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https://read.qxmd.com/read/30761788/-biopotentials-of-the-urinary-bladder-during-functional-load
#1
A P Rytik, O Yu Kutikova, D A Usanov, V I Goremykin, E E Prosova
The study aimed to investigate the specific bioelectrical activity of the urinary bladder walls at a functional load. MATERIALS AND METHODS: The study comprised five subjects aged 18-22 years who had no diseases of the urinary system. Participants signed an informed consent form before entering the study, which was approved by the Ethics Committee of our organization. Biopotentials from the ureter and urinary bladder area were recorded using the Neuro-Spectrum NeuroSoft-21 Neuron Spectrum-4 electroencephalograph, which has a higher sensitivity compared to other biopotential amplifiers...
October 2018: Urologii︠a︡
https://read.qxmd.com/read/30759813/differential-response-following-infection-of-mouse-cns-with-virulent-and-attenuated-vaccinia-virus-strains
#2
Tomer Israely, Nir Paran, Noam Erez, Lilach Cherry, Hadas Tamir, Hagit Achdout, Boaz Politi, Ofir Israeli, Galia Zaide, Inbar Cohen-Gihon, Einat B Vitner, Shlomo Lustig, Sharon Melamed
Viral infections of the central nervous system (CNS) lead to a broad range of pathologies. CNS infections with Orthopox viruses have been mainly documented as an adverse reaction to smallpox vaccination with vaccinia virus. To date, there is insufficient data regarding the mechanisms underlying pathological viral replication or viral clearance. Therefore, informed risk assessment of vaccine adverse reactions or outcome prediction is limited. This work applied a model of viral infection of the CNS, comparing neurovirulent with attenuated strains...
February 12, 2019: Vaccines
https://read.qxmd.com/read/30747297/synthesis-of-chitosan-biocomposites-loaded-with-pyrrole-2-carboxylic-acid-and-assessment-of-their-antifungal-activity-against-aspergillus-niger
#3
Alma Carolina Gálvez-Iriqui, Mario Onofre Cortez-Rocha, Armando Burgos-Hernández, Montserrat Calderón-Santoyo, Waldo Manuel Argüelles-Monal, Maribel Plascencia-Jatomea
A wide variety of chitosan (CS) biomaterials have been loaded with different antimicrobial agents to improve the activity of CS against phytopathogenic fungi. Recently, the antimicrobial activity of 1H-pyrrole-2-carboxylic acid (PCA) has been reported as a secondary metabolite of Streptomyces griseus, which was identified as the main bioactive compound in the biological control. However, it is sensitive to light and its activity against filamentous fungi has not yet been reported. The aim of the present research work was to evaluate the biological activity of CS-PCA biocomposites for the control of Aspergillus niger...
February 12, 2019: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/30746574/ergonomics-in-handheld-and-robot-assisted-camera-control-a-randomized-controlled-trial
#4
Paul J M Wijsman, Lennert Molenaar, Cas D P Van't Hullenaar, Bas S T van Vugt, Wim A Bleeker, Werner A Draaisma, Ivo A M J Broeders
BACKGROUND: Laparoscopic surgery potentially increases the physical burden to operating theater personnel and can cause physical discomfort. This study aims to evaluate if a robotic camera holder (AutoLap™ system) can improve ergonomics for the surgeon and the camera assistant during laparoscopic procedures. METHODS: A total of thirty cases were included and randomized (15 AutoLap™, 15 control). Five types of surgery were included: right hemicolectomy, fundoplication, sigmoid resection, rectopexy, and low anterior resection...
February 11, 2019: Surgical Endoscopy
https://read.qxmd.com/read/30741873/posterior-thigh-foam-rolling-increases-knee-extension-fatigue-and-passive-shoulder-range-of-motion
#5
Estêvão R Monteiro, Pablo B Costa, Victor Gonçalves Corrêa Neto, Barbara J Hoogenboom, James Steele, Jefferson da Silva Novaes
Monteiro, ER, Costa, PB, Corrêa Neto, VG, Hoogenboom, BJ, Steele, J, and da Silva Novaes, J. Posterior thigh foam rolling increases knee extension fatigue and passive shoulder range-of-motion. J Strength Cond Res XX(X): 000-000, 2019-The purpose of this study was to analyze the acute effects of different foam rolling (FR) volumes on knee extensors fatigue and shoulder passive range-of-motion (PROM). Twelve recreationally active women were recruited for participation in 2 experiments separated by 3 weeks, and the same subjects performed all procedures in each experiment...
February 6, 2019: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/30741823/predictors-of-faster-virological-suppression-in-early-treated-infants-with-perinatal-hiv-from-europe-and-thailand
#6
Man K Chan, Ruth Goodall, Ali Judd, Nigel Klein, Elena Chiappini, Thomas Klimkait, Nicole Ngo-Giang-Huong, Paolo Palma, Paolo Rossi, Claire Thorne, Anna Turkova, Paola Zangari, Pieter L Fraaij, Dasja Pajkrt, Laura Marques, Intira J Collins, Diana M Gibb, Maria I Gonzalez-Tome, Maria L Navarro, Jose T Ramos, Antoni Noguera-Julian, Josiane Warszawski, Christoph Königs, Vana Spoulou, Filipa Prata, Tessa Goetghebuer, Luisa Galli, Lars Naver, Carlo Giaquinto, Magdalena Marczynska, Liubov Okhonskaia, Ruslan Malyuta, Alla Volokha, Luminita Ene, Pablo Rojo, Abdel G A Babiker
OBJECTIVE: To identify predictors of faster time to virological suppression among infants starting combination antiretroviral therapy (cART) early in infancy. DESIGN: Cohort study of infants from Europe and Thailand included in studies participating in the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC). METHODS: Infants with perinatal HIV starting cART aged <6 months with ≥1 viral load (VL) measurement within 15 months of cART initiation were included...
February 7, 2019: AIDS
https://read.qxmd.com/read/30738946/adepedia-on-ohdsi-a-next-generation-pharmacovigilance-signal-detection-platform-using-the-ohdsi-common-data-model
#7
Yue Yu, Kathryn J Ruddy, Na Hong, Shintaro Tsuji, Andrew Wen, Nilay D Shah, Guoqian Jiang
OBJECTIVE: Supplementing the Spontaneous Reporting System (SRS) with Electronic Health Record (EHR) data for adverse drug reaction detection could augment sample size, increase population heterogeneity and cross-validate results for pharmacovigilance research. The difference in the underlying data structures and terminologies between SRS and EHR data presents challenges when attempting to integrate the two into a single data base. The Observational Health Data Sciences and Informatics (OHDSI) collaboration provides a Common Data Model (CDM) for organizing and standardizing EHR data to support large-scale observational studies...
February 7, 2019: Journal of Biomedical Informatics
https://read.qxmd.com/read/30737611/risedronate-loaded-macroporous-gel-foam-enriched-with-nanohydroxyapatite-preparation-characterization-and-osteogenic-activity-evaluation-using-saos-2-cells
#8
Nadia M Morsi, Rehab Nabil Shamma, Nouran Osama Eladawy, Abdelfattah A Abdelkhalek
The application of minimally invasive surgical techniques in the field of orthopedic surgery has created a growing need for new injectable synthetic materials that can be used for bone grafting. In this work, novel injectable thermosensitive foam was developed by mixing nHAP powder with a thermosensitive polymer with foaming power (Pluronic F-127) and loaded with a water-soluble bisphosphonate drug (risedronate) to promote osteogenesis. The foam was able to retain the porous structure after injection and set through temperature change of PF-127 solution to form gel inside the body...
February 8, 2019: AAPS PharmSciTech
https://read.qxmd.com/read/30733893/factors-influencing-work-life-balance-in-physicians-and-advance-practice-clinicians-and-the-effect-of-heartfulness-meditation-conference-on-burnout
#9
Jayaram R Thimmapuram, Rodney Grim, Theodore Bell, Ronald Benenson, Mark Lavallee, Mihir Modi, David Noll, Ridgley Salter
Background: Burnout levels have risen in recent years and satisfaction with work-life balance has decreased. Individual and organizational factors may affect burnout in physicians and advance practice clinicians (APCs). Meditation is a tool to mitigate stress and enhance well-being. In this study, we assessed the factors affecting work-life balance in physicians and APCs. We also measured the impact of Heartfulness meditation conference on burnout. Methods: Physicians and APCs were surveyed through an abbreviated Maslach burnout inventory (aMBI) to assess the burnout levels and a question to assess the factors influencing work-life balance...
2019: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://read.qxmd.com/read/30732546/the-portuguese-version-of-the-hartford-geriatric-social-work-competency-scale-ii-assessment-subscale-factor-structure-and-psychometric-properties
#10
Fernanda Daniel, Rosa Monteiro, Jorge Ferreira, Ana Galhardo
The current study aimed to test the fit of the Portuguese version of the Hartford Geriatric Social Work Competency Scale II - Assessment subscale (GSWCS-A) and explore its factor structure and psychometric properties in a sample of 534 social workers working in the gerontology field. Confirmatory factor analysis showed that all items presented good factor loadings and that the single-component model fit the data well. The GSWCS-A showed very good internal consistency. Despite the existence of different theoretical perspectives on Social Work, which frame the required competencies for professional practice, the GSWCS-A Portuguese version revealed similitudes with studies conducted in other countries...
February 8, 2019: Journal of Gerontological Social Work
https://read.qxmd.com/read/30722827/the-effect-of-mental-health-on-weight-loss-after-bariatric-surgery
#11
Louise Tækker, Susanne Lunn
INTRODUCTION: Psychosocial assessment of pre-bariatric patients is an internationally recommended practice. However, the applicability of the assessments remains unaccounted for. This study investigated if the allocation of bariatric surgery candidates to a high-risk category on the basis of a psychosocial assessment correlates with attenuated weight loss and reduced mental health improvements. METHODS: The assessment procedure consisted of standardised psychometric questionnaires, structured diagnostic interviews and semi-structured interviews...
February 2019: Danish Medical Journal
https://read.qxmd.com/read/30712507/outcomes-and-implementation-challenges-of-using-daily-treatment-regimens-with-an-innovative-adherence-support-tool-among-hiv-infected-tuberculosis-patients-in-karnataka-india-a-mixed-methods-study
#12
Pruthu Thekkur, Ajay Nv Kumar, Palanivel Chinnakali, Sriram Selvaraju, Ramachandra Bairy, Akash Ranjan Singh, Abhay Nirgude, Kalaiselvi Selvaraj, Vinayagamoorthy Venugopal, Suresh Shastri
BACKGROUND: In India, a new care package consisting of (i) daily regimen with fixed-dose combination drugs, collected once-a-month and self-administered by the patient, (ii) 'one stop service' at antiretroviral treatment (ART) centre for both HIV and tuberculosis (TB) treatment and (iii) technology-enabled adherence support (99DOTS, which required patients to give a missed phone call after consuming drugs) was piloted for treatment of TB among HIV-infected TB patients. Conventional care included intermittent regimen (drugs consumed thrice-weekly) delivered under direct observation of treatment supporter and the patients needing to visit TB and HIV care facilities, separately for treatment...
2019: Global Health Action
https://read.qxmd.com/read/30710796/biomechanical-analysis-of-metacarpophalangeal-joint-arthroplasty-with-metal-polyethylene-implant-an-in-vitro-study
#13
D Melo, A Completo, A Nascimento, F Fonseca
BACKGROUND: The most common implant options for the metacarpophalangeal joint arthroplasty include silicone, pyrocarbon and metal-polyethylene. A systematic review of outcomes of silicone and pyrocarbon implants was conducted; however, a similar exercise for metal-polyethylene implants revealed a scarcity of published results and lack of long-term follow-up studies. The aim of the present work is to test the hypothesis that the magnitude of metacarpophalangeal joint cyclic loads generates stress and strain behaviour, which leads to long-term reduced risk of metal-polyethylene component loosening...
January 22, 2019: Clinical Biomechanics
https://read.qxmd.com/read/30707640/identifying-troublesome-jargon-in-biology-discrepancies-between-student-performance-and-perceived-understanding
#14
Jenna M Zukswert, Megan K Barker, Lisa McDonnell
The excessive "jargon" load in biology may be a hurdle for developing conceptual understanding as well as achieving core competencies such as scientific literacy and communication. Little work has been done to characterize student understanding of biology--specific jargon. To address this issue, we aimed to determine the types of biology jargon terms that students struggle with most, the alignment between students' perceived understanding and performance defining the terms, and common errors in student-provided definitions...
March 2019: CBE Life Sciences Education
https://read.qxmd.com/read/30706276/techno-economic-assessment-of-coconut-biodiesel-as-a-potential-alternative-fuel-for-compression-ignition-engines
#15
Jeyaseelan Thangaraja, Vignesh Srinivasan
Over the past years, there were dramatic improvements in identifying and assessing various feedstocks for the production of biodiesel fuels. To promote a particular feedstock as a renewable source of energy, it is important to analyze their energy, economic, and engine performance characteristics. The current work attempts to evaluate the net energy and economic indices for both fossil diesel and coconut-blended diesel (B20) considering the diesel consumption by the Indian railways. Further, we present the experimental results of a multi-cylinder diesel engine operated with neat coconut biodiesel (B100) and fossil diesel at various load and speed conditions...
February 1, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30699170/objective-measures-of-rollator-user-stability-and-device-loading-during-different-walking-scenarios
#16
Eleonora Costamagna, Sibylle B Thies, Laurence P J Kenney, David Howard, Ulrich Lindemann, Jochen Klenk, Rose Baker
Walking aids are widely used by older adults, however, alarmingly, their use has been linked to increased falls-risk, yet clinicians have no objective way of assessing user stability. This work aims to demonstrate the application of a novel methodology to investigate how the type of walking task, the amount of body weight supported by the device (i.e., device loading), and task performance strategy affect stability of rollator users. In this context, ten users performed six walking tasks with an instrumented rollator...
2019: PloS One
https://read.qxmd.com/read/30697479/gps-motivation-for-teaching-medical-students-in-a-rural-area-development-of-the-motivation-for-medical-education-questionnaire-mome-q
#17
Charles Christian Adarkwah, Annette Schwaffertz, Joachim Labenz, Annette Becker, Oliver Hirsch
Background: The establishment of a medical education program in the rural area of Siegen is planned to be the first step against a shortage of physicians in this region. General practitioners (GPs) will be extensively involved in this program as Family Medicine (Allgemeinmedizin) will become a core subject in the curriculum nationwide. Based on this situation we aim to figure out GPs motivation to participate in medical education. For this purpose, we had to construct and test a new questionnaire...
2019: PeerJ
https://read.qxmd.com/read/30694972/blood-flow-restriction-only-increases-myofibrillar-protein-synthesis-with-exercise
#18
Jean Nyakayiru, Cas J Fuchs, Jorn Trommelen, Joey S J Smeets, Joan M Senden, Annemie P Gijsen, Antoine H Zorenc, Luc J C van Loon, Lex B Verdijk
PURPOSE: Combining blood flow restriction (BFR) with exercise can stimulate skeletal muscle hypertrophy. Recent observations in an animal model suggest that BFR performed without exercise can also induce anabolic effects. We assessed the impact of BFR performed both with and without low-load resistance-type exercise (LLRE) on in vivo myofibrillar protein synthesis rates in young men. METHODS: Twenty healthy young men (age: 24±1 y, BMI: 22.9±0.6 kg/m) were randomly assigned to remain in resting condition (REST+/-BFR; n=10), or to perform LLRE (LLRE+/-BFR at 20%1RM; n=10), combined with two 5-min cycles of single leg BFR...
January 25, 2019: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/30691145/weight-bearing-estimation-for-cane-users-by-using-onboard-sensors
#19
Joaquin Ballesteros, Alberto Tudela, Juan Rafael Caro-Romero, Cristina Urdiales
Mobility is a fundamental requirement for a healthy, active lifestyle. Gait analysis is widely acknowledged as a clinically useful tool for identifying problems with mobility, as identifying abnormalities within the gait profile is essential to correct them via training, drugs, or surgical intervention. However, continuous gait analysis is difficult to achieve due to technical limitations, namely the need for specific hardware and constraints on time and test environment to acquire reliable data. Wearables may provide a solution if users carry them most of the time they are walking...
January 26, 2019: Sensors
https://read.qxmd.com/read/30690824/danish-translation-and-adaptation-of-the-context-assessment-index-with-implications-for-evidence-based-practice
#20
Bibi Hølge-Hazelton, Line Zacho Bruun, Paul Slater, Brendan McCormack, Thora Grothe Thomsen, Susanne Hwiid Klausen, Tracey Bucknall
BACKGROUND: Healthcare contexts are rapidly changing, with growing demand for health services to accommodate an aging population and financial pressures. Assessment of context in healthcare settings has been the subject of increasing debate. The Context Assessment Index (CAI) examines three interconnected contextual elements derived from the Promoting Action on Research Implementation in Health Services (PARIHS) framework to provide practitioners with an understanding of the context in which they work...
January 28, 2019: Worldviews on Evidence-based Nursing
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