Karen M Elias, Shanchita R Khan, Eva Stadler, Timothy E Schlub, Deborah Cromer, Mark N Polizzotto, Stephen J Kent, Tari Turner, Miles P Davenport, David S Khoury
BACKGROUND: Surrogates of antiviral efficacy are needed for COVID-19. We aimed to investigate the relationship between the virological effect of treatment and clinical efficacy as measured by progression to severe disease in outpatients treated for mild-to-moderate COVID-19. METHODS: In this systematic review and meta-analysis, we searched PubMed, Scopus, and medRxiv from database inception to Aug 16, 2023, for randomised placebo-controlled trials that tested virus-directed treatments (ie, any monoclonal antibodies, convalescent plasma, or antivirals) in non-hospitalised individuals with COVID-19...
April 4, 2024: The Lancet. Microbe