicine Reports
https://read.qxmd.com/read/38523608/the-efficacy-and-safety-of-novel-antiepileptic-drugs-in-treatment-of-epilepsy-of-patients-with-brain-tumors
#9
REVIEW
Weiwei Zhai, Qiaoling Yu, Huizhen Wu
OBJECTIVE: This meta-analysis aimed to assess the effectiveness and safety of novel antiepileptic drugs (AEDs) in treating epilepsy in patients with brain tumors (BTRE). METHODS: A search was conducted on PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to February 2023, with English language restriction. RESULTS: In this meta-analysis, 18 clinical trials involving 755 BTRE patients were included to assess the efficacy and safety of novel AEDs in BTRE treatment...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38523379/evaluation-of-functional-gastrointestinal-disorders-in-children-aged-4-10-years-with-autism-spectrum-disorder
#10
JOURNAL ARTICLE
Özlem Gülpınar Aydın, Hüseyin Burak Baykara, Kardelen Akın, Sinem Kahveci, Gül Şeker, Yunus Güler, Yeşim Öztürk
BACKGROUND: Gastrointestinal system disorders are known to be prevalent among children with autism spectrum disorder (ASD). Some ASD-associated comorbidities are abdominal pain, constipation, diarrhea, gastroesophageal reflux, sleep disturbances, epilepsy, and psychiatric problems. Nonetheless, there is still limited information about the presence of functional GI disorders (FGIDs) among children with ASD, especially in Türkiye. Using the Rome criteria, we aimed to investigate FGIDs in children with ASD...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38523034/reprint-of-recessive-apc2-missense-variants-associated-with-epilepsies-without-neurodevelopmental-disorders
#11
JOURNAL ARTICLE
Liang Jin, Yun Li, Sheng Luo, Qian Peng, Qiong-Xiang Zhai, Jin-Xia Zhai, Liang-Di Gao, Jia-Jun Guo, Wang Song, Yong-Hong Yi, Na He, Yong-Jun Chen
OBJECTIVES: The APC2 gene, encoding adenomatous polyposis coli protein-2, is involved in cytoskeletal regulation in neurons responding to endogenous extracellular signals and plays an important role in brain development. Previously, the APC2 variants have been reported to be associated with cortical dysplasia and intellectual disability. This study aims to explore the association between APC2 variants and epilepsy. METHODS: Whole-exome sequencing (WES) was performed in cases (trios) with epilepsies of unknown causes...
March 21, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38521695/development-of-an-mr-guided-focused-ultrasound-mrgfus-lesioning-approach-for-the-fornix-in-the-rat-brain
#12
JOURNAL ARTICLE
Carena Cornelssen, Allison Payne, Dennis L Parker, Matthew Alexander, Robb Merrill, Sharayu Senthilkumar, Jacob Christensen, Karen S Wilcox, Henrik Odéen, John D Rolston
OBJECTIVE: High-intensity magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive therapy to lesion brain tissue, used clinically in patients and pre-clinically in several animal models. Challenges with focused ablation in rodent brains can include skull and near-field heating and accurately targeting small and deep brain structures. We overcame these challenges by creating a novel method consisting of a craniectomy skull preparation, a high-frequency transducer (3 MHz) with a small ultrasound focal spot, a transducer positioning system with an added manual adjustment of ∼0...
March 22, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38521027/breathing-control-training-for-functional-seizures-a-multi-site-open-label-pilot-study
#13
JOURNAL ARTICLE
Roderick Duncan, David J Berlowitz, Saul Mullen, Janet Bondarenko, Toby T Winton-Brown, Terence J O'Brien, Sophie Zaloumis, Sabine Braat, Georgina Oliver, Richard A Kanaan
There are no well-validated treatments for functional seizures. While specialist psychotherapy is usually recommended, the evidence for its benefit is qualified, and it can be difficult to obtain. Given the association between hyperventilation and functional seizures we explored an alternative modality, breathing control training, in a multi-site open label pilot trial. Participants with functional seizures over the age of 16 received an hour of breathing training from a respiratory physiotherapist, with a half-hour booster session a month later...
March 22, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38520962/long-term-prognosis-of-patients-with-photosensitive-idiopathic-generalized-epilepsy
#14
JOURNAL ARTICLE
Tülay Yılmaz Erol, Tuba Cerrahoğlu Şirin, Nermin Görkem Şirin, Nerses Bebek, Betül Baykan
OBJECTIVE: The long-term prognosis of photosensitive idiopathic generalized epilepsy (p-IGE) is generally considered favorable; however, its specific characteristics remain unclear. Our objective was to investigate the extended prognosis of p-IGE. METHODS: We analyzed the demographics, clinical, and electroencephalographic (EEG) data of consecutive patients who were diagnosed as having p-IGE, who were under follow-up for a minimum of 10 years and exhibited a photoparoxysmal response (PPR) in their EEGs...
February 23, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38519006/complex-biophysical-changes-and-reduced-neuronal-firing-in-an-scn8a-variant-associated-with-developmental-delay-and-epilepsy
#15
JOURNAL ARTICLE
Shir Quinn, Nan Zhang, Timothy A Fenton, Marina Brusel, Preethi Muruganandam, Yoav Peleg, Moshe Giladi, Yoni Haitin, Holger Lerche, Haim Bassan, Yuanyuan Liu, Roy Ben-Shalom, Moran Rubinstein
Mutations in the SCN8A gene, encoding the voltage-gated sodium channel NaV 1.6, are associated with a range of neurodevelopmental syndromes. The p.(Gly1625Arg) (G1625R) mutation was identified in a patient diagnosed with Developmental epileptic encephalopathy (DEE). While most of the characterized DEE-associated SCN8A mutations were shown to cause a gain-of-channel function, we show that the G1625R variant, positioned within the S4 segment of domain IV, results in complex effects. Voltage-clamp analyses of NaV 1...
March 20, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38517477/edge-wise-analysis-reveals-white-matter-connectivity-associated-with-focal-to-bilateral-tonic-clonic-seizures
#16
JOURNAL ARTICLE
Sam S Javidi, Xiaosong He, Ankeeta Ankeeta, Qirui Zhang, Salvatore Citro, Michael R Sperling, Joseph I Tracy
OBJECTIVE: Focal to bilateral tonic-clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms of both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic to the distribution of white matter (WM) pathways associated with a node. We implemented a more selective, edge-wise approach that allowed for identification of the individual connections unique to FBTCS. METHODS: T1-weighted and diffusion-weighted images were obtained from 22 patients with solely focal seizures (FS), 43 FBTCS patients, and 65 age/sex-matched healthy participants (HPs), yielding streamline (STR) connectome matrices...
March 22, 2024: Epilepsia
https://read.qxmd.com/read/38517356/circadian-changes-in-aperiodic-activity-are-correlated-with-seizure-reduction-in-patients-with-mesial-temporal-lobe-epilepsy-treated-with-responsive-neurostimulation
#17
JOURNAL ARTICLE
Chantel M Charlebois, Daria Nesterovich Anderson, Elliot H Smith, Tyler S Davis, Blake J Newman, Angela Y Peters, Amir M Arain, Alan D Dorval, John D Rolston, Christopher R Butson
OBJECTIVES: Responsive neurostimulation (RNS) is an established therapy for drug-resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite an overall reduction in seizure frequency, clinical outcomes are variable, and few patients become seizure-free. The aim of this retrospective study was to evaluate aperiodic electrophysiological activity, associated with excitation/inhibition balance, as a novel electrographic biomarker of seizure reduction to aid early prognostication of the clinical response to RNS...
March 22, 2024: Epilepsia
https://read.qxmd.com/read/38515450/fear-of-disease-in-patients-with-epilepsy-a-network-analysis
#18
JOURNAL ARTICLE
Xiaoxiao Yin, Shan Niu, Qun Yu, Yejing Xuan, Xiuqin Feng
BACKGROUND: Disease-related fear among patients with epilepsy has significantly impacted their quality of life. The Disease-Related Fear Scale (D-RFS), comprising three dimensions, serves as a relatively well-established tool for assessing fear in these patients. However, certain problems potentially exist within the D-RFS's attribution of items, and its internal structure is still unclear. To establish an appropriate dimensional structure and gain deeper comprehension of its internal structure-particularly its core variables-is vital for developing more effective interventions aimed at alleviating disease-related fear among patients with epilepsy...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38514172/clinical-features-and-outcome-of-10-dogs-with-suspected-idiopathic-vestibular-epilepsy
#19
JOURNAL ARTICLE
Tania Al Kafaji, Fabio Tocco, Samuel Okonji, Antonella Gallucci
BACKGROUND: In humans, vestibular epilepsy (VE) is described as focal seizures with transient signs of vestibular disease. In dogs, 2 cases of vestibular episodes, called vestibular paroxysmia, are reported. HYPOTHESIS/OBJECTIVES: The objective of this study was to define the clinical features, phenotypical manifestation, and outcome of suspected VE in dogs. ANIMALS: Ten dogs with recurrent vestibular episodes. METHODS: Retrospective study...
March 21, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38513572/mediating-effects-of-sleep-quality-between-clinical-characteristics-and-quality-of-life-in-children-with-epilepsy-a-cross-sectional-study-from-southwest-china
#20
JOURNAL ARTICLE
Lisi Yan, Jin Chen, Lingling Xie, Tianyi Li, Yue Hu, Siqi Hong, Li Jiang
BACKGROUND: Although sleep quality (SQ) reportedly affects the health-related quality of life (QOL) of patients with epilepsy, little is known about the potential association between SQ and QOL, particularly in children with epilepsy (CWE). Our study aimed to investigate the mediating effect of SQ on the QOL of CWE to obtain more information for the prevention and treatment of epilepsy in children. METHODS: We collected general demographic and clinical data of 212 CWE and 79 controls (children who visited the Health Examination Department), and their guardians were instructed to answer the Children's Sleep Habits Questionnaire (CSHQ) and the optimized Quality of Life in Childhood Epilepsy Questionnaire-16 (QOLCE-16)...
March 20, 2024: Epilepsy & Behavior: E&B
keyword
keyword
160485
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.