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fetal medicine foundation

Kathryn Graham, Felicity Park, Andrew McLennan, Marilena Pelosi, Paul Williams, Liona C Poon, Jon Hyett
BACKGROUND: The Fetal Medicine Foundation developed a multiple logistic regression algorithm for risk prediction of delivering a small for gestational age neonate. AIM: To validate this algorithm in an Australian population. METHODS: At the combined first trimester screen participants' medical histories, demographic data, mean arterial pressure, uterine artery pulsatility index and pregnancy-associated plasma protein-A were assessed. After delivery, risk of delivering a small for gestational age neonate at <37 or ≥37 weeks gestation was retrospectively calculated using the Fetal Medicine Foundation algorithm...
January 24, 2019: Australian & New Zealand Journal of Obstetrics & Gynaecology
Fionnuala Mone, Cecilia Mulcahy, Peter McParland, Paul Downey, Marie Culliton, Orla C Maguire, Eoghan E Mooney, Philip Clarke, David Fitzgerald, Elizabeth Tully, Fergal D Malone, Fionnuala M McAuliffe
OBJECTIVE:  To assess the effect of aspirin use in low-risk pregnancy on: (1) pregnancy-associated plasma protein-A (PAPP-A) and placental-like growth factor (PLGF); (2) urinary albumin-to-creatinine ratio (ACR) and blood pressure; (3) fetal growth parameters; and (4) placental histopathology. STUDY DESIGN:  This secondary analysis from the <u>T</u> rial of low-dose aspirin with an <u>E</u> arly <u>S</u> creening <u>T</u> est for preeclampsia and growth restriction randomized controlled trial was based on low-risk nulliparous women randomized at 11 weeks to (1) aspirin 75 mg; (2) no aspirin; and (3) aspirin based on the preeclampsia Fetal Medicine Foundation screening test...
January 15, 2019: American Journal of Perinatology
Stamatios Petousis, Alexandros Sotiriadis, Chrysoula Margioula-Siarkou, Ioannis Tsakiridis, Panagiotis Christidis, Menelaos Kyriakakis, Apostolos Mamopoulos, Apostolos Athanasiadis, Themistoklis Dagklis
OBJECTIVE: To assess the performance of sonography in the detection of fetal nonchromosomal abnormalities using a standard anatomic examination protocol proposed by International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) at 11+0 -13+6 weeks. MATERIALS AND METHODS: A prospective observational study was conducted between June 2013-May 2017 in singleton pregnancies attending for a routine scan at 11+0 -13+6 weeks. All examinations were performed by maternal-fetal medicine specialists certified by the Fetal Medicine Foundation according to the anatomic examination protocol described in the ISUOG guidelines...
January 7, 2019: Journal of Maternal-fetal & Neonatal Medicine
Fionnuala Mone, James F O'Mahony, Ella Tyrrell, Cecilia Mulcahy, Peter McParland, Fionnuala Breathnach, John J Morrison, John Higgins, Sean Daly, Amanda Cotter, Alyson Hunter, Patrick Dicker, Elizabeth Tully, Fergal D Malone, Charles Normand, Fionnuala M McAuliffe
The objective was to evaluate whether routine aspirin 75 mg is more cost-effective than the Fetal Medicine Foundation screen-and-treat approach for preeclampsia prevention in low-risk nulliparous women. A health economic decision analytical model was devised to estimate the discounted net health and cost outcomes of routine aspirin versus Fetal Medicine Foundation screening test-indicated aspirin for a cohort of 100 000 low-risk nulliparous women. Both strategies were compared with no intervention. A subanalysis also compared disaggregated components of the algorithm...
December 2018: Hypertension
Ioana C Lakovschek, Daniela Ulrich, Stefanie Jauk, Bence Csapo, Vassiliki Kolovetsiou-Kreiner, Karoline Mayer-Pickel, Christina Stern, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
OBJECTIVE: To better adjust the risk for preeclampsia, multifactorial models in first trimester of pregnancy have found the way in clinical practice. This study compares the available test algorithms. STUDY DESIGN: In a cross-sectional study between November 2013 and April 2016 we compared the tests results of three first trimester testing algorithms for preeclampsia in 413 women. Risk for preterm preeclampsia was calculated with three different algorithms: Preeclampsia Predictor™ Software by PerkinElmer (PERK), ViewPoint® Software by GE Healthcare (VP) and the online calculator of the Fetal Medicine Foundation (FMF)...
December 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
A Ciobanu, A Wright, A Syngelaki, D Wright, R Akolekar, K H Nicolaides
OBJECTIVES: To develop gestational age-based reference ranges for the pulsatility index in the umbilical artery (UA-PI) and fetal middle cerebral artery (MCA-PI) and the cerebroplacental ratio (MCA-PI/UA-PI), and to examine the maternal characteristics and medical history that affect these measurements. METHODS: This was a cross-sectional study of 72 387 pregnancies undergoing routine ultrasound examination at 20 + 0 to 22 + 6 weeks' gestation (n = 3712), 31 + 0 to 33 + 6 weeks (n = 29 035), 35 + 0 to 36 + 6 weeks (n = 37 252) or 41 + 0 to 41 + 6 weeks (n = 2388)...
October 24, 2018: Ultrasound in Obstetrics & Gynecology
Kun Huang, Yujie Dang, Pan Zhang, Cong Shen, Xuesong Sui, Guoliang Xia, Yingying Qin, Xue Jiao, Chao Wang, Ran Huo, Zi-Jiang Chen
STUDY QUESTION: What is the function of CAV1 in folliculogenesis and female reproduction? SUMMARY ANSWER: CAV1 regulates germline cyst breakdown and primordial follicle (PF) formation in mice, and CAV1 mutation may be related to premature ovarian insufficiency (POI). WHAT IS KNOWN ALREADY: Pre-granulosa cells are essential for the establishment of the PF pool, which determines female fertility and reproductive lifespan. Cav1 participates in vascularization in fetal mouse ovaries...
November 1, 2018: Human Reproduction
R K Kazal, S A Chowdhury, T T Mirza, H H Pervin, F Noor, B Chakma, F Z Aalpona
Thalassaemia is one of the commonest inherited disorders in Bangladesh. Since population is rapidly increasing in Bangladesh, therefore birth of large number of new cases is expected every year. Chorionic villus sampling (CVS) is an invasive diagnostic procedure done in early pregnancy to obtain fetal cells for the prenatal diagnosis of chromosomal and genetic disorders like thalassemia. To investigate the feasibility, safety, and outcome of transabdominal Chorionic Villus Sampling (CVS) for prenatal diagnosis of Beta Thalassemia, this retrospective analytical study was carried out on women who had undergone transabdominal CVS for prenatal diagnosis of Beta thalassemia...
July 2018: Mymensingh Medical Journal: MMJ
Daniel E Roth, Shaun K Morris, Stanley Zlotkin, Alison D Gernand, Tahmeed Ahmed, Shaila S Shanta, Eszter Papp, Jill Korsiak, Joy Shi, M Munirul Islam, Ishrat Jahan, Farhana K Keya, Andrew R Willan, Rosanna Weksberg, Minhazul Mohsin, Qazi S Rahman, Prakesh S Shah, Kellie E Murphy, Jennifer Stimec, Lisa G Pell, Huma Qamar, Abdullah Al Mahmud
BACKGROUND: It is unclear whether maternal vitamin D supplementation during pregnancy and lactation improves fetal and infant growth in regions where vitamin D deficiency is common. METHODS: We conducted a randomized, double-blind, placebo-controlled trial in Bangladesh to assess the effects of weekly prenatal vitamin D supplementation (from 17 to 24 weeks of gestation until birth) and postpartum vitamin D supplementation on the primary outcome of infants' length-for-age z scores at 1 year according to World Health Organization (WHO) child growth standards...
August 9, 2018: New England Journal of Medicine
Fionnuala Mone, Cecilia Mulcahy, Peter McParland, Fionnuala Breathnach, Paul Downey, Dorothy McCormack, Marie Culliton, Alice Stanton, Fiona Cody, John J Morrison, Sean Daly, John Higgins, Amanda Cotter, Alyson Hunter, Elizabeth C Tully, Patrick Dicker, Zarko Alfirevic, Fergal D Malone, Fionnuala M McAuliffe
OBJECTIVE: Evaluate the feasibility and acceptability of routine aspirin in low-risk women, compared with screening-test indicated aspirin for the prevention of pre-eclampsia and fetal growth restriction. DESIGN: Multicentre open-label feasibility randomised controlled trial. SETTING: Two tertiary maternity hospitals in Dublin, Ireland. PARTICIPANTS: 546 low-risk nulliparous women completed the study. INTERVENTIONS: Women underwent computerised randomisation to: Group 1-routine aspirin 75 mg from 11 until 36 weeks; Group 2-no aspirin and; Group 3-aspirin based on the Fetal Medicine Foundation screening test...
July 28, 2018: BMJ Open
Laila Pinheiro Abi Abib, Renato Augusto Moreira de Sá, Fernando Maia Peixoto-Filho
OBJECTIVE:  The main objective of this study was to examine the diagnostic performance of the first-trimester combined test for aneuploidies in unselected pregnancies from Rio de Janeiro and compare it with the examples available in the literature. METHODS:  We investigated 3,639 patients submitted to aneuploidy screening from February 2009 to September 2015. The examination is composed of the Fetal Medicine Foundation risk evaluation based on nuchal translucency evaluation, mother's age, presence of risk factors, presence of the nasal bone and Doppler of the ductus venous in addition to biochemical analysis of pregnancy-associated plasma protein A (PAPP-A) and beta-human chorionic gonadotropin (β-hCG) markers...
July 2018: Revista Brasileira de Ginecologia e Obstetrícia
Rebecca Fischbein, Lauren Nicholas, Julie Aultman, Kristin Baughman, Lynn Falletta
OBJECTIVE: Using patient-reported experiences, this study: 1) quantitatively evaluated TTTS screening trends, 2) examined screening and diagnostic experiences using a mixed methods approach, and 3) determined gaps in clinical care experiences. DESIGN: This was a cross-sectional study. Data was collected using a self-report, retrospective survey. A triangulation design was used to validate quantitative survey data with thematically analyzed qualitative data. SETTING: Participants were recruited through social media and national foundations and completed the survey online...
2018: PloS One
Jing Li, Ziqiang Fu, Hua Jiang, Liping Chen, Xian Wu, Hongjuan Ding, Yankai Xia, Xinru Wang, Qiuqin Tang, Wei Wu
STUDY QUESTION: What is the role of insulin-like growth factor 2 (IGF2)-derived miR-483-3p in macrosomia? SUMMARY ANSWER: IGF2-derived intronic miR-483-3p is overexpressed in macrosomia placentas, and miR-483-3p prompts HTR-8/SVneo extravillous trophoblast cell line proliferation through down-regulation of its target RB1 inducible coiled-coil 1 (RB1CC1). WHAT IS KNOWN ALREADY: Macrosomia is a common pregnancy-associated disease and causes a number of adverse maternal and perinatal outcomes...
September 1, 2018: Molecular Human Reproduction
Eric Courchesne, Tiziano Pramparo, Vahid H Gazestani, Michael V Lombardo, Karen Pierce, Nathan E Lewis
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, cellular, postmortem, animal model, and cell model evidence that shows ASD begins in the womb. This evidence leads to a new theory that ASD is a multistage, progressive disorder of brain development, spanning nearly all of prenatal life. ASD can begin as early as the 1st and 2nd trimester with disruption of cell proliferation and differentiation...
June 22, 2018: Molecular Psychiatry
Daniel L Rolnik, Fabricio da Silva Costa, Daljit Sahota, Jon Hyett, Andrew McLennan
AIM: To assess the quality of mean uterine artery pulsatility index (UtAPI) measurement in a first trimester pre-eclampsia screening program. METHODS: Consecutive patients attending first trimester screening for fetal chromosomal abnormalities also had combined screening for pre-eclampsia based on the Fetal Medicine Foundation (FMF) algorithm, in a large practice in Sydney, Australia, from May 2014 to February 2017. Distributions of mean UtAPI multiples of the median (MoM) on the logarithmic scale were plotted in relation to the normal median with 95% confidence interval (CI) for each operator and for each month...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
A Genoux, P Guerby, M Morin, B Perret, C Vayssière, S M Hamdi
GOALS: Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality. Early treatment by aspirin has been shown to significantly reduce PE risk before 37weeks supporting the implementation of first-trimester screening. SUBJECTS AND METHODS: A targeted screening was recently implemented at Toulouse University Hospital for women in their first pregnancy or those with personal or familial history of PE. It uses Fetal Medicine Foundation (FMF) algorithm that combines maternal characteristics, clinical, biophysical and biochemical (PAPP-A, Pregnancy Associated Plasma Protein-A, and PlGF, Placental Growth Factor) data...
June 2018: Annales de Cardiologie et D'angéiologie
Dayne Ortved, T Lee-Ann Hawkins, Jo-Ann Johnson, Jon Hyett, Amy Metcalfe
OBJECTIVE: Pre-eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first trimester screening algorithm predicting the risk of early onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11 to 13 weeks in women identified as high risk is effective at reducing the prevalence of early onset PE. The aim of this study is to evaluate the cost-effectiveness of this first trimester screening program coupled with early use of low-dose aspirin in women at high risk of developing early onset PE versus current practice...
April 27, 2018: Ultrasound in Obstetrics & Gynecology
K H Nicolaides, D Wright, A Syngelaki, A Wright, R Akolekar
OBJECTIVE: To develop fetal and neonatal population weight charts. The rationale was that, while reference ranges of estimated fetal weight (EFW) are representative of the whole population, the traditional approach of deriving birth-weight (BW) charts is misleading, because a large proportion of babies born preterm arise from pathological pregnancy. We propose that the reference population for BW charts, as in the case of EFW charts, should comprise all babies at a given gestational age, including those still in utero...
July 2018: Ultrasound in Obstetrics & Gynecology
Anca-Daniela Stanescu, Roxana Banica, Romina-Marina Sima, Liana Ples
No abstract text is available yet for this article.
September 25, 2018: Journal of Perinatal Medicine
L C Poon, D L Rolnik, M Y Tan, J L Delgado, T Tsokaki, R Akolekar, M Singh, W Andrade, T Efeturk, J C Jani, W Plasencia, G Papaioannou, A R Blazquez, I F Carbone, D Wright, K H Nicolaides
OBJECTIVE: To report the incidence of preterm pre-eclampsia (PE) in women who are screen positive according to the criteria of the National Institute for Health and Care Excellence (NICE) and the American College of Obstetricians and Gynecologists (ACOG), and compare the incidence with that in those who are screen positive or screen negative by The Fetal Medicine Foundation (FMF) algorithm. METHODS: This was a secondary analysis of data from the ASPRE study. The study population consisted of women with singleton pregnancy who underwent prospective screening for preterm PE by means of the FMF algorithm, which combines maternal factors and biomarkers at 11-13 weeks' gestation...
June 2018: Ultrasound in Obstetrics & Gynecology
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