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Keywords tissue extract extracellular v...

tissue extract extracellular vesicles

https://read.qxmd.com/read/38071409/spinal-cord-injury-affects-gene-expression-of-transmembrane-proteins-in-tissue-and-release-of-extracellular-vesicle-in-blood-in-silico-and-in-vivo-analysis
#21
JOURNAL ARTICLE
Yasmin Mirzaalikhan, Nasim Eslami, Amin Izadi, Faezeh Shekari, Sahar Kiani
OBJECTIVE: Spinal cord injury (SCI) can disrupt membrane transmission by affecting transmembrane channels or neurotransmitter release. This study aimed to explore gene expression changes of transmembrane proteins underlying SCI through bioinformatics approaches and confirming in SCI model in rats. MATERIALS AND METHODS: In this experimental study, the differentially expressed genes (DEGs) in acute and subacute SCI were obtained based on microarray data downloaded from the gene expression omnibus (GEO)...
November 28, 2023: Cell Journal
https://read.qxmd.com/read/38065677/the-value-of-platelet-rich-plasma-derived-extracellular-vesicles-in-modern-medicine
#22
REVIEW
Ya Hou, Xiaoyun Wen, Liang Zhou, Xiansong Fang
Platelet-rich plasma (PRP) has been widely used in clinical practice. The mechanism by which PRP promotes tissue repair lies in the release of multiple growth factors upon platelet activation, which accelerates the proliferation and differentiation of repair cells and the synthesis of extracellular matrix. In recent years, as extracellular vesicles (EVs) research has increased and intensified, it has been found that EVs also play an important role in tissue repair. This article provides a comprehensive review of the role of PRP and PRP-derived extracellular vesicles (PRP-EVs) in tissue repair...
December 2023: Annals of Medicine
https://read.qxmd.com/read/38004116/effect-of-extracelluar-vesicles-derived-from-akkermansia-muciniphila-on-intestinal-barrier-in-colitis-mice
#23
JOURNAL ARTICLE
Ting Zheng, Haining Hao, Qiqi Liu, Jiankun Li, Yukun Yao, Yisuo Liu, Tai Zhang, Zhe Zhang, Huaxi Yi
Inflammatory bowel disease (IBD) is a chronic and recurrent disease. It has been observed that the incidence and prevalence of IBD are increasing, which consequently raises the risk of developing colon cancer. Recently, the regulation of the intestinal barrier by probiotics has become an effective treatment for colitis. Akkermansia muciniphila -derived extracellular vesicles (Akk EVs) are nano-vesicles that contain multiple bioactive macromolecules with the potential to modulate the intestinal barrier. In this study, we used ultrafiltration in conjunction with high-speed centrifugation to extract Akk EVs...
November 8, 2023: Nutrients
https://read.qxmd.com/read/37998109/establishing-the-callus-based-isolation-of-extracellular-vesicles-from-cissus-quadrangularis-and-elucidating-their-role-in-osteogenic-differentiation
#24
JOURNAL ARTICLE
Ritu Gupta, Sneha Gupta, Purva Gupta, Andreas K Nüssler, Ashok Kumar
Extracellular vesicles (EVs) are nano-sized vehicles secreted by all live cells to establish communication with adjacent cells. In recent years, mammalian EVs (MEVs) have been widely investigated for their therapeutic implications in human disease conditions. As the understanding of MEV composition and nature is advancing, scientists are constantly exploring alternatives for EV production with similar therapeutic potential. Plant-derived exosome-like nanovesicles (PDEVs) may be a better substitute for MEVs because of their widespread sources, cost-effectiveness, and ease of access...
November 2, 2023: Journal of Functional Biomaterials
https://read.qxmd.com/read/37983660/white-adipose-tissue-derived-small-extracellular-vesicles-a%C3%A2-new-potential-therapeutic-reagent-for-accelerating-diabetic-wound-healing
#25
JOURNAL ARTICLE
Chi Zhang, Tao Jiang, Guoyong Jiang, Xiang Xu, Chengqi Yan, Yu Kang, Xuejiao Xiang, Shuoyuan Liu, Pengjuan Nie, Maojie Zhang, Jing Chen, Meng Yuan, Yingpeng Xu, Xiaofan Yang, Zhenbing Chen
Small extracellular vesicles (sEVs) from adipose-derived stem cells (ADSCs) have gained great attention and have been widely used in cell-free therapies for treating diabetic non-healing wounds in recent years. However, further clinical application of ADSC-sEVs have been limited due to their unsolvable defects, including cumbersome extraction procedure, high cost, low yield, etc. Thus, we urgently need to find one therapeutic reagent that could not only accelerate diabetic wound healing as ADSC-sEVs but also overcome these shortcomings...
December 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37900939/mechanism-of-adipose-derived-mesenchymal-stem-cell-exosomes-in-the-treatment-of-heart-failure
#26
JOURNAL ARTICLE
Lei Wang, Jin-Jin Zhang, Sha-Sha Wang, Liang Li
BACKGROUND: Heart failure (HF) is a global health problem characterized by impaired heart function. Cardiac remodeling and cell death contribute to the development of HF. Although treatments such as digoxin and angiotensin receptor blocker drugs have been used, their effectiveness in reducing mortality is uncertain. Researchers are exploring the use of adipose-derived mesenchymal stem cell (ADMSC) exosomes (Exos) as a potential therapy for HF. These vesicles, secreted by cells, may aid in tissue repair and regulation of inflammation and immune responses...
September 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37794449/exosome-derived-circ_0001785-delays-atherogenesis-through-the-cerna-network-mechanism-of-mir-513a-5p-tgfbr3
#27
JOURNAL ARTICLE
Xiao Tong, Xuan Dang, Dongmei Liu, Ning Wang, Miao Li, Jianbin Han, Jinjin Zhao, Yueqing Wang, Meijiao Huang, Yanliang Yang, Yuhang Yang, Weili Wang, Yan Kou, Junjie Kou
PURPOSE: Endothelial cell dysfunction is a major cause of early atherosclerosis. Although the role of extracellular vesicles in stabilizing atherosclerotic plaques is well established, the effect of circulating exosomes on plaque formation is still unknown. Here, we explored the effect of exosomes on atherosclerosis based on the function that exosomes can act on intercellular communication. PATIENTS AND METHODS: We extracted serum exosomes from the blood of CHD patients (CHD-Exo) and healthy individuals (Con-Exo)...
October 4, 2023: Journal of Nanobiotechnology
https://read.qxmd.com/read/37781809/small-rna-profiles-of-brain-tissue-derived-extracellular-vesicles-in-alzheimer-s-disease
#28
JOURNAL ARTICLE
Yiyao Huang, Tom A P Driedonks, Lesley Cheng, Andrey Turchinovich, Olga Pletniková, Javier Redding-Ochoa, Juan C Troncoso, Andrew F Hill, Vasiliki Mahairaki, Lei Zheng, Kenneth W Witwer
BACKGROUND: Extracellular vesicles (EVs) and non-coding RNAs (ncRNAs) are emerging contributors to Alzheimer's disease (AD) pathophysiology. Differential abundance of ncRNAs carried by EVs may provide valuable insights into underlying disease mechanisms. Brain tissue-derived EVs (bdEVs) are particularly relevant, as they may offer valuable insights about the tissue of origin. However, there is limited research on diverse ncRNA species in bdEVs in AD. OBJECTIVE: This study explored whether the non-coding RNA composition of EVs isolated from post-mortem brain tissue is related to AD pathogenesis...
September 28, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37778691/extracellular-vesicles-from-neural-stem-cells-carry-microrna-16-5p-to-reduce-corticosterone-induced-neuronal-injury-in-depression-rats
#29
JOURNAL ARTICLE
Xiao-Li Min, Hai-Jing Liu, Xing-Kui Dou, Fei-Xiong Chen, Qing Zhao, Xiao-Hong Zhao, Ying Shi, Qun-Yuan Zhao, Sheng-Jie Sun, Zhen Wang, Si-Hang Yu
OBJECTIVE: Depression is a common mental illness. Neural stem cell-derived extracellular vesicles (NSC-EVs) are involved in repairing neuronal injury. We estimated the mechanism of miR-16-5p in depression rats. METHODS: EVs were extracted from NSCs. The depression rat model was established by corticosterone (CORT) induction and treated with NSC-EVs. The depression behavioral/pathological changes in rats were assessed using forced swimming test, open field test, sucrose consumption test and western blotting...
September 29, 2023: Neuroscience
https://read.qxmd.com/read/37759281/mesenchymal-stem-cell-derived-extracellular-vesicles-prevent-the-formation-of-pulmonary-arterial-hypertension-through-a-microrna-200b-dependent-mechanism
#30
JOURNAL ARTICLE
Mengzhi Wan, Caiju Lu, Yu Liu, Feng Luo, Jing Zhou, Fei Xu
BACKGROUND: Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) have been highly studied with their critical roles as carriers of therapeutic targets such as microRNAs (miRNAs) in the treatment of human diseases, including pulmonary arterial hypertension (PAH). Herein, we tried to study the potential of BMSC-EVs to deliver miR-200b for the regulation of macrophage polarization in PAH. METHODS: Rat models of PAH were induced with monocrotaline treatment, followed by miR-200b expression detection in lung tissues, pulmonary artery smooth muscle cells (PASMCs) and macrophages...
September 27, 2023: Respiratory Research
https://read.qxmd.com/read/37743008/exosomal-eif5a-derived-from-lewis-lung-carcinoma-induced-adipocyte-wasting-in-cancer-cachexia
#31
JOURNAL ARTICLE
Hairong Xiong, Jiaxin Ye, Qianqian Luo, Wen Li, Ning Xu, Hongmei Yang
Cancer cachexia is a systemic inflammation-driven syndrome, characterized by muscle atrophy and adipose tissue wasting, with progressive weight loss leading to serious impairment of physiological function. Extracellular vesicles (EVs) derived from cancer cells play a significant role in adipocyte lipolysis, yet the mechanism remain uneclucidated. In this study, EVs derived from Lewis lung carcinoma (LLC) cells were extracted and characterized. 3 T3-L1 and HIB1B adipocytes were cultured with conditioned medium or EVs from LLC, and LLC cells were used to establish a cancer cachexia mouse model...
September 22, 2023: Cellular Signalling
https://read.qxmd.com/read/37724958/human-umbilical-cord-mesenchymal-stem-cell-derived-extracellular-vesicles-loaded-with-tfcp2-activate-wnt-%C3%AE-catenin-signaling-to-alleviate-preeclampsia
#32
JOURNAL ARTICLE
Zhongmei Yang, Xiaoyan Jia, Qinyin Deng, Mengdie Luo, Yan Hou, Jun Yue, Jie Mei, Nan Shan, Zhao Wu
BACKGROUND: Failures in invasive extravillous trophoblasts (EVTs) migration into the maternal uterus have been noticed in preeclampsia (PE). Human umbilical cord mesenchymal stem cell (hUCMSC)-derived extracellular vesicles (EVs) have been highlighted for the role as a potential therapeutic method in PE. This study intends to investigate the mechanistic basis of hUCMSCs-derived EVs loaded with bioinformatically identified TFCP2 in the activities of EVTs of PE. METHODS: Primary human EVTs were exposed to hypoxic/reoxygenation (H/R) to mimic the environment encountered in PE...
February 2023: International Immunopharmacology
https://read.qxmd.com/read/37697490/apoptotic-vesicles-derived-from-human-red-blood-cells-promote-bone-regeneration-via-carbonic-anhydrase-1
#33
JOURNAL ARTICLE
Yuzi Shao, Yuhe Jiang, Kunkun Yang, Yuan Zhu, Yunsong Liu, Ping Zhang, Longwei Lv, Xiao Zhang, Yongsheng Zhou
Apoptotic vesicles (apoVs) are nanoscale vesicles derived from billions of apoptotic cells involved in the maintenance of the human body's homeostasis. Previous researches have shown that some apoVs, such as those derived from mesenchymal stem cells, contribute to bone formation. However, those apoVs cannot be extracted from patients in large quantities, and cell expansion is needed before apoV isolation, which limits their clinical translation. Mature RBCs, which have no nuclei or genetic material, are easy to obtain, showing high biological safety as a source of extracellular vesicles (EVs)...
September 11, 2023: Cell Proliferation
https://read.qxmd.com/read/37641874/hypoxic-preconditioned-mesenchymal-stem-cell-derived-small-extracellular-vesicles-promote-the-recovery-of-spinal-cord-injury-by-affecting-the-phenotype-of-astrocytes-through-the-mir-21-jak2-stat3-pathway
#34
JOURNAL ARTICLE
Zhelun Yang, Zeyan Liang, Jian Rao, Haishu Xie, Maochao Zhou, Xiongjie Xu, Yike Lin, Fabin Lin, Chunhua Wang, Chunmei Chen
BACKGROUND: Secondary injury after spinal cord injury (SCI) is a major obstacle to their neurological recovery. Among them, changes in astrocyte phenotype regulate secondary injury dominated by neuroinflammation. Hypoxia-preconditioned mesenchymal stem cells (MSCs)-derived extracellular vesicle (H-EV) plays a multifaceted role in secondary injury by interacting with cellular components and signaling pathways. They possess anti-inflammatory properties, regulate oxidative stress, and modulate apoptotic pathways, promoting cell survival and reducing neuronal loss...
August 29, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37627315/mesenchymal-stem-cell-derived-extracellular-vesicles-an-emerging-diagnostic-and-therapeutic-biomolecules-for-neurodegenerative-disabilities
#35
REVIEW
Mahmoud Kandeel, Mohamed A Morsy, Khalid M Alkhodair, Sameer Alhojaily
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. This article examines the potential therapeutic applications of MSC-derived EVs in addressing neurodegenerative disorders such as Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD)...
August 16, 2023: Biomolecules
https://read.qxmd.com/read/37626167/an-enzyme-based-system-for-extraction-of-small-extracellular-vesicles-from-plants
#36
JOURNAL ARTICLE
Qing Zhao, Guilong Liu, Fubin Liu, Manlin Xie, Yanfang Zou, Shengpeng Wang, Zhaodi Guo, Jiaming Dong, Jiali Ye, Yue Cao, Lei Zheng, Kewei Zhao
Plant-derived nanovesicles (NVs) and extracellular vesicles (EVs) are the next generation of nanocarrier platforms for biotherapeutics and drug delivery. EVs exist not only in the extracellular space, but also within the cell wall. Due to the limitations of existing isolation methods, the EVs extraction efficiency is low, and a large amount of plant material is wasted, which is of concern for rare and expensive medicinal plants. We proposed and validated a novel method for isolation of plant EVs by enzyme degradation of the plant cell wall to release the EVs...
August 25, 2023: Scientific Reports
https://read.qxmd.com/read/37603269/updated-methods-of-extracellular-vesicles-isolation
#37
JOURNAL ARTICLE
Hongyun Wang, Zijiang Yang, Songwei Ai, Junjie Xiao
Extracellular vesicles (EVs) are considered as cargo and mediate intercellular communication. As natural biological nanoparticles, EVs can be secreted by almost all kinds of cells and exist in biofluids such as milk, urine, blood, etc. In the past decades, several methods have been utilized to isolate EVs from cell culture medium, biofluids, and tissues. Here in this chapter, we summarized conventional and novel methods and fundamental procedures of EVs extraction and purification from different biofluids (plasma, urine, milk, and saliva) and tissues (brain, intestinal tissue, muscles, and heart)...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/37573648/pm-2-5-induces-alterations-in-gene-expression-profile-of-platelet-derived-extracellular-vesicles-and-mediates-cardiovascular-injury-in-rats
#38
JOURNAL ARTICLE
Ling Kong, Zhen Mao, Shiyu He, Kexin Li, Lihong Zhou, Xiaodan Zhang, Peili Huang
Platelet-derived extracellular vesicles (P-EVs), as the most abundant vesicles in blood, have been proven to play cardinal roles in cardiovascular injury. RNAs (especially miRNAs) carried by P-EVs can be transferred to the receptor, which plays a critical role in regulating vascular endothelial function. PM2.5 is one of the most well-known risk factors that cause cardiovascular disease. Therefore, the objective of the current study was to explore whether exposure to PM2.5 would alter the gene expression profile of P-EVs, and to further elucidate the role of RNAs (especially miRNAs) carried by P-EVs in cardiovascular injury induced by PM2...
August 11, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37541177/exploring-the-efficacy-of-herbal-medicinal-products-as-oral-therapy-for-inflammatory-bowel-disease
#39
REVIEW
Min-Zheng Zhu, Mei-Feng Yang, Yang Song, Hao-Ming Xu, Jing Xu, Ning-Ning Yue, Yuan Zhang, Cheng-Mei Tian, Rui-Yue Shi, Yu-Jie Liang, Jun Yao, Li-Sheng Wang, Yu-Qiang Nie, De-Feng Li
Inflammatory bowel disease (IBD) encompasses a collection of idiopathic diseases characterized by chronic inflammation in the gastrointestinal (GI) tract. Patients diagnosed with IBD often experience necessitate long-term pharmacological interventions. Among the multitude of administration routes available for treating IBD, oral administration has gained significant popularity owing to its convenience and widespread utilization. In recent years, there has been extensive evaluation of the efficacy of orally administered herbal medicinal products and their extracts as a means of treating IBD...
August 2, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37508574/liquid-biopsy-in-neurological-diseases
#40
REVIEW
Sunny Malhotra, Mari Carmen Martín Miras, Agustín Pappolla, Xavier Montalban, Manuel Comabella
The most recent and non-invasive approach for studying early-stage biomarkers is liquid biopsy. This implies the extraction and analysis of non-solid biological tissues (serum, plasma, saliva, urine, and cerebrospinal fluid) without undergoing invasive procedures to determine disease prognosis. Liquid biopsy can be used for the screening of several components, such as extracellular vesicles, microRNAs, cell-free DNA, cell-free mitochondrial and nuclear DNA, circulating tumour cells, circulating tumour DNA, transfer RNA, and circular DNA or RNA derived from body fluids...
July 22, 2023: Cells
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