Evelyn Ochoa, Lucia Morelli, Lucia Salvioni, Marco Giustra, Beatrice De Santes, Francesca Spena, Linda Barbieri, Stefania Garbujo, Matteo Viganò, Brian Novati, Giulia Tomaino, Saliha Moutaharrik, Davide Prosperi, Luca Palugan, Miriam Colombo
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of commercially available co-processed excipients, conventionally applied in compression protocols, for the preparation of ODTs with binder jetting-3D printing technology. The latter was selected among the 3D printing techniques because the deposition of multiple powder layers allows for obtaining highly porous and easily disintegrating dosage forms...
December 2, 2023: European Journal of Pharmaceutics and Biopharmaceutics