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EEG epilepsy

M B Korsakova, A B Kozlova, N A Arkhipova, L V Shishkina, P A Vlasov, E M Troshina
Currently, there is no single standard defining what rhythmic activity should be considered as the area of ictal pattern onset. Differences in electroencephalographic patterns associated with different types of focal cortical dysplasias (FCDs) have not been defined. Aim - we aimed to identify features of the ictal onset pattern on a scalp EEG, depending on the histology, location, and extension of epileptogenic zone, as well as to elucidate the relationship between concordance of the interictal and ictal activity localization and ictal onset pattern types...
2019: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Catherine A Schevon, Steven Tobochnik, Tahra Eissa, Edward Merricks, Brian Gill, R Ryley Parrish, Lisa M Bateman, Guy McKhann, Ronald G Emerson, Andrew J Trevelyan
The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical settings. The increasing use of microelectrodes in epilepsy surgery patients has made it possible to apply principles derived from laboratory research to the problem of mapping the spatiotemporal structure of human focal seizures, and characterizing the corresponding EEG signatures...
March 18, 2019: Neurobiology of Disease
Gia Melikishvili, Nino Epitashvili, Nazi Tabatadze, Gocha Chikvinidze, Olivier Dulac, Thierry Bienvenu, Svetlana Gataullina
Eight patients, seven girls and one boy, had CDKL5 gene mutation, duplication, or deletion. Epileptic spasms started at a mean age of 3.5 months (range = 4 weeks-8 months). In five cases, tonic seizures preceded spasms at a median age of 6 weeks. In one patient who started at 8 months, spasms had a component of terror on awakening, reminding sleep terror. In two patients, electroencephalogram polygraphy of a so-called tonic seizure revealed that the tonic phase was followed by an overlooked clonic phase and then by a cluster of spasms during which each spasm was preceded by a brief clonic jerk revealed by electromyography...
March 18, 2019: Epilepsy & Behavior: E&B
Ann Hempel, Michael Frost, Nitin Agarwal
Few studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. For all patients, focal, multifocal, or generalized spike and wave activity occupied greater than 50% of the nonrapid eye movement (REM) sleep record...
March 18, 2019: Epilepsy & Behavior: E&B
Yun Qin, Sisi Jiang, Qiqi Zhang, Li Dong, Xiaoyan Jia, Hui He, Yutong Yao, Huanghao Yang, Tao Zhang, Cheng Luo, Dezhong Yao
Epilepsy is marked by hypersynchronous bursts of neuronal activity, and seizures can propagate variably to any and all areas, leading to brain network dynamic organization. However, the relationship between the network characteristics of scalp EEG and blood oxygenation level-dependent (BOLD) responses in epilepsy patients is still not well known. In this study, simultaneous EEG and fMRI data were acquired in 18 juvenile myoclonic epilepsy (JME) patients. Then, the adapted directed transfer function (ADTF) values between EEG electrodes were calculated to define the time-varying network...
March 12, 2019: NeuroImage: Clinical
Jordan S Farrell, Quynh-Anh Nguyen, Ivan Soltesz
Current drug treatments for epilepsy attempt to broadly restrict excitability to mask a symptom, seizures, with little regard for the heterogeneous mechanisms that underlie disease manifestation across individuals. Here, we discuss the need for a more complete view of epilepsy, outlining how key features at the cellular and microcircuit level can significantly impact disease mechanisms that are not captured by the most common methodology to study epilepsy, electroencephalography (EEG). We highlight how major advances in neuroscience tool development now enable multi-scale investigation of fundamental questions to resolve the currently controversial understanding of seizure networks...
March 20, 2019: Neuron
Martin Salinsky, Paul Rutecki, Karen Parko, Elizabeth Goy, Daniel Storzbach, Sheila Markwardt, Laurence Binder, Sandra Joos
RATIONALE: Health-related quality of life (HRQoL) is compromised in civilians with epileptic seizures (ES) or psychogenic nonepileptic seizures (PNES). U.S. Veterans are a distinct patient group with regard to gender, age, and background. We studied HRQoL in Veterans and asked the following: (1) Is there a difference in HRQoL in Veterans with ES vs. PNES?; (2) What factors influence HRQoL in each group?; (3) What factors influenced the difference between seizure groups? METHODS: We studied consecutive Veterans entering the epilepsy monitoring units (EMUs) of three VA Epilepsy Centers of Excellence...
March 17, 2019: Epilepsy & Behavior: E&B
Laura Vilella, Nuria Lacuey, Johnson P Hampson, M R Sandhya Rani, Kenneth Loparo, Rup K Sainju, Daniel Friedman, Maromi Nei, Kingman Strohl, Luke Allen, Catherine Scott, Brian K Gehlbach, Bilal Zonjy, Norma J Hupp, Anita Zaremba, Nassim Shafiabadi, Xiuhe Zhao, Victoria Reick-Mitrisin, Stephan Schuele, Jennifer Ogren, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Adriana Tanner, Curtis Tatsuoka, Samden D Lhatoo
Introduction: Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e., post-ictal generalized EEG suppression (PGES) and recurrence. Methods: Prospective, multi-center seizure monitoring study of autonomic, and breathing biomarkers of SUDEP in adults with intractable epilepsy and monitored seizures. Video EEG, thoraco-abdominal excursions, capillary oxygen saturation, and electrocardiography were analyzed...
2019: Frontiers in Neurology
Kemal Tutkavul, Yılmaz Çetinkaya
Background/aim: This study aimed to reveal the optimum recording time of routine electroencephalogram (EEG) for adults with epilepsy. Materials and methods: In this clinical observational study we investigated features of paroxysms that emerged in EEGs recorded for 45 min in adults with epilepsy. Results: Paroxysms were detected in 38.14% of 97 patients. The probability of occurrence of paroxysm during the first 10 min was found to be statistically significantly low in comparison to the first 30 and 45 min (respectively P = 0...
March 20, 2019: Turkish Journal of Medical Sciences
Rebecca Emily Feldman, Bradley Neil Delman, Puneet Singh Pawha, Hadrien Dyvorne, John Watson Rutland, Jiyeoun Yoo, Madeline Cara Fields, Lara Vanessa Marcuse, Priti Balchandani
OBJECTIVE: To compare by 7 Tesla (7T) magnetic resonance imaging (MRI) in patients with focal epilepsy who have non-lesional clinical MRI scans with healthy controls. METHODS: 37 patients with focal epilepsy, based on clinical and electroencephalogram (EEG) data, with non-lesional MRIs at clinical field strengths and 21 healthy controls were recruited for the 7T imaging study. The MRI protocol consisted of high resolution T1-weighted, T2-weighted and susceptibility weighted imaging sequences of the entire cortex...
2019: PloS One
Guangda Liu, Xing Wei, Shang Zhang, Jing Cai, Songyang Liu
In order to improve the accuracy and efficiency of automatic seizure detection, the paper proposes a method based on improved genetic algorithm optimization back propagation (IGA-BP) neural network for epilepsy diagnosis, and uses the method to achieve detection of clinical epilepsy rapidly and effectively. Firstly, the method extracted the linear and nonlinear features of the epileptic electroencephalogram (EEG) signals and used a Gaussian mixture model (GMM) to perform cluster analysis on EEG features. Next, expectation maximization (EM) algorithm was used to estimate GMM parameters to calculate the optimal parameters for the selection operator of genetic algorithm (GA)...
February 25, 2019: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Yvonne A C Bekker, Danielle A Lambrechts, Judith S Verhoeven, Jessy van Boxtel, Caroline Troost, Erik-Jan Kamsteeg, Michèl A Willemsen, Hilde M H Braakman
PURPOSE: Epilepsy in GLUT1 deficiency syndrome is generally drug-resistant; ketogenic diet (KD) therapy is the mainstay of therapy, as production of ketones provides the brain with an alternative energy source, bypassing the defect in GLUT1. Failure of KD therapy and risk factors for failure have been sparsely published. METHODS: We performed a retrospective study of GLUT1DS patients with refractory epilepsy failing on KD therapy, to identify their clinical characteristics...
February 27, 2019: European Journal of Paediatric Neurology: EJPN
Si Chen, Yingying Hu, Yumei Huang, Yan Nan, Xiaojian Zhou, Shangqin Chen, Jin Lin, Zhenlang Lin
BACKGROUND: Maternofetal carnitine transport through the placenta is the main route of fetal carnitine uptake. Decreased free carnitine levels discovered by newborn screening has identified many asymptomatic adult women with systemic primary carnitine deficiency (PCD). Here, we presented amplitude integrated electroencephalogram (aEEG) and magnetic resonance imaging (MRI) findings from a neonate with epilepsy whose mother was carnitine deficient. CASE PRESENTATION: A one-day-old female newborn was admitted after experiencing seizures for half a day; status epilepticus was found on the continuous normal voltage background pattern with immature sleep-wake cycling during aEEG monitoring...
March 18, 2019: BMC Pediatrics
Arun Raj Antony, Sergiu Abramovici, Robert Todd Krafty, Jullie Pan, Robert Mark Richardson, Anto Bagic, Zulfi Haneef
No abstract text is available yet for this article.
March 14, 2019: Seizure: the Journal of the British Epilepsy Association
E Hartl, M Seethaler, M Lauseker, J Rémi, C Vollmar, S Noachtar
PURPOSE: To systematically evaluate the duration of focal onset seizures under medication withdrawal as a function of drug half-life. METHODS: Adults with drug resistant focal epilepsy and invasive electroencephalographic (iEEG) recording between 01/2006 and 06/2016 (n = 128) were identified. Patients with multifocal or unknown epileptic foci were excluded, as well as subclinical seizures, isolated auras, or status epileptic. Antiepileptic drugs (AEDs) were withdrawn upon admission...
March 8, 2019: Seizure: the Journal of the British Epilepsy Association
Prisca R Bauer, Robert M Helling, Matthijs J L Perenboom, Fernando H Lopes da Silva, Else A Tolner, Michel D Ferrari, Josemir W Sander, Gerhard H Visser, Stiliyan N Kalitzin
BACKGROUND: Epilepsy and migraine are paroxysmal neurological conditions associated with disturbances of cortical excitability. No useful biomarkers to monitor disease activity in these conditions are available. Phase clustering was previously described in electroencephalographic (EEG) responses to photic stimulation and may be a potential epilepsy biomarker. OBJECTIVE: The objective of this study was to investigate EEG phase clustering in response to transcranial magnetic stimulation (TMS), compare it with photic stimulation in controls, and explore its potential as a biomarker of genetic generalized epilepsy or migraine with aura...
March 12, 2019: Epilepsy & Behavior: E&B
Udaya Seneviratne, Philippa Karoly, Dean R Freestone, Mark J Cook, Ray C Boston
Background: Seizure clusters and "bursts" are of clinical importance. Clusters are reported to be a marker of antiepileptic drug resistance. Additionally, seizure clustering has been found to be associated with increased morbidity and mortality. However, there are no statistical methods described in the literature to delineate bursting phenomenon in epileptic seizures. Methods: We present three automatic burst detection methods referred to as precision constrained grouping (PCG), burst duration constrained grouping (BCG), and interseizure interval constrained grouping (ICG)...
2019: Frontiers in Neurology
Zhibin Jiang, Fu-Lai Chung, Shitong Wang
Electroencephalogram (EEG) signal recognition based on machine learning models is becoming more and more attractive in epilepsy detection. For multiclass epileptic EEG signal recognition tasks including the detection of epileptic EEG signals from different blends of different background data and epilepsy EEG data and the classification of different types of seizures, we may perhaps encounter two serious challenges: (1) a large amount of EEG signal data for training are not available; (2) the models for epileptic EEG signal recognition are often so complicated that they are not as easy to explain as a linear model...
March 13, 2019: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Damon Hyde, Jurriaan M Peters, Simon Warfield
OBJECTIVE: Modern clinical MRI collects millimeter scale anatomic information, but scalp electroencephalography (EEG) source localization (ESL) is ill-posed, and cannot resolve individual sources at that resolution. Dimensionality reduction in the space of cortical sources is needed to improve computational and storage complexity. Surface based cortical source models allow scalable complexity, but volumetric methods still employ simplistic grid coarsening that eliminates fine scale anatomic structure...
March 13, 2019: IEEE Transactions on Bio-medical Engineering
Nicole van Klink, Anne Mooij, Geertjan Huiskamp, Cyrille Ferrier, Kees Braun, Arjan Hillebrand, Maeike Zijlmans
OBJECTIVE: We studied ripples (80-250 Hz) simultaneously recorded in electroencephalography (EEG) and magnetoencephalography (MEG) to evaluate the differences. METHODS: Simultaneous EEG and MEG were recorded in 30 patients with drug resistant focal epilepsy. Ripples were automatically detected and visually checked in virtual channels throughout the cortex. The number and location of ripples in EEG and MEG were compared to each other and to a region of interest (ROI) defined by clinically available information...
February 23, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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