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https://read.qxmd.com/read/30878843/epilepsy-as-a-derailment-of-sleep-plastic-functions-may-cause-chronic-cognitive-impairment-a-theoretical-review
#1
REVIEW
Péter Halász, Péter Przemyslaw Ujma, Dániel Fabó, Róbert Bódizs, Anna Szűcs
We report on a peculiar way of chronic cognitive impairment associated with interictal epileptic activity during NREM sleep. We review three major groups of epilepsy: mesiotemporal epilepsy (MTLE) involving the epileptic derailment of the hippocampal declarative memory system; childhood developmental epileptic encephalopathies; and the spectrum disorders of the perisylvian communication network with the centrotemporal spike phenomenon, overarching child- and adulthood epilepsies, totaling up the majority of epilepsies in childhood...
February 10, 2019: Sleep Medicine Reviews
https://read.qxmd.com/read/30877521/inhibition-of-microrna-34a-suppresses-epileptiform-discharges-through-regulating-notch-signaling-and-apoptosis-in-cultured-hippocampal-neurons
#2
Jinli Wang, Yuan Zheng, Xu Cheng, Fenfen Xu, Piaopiao Zhang, Xiao Zhou, Hongyang Zhao
Epilepsy is characterized by recurrent unprovoked seizures and some seizures can cause neuronal apoptosis, which is possible to make contributions to the epilepsy phenotype, impairments in cognitive function or even epileptogenesis. Moreover, many studies have indicated that microRNA-34a (miRNA-34a) is involved in apoptosis through regulating Notch signaling. However, whether miRNA-34a participates in neuronal apoptosis after seizures remain unclear. Therefore, we aimed to explore the expression of miRNA-34a and its effects on the epileptiform discharge in spontaneous recurrent epileptiform discharges (SREDs) rat hippocampal neuronal pattern...
March 15, 2019: Neurochemical Research
https://read.qxmd.com/read/30875668/impact-of-withdrawal-of-antiepileptic-medication-on-the-duration-of-focal-onset-seizures
#3
E Hartl, M Seethaler, M Lauseker, J Rémi, C Vollmar, S Noachtar
PURPOSE: To systematically evaluate the duration of focal onset seizures under medication withdrawal as a function of drug half-life. METHODS: Adults with drug resistant focal epilepsy and invasive electroencephalographic (iEEG) recording between 01/2006 and 06/2016 (n = 128) were identified. Patients with multifocal or unknown epileptic foci were excluded, as well as subclinical seizures, isolated auras, or status epileptic. Antiepileptic drugs (AEDs) were withdrawn upon admission...
March 8, 2019: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/30875437/hippocampal-atrophy-disrupts-the-language-network-but-not-hemispheric-language-lateralization
#4
Tátila Martins Lopes, Brunno Machado de Campos, Tamires Araújo Zanão, Marcio L F Balthazar, Clarissa Lin Yasuda, Fernando Cendes
OBJECTIVE: It is still unclear how temporal lobe epilepsy (TLE) with and without hippocampal atrophy (HA) affects cortical language distribution. We aimed to investigate the role of the hippocampus on language lateralization, activation pattern, and functional connectivity (FC) in patients with TLE. METHODS: We investigated 93 patients with TLE-divided into right HA (RHA), left HA (LHA), and negative magnetic resonance imaging (MRI) (non-HA)-and 101 controls using a semantic-language functional MRI (fMRI) task and the Boston Naming Test (BNT)...
March 15, 2019: Epilepsia
https://read.qxmd.com/read/30869167/a-post-hoc-analysis-of-the-long-term-safety-and-efficacy-of-perampanel-in-asian-patients-with-epilepsy
#5
Yushi Inoue, Sunao Kaneko, Peiyuan F Hsieh, Chandrashekhar Meshram, Sang-Ahm Lee, Zariah Abdul Aziz, Charcrin Nabangchang, Amitabh Dash
This post hoc analysis assessed the long-term safety, tolerability, and efficacy of perampanel in Asian patients with refractory focal seizures; an additional analysis assessed the effect of perampanel on focal impaired awareness seizures (FIAS) with focal to bilateral tonic-clonic (FBTC) seizures. In this subanalysis, data from Asian patients ≥12 years of age who had focal seizures with FBTC seizures despite taking one to 3 concomitant antiepileptic drugs at baseline, and who had entered either the long-term extension phase of 3 phase-3 perampanel trials (study 307) or the 10-week extension phase of study 335, were analyzed for the effect of perampanel on duration of exposure, safety, and seizure outcomes...
March 2019: Epilepsia
https://read.qxmd.com/read/30869165/efficacy-safety-and-tolerability-of-perampanel-in-asian-and-non-asian-patients-with-epilepsy
#6
Jing-Jane Tsai, Akio Ikeda, Seung Bong Hong, Surachai Likasitwattanakul, Amitabh Dash
People of different ethnic or racial backgrounds may experience variations in pharmacokinetic and pharmacodynamic responses to drug therapies. Our post hoc analysis evaluated the efficacy, safety, and tolerability of perampanel in Asian and non-Asian populations with refractory focal seizures with or without focal to bilateral tonic-clonic (FBTC) seizures. This analysis pooled data from 4 randomized, placebo-controlled, phase-3 studies involving patients aged ≥12 years who have focal seizures with or without FBTC seizures...
March 2019: Epilepsia
https://read.qxmd.com/read/30868705/illusory-own-body-perceptions-mapped-in-the-cingulate-cortex-an-intracranial-stimulation-study
#7
Irina Popa, Andrei Barborica, Julia Scholly, Cristian Donos, Fabrice Bartolomei, Stanislas Lagarde, Edouard Hirsch, Maria-Paola Valenti-Hirsch, Mihai Dragos Maliia, Anca Adriana Arbune, Andrei Daneasa, Jean Ciurea, Ovidiu-Alexandru Bajenaru, Ioana Mindruta
Body awareness is the result of sensory integration in the posterior parietal cortex; however, other brain structures are part of this process. Our goal is to determine how the cingulate cortex is involved in the representation of our body. We retrospectively selected patients with drug-resistant epilepsy, explored by stereo-electroencephalography, that had the cingulate cortex sampled outside the epileptogenic zone. The clinical effects of high-frequency electrical stimulation were reviewed and only those sites that elicited changes related to body perception were included...
March 13, 2019: Human Brain Mapping
https://read.qxmd.com/read/30868130/responsive-neurostimulation-targeting-the-anterior-nucleus-of-the-thalamus-in-3-patients-with-treatment-resistant-multifocal-epilepsy
#8
Christopher Elder, Daniel Friedman, Orrin Devinsky, Werner Doyle, Patricia Dugan
Electrical stimulation in the anterior nucleus of the thalamus (ANT) has previously been found to be efficacious for reducing seizure frequency in patients with epilepsy. Bilateral deep brain stimulation (DBS) of the ANT is an open-loop system that can be used in the management of treatment-resistant epilepsy. In contrast, the responsive neurostimulation (RNS) system is a closed-loop device that delivers treatment in response to prespecified electrocorticographic triggers. The efficacy and safety of RNS targeting the ANT is unknown...
March 2019: Epilepsia Open
https://read.qxmd.com/read/30868125/randomized-trial-of-add-on-triheptanoin-vs-medium-chain-triglycerides-in-adults-with-refractory-epilepsy
#9
Karin Borges, Neha Kaul, Jack Germaine, Patrick Kwan, Terence J O'Brien
Objective: To investigate the feasibility, safety, and tolerability of add-on treatment of the triglycerides of heptanoate (triheptanoin) vs the triglycerides of octanoate and decanoate (medium chain triglycerides [MCTs]) in adults with treatment-refractory epilepsy. Methods: After an 8-week prospective baseline period, people with drug-resistant epilepsy were randomized in a double-blind fashion to receive triheptanoin or MCTs. Treatment was titrated over 3 weeks to a maximum of 100 mL/d to be distributed over 3 meals and mixed into food, followed by 12-week maintenance before tapering...
March 2019: Epilepsia Open
https://read.qxmd.com/read/30868121/an-automated-machine-learning-based-detection-algorithm-for-spike-wave-discharges-swds-in-a-mouse-model-of-absence-epilepsy
#10
Jesse A Pfammatter, Rama K Maganti, Mathew V Jones
Objective: Manual detection of spike-wave discharges (SWDs) from electroencephalography (EEG) records is time intensive, costly, and subject to inconsistencies/biases. In addition, manual scoring often omits information on SWD confidence/intensity, which may be important for the investigation of mechanistic-based research questions. Our objective is to develop an automated method for the detection of SWDs in a mouse model of absence epilepsy that is focused on the characteristics of human scoring of preselected events to establish a confidence-based, continuous-valued scoring...
March 2019: Epilepsia Open
https://read.qxmd.com/read/30867113/modified-ketogenic-diets-in-adults-with-refractory-epilepsy-efficacious-improvements-in-seizure-frequency-seizure-severity-and-quality-of-life
#11
Kelly Roehl, Jessica Falco-Walter, Bichun Ouyang, Antoaneta Balabanov
OBJECTIVE: This study evaluates the efficacy of a modified ketogenic diet (MKD) on seizure frequency, severity, and quality of life (QOL), as well as potential complications of MKD therapy among adults with drug-resistant epilepsy (DRE). METHODS: Changes in seizure frequency, severity, QOL, and side effects were retrospectively examined among adults, ≥17 years of age, with DRE (≥2 antiepileptic drugs [AEDs]), after 3 months of MKD therapy. Attention was paid to medication or vagus nerve stimulator (VNS) changes as well to evaluate potential confounders...
March 10, 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30866067/clinical-features-of-sleep-related-hypermotor-epilepsy-in-relation-to-the-seizure-onset-zone-a-review-of-135-surgically-treated-cases
#12
Steve A Gibbs, Paola Proserpio, Stefano Francione, Roberto Mai, Francesco Cardinale, Ivana Sartori, Laura Castana, Giuseppe Plazzi, Paolo Tinuper, Massimo Cossu, Giorgio Lo Russo, Laura Tassi, Lino Nobili
OBJECTIVES: Sleep-related hypermotor epilepsy (SHE), formerly nocturnal frontal lobe epilepsy, is characterized by abrupt and typically sleep-related seizures with motor patterns of variable complexity and duration. They seizures arise more frequently in the frontal lobe than in the extrafrontal regions but identifying the seizure onset-zone (SOZ) may be challenging. In this study, we aimed to describe the clinical features of both frontal and extrafrontal SHE, focusing on ictal semiologic patterns in order to increase diagnostic accuracy...
March 13, 2019: Epilepsia
https://read.qxmd.com/read/30866062/a-universal-automated-tool-for-reliable-detection-of-seizures-in-rodent-models-of-acquired-and-genetic-epilepsy
#13
Pablo M Casillas-Espinosa, Armen Sargsyan, Dmitri Melkonian, Terence J O'Brien
OBJECTIVE: Prolonged electroencephalographic (EEG) monitoring in chronic epilepsy rodent models has become an important tool in preclinical drug development of new therapies, in particular those for antiepileptogenesis, disease modification, and treating drug-resistant epilepsy. We have developed an easy-to-use, reliable, computational tool for automated detection of electrographic seizures from prolonged EEG recordings in rodent models of epilepsy. METHODS: We applied a novel method based on advanced time-frequency analysis that detects EEG episodes with excessive activity in certain frequency bands...
March 13, 2019: Epilepsia
https://read.qxmd.com/read/30866059/diagnostic-implications-of-genetic-copy-number-variation-in-epilepsy-plus
#14
Antonietta Coppola, Elena Cellini, Hannah Stamberger, Elmo Saarentaus, Valentina Cetica, Dennis Lal, Tania Djémié, Magdalena Bartnik-Glaska, Berten Ceulemans, J Helen Cross, Tine Deconinck, Salvatore De Masi, Thomas Dorn, Renzo Guerrini, Dorotha Hoffman-Zacharska, Frank Kooy, Lieven Lagae, Nicholas Lench, Johannes R Lemke, Ersilia Lucenteforte, Francesca Madia, Heather C Mefford, Deborah Morrogh, Peter Nuernberg, Aarno Palotie, An Sofie Schoonjans, Pasquale Striano, Elzbieta Szczepanik, Anna Tostevin, Joris R Vermeesch, Hilde Van Esch, Wim Van Paesschen, Jonathan J Waters, Sarah Weckhuysen, Federico Zara, Peter De Jonghe, Sanjay M Sisodiya, Carla Marini
OBJECTIVE: Copy number variations (CNVs) represent a significant genetic risk for several neurodevelopmental disorders including epilepsy. As knowledge increases, reanalysis of existing data is essential. Reliable estimates of the contribution of CNVs to epilepsies from sizeable populations are not available. METHODS: We assembled a cohort of 1255 patients with preexisting array comparative genomic hybridization or single nucleotide polymorphism array based CNV data...
March 13, 2019: Epilepsia
https://read.qxmd.com/read/30865078/depressive-symptom-severity-in-individuals-with-epilepsy-and-recent-health-complications
#15
Neha Kumar, Rigzin Lhatoo, Hongyan Liu, Kari Colon-Zimmermann, Curtis Tatsuoka, Peijun Chen, Mustafa Kahriman, Martha Sajatovic
Identifying relationships between depression severity and clinical factors may help with appropriate recognition and management of neuropsychiatric conditions in persons with epilepsy (PWE). Demographic characteristics, epilepsy variables, and medical and psychiatric comorbidities were examined from a baseline randomized controlled trial sample of 120 PWE. Among demographic characteristics, only inability to work was significantly associated with depression severity (p = 0.05). Higher 30-day seizure frequency (p < 0...
March 6, 2019: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/30864528/investigation-of-the-roles-of-new-antiepileptic-drugs-and-serum-bdnf-levels-in-efficacy-and-safety-monitoring-and-quality-of-life-a-clinical-research
#16
Meral Demir, Emel Oğuz Akarsu, Hava Özlem Dede, Nerses Bebek, Sevda Özel Yıldız, Betül Baykan, Ahmet Gökhan Akkan
OBJECTIVE: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to brain-derived neurotropic factor (BDNF) of frequently used new antiepileptic drugs (NAD) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). Moreover, we investigated their effect on the quality of life (QoL). METHODS: Eighty epileptic patients who had been using the NAD, thirteen healthy participants were included in this cross-sectional study...
March 12, 2019: Current Clinical Pharmacology
https://read.qxmd.com/read/30862697/etiology-and-outcomes-of-thrombotic-microangiopathies
#17
Guillaume Bayer, Florent von Tokarski, Benjamin Thoreau, Adeline Bauvois, Christelle Barbet, Sylvie Cloarec, Elodie Mérieau, Sébastien Lachot, Denis Garot, Louis Bernard, Emmanuel Gyan, Franck Perrotin, Claire Pouplard, François Maillot, Philippe Gatault, Bénédicte Sautenet, Emmanuel Rusch, Matthias Buchler, Cécile Vigneau, Fadi Fakhouri, Jean-Michel Halimi
BACKGROUND AND OBJECTIVES: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective study in a four-hospital institution in 564 consecutive patients with adjudicated thrombotic microangiopathies during the 2009-2016 period...
March 12, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30859143/lateralized-periodic-discharges-in-insular-status-epilepticus-a-case-report-of-a-periodic-eeg-pattern-associated-with-ictal-manifestation
#18
Fedele Dono, Mirella Russo, Claudia Carrarini, Vincenzo Di Stefano, Stefania Nanni, Camilla Ferrante, Marco Onofrj, Francesca Anzellotti
Objective: Insular lobe seizures generally represent a misconceived ictal phenomenon characterized by specific neurological signs. Aphasia can be a rare presenting sign associated with insular lobe epilepsy which could be easily mistaken for a manifestation of other acute brain diseases. Method: We describe an insular status epilepticus (SE) characterized by sudden onset of language disturbance associated with hypersalivation and paraesthesia. A concomitant EEG recording showed the presence of Lateralized Periodic Discharges plus superimposed fast activity (LPDs + F)...
2019: Clinical Neurophysiology Practice
https://read.qxmd.com/read/30858065/the-onset-mechanism-of-parkinson-s-beta-oscillations-a-theoretical-analysis
#19
Bing Hu, Xiyezi Diao, Liqing Zong, Jingsong Zhang, Liang Yu, Hao Dai, Luonan Chen
In this paper, we build a basal ganglia-cortex-thalamus model to study the oscillatory mechanisms and boundary conditions of the beta frequency band (13-30 Hz) that appears in the subthalamic nucleus. First, a theoretical oscillatory boundary formula is obtained in a simplified model by using the Laplace transform and linearization process of the system at fixed points. Second, we simulate the oscillatory boundary conditions through numerical calculations, which fit with our theoretical results very well, at least in the changing trend...
March 8, 2019: Journal of Theoretical Biology
https://read.qxmd.com/read/30857949/management-of-epilepsy-in-women
#20
REVIEW
Linda J Stephen, Cynthia Harden, Torbjörn Tomson, Martin J Brodie
Epilepsy is a common neurological condition in women worldwide. Hormonal changes occurring throughout a woman's life can influence and be influenced by seizure mechanisms and antiepileptic drugs, presenting unique management challenges. Effective contraception is particularly important for women with epilepsy of childbearing potential because of antiepileptic drug-related teratogenicity and hormonal interactions; although studies reveal many women do not receive contraceptive and preconceptual counselling. Management challenges in this population include the higher risk of pregnancy complications and peripartum psychiatric problems than in women without epilepsy...
March 8, 2019: Lancet Neurology
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