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Feeding AND intolerance

Wei Shuai, Bin Kong, Hui Fu, Caijie Shen, Xiaobo Jiang, He Huang
BACKGROUND: Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling. METHODS: A high-fat diet (HFD) feeding was performed in 6-week-old MD1-knockout (MD1-KO) mice and wild-type (WT) littermates for 20 weeks...
February 2019: Canadian Journal of Cardiology
Nicholas C Woodward, Amanda L Crow, Yang Zhang, Sam Epstein, Jaana Hartiala, Richard Johnson, Heidi Kocalis, Arian Saffari, Ishwarya Sankaranarayanan, Omid Akbari, Gajalakshmi Ramanathan, Jesus A Araujo, Caleb E Finch, Sebastien G Bouret, Constantinos Sioutas, Todd E Morgan, Hooman Allayee
Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM2.5 ) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice...
February 12, 2019: Scientific Reports
Ozgun Uygur, Mehmet Yalaz, Nazmiye Can, Ozge Altun Koroglu, Nilgun Kultursay
PURPOSE: Feeding intolerance is one of the most frequent problems among preterm infants. These infants are fed with expressed breast milk or preterm formulas of which the temperature is not routinely measured. In this study, we aimed to examine the effects of feeds with warm milk versus room temperature milk in preterm infants. MATERIALS AND METHODS: Infants with a birth weight ≤1,500 g or gestational age ≤34 weeks were included in the study and assigned to two different feeding temperature groups (22-24°C and 32-34°C)...
February 5, 2019: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Zhouguang Wang, Sinan Khor, Dongsheng Cai
Hypoxia-inducible factor-2α (HIF2α) is a nuclear transcription factor that plays a critical role in cell survival including metabolic adaptation under hypoxia as well as normoxia, but whether HIF2α contributes to the control of whole-body metabolic balance is unclear. In this study, we found that hypothalamic HIF2α protein level rapidly increases in young mice that are centrally stimulated with insulin. However, this insulin-induced HIF2α up-regulation is substantially attenuated in mice of advanced age...
February 1, 2019: Journal of Biological Chemistry
Sushma Nangia, Vinoth Vadivel, Anu Thukral, Arvind Saili
OBJECTIVE: To evaluate the effect of early total enteral feeding (ETEF) when compared with conventional enteral feeding (CEF) in stable very-low-birth-weight (VLBW; 1,000-1,499 g) infants on the postnatal age (in days) at attaining full enteral feeds. METHODS: In this unblinded randomised controlled trial, 180 infants were allocated to an ETEF (n = 91) or a CEF group (n = 89). Feeds were initiated as total enteral feeds in the ETEF group and as minimal enteral nutrition (20 mL/kg) in the CEF group...
January 30, 2019: Neonatology
Fumiyoshi Okazaki, Liqing Zang, Hiroko Nakayama, Zhen Chen, Zi-Jun Gao, Hitoshi Chiba, Shu-Ping Hui, Takahiko Aoki, Norihiro Nishimura, Yasuhito Shimada
Understanding the gut microbiota in metabolic disorders, including type 2 diabetes mellitus (T2DM), is now gaining importance due to its potential role in disease risk and progression. We previously established a zebrafish model of T2DM, which shows glucose intolerance with insulin resistance and responds to anti-diabetic drugs. In this study, we analysed the gut microbiota of T2DM zebrafish by deep sequencing the 16S rRNA V3-V4 hypervariable regions, and imputed a functional profile using predictive metagenomic tools...
January 29, 2019: Scientific Reports
Zhuo Wang, Wei Ding, Qi Fang, Lulu Zhang, Xueyun Liu, Zaixiang Tang
BACKGROUND: Monitoring gastric residual volume has been a common practice in intensive care patients receiving enteral feeding worldwide. Recent studies though, have challenged the reliability and necessity of this routine monitoring process. Several studies even reported improvements in the delivery of enteral feeding without monitoring gastric residual volume, while incurring no additional adverse events. However, the benefit of monitoring gastric residual volume remains controversial in intensive care patients...
January 3, 2019: International Journal of Nursing Studies
Manijeh Kahbazi, Mojtaba Sharafkhah, Parsa Yousefichaijan, Hassan Taherahmadi, Mohammad Rafiei, Parisa Kaviani, Sahand Abaszadeh, Ali Massoudifar, Abolfazl Mohammadbeigi
INTRODUCTION: It is believed that tubulointerstitial inflammation plays a role in the formation of renal scarring secondary to acute pyelonephritis (APN). Vitamin A is an anti-inflammatory agent that is involved in the re-epithelialization of damaged mucosal surfaces. OBJECTIVE: The aim of this study was to evaluate the efficacy of vitamin A supplementation in combination with antibiotics for improving urinary tract infections (UTIs) symptoms and preventing renal scarring in girls with APN...
February 2019: Complementary Therapies in Medicine
Zhenya Yuan, Junmei Yan, Hongyu Wen, Xiaoyi Deng, Xianbin Li, Siting Su
Feeding intolerance (FI) is a common disease in preterm infants, often causing a delay in individual development. Gut microbiota play an important role in nutrient absorption and metabolism of preterm infants. To date, few studies have focused on the community composition of gut microbiota of preterm infants with feeding intolerance. In this study, we collected fecal samples from 41 preterm infants diagnosed with feeding intolerance and 29 preterm infants without feeding intolerance, at three specific times during the development and prevalence of feeding intolerance (after birth, when feeding intolerance was diagnosed, after feeding intolerance was gone), from different hospitals for 16S rRNA gene sequencing...
2019: PloS One
Francesco Cresi, Elena Maggiora, Silvia Maria Borgione, Elena Spada, Alessandra Coscia, Enrico Bertino, Fabio Meneghin, Luigi Tommaso Corvaglia, Maria Luisa Ventura, Gianluca Lista
BACKGROUND: Respiratory distress syndrome (RDS) and feeding intolerance are common conditions in preterm infants and among the major causes of neonatal mortality and morbidity. For many years, preterm infants with RDS have been treated with mechanical ventilation, increasing risks of acute lung injury and bronchopulmonary dysplasia. In recent years non-invasive ventilation techniques have been developed. Showing similar efficacy and risk of bronchopulmonary dysplasia, nasal continuous positive airway pressure (NCPAP) and heated humidified high-flow nasal cannula (HHHFNC) have become the most widespread techniques in neonatal intensive care units...
January 18, 2019: Trials
Flavia Indrio, Vanessa Nadia Dargenio, Paola Giordano, Ruggiero Francavilla
Colic is a common and distressing functional gastrointestinal disorder during infancy. It is a behavioral phenomenon in infants aged 1-4 months involving prolonged inconsolable crying and agitated status with multifactorial etiology. Colic can be considered as a benign, self-limited process because the baby normally grows and feeds even with transient irritable mood. Nevertheless, infantile colic is a common difficulty causing anxiety during parenthood and a recurrent reason for them to seek medical help, especially if it is the first child...
January 18, 2019: Advances in Experimental Medicine and Biology
Alicia Nicole Wiese, Matthew Jm Rogers, Mandy Way, Emma Ballard
BACKGROUND: Monitoring gastric residual volume (GRV) and titrating enteral nutrition (EN) towards goal rate are common practices in the intensive care unit (ICU) despite limited supportive evidence. We investigated the effect of removal of GRV monitoring and commencing EN at goal rate had on EN provision in mechanically ventilated ICU patients. METHODS: We conducted a single-centre, pre-post implementation study, in a 10-bed ICU comprising 181 patients with ventilation ≥48 h and given EN within 24 h of intubation...
January 14, 2019: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Gayatri Athalye-Jape, Sanjay Patole
Mortality, necrotising enterocolitis (NEC), late onset sepsis (LOS) and feeding intolerance are significant issues for very preterm (< 32 weeks) and extremely preterm (< 28 weeks) infants. The complications of ≥ Stage II NEC [e.g. Resection of the gangrenous gut, survival with intestinal failure, recurrent infections, prolonged hospital stay, and long-term neurodevelopmental impairment (NDI)] impose a significant health burden. LOS also carries significant burden including long-term NDI due to adverse effects of inflammation on the preterm brain during the critical phase of development...
January 13, 2019: Microbial Biotechnology
Flory L Nkoy, Michelle G Hofmann, Bryan L Stone, Justin Poll, Lauren Clark, Bernhard A Fassl, Nancy A Murphy
Background Children with medical complexity (CMC) are a growing population of medically fragile children with unique healthcare needs, who have recurrent emergency department (ED) and hospital admissions due to frequent acute escalations of their chronic conditions. Mobile health (mHealth) tools have been suggested to support CMC home monitoring and prevent admissions. No mHealth tool has ever been developed for CMC and challenges exist. Objective To: 1) assess information needs for operationalizing CMC home monitoring, and 2) determine technology design functionalities needed for building a mHealth application for CMC...
February 2019: International Journal of Medical Informatics
Shota Fukuhara, Hisakazu Nakajima, Satoru Sugimoto, Kazuki Kodo, Keiichi Shigehara, Hidechika Morimoto, Yusuke Tsuma, Masaharu Moroto, Jun Mori, Kitaro Kosaka, Masafumi Morimoto, Hajime Hosoi
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutation of the methyl-CpG-binding protein 2 (MECP2) gene. Although RTT has been associated with obesity, the underlying mechanism has not yet been elucidated. In this study, female heterozygous Mecp2-null mice (Mecp2+/- mice), a model of RTT, were fed a normal chow diet or high-fat diet (HFD), and the changes in molecular signaling pathways were investigated. Specifically, we examined the expression of genes related to the hypothalamus and dopamine reward circuitry, which represent a central network of feeding behavior control...
2019: PloS One
Thomas A Aloysius, Ana Karina Carvajal, Rasa Slizyte, Jon Skorve, Rolf K Berge, Bodil Bjørndal
Background : Studies have shown that dietary source of protein and peptides can affect energy metabolism and influence obesity-associated diseases. This study aimed to investigate the impact of different chicken protein hydrolysates (CPHs) generated from chicken rest raw materials in a mouse obesity model. Methods : Male C57BL/6 mice were fed a high-fat, high-sucrose diet with casein or CPHs generated using Papain + Bromelain, Alcalase, Corolase PP, or Protamex for 12 weeks ( n = 12). Body weight, feed intake, and intraperitoneal glucose tolerance was determined, and plasma and liver and adipose tissues were collected at sacrifice...
December 28, 2018: Medicines (Basel, Switzerland)
Ryan T Hurt, Lisa M Epp, Wanda M Duellman, Adele K Pattinson, Lisa Lammert, Margaret R Baker, Lisa D Miller, Aravind Reddy Kuchkuntla, Manpreet S Mundi
OBJECTIVE: Despite surveys indicating a high prevalence of blenderized tube feeding (BTF) as an alternative to commercial enteral nutrition (EN), there remains a paucity of data regarding use in clinical practice. The objective of the present open-label pilot study was to assess the safety and effectiveness of BTF in adult patients being given home enteral nutrition (HEN). DESIGN: This is an open-label pilot study, in which all participants who had been on traditional EN formulas were changed to BTF for 6 weeks...
December 31, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Lyvonne N Tume, Frédéric V Valla, Alejandro A Floh, Praveen Goday, Corinne Jotterand Chaparro, Bodil Larsen, Jan Hau Lee, Yara M F Moreno, Nazima Pathan, Sascha Verbruggen, Nilesh M Mehta
BACKGROUND: Widespread variation exists in pediatric critical care nutrition practices, largely because of the scarcity of evidence to guide best practice recommendations. OBJECTIVE: The objective of this paper was to develop a list of topics to be prioritized for nutrition research in pediatric critical care in the next 10 years. METHODS: A modified 3-round Delphi process was undertaken by a newly established multidisciplinary group comprising 11 international researchers in the field of pediatric critical care nutrition...
December 26, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Ann-Marie Brown, Elaine Fisher, Michael L Forbes
BACKGROUND: Malnutrition increases the risk of mortality and morbidity in the pediatric intensive care unit (PICU). Barriers to adequate delivery of enteral nutrition (EN) include hemodynamic instability, feeding interruptions and intolerance, and lack of standardized feeding protocols. The most recent guidelines on nutrition support for the critically ill child describe a paucity of evidence around the best method to deliver EN. There is an untested clinical assumption that bolus gastric feeding (B-GF) in intubated patients is associated with aspiration events, lung injury, and associated morbidity compared with continuous gastric feeding (C-GF)...
December 20, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Cheng Chi, Nicholas Buys, Cheng Li, Jing Sun, Chenghong Yin
BACKGROUND/OBJECTIVES: Prebiotics are increasingly recognized as an effective measure to promote health and prevent adverse health outcomes in preterm infants. We aimed to systematically review the randomized controlled trials (RCTs) in this area. SUBJECTS/METHODS: Relevant studies from January 2000 to June 2018 were searched and selected from PubMed, Medline, Scopus, and the Cochrane Library. RCTs were included if they involved preterm infant participants, included a prebiotic intervention group, measured incidence of sepsis, feeding intolerance, mortality, time to full enteral feeding, necrotizing enterocolitis (NEC), length of hospital stay, and stool frequency as outcomes...
December 19, 2018: European Journal of Clinical Nutrition
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