Hailei Zhang, Boyan Tang, Bo Zhang, Kai Huang, Shanshan Li, Yuangong Zhang, Haisong Zhang, Libin Bai, Yonggang Wu, Yongqiang Cheng, Yanmin Yang, Gang Han
Photo-crosslinking polymerization stands as a fundamental pillar in the domains of chemistry, biology, and medicine. Yet, prevailing strategies heavily rely on ultraviolet/visible (UV/Vis) light to elicit in situ crosslinking. The inherent perils associated with UV radiation, namely the potential for DNA damage, coupled with the limited depth of tissue penetration exhibited by UV/Vis light, severely restrict the scope of photo-crosslinking within living organisms. Although near-infrared light has been explored as an external excitation source, enabling partial mitigation of these constraints, its penetration depth remains insufficient, particularly within bone tissues...
April 15, 2024: Nature Communications