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Knee Osteoarthitis

Mohd Yunus Mohd Heikal, Shuid Ahmad Nazrun, Kien Hui Chua, Abd Ghafar Norzana
The proinflammatory cytokines, metalloproteinases family (MMPs), inflammatory mediators PGE2, COX-2 and NO are the most important group of compounds responsible for the loss of metabolic homeostasis of articular cartilage by promoting catabolic and destructive processes in the pathogenesis of osteoarthritis (OA). Stichopus chloronotus, a marine sea cucumber which is rich in n-3 PUFAs and phenolic compound, may exert a favorable influence on the course of the disease. The objective of this study was to investigate the regeneration and anti-inflammatory potential of S...
February 4, 2019: Cytotechnology
S Tigchelaar, J van Sambeeck, S Koeter, A van Kampen
PURPOSE AND HYPOTHESIS: Trochlear osteotomy is a rarely performed procedure, only indicated in selected cases. Due to its nature, it can potentially lead to cartilage damage and subsequent early osteoarthritis. Satisfactory short-term results from lateral condyle-elevating osteotomy have previously been reported. The long-term effects of this procedure on clinical outcomes, patellar stability and radiological osteoarthritis are reported here. METHODS: Sixteen patients (19 knees) with patellar instability due to trochlear dysplasia were included...
April 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Jean-François Budzik, Juliette Ding, Laurène Norberciak, Tristan Pascart, Hechmi Toumi, Sébastien Verclytte, Raphaël Coursier
The role of inflammation in the pathogenesis of osteoarthritis is being given major interest, and inflammation is closely linked with vascularization. It was recently demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could identify the subchondral bone marrow vascularization changes occurring in osteoarthritis in animals. These changes appeared before cartilage lesions were visible and were correlated with osteoarthritis severity. Thus the opportunity to obtain an objective assessment of bone vascularization in non-invasive conditions in humans might help better understanding osteoarthritis pathophysiology and finding new biomarkers...
March 2017: European Journal of Radiology
Hassan Bassiouni, Hany Aly, Khaled Zaky, Nouran Abaza, Thomas Bardin
OBJECTIVE: To compare serum 25 OH vitamin D (25 (OH) D) levels between medial femoro-tibial knee osteoarthritis (OA) patients and controls, and to detect structural progression in patients with mild to moderate knee osteoarthritis in relation to baseline 25(OH) D levels in a oneyear longitudinal prospective cohort study. METHODS: Thirty eight patients with medial femoro-tibial knee OA according to the ACR criteria and no knee malalignement, and 20 age, sex and BMI-matched pain free controls were included in the vitamin D study...
2017: Current Rheumatology Reviews
Pu Wang, Lin Yang, Chuan Liu, Xiaofei Wei, Xiaotian Yang, Yujing Zhou, Hua Jiang, Zhongjie Lei, Jan D Reinhardt, Chengqi He
OBJECTIVE: To determine effects of Whole Body Vibration Exercise (WBVE) associated with quadriceps resistance exercises (QRE) versus QRE only on pain, physical function, biomarkers in serum and urine, activities of daily living (ADL), and quality of life in patients with knee osteoarthitis (OA). DESIGN: Randomized-controlled trial . SETTING: Rehabilitation medicine outpatient department of West China Hospital, Chengdu, Sichuan, People's Republic of China...
November 2016: Clinical Rehabilitation
Gustavo Constantino De Campos, Marcelo Tomio Kohara, Marcia Uchoa Rezende, Olga Fugiko Magashima Santana, Merilu Marins Moreira, Olavo Pires De Camargo
OBJECTIVE: To evaluate the consistency of the questionnaires (WOMAC, Lequesne, VAS, SF 36-PCS and SF 36-MCS) when applied in patients with osteoarthritis of the knees (KOA) verifying if age and level of education interfere with the completion of the questionnaires. METHOD: One hundred and two patients with KOA answered WOMAC, LESQUESNE, VAS and SF-36 questionnaires and provided data correlated with age and education. The internal consistency of the WOMAC questionnaire was verified with Cronbach's alpha...
2014: Acta Ortopedica Brasileira
M D Crema, M C Nevitt, A Guermazi, D T Felson, K Wang, J A Lynch, M D Marra, J Torner, C E Lewis, F W Roemer
PURPOSE: To determine the association of MRI-assessed worsening of tibiofemoral cartilage damage, meniscal damage, meniscal extrusion, separately and together, with progression of radiographic joint space narrowing (JSN). METHOD AND MATERIALS: The Multicenter Osteoarthitis Study (MOST) Study is a cohort study of subjects with or at risk for knee osteoarthritis (OA). Knees with radiographic OA Kellgren-Lawrence grade 2 at baseline and with baseline and 30-month 1...
October 2014: Osteoarthritis and Cartilage
Heng Li, Liqin Li, Jikang Min, Honghang Yang, Xuchun Xu, Yongjian Yuan, Dan Wang
BACKGROUND: The aim of this study was to judge whether there is a correlation between some biochemical features of knee osteoarthritic blood and clinical characteristics and to evaluate the potential relationship between osteoarthitis (OA) severity and putative biomarkers for the disease. METHODS: 105 patients suffering from knee OA were analyzed clinically (Lequesne's index) and radiographically (Kellgren and Lawrence, K&L). Plasma and peripheral blood mononuclear cells (PBMC) were harvested separately...
2012: Clinical Laboratory
Hansjoerg Heep, Gero Hilken, Sebastian Hofmeister, Christian Wedemeyer
OBJECTIVE: Mechanotransduction is the mechanism that due to reacting chondrocytes on biomechanical loading of body mass. Higher biomechanical loading lead to increased degeneration of chondrocytes, whereas moderate loading is protecting. This suggests that body fat regulates bone metabolism first by means of hormonal factors and second that the effects of muscle and loading are signaling factors in mechanotransduction. Leptin, a peptide hormone produced predominantly by white fat cells, is one of these hormonal factors...
2009: International Journal of Biological Sciences
Catherine M Phan, Thomas M Link, Gabrielle Blumenkrantz, Timothy C Dunn, Michael D Ries, Lynne S Steinbach, Sharmila Majumdar
OBJECTIVE: To assess the rate of cartilage loss, the change in bone marrow edema pattern and internal joint derangement at 1.5-T MRI in patients with knee osteoarthritis and to correlate these findings with the clinical Western Ontario and McMaster University Osteoarthitis (WOMAC) score. METHODS: Forty subjects (mean age 57.7+/-15 years; 16 females and 24 males) were recruited: 6 healthy volunteers (OA0), 17 patients with mild osteoarthritis (OA1) and 17 with severe osteoarthritis (OA2) based on the Kellgren-Lawrence scale...
March 2006: European Radiology
R-M Flipo, T Conrozier
COMMENT: Osteoarthritis represents one of the most frequent pathologies today, and its current management requires the combination of pharmaceutical and non pharmacological strategies. Moreover, osteoarthritis constitutes one of the main diseases leading to the requirement to the alternative medicines. NEWS AND KEY POINTS: This overview resumes the main recommendations in the light of recent controlled clinical trials concerning the not medicinal coverage of osteoarthritis : importance of the information and the education of the patient, the importance of the establishment of programs of physical exercises, the need for a reduction of the weight excess for knee osteoarthitis...
April 2003: La Revue de Médecine Interne
I Sulzbacher
Osteoarthitis is the most common joint disease affecting over 60% of the elderly population. It is characterized by the progressive erosion of articular cartilage leading to incapacity of movement. In the great majority of instances, osteoarthritis appears insidiously, without apparent initiating cause. This primary form is usually oligoarticular involving hip, knee, cervical vertebrae, interphalangeal joints of the fingers or tarsometatarsal joints of the feet. In case of an underlying systemic disease or local injury the cartilage destruction is considered as secondary osteoarthritis...
December 2000: Der Radiologe
S Robertson, H Frost, H Doll, J J O'Connor
OBJECTIVE: To assess the repeatability of two muscle function measures -- leg extensor power (LEP) and isometric quadriceps force (IQF) -- in a population of patients with osteoarthritis of the knee. DESIGN: Repeat measures of LEP and IQF at 25 degrees and 50 degrees knee flexion were taken within seven days. Both legs were measured and a numerical rating scale was used to assess pain on the two occasions. SUBJECTS: Patients who were on a waiting list for a primary unilateral knee replacement for osteoarthritis were invited to take part in the study...
April 1998: Clinical Rehabilitation
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