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https://read.qxmd.com/read/30785938/sexual-dimorphism-of-acute-doxorubicin-induced-nephrotoxicity-in-c57bl-6-mice
#1
Marianne K O Grant, Davis M Seelig, Leslie C Sharkey, Wan S V Choi, Ibrahim Y Abdelgawad, Beshay N Zordoky
Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Therefore, in the current study, we investigated the sex and time-dependent changes in pathological lesions as well as apoptotic and fibrotic markers in response to acute DOX-induced nephrotoxicity...
2019: PloS One
https://read.qxmd.com/read/30785784/timing-of-renal-replacement-therapy-for-severe-acute-kidney-injury-in-critically-ill-patients
#2
Stéphane Gaudry, Jean-Pierre Quenot, Alexandre Hertig, Saber Davide Barbar, David Hajage, Jean-Damien Ricard, Didier Dreyfuss
Acute kidney injury (AKI) affects many intensive care unit patients and is responsible for increased morbidity and mortality. Although life-saving in many situations, renal replacement therapy (RRT) may be associated with complications and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications whereas a delayed one may allow for renal function recovery in some patients without need for this costly and potentially dangerous technique...
February 20, 2019: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30785678/-renal-risks-of-nsaids-in-endurance-sports
#3
Elise Chabbey, Pierre-Yves Martin
Endurance athletes, either professional or amateur, are consuming non steroidal anti-inflammatory drugs (NSAIDs) during their training and races. The goal is to decrease pain or to prevent a potential pain. These athletes, especially, the amateurs, do not do not know the side effects and have no medical supervision. In association with other risks factors such as overhydratation, NSAIDs increase the risk of exercise associated hyponatremia (EAH). Its frequency increases as the number of long distance events is increasing but it is still unknown...
February 20, 2019: Revue Médicale Suisse
https://read.qxmd.com/read/30785676/-hepatorenal-syndrome-something-new
#4
Hannah Wozniak, Patrick Saudan, Pierre-Yves Martin, Belen Ponte
Hepatorenal syndrome is a serious and frequent complication in patients suffering from liver cirrhosis. Its most severe type is characterized by the rapid occurrence of a functional acute kidney injury. However it is mainly an exclusion diagnosis. Although the pathophysiology is not yet fully understood, the principal hypothesis is a splanchnic vasodilatation leading to a systemic and renal vasoconstriction associated with sodium and water retention and progressive cardiac failure. Intravenous albumin associated with systemic vasoconstrictors, terlipressin or noradrenaline, is recommended...
February 20, 2019: Revue Médicale Suisse
https://read.qxmd.com/read/30785502/an-experimental-study-of-exenatide-effects-on-renal-injury-in-diabetic-rats1
#5
Xiaodong Wang, Zhaoliang Li, Xiaolei Huang, Fenghua Li, Jinbo Liu, Zhenzuo Li, Dongfang Bai
PURPOSE: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats. METHODS: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Then, the later 3 groups were treated with 2, 4 and 8 μg/kg exenatide for 8 weeks, respectively. The serum and urine biochemical indexes and oxidative stress and inflammatory indexes in renal tissue were determined...
February 14, 2019: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/30785352/time-dependent-p53-inhibition-determines-senescence-attenuation-and-long-term-outcome-after-renal-ischemia-reperfusion
#6
Arpita Baisantry, Birgit Berkenkamp, Song Rong, Raj Bhayadia, Inga Sörensen-Zender, Roland Schmitt, Anette Melk
Inhibition of p53 has been shown to be an efficient strategy for ameliorating kidney ischemia/reperfusion (I/R) injury in experimental models. The therapeutic value of p53 siRNA based inhibition for I/R in renal transplantation is currently evaluated in clinical studies. While the major rationale for these studies is the suppression of pro-apoptotic properties, there are more, equally important injury response pathways regulated by p53. A p53-dependent pathway shown to be crucial for renal long-term outcome is cellular senescence...
February 20, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30785351/physiological-effects-of-altering-oxygenation-during-kidney-normothermic-machine-perfusion
#7
Thomas D Adams, Sarah Hosgood, Michael L Nicholson
Kidney normothermic machine perfusion (NMP) has historically employed a 95% O2 /5% CO2 gas mixture. Using a porcine model of organ retrieval, NMP and reperfusion, we tested the hypothesis that reducing perfusate oxygenation (PP O2 ) would be detrimental to renal function and cause injury. In a minimal-ischemic-injury (MI) experiment, kidneys sustained 10min of warm ischemia (WI) and 2hr of static cold storage (SCS) before 1hr of NMP with either 95%, 25% or 12% O2 with 5% CO2 and N2 balance. In a clinical-injury (CI) model, kidneys with 10min WI and 17hr SCS underwent 1hr of NMP with the above gas combinations, or 18hr SCS as a control...
February 20, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30785350/angiotensin-ii-and-salt-induced-decompensation-in-balb-cj-mice-is-aggravated-by-fluid-retention-related-to-low-oxidative-stress
#8
Sofia Jönsson, Mediha Becirovic-Agic, Henrik Isackson, Maria K Tveitarås, Trude Skogstrand, Fredrik Narfström, Tine Veronica Karlsen, Åsa Lidén, Sabine Leh, Madelene Ericsson, Stefan K Nilsson, Rolf K Reed, Michael Hultström
AIM: Balb/CJ mice are more sensitive to treatment with Angiotensin II (AngII) and high salt (Salt) diet compared to C57BL/6J. Together with higher mortality, they develop edema, signs of heart failure and acute kidney injury. The aim of the present study was to identify differences in renal gene regulation that may affect kidney function and fluid balance, which could contribute to decompensation in Balb/CJ after AngII+Salt treatment. METHODS: Male Balb/CJ and C57BL/6J mice were divided into five different treatment groups: Control, AngII, Salt, AngII+Salt, AngII+Salt+N-acetylcysteine...
February 20, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30785018/resveratrol-exerts-dose-dependent-anti-fibrotic-or-pro-fibrotic-effects-in-kidneys-a-potential-risk-to-individuals-with-impaired-kidney-function
#9
Shuyun Liu, Meng Zhao, Yijie Zhou, Chengshi Wang, Yujia Yuan, Lan Li, William Bresette, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
BACKGROUND: Renal fibrosis is the pathological feature of chronic kidney disease (CKD) which leads to end-stage renal disease (ESRD) and renal failure. Resveratrol [3,5,4'-trihydroxy-trans-stilbene (RSV)] has shown benefits for metabolic diseases and anti-cancer therapy, but its potential risk on renal health has not been fully evaluated. PURPOSE: To investigate the global effects of RSV on renal fibrosis in human tubular epithelial cell (TEC) line HK-2, and in mice with unilateral ureteral obstruction (UUO)...
December 17, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30784936/g-protein-coupled-estrogen-receptor-activation-improves-contractile-and-diastolic-functions-in-rat-renal-interlobular-artery-to-protect-against-renal-ischemia-reperfusion-injury
#10
Yuechen Chang, Ziwei Han, Yang Zhang, Ying Zhou, Ziyi Feng, Long Chen, XueRui Li, Li Li, Jun-Qiang Si
OBJECTIVE: This work aimed to investigate whether G protein-coupled estrogen receptor (GPER) can improve the renal interlobular artery vascular function by increasing the NO content, thereby protecting against renal ischemia-reperfusion (IR) injury. METHODS: This study classified ovariectomised (OVX) female Sprague-Dawley rats into OVX, OVX + IR, OVX + IR + G1 (the GPER agonist G1), OVX + IR + G1+G15 (GPER blocker) and OVX + IR + G1+L-NAME (eNOS blocker) groups...
February 20, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30784934/morin-has-protective-potential-against-er-stress-induced-apoptosis-in-renal-proximal-tubular-hk-2-cells
#11
Jung-Soon Mo, Dabin Choi, Yu-Ran Han, Nambin Kim, Han-Sol Jeong
ER stress is an early event of acute kidney injury and has been linked to accelerate the development of chronic kidney disease. Therefore, the compounds that can mimic ER stress inhibitor may confer regulatory effects on ER stress induced apoptosis. In this study, we investigated the protective effects of flavonoid morin against ER stress induced apoptosis in human renal proximal tubular HK-2 cells. Morin downregulated the expression of GRP78, central regulator of ER stress response, induced by ER stress inducer tunicamycin...
February 19, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://read.qxmd.com/read/30784660/executive-summary-for-the-2015-annual-data-report-of-the-china-kidney-disease-network-ck-net
#12
Fang Wang, Chao Yang, Jianyan Long, Xinju Zhao, Wen Tang, Dongliang Zhang, Kunhao Bai, Zaiming Su, Bixia Gao, Hong Chu, Jinwei Wang, Xiaoyu Sun, Song Wang, Li Zuo, Yue Wang, Feng Yu, Haibo Wang, Luxia Zhang, Ming-Hui Zhao
Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. One major output of CK-NET is to generate an Annual Data Report (ADR) providing resourceful information regarding kidney disease in China...
March 2019: Kidney International
https://read.qxmd.com/read/30784655/dampening-sterile-inflammation-of-the-kidney
#13
Mirjam Meissner, Susanne F Viehmann, Christian Kurts
Renal ischemia reperfusion injury (IRI) is a serious cause of acute kidney injury (AKI). Danger-associated-molecular pattern molecules (DAMPs) are thought to promote IRI by initiating immune cell infiltration and driving disease progression, but the underlying pathophysiological mechanisms are mainly unclear. Poluzzi et al. demonstrate that soluble biglycan is a bimodal DAMP that both recruits proinflammatory macrophages and initiates resolution of inflammation and tissue remodeling in IRI, identifying a potential therapeutic target...
March 2019: Kidney International
https://read.qxmd.com/read/30784349/klotho-attenuates-diabetic-nephropathy-in-db-db-mice-and-ameliorates-high-glucose-induced-injury-of-human-renal-glomerular-endothelial-cells
#14
Yebei Li, Daijin Ren, Gaosi Xu
Glomerular endothelial cell injury plays an important role in the development and progression of diabetic nephropathy (DN). The expression and function of klotho in glomerular endothelial cells remain unclear. Thus, this study aimed to investigate the expression and the functional role of klotho in DN progression in mice and in high glucose (HG)-induced cell injury of human renal glomerular endothelial cells (HRGECs) and the underlying mechanism. In this study, HRGECs were cultured with media containing HG to induce endothelial cell injury and db/db mice were used as DN model mice...
February 20, 2019: Cell Cycle
https://read.qxmd.com/read/30784230/burden-access-and-disparities-in-kidney-disease
#15
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
March 2019: Journal of Renal Care
https://read.qxmd.com/read/30784180/chemerin-chemr23-axis-promotes-inflammation-of-glomerular-endothelial-cells-in-diabetic-nephropathy
#16
Jin Shang, Luyao Wang, Ya Zhang, Shiyi Zhang, Lina Ning, Jifang Zhao, Genyang Cheng, Dong Liu, Jing Xiao, Zhanzheng Zhao
Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in inflammation and protein leakage in urine in DN patients. Chemerin and its receptor ChemR23 are inducers of inflammation. The aim of this study was to investigate the function of chemerin/ChemR23 in GEnCs of DN patients. Immunohistochemical staining and qRT-PCR were used to measure the expression of chemerin, ChemR23 and inflammatory factors in renal tissues of DN patients...
February 19, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30783949/clinical-practice-guideline-for-renal-hypouricemia-1st-edition
#17
REVIEW
Akiyoshi Nakayama, Hirotaka Matsuo, Akira Ohtahara, Kazuhide Ogino, Masayuki Hakoda, Toshihiro Hamada, Makoto Hosoyamada, Satoshi Yamaguchi, Ichiro Hisatome, Kimiyoshi Ichida, Nariyoshi Shinomiya
Renal hypouricemia (RHUC) is a disease caused by dysfunction of renal urate reabsorption transporters; however, diagnostic guidance and guidelines for RHUC have been lacking, partly due to the low evidence level of studies on RHUC. This review describes a world-first clinical practice guideline (CPG) and its first version in English for this condition. It was developed following the "MINDS Manual for Guideline Development" methodology, which prioritizes evidence-based medicine. It was published in Japanese in 2017 and later translated into English...
February 19, 2019: Human Cell
https://read.qxmd.com/read/30783919/propolis-and-its-combination-with-boric-acid-protect-against-ischemia-reperfusion-induced-acute-kidney-injury-by-inhibiting-oxidative-stress-inflammation-dna-damage-and-apoptosis-in-rats
#18
Fatime Geyikoglu, Kubra Koc, Suat Colak, Huseyin Serkan Erol, Salim Cerig, Berna Kavakcioglu Yardimci, Ozge Cakmak, Muhammed Bahaeddin Dortbudak, Gizem Eser, Ferhunde Aysin, Nihal Simsek Ozek, Serkan Yildirim
Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Sprague-Dawley rats were subjected to 50 min of ischemia followed by 3 h of reperfusion. Animals were randomly divided into a control group (the abdominal wall was just opened and closed), an I/R injury group, the propolis intervention group (200 mg/kg, intragastric administration, 1 h before ischemia), boric acid intervention group (14 mg/kg, intragastric administration 1 h before ischemia), and the propolis + boric acid intervention group (intragastric administration 1 h before ischemia)...
February 19, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30783195/analysis-of-postmarketing-safety-data-for-proton-pump-inhibitors-reveals-increased-propensity-for-renal-injury-electrolyte-abnormalities-and-nephrolithiasis
#19
Tigran Makunts, Isaac V Cohen, Linda Awdishu, Ruben Abagyan
Proton pump inhibitors, PPIs, are widely prescribed and sold globally. Although initially intended for time-limited treatment of acute disorders, such as gastric ulcers and esophagitis, PPIs are now commonly used for prolonged durations and are considered safe for over the counter access. Recent studies have raised concern over associations between PPI use and acute kidney injury, chronic kidney disease, end-stage renal disease, and electrolyte abnormalities. The growing concern over potentially serious adverse drug reactions warrants an evaluation of post marketing surveillance data...
February 19, 2019: Scientific Reports
https://read.qxmd.com/read/30783187/interleukin-17a-promotes-diabetic-kidney-injury
#20
Jin Ma, Yan J Li, Xiaochen Chen, Tony Kwan, Steven J Chadban, Huiling Wu
The role of the pro-inflammatory cytokine IL-17 in the pathogenesis of numerous inflammatory disorders is well-documented, but conflicting results are reported for its role in diabetic nephropathy. Here we examined the role of IL-17 signalling in a model of streptozotocin-induced diabetic nephropathy through IL-17 knockout mice, administration of neutralising monoclonal anti-IL-17 antibody and in vitro examination of gene expression of renal tubular cells and podocytes under high glucose conditions with or without recombinant IL-17...
February 19, 2019: Scientific Reports
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