Read by QxMD icon Read

gamma epilepsy

Barbara C Jobst, Jorge Gonzalez-Martinez, Jean Isnard, Philippe Kahane, Nuria Lacuey, Samden D Lahtoo, Dang K Nguyen, Chengyuan Wu, Fred Lado
Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian spread, for example, manifest first as throat constriction, followed next by perioral and hemisensory symptoms, and then by unilateral motor symptoms. On the other hand, insular seizures may spread instead to the temporal and frontal lobes and present like seizures originating from these regions...
January 2019: Epilepsy Currents
Yao-Chung Chuang, Shang-Der Chen, Chung-Yao Hsu, Shu-Fang Chen, Nai-Ching Chen, Shuo-Bin Jou
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known to regulate mitochondrial biogenesis. Resveratrol is present in a variety of plants, including the skin of grapes, blueberries, raspberries, mulberries, and peanuts. It has been shown to offer protective effects against a number of cardiovascular and neurodegenerative diseases, stroke, and epilepsy. This study examined the neuroprotective effect of resveratrol on mitochondrial biogenesis in the hippocampus following experimental status epilepticus...
February 25, 2019: International Journal of Molecular Sciences
Daniel R Kramer, Michael F Barbaro, Morgan Lee, Terrance Peng, George Nune, Charles Y Liu, Spencer Kellis, Brian Lee
OBJECTIVE: Restoration of somatosensory deficits in humans requires a clear understanding of the neural representations of percepts. To characterize the cortical response to naturalistic somatosensation, we examined field potentials in the primary somatosensory cortex of humans. METHODS: Four patients with intractable epilepsy were implanted with subdural electrocorticography (ECoG) electrodes over the hand area of S1. Three types of stimuli were applied, soft-repetitive touch, light touch, and deep touch...
February 22, 2019: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Kiyohide Usami, Anna Korzeniewska, Riki Matsumoto, Katsuya Kobayashi, Takefumi Hitomi, Masao Matsuhashi, Takeharu Kunieda, Nobuhiro Mikuni, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, Nathan E Crone
Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing vs planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates...
February 22, 2019: Sleep
Dan Y Song, Sally M Stoyell, Erin E Ross, Lauren M Ostrowski, Emily L Thorn, Steven M Stufflebeam, Amy K Morgan, Britt C Emerton, Mark A Kramer, Catherine J Chu
INTRODUCTION: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy with the majority of those afflicted remitting during their early teenage years. Seizures arise from the lower half of the sensorimotor cortex of the brain (e.g. seizure onset zone) and the abnormal epileptiform discharges observed increase during NREM sleep. To date no clinical factors reliably predict disease course, making determination of ongoing seizure risk a significant challenge...
February 20, 2019: Brain and Behavior
Yinian Zhang, Hua-Teng Dong, Lei Duan, Liang Niu, Guo-Qiang Yuan, Jun-Qiang Dai, Bo-Ru Hou, Ya-Wen Pan
Objectives: Despite the availability of effective antiepileptic drugs, epileptic patients still suffer from intractable seizures and adverse events. Better control of both seizures and fewer side effects is needed in order to enhance the patient's quality of life. We performed the present study with an attempt to explore the effect that HDAC4 gene silencing would have on epilepsy simulated by model rats. Furthermore, the study made additional analysis on the relativity of the HDAC4 gene in regard to its relationship with the gamma-aminobutyric acid (GABA) signaling pathway...
2019: Neuropsychiatric Disease and Treatment
Vikram Jakkamsetti, Isaac Marin-Valencia, Qian Ma, Levi B Good, Tyler Terrill, Karthik Rajasekaran, Kumar Pichumani, Chalermchai Khemtong, M Ali Hooshyar, Chandrasekhar Sundarrajan, Mulchand S Patel, Robert M Bachoo, Craig R Malloy, Juan M Pascual
Glucose is the ultimate substrate for most brain activities that use carbon, including synthesis of the neurotransmitters glutamate and γ-aminobutyric acid via mitochondrial tricarboxylic acid (TCA) cycle. Brain metabolism and neuronal excitability are thus interdependent. However, the principles that govern their relationship are not always intuitive because heritable defects of brain glucose metabolism are associated with the paradoxical coexistence, in the same individual, of episodic neuronal hyperexcitation (seizures) with reduced basal cerebral electrical activity...
February 20, 2019: Science Translational Medicine
Ravindra Arya, Brian Ervin, J Adam Wilson, Anna W Byars, Leonid Rozhkov, Jason Buroker, Paul S Horn, Craig Scholle, Hisako Fujiwara, Hansel M Greiner, James L Leach, Douglas F Rose, Francesco T Mangano, Tracy A Glauser, Katherine D Holland
OBJECTIVE: We studied age-related dynamics of information sharing among cortical language regions with electrocorticographic high-gamma modulation during picture-naming and story-listening tasks. METHODS: Seventeen epilepsy patients aged 4-19 years, undergoing extraoperative monitoring with left-hemispheric subdural electrodes, were included. Mutual information (MI), a nondirectional measure of shared information, between 16 pairs of cortical regions of interest, was computed from trial-averaged 70-150 Hz power modulations during language tasks...
March 2019: Epilepsia
Jana Tchekalarov, Dimitrinka Atanasova, Lidia Kortenska, Nikolai Lazarov, Mihaela Shishmanova-Doseva, Tzeno Galchev, Pencho Marinov
Recently, we have reported that while agomelatine (Ago) is unable to prevent development of epilepsy it exerts a strong neuroprotective and anti-inflammatory response in the KA post-status epilepticus (SE) rat model. In the present study, we aimed to explore whether the brain-derived neurotrophic factor (BDNF) in the hippocampus is involved in the neuroprotective effect of Ago against the KA-induced SE and epileptiform activity four months later in rats. Lacosamide (LCM) was used as a positive control. The EEG-recorded seizure activity was also evaluated in two treatment protocols...
February 6, 2019: Brain Research Bulletin
Michael Chang, Suzie Dufour, Peter L Carlen, Taufik A Valiante
Controlling seizures remains a challenging issue for the medical community. To make progress, researchers need a way to extensively study seizure dynamics and investigate its underlying mechanisms. Acute seizure models are convenient, offer the ability to perform electrophysiological recordings, and can generate a large volume of electrographic seizure-like (ictal) events. The promising findings from acute seizure models can then be advanced to chronic epilepsy models and clinical trials. Thus, studying seizures in acute models that faithfully replicate the electrographic and dynamical signatures of a clinical seizure will be essential for making clinically relevant findings...
January 19, 2019: Journal of Visualized Experiments: JoVE
Ravindra Arya, Celie Roth, James L Leach, Denise Middeler, J Adam Wilson, Jennifer Vannest, Leonid Rozhkov, Hansel M Greiner, Jason Buroker, Craig Scholle, Hisako Fujiwara, Paul S Horn, Douglas F Rose, Nathan E Crone, Francesco T Mangano, Anna W Byars, Katherine D Holland
BACKGROUND: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. METHODS: Pediatric drug-resistant epilepsy (DRE) patients underwent pre-surgical language localization with ESM and HGM using a visual naming task...
January 29, 2019: Epilepsy Research
Reza Rahmanzadeh, Soraya Mehrabi, Mahmood Barati, Milad Ahmadi, Fereshteh Golab, Sareh Kazmi, Mohammad Taghi Joghataei, Morteza Seifi, Mazaher Gholipourmalekabadi
Introduction: The resistance of temporal lobe epilepsy to classic drugs is thought to be due to disruption in the excitation/inhibition of this pathway. Two chloride transporters, NKCC1 and KCC2, are expressed differently for the excitatory state of Gamma-Amino Butyric Acid (GABA). The present study explored the effect of bumetanide as a selective NKCC1 inhibitor either alone or in combination with the phenobarbital in the pilocarpine model of epilepsy. Methods: An animal model of Status Epilepticus (SE) was induced with pilocarpine in Wistar male rats followed by phenobarbital and or bumetanide or saline administration for 45 days after the induction of SE by Intraperitoneal (IP) injection...
November 2018: Basic and Clinical Neuroscience
Yasuo Nakai, Ayaka Sugiura, Erik C Brown, Masaki Sonoda, Jeong-Won Jeong, Robert Rothermel, Aimee F Luat, Sandeep Sood, Eishi Asano
OBJECTIVE: The strength of presurgical language mapping using electrocorticography (ECoG) is its outstanding signal fidelity and temporal resolution, but the weakness includes limited spatial sampling at an individual patient level. By averaging naming-related high-gamma activity at nonepileptic regions across a large number of patients, we provided the functional cortical atlases animating the neural dynamics supporting visual-object and auditory-description naming at the whole brain level...
February 1, 2019: Epilepsia
Svetlana Gataullina, Thierry Bienvenu, Rima Nabbout, Gilles Huberfeld, Olivier Dulac
The aim of this study was to disentangle mechanisms of epileptogenesis in monogenic epilepsies in children. We reviewed paediatric monogenic epilepsies excluding brain malformation or an inborn error of metabolism, but including the gene function whether there is loss-of-function or gain-of-function, age at gene expression when available, and associated epilepsy syndrome. Genes for which at least five patients with similar epilepsy phenotype had been reported were selected. Three mechanisms are shared by most monogenic epilepsies: (1) excess of N-methyl-d-aspartate (NMDA) transmission activation (NMDA-pathies); (2) abnormal gamma-aminobutyric acid (GABA) transmission with reduced inhibition (phasic GABA-pathies); and (3) tonic activation of extrasynaptic GABAA receptors by extracellular GABA (tonic GABA-pathies)...
January 25, 2019: Developmental Medicine and Child Neurology
Simon Henin, Anita Shankar, Nicholas Hasulak, Daniel Friedman, Patricia Dugan, Lucia Melloni, Adeen Flinker, Cansu Sarac, May Fang, Werner Doyle, Thomas Tcheng, Orrin Devinsky, Lila Davachi, Anli Liu
Direct recordings from the human brain have historically involved epilepsy patients undergoing invasive electroencephalography (iEEG) for surgery. However, these measurements are temporally limited and affected by clinical variables. The RNS System (NeuroPace, Inc.) is a chronic, closed-loop electrographic seizure detection and stimulation system. When adapted by investigators for research, it facilitates cognitive testing in a controlled ambulatory setting, with measurements collected over months to years...
January 24, 2019: Scientific Reports
Ozlem Ergul Erkec, Okan Arihan, Mehmet Kara, Ersin Karatas, Remzi Erten, Halit Demir, Ismail Meral, Muzaffer Mukemre, Fevzi Ozgokce
We investigated the effects of Leontice leontopetalum and Bongardia chrysogonum on apoptosis, gamma-aminobutyric acid (GABAA) receptor positive cell number, cyclin-B1 and bcl-2 levels and oxidative stress in pentylenetetrazol (PTZ) kindling in rats. Kindling was produced by subconvulsant doses of PTZ treatments in rats. Wistar albino rats were divided into 4 groups; Control, PTZ treated (PTZ), PTZ+L. leontopetalum extract treated (PTZ+LLE) and PTZ+B. chrysogonum extract treated (PTZ+BCE) groups. Extracts were given a dose (200 mg/kg) 2h before each PTZ injection...
December 31, 2018: Cellular and Molecular Biology
Melissa L DiBacco, Jean-Baptiste Roullet, Kush Kapur, Madalyn N Brown, Dana C Walters, K Michael Gibson, Phillip L Pearl
Objective: Succinic Semialdehyde Dehydrogenase (SSADH) deficiency is a disorder of elevated gamma-amino butyric acid (GABA) and gamma hydroxybutyric acid (GHB) and a complex neuropsychiatric profile. Adult reports suggest worsening epilepsy and high SUDEP risk. Methods: Subjects with confirmed SSADH deficiency were recruited into a longitudinal study. Plasma thyroid hormone and total GABA/GHB were quantified by standard clinical chemistry methodologies and mass spectrometry, respectively...
January 2019: Annals of Clinical and Translational Neurology
Xiashuang Wang, Guanghong Gong, Ni Li
Automatic recognition methods for non-stationary electroencephalogram (EEG) data collected from EEG sensors play an essential role in neurological detection. The integrated approaches proposed in this study consist of Symlet wavelet processing, a gradient boosting machine, and a grid search optimizer for a three-class classification scheme for normal subjects, intermittent epilepsy, and continuous epilepsy. Fourth-order Symlet wavelets are adopted to decompose the EEG data into five frequencies sub-bands, such as gamma, beta, alpha, theta, and delta, whose statistical features were computed and used as classification features...
January 9, 2019: Sensors
Jake H McKay, Elliot L Dimberg, Alfonso S Lopez Chiriboga
OBJECTIVE: To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies. METHODS: Literature was reviewed on PubMed, Mendeley literature search, and the American Academy of Neurology database for articles published from June 2008 to October of 2018 using a variety of key words. These key words include: "gamma-aminobutyric acid seizures," "gamma-aminobutyric acid limbic encephalitis", "GABA(B) receptor antibodies," "autoimmune encephalitis," "autoimmune epilepsy," "GABA(B) encephalitis, " and "GABA paraneoplastic...
January 8, 2019: Neurologia i Neurochirurgia Polska
Chang Kyu Park, Su Jeong Hwang, Na Young Jung, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
OBJECTIVE: Most surgical treatments for medically intractable temporal lobe epilepsy are favorable. However, when a patient has persistent symptoms after surgery, there are no tests that can accurately predict whether a patient will have remnant epileptic foci. The purpose of this study was to evaluate the usefulness of magnetoencephalography (MEG) as a prognostic method in patients with temporal lobe epilepsy METHODS: From July 2012 to July 2016, a total of 21 patients underwent pre- and postoperative MEG at our center...
December 19, 2018: World Neurosurgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"