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Ismaël Atchia, David Kane, Mike R Reed, John D Isaacs, Fraser Birrell
BACKGROUND: Intra-articular injection is effective for osteoarthritis, but the best single injection strategy is not known, nor are there established predictors of response. The objectives of this study were to assess and predict response to a single ultrasound-guided injection in moderate to severe hip osteoarthritis. METHODS: 77 hip osteoarthritis patients entered a prospective, randomised controlled trial, randomised to one of four groups: standard care (no injection); normal saline; non-animal stabilised hyaluronic acid (durolane) or methylprednisolone acetate (depomedrone)...
January 2011: Annals of the Rheumatic Diseases
M K Aneeshkumar, Su Kale, M Kabbani, V C David
Cystic lymphangioma is a rare congenital anomaly of the lymphatic system. Most lesions present in infancy or early childhood with a swelling in the head and neck region. We report the case of a lady who presented with a cystic swelling in the suprascapular region that appeared after a fall on outstretched hands. Repeated aspiration and depomedrone injection failed to prevent recurrence. Surgical excision achieved complete removal, and histology showed the lesion as cystic lymphangioma, a rare condition to appear on the shoulder in an adult after trauma...
April 2005: European Archives of Oto-rhino-laryngology
E H Choy, G H Kingsley, B Khoshaba, N Pipitone, D L Scott
BACKGROUND: In rheumatoid arthritis (RA), intramuscular (IM) pulsed depomedrone expedites an immediate response to disease modifying antirheumatic drugs (DMARDs). Although IM depomedrone is also widely used to treat disease flares in patients treated with DMARDs, its effect on radiological progression has not been assessed. OBJECTIVE: To evaluate the benefits of 120 mg IM depomedrone versus placebo in patients with established RA whose disease was inadequately controlled by existing DMARDs...
September 2005: Annals of the Rheumatic Diseases
Paolo Ferrante, Andrew Ramsey, Catey Bunce, Susan Lightman
AIM: To compare the efficacy and side-effects of posterior sub-Tenon injection of triamcinolone acetonide (Kenalog) with orbital floor injection of methylpredisolone acetate (Depomedrone) in the management of posterior uveitis. METHODS: Non-randomized comparative prospective clinical study. Sixty-four eyes from 60 consecutive patients with non-infectious posterior uveitis requiring treatment were allocated on an alternate 1:1 basis to receive either orbital floor methylprednisolone or sub-Tenon triamcinolone using standard procedures and assessed at 6 and 12 weeks...
December 2004: Clinical & Experimental Ophthalmology
H N Khan, R Rampaul, R W Blamey
AIMS: We aimed to assess the effectiveness of a local anaesthetic and steroid combination injection therapy in the management of non-cyclical mastalgia. METHODS: Patients with non-cyclical mastalgia were assessed for rib tenderness (lateral chest wall tenderness-LCWT). The tenderest spot was injected with a combined preparation of 1 ml 2% lignocaine and 1 ml 40 mg depomedrone. Those who declined injection therapy were advised on topical or oral NSAIDs or reassurance...
April 2004: Breast: Official Journal of the European Society of Mastology
S Cheema, J Richardson, P McGurgan
Factors affecting the spread of bupivacaine in the paravertebral space were investigated in patients undergoing paravertebral nerve blocks for the treatment of chronically painful conditions. Injections of bupivacaine 0.5%, 10-15 ml mixed with depomedrone up to 80 mg were repeated at 2-wk intervals up to a maximum of four times. A blinded observer mapped out the subsequent distribution of sensory loss to cold on both sides of the torso at 5-min intervals after each injection. Age, sex, height and weight did not correlate with the block; nor did injectate volume, mass of bupivacaine, previous posterolateral thoractomy and spread of radiocontrast...
July 2003: Anaesthesia
J Richardson, P McGurgan, S Cheema, R Prasad, S Gupta
All 38 patients listed for day-case spinal endoscopy over a 12-month period (April 1998 - April 1999), who had chronic severe low back pain with a radiculopathic element, were studied prospectively. The mean [range] pain duration before treatment was 10.9 [2-26] years and 50% had failed back surgery syndrome. In all patients in whom treatment was completed (n = 34), the pain-generating nerve roots were located through symptom interaction with the patient. All had epidural scar tissue, 14 (41%) having dense adhesions...
May 2001: Anaesthesia
R M Meek, S McLellan, J F Crossan
Dupuytren's disease is a chronic inflammatory process which produces contractures of the fingers. The nodules present in Dupuytren's tissue contain inflammatory cells, mainly lymphocytes and macrophages. These express a common integrin known as VLA4. The corresponding binding ligands to VLA4 are vascular cell adhesion molecule-1 (VCAM-1) present on the endothelial cells and the CS1 sequence of the fibronectin present in the extracellular matrix. Transforming growth factor-beta (TGF-beta) is a peptide hormone which has a crucial role in the process of fibrosis...
July 1999: Journal of Bone and Joint Surgery. British Volume
A Bushell, L Klenerman, H Davies, I Grierson, M J Jackson
We examined the potential protective effect of pretreatment with corticosteroids or antioxidants (ascorbic acid or allopurinol) in rabbits with reperfusion-induced damage to skeletal muscle after ischemia. 4 hours of limb ischemia induced by a pneumatic tourniquet, followed by reperfusion for 1 hour, caused a considerable amount of ultrastructural damage to the anterior tibialis muscles accompanied by a rise in circulating creatine kinase activity. Pretreatment of animals with depomedrone by a single 8 mg bolus injection led to a preservation of the anterior tibialis structure on both light and electron microscopy...
August 1996: Acta Orthopaedica Scandinavica
P J Robinson, J P Davis, J G Fraser
This paper reports on 13 patients with a pain syndrome arising from the region of the greater cornu of the hyoid bone. It is often missed and yet is readily treatable. The syndrome causes pain on swallowing in the region of the hyoid which may radiate to the ear, face and lower jaw or may be felt also in the pharynx. Treatment by an injection of a mixture of depomedrone and one per cent lignocaine is very effective. The underlying pathology is discussed and it is suggested that in some cases the pain and discomfort experienced by patients may be due to tenosynovitis of the intermediate tendon of the digastric muscle...
October 1994: Journal of Laryngology and Otology
L Klenerman, R Greenwood, H T Davenport, D C White, S Peskett
A randomized trial of lumbar epidural injections for the treatment of acute sciatic pain was carried out. All the patients had unilateral sciatica for less than six months and had never previously been treated in hospital for their backs. The treatments used were 20 ml normal saline, 80 mg Depomedrone in normal saline made up to 20 ml, 20 ml, 20 ml 0.25% bupivacaine solution and needling with a standard Touhy injection needle into the interspinous ligament but with no injection. The patients improved at about the same rate for all four treatments...
February 1984: British Journal of Rheumatology
P I Brånemark, I Goldie
No abstract text is available yet for this article.
1967: Acta Rheumatologica Scandinavica
A W Sollom, J L Pearce, K Rubinstein
No abstract text is available yet for this article.
1969: Ophthalmologica. Journal International D'ophtalmologie
J S Phillpotts
No abstract text is available yet for this article.
1969: Transactions of the Ophthalmological Societies of the United Kingdom
T M Mukhtar
No abstract text is available yet for this article.
October 1974: Journal of Laryngology and Otology
A K Nachemson, G Lundborg, R Myrhage, F Rank
Pharmacological suppression of the scar reaction was tested as a possible method for improving axonal regeneration after transection and suture of the sciatic nerve of rats. The animals in the experimental groups were systemically treated post-operatively with estrogen-progesterone, methylprednisolone-acetate (Depomedrone) or cis-hydroxyproline. Only in the cis-hydroxyproline treated animals was there a tendency towards a decrease in fibroblastic activity at the suture site after 4 weeks. However, there was no difference in the growth of axons to the distal nerve segment after pharmacological treatment as compared to non-treated animals, when tested 12 weeks post-operatively...
1985: Scandinavian Journal of Plastic and Reconstructive Surgery
N C Andrew, Z J Gregor
A case of inadvertent intraocular injection of Depomedrone (methylprednisolone acetate) and its management by vitrectomy is discussed, with a review of previously reported cases.
April 1986: British Journal of Ophthalmology
S B Kelly, J Cooper, S Llewellyn, D E Khoo, J Virjee, C B Wood, R C Williamson, N A Habib
This phase II non-comparative trial evaluated the efficacy of intramuscular iodostearic acid in the treatment of 30 patients with advanced carcinoma of the gastrointestinal tract. These included 17 patients with colorectal carcinoma, seven with pancreatic carcinoma, four with gastric carcinoma, one with hepatocellular carcinoma and one with cholangiocarcinoma. Iodostearic acid emulsion (2 ml/1.2 g) followed by depomedrone (0.5 ml/10 mg) was injected intramuscularly twice weekly. No serious toxic effects were observed, the main side effects being local pain at the injection site and hot flushes...
August 1992: European Journal of Surgical Oncology
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