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Advanced glycation endproduct

Jiao Qin, Zhangzhe Peng, QiongJing Yuan, Qian Li, Yu Peng, Rui Wen, Zhaolan Hu, Jun Liu, Xiongfang Xia, Hong Deng, Xuan Xiong, Jinyue Hu, Lijian Tao
Diabetic nephropathy (DN) is a major complication of diabetes. Currently, drugs are not available to effectively control the disease. Fluorofenidone (AKF-PD) is a recently developed drug; it possesses activities in reducing DN progression in preclinical research. Nonetheless, its renal protection and the underlying mechanisms have not been thoroughly investigated. We report here that AKF-PD significantly alleviatesrenal oxidative stress (OS) in db/dbmice through downregulation of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase and upregulation of glutathione peroxidase and superoxide dismutase, thereby protecting kidney from DN pathogenesis...
March 13, 2019: Scientific Reports
HeatherB Hunt, AshleyM Torres, PabloM Palomino, Eric Marty, Rehan Saiyed, Matthew Cohn, Jonathan Jo, Stephen Warner, GrazynaE Sroga, KarenB King, JosephM Lane, Deepak Vashishth, ChristopherJ Hernandez, Eve Donnelly
People with type 2 diabetes mellitus (T2DM) have normal to high bone mineral densities, but, counterintuitively, have greater fracture risks than people without T2DM, even after accounting for potential confounders like BMI and falls. Therefore, T2DM may alter aspects of bone quality, including material properties or microarchitecture, that increase fragility independently of bone mass. Our objective was to elucidate the factors that influence fragility in T2DM by comparing the material properties, microarchitecture, and mechanical performance of cancellous bone in a clinical population of men with and without T2DM...
March 13, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Ya-Jing Chen, Li Kong, Zhuang-Zhuang Tang, Yu-Meng Zhang, Yue Liu, Tao-Yun Wang, Yao-Wu Liu
Diabetic nephropathy (DN) is one of the most common diabetic complications, and alpha-carbonyl aldehydes and their detoxicating enzyme glyoxalase 1 (Glo-1) play vital roles in pathogenesis of diabetic complications. The aim of this study was to evaluate the renoprotective effects of hesperetin against DN in rats, and to investigate mechanisms from the aspect of Nrf2/ARE/Glo-1 pathway. Streptozotocin-induced diabetic rats were treated orally with hesperetin (50 and 150 mg/kg), or nuclear factor erythroid-derived-2-like 2 (Nrf2) inducer tert-butylhydroquinone (tBHQ, 25 mg/kg) for 10 weeks...
March 2019: Biomedicine & Pharmacotherapy
Meltem Sertbas, Yasar Sertbas, Ozden Ezgi Uner, Serkan Elarslan, Nalan Okuroglu, Feyza Ak, Akin Dayan, Ali Ozdemır
INTRODUCTION Diabetes and its complications are a significant cause of morbidity and mortality. Advanced glycation endproducts (AGEs) play a major role in the pathogenesis of  diabetes complications. OBJECTIVES To investigate the possible uses of a biomicroscope (ClearPath DS-120) that shows age-adjusted lens fluorescence ratios (LFRs) for the diagnosis of diabetic peripheral neuropathy (DPN). PATIENTS AND METHODS One hundred and sixty type 2 diabetic patients who underwent LFR measurement were recruited to this study...
February 14, 2019: Polish Archives of Internal Medicine
Wei Wang, Nicole M Chapman, Bo Zhang, Mingqi Li, Meiyun Fan, R Nicholas Laribee, M Raza Zaidi, Lawrence M Pfeffer, Hongbo Chi, Zhao-Hui Wu
Solar ultraviolet radiation (UVR) suppresses skin immunity, which facilitates initiation of skin lesions and establishment of tumors by promoting immune evasion. It is unclear whether immune checkpoints are involved in the modulation of skin immunity by UVR. Here we report that UVR exposure significantly increased expression of immune checkpoint molecule PD-L1 in melanoma cells. The damage-associated molecular patterns molecule HMGB1 was secreted by melanocytes and keratinocytes upon UVR, which subsequently activated the receptor for advanced glycation endproducts (RAGE) receptor to promote NF-kB- and IRF3-dependent transcription of PD-L1 in melanocytes...
February 8, 2019: Cancer Research
Rosanna Squitti, Armando Mendez, Camillo Ricordi, Mariacristina Siotto, Ron Goldberg
Trace metal dyshomeostasis has been linked to loss of cognitive performance. In particular, a disturbance in the regulation of copper (Cu), characterized by an increase in circulating Cu not bound to ceruloplasmin (non-Cp Cu), is thought to play a role in the development of Alzheimer disease (AD) and other neurodegenerative diseases in the aging population. Non-Cp Cu is redox active and its toxicity is thought to result from its ability to accelerate oxidative stress and advanced glycation endproduct (AGE) formation, leading to extracellular matrix damage in tissues including the brain...
January 10, 2019: Alzheimer Disease and Associated Disorders
Ruslan Rafikov, Matthew L McBride, Marina Zemskova, Sergey Kurdyukov, Nolan McClain, Maki Niihori, Paul R Langlais, Olga Rafikova
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by progressive pulmonary vascular remodeling. The receptor for advanced glycation endproducts (RAGE) plays an important role in PAH by promoting proliferation of pulmonary vascular cells. RAGE is also known to mediate activation of Akt signaling, although the particular molecular mechanism remains unknown. This study aimed to identify the interacting partner of RAGE that could facilitate RAGE-mediated Akt activation and vascular remodeling in PAH...
January 3, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
Minzhuo Liu, Fen Tang, Qi Liu, Jianbo Xiao, Hui Cao, Xiaoqing Chen
The study on inhibitory effects of resveratrol glucosides (REs) on advanced glycation endproducts (AGEs) formation is still unmet. Herein, for the first time, the antiglycation activities of five REs in the fetal bovine serum proteins (FBS)/fructose system were evaluated, and its structure-activity relationship and antiglycation mechanism were further explored. These REs showed remarkable inhibition toward AGEs formation. Among them, Piceatannol-3'-O-glucoside (PG) exhibited highest antiglycation activity as reflected in approximately 80% inhibition of fluorescent AGEs at the concentration of 1...
December 22, 2018: Natural Product Research
Julia Derk, Michael MacLean, Judyta Juranek, Ann Marie Schmidt
No abstract text is available yet for this article.
2018: Journal of Alzheimer's Disease and Parkinsonism
Zhen Zhang, Hanlin Yang, Jingyu Yang, Jun Xie, Jiaoyan Xu, Chen Liu, Chunfu Wu
Oxidative stress and neuroinflammation are thought to be the two key early events during the process of mild cognitive impairment (MCI). Therefore, effective regulation of oxidative stress and neuroinflammation is an important aspect of preventing and improving MCI. We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, markedly reduced cognitive impairment in APP/PS1 mice and oAβ1-42 -injected mice. In the present study, we further evaluate the effect of PF11 on learning and memory dysfunction in d‑galactose (d‑gal)-treated mice model of MCI...
December 8, 2018: International Immunopharmacology
Raelene J Pickering, Christos Tikellis, Carlos J Rosado, Despina Tsorotes, Alexandra Dimitropoulos, Monique Smith, Olivier Huet, Ruth M Seeber, Rekhati Abhayawardana, Elizabeth Km Johnstone, Jonathan Golledge, Yutang Wang, Karin A Jandeleit-Dahm, Mark E Cooper, Kevin Dg Pfleger, Merlin C Thomas
Activation of the type 1 angiotensin II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glycation endproducts (RAGE). Activation of the AT1 receptor by angiotensin II (Ang II) triggered transactivation of the cytosolic tail of RAGE and NF-κB-driven proinflammatory gene expression independently of the liberation of RAGE ligands or the ligand-binding ectodomain of RAGE...
December 10, 2018: Journal of Clinical Investigation
Timme van der Lugt, Antje R Weseler, Wouter A Gebbink, Misha F Vrolijk, Antoon Opperhuizen, Aalt Bast
Advanced glycation endproducts (AGEs) can be found in protein- and sugar-rich food products processed at high temperatures, which make up a vast amount of the Western diet. The effect of AGE-rich food products on human health is not yet clear and controversy still exists due to possible contamination of samples with endotoxin and the use of endogenous formed AGEs. AGEs occur in food products, both as protein-bound and individual molecules. Which form exactly induces a pro-inflammatory effect is also unknown...
December 2, 2018: Nutrients
Zeba Siddiqui, Mohammad Faisal, Abdulrahman A Alatar, Saheem Ahmad
Non-enzymatic glycation occurs rapidly which ultimately leads to the formation of advanced glycation endproducts (AGEs). These AGEs have shown to associated with the development of many diseases such as diabetes-mellitus. This study is focused on immunological characterization of glycated-Hb induced by d-ribose. Here, we analysed the immunogenicity of glycated-Hb by direct binding and competitive inhibition ELISA. Direct binding ELISA confirmed that glycated-Hb was highly immunogenic and induced high titre antibodies as compared to native-Hb...
November 13, 2018: International Journal of Biological Macromolecules
Qiaochu Zhu, Emily A Smith
The interactions between the cytoplasmic protein diaphanous-1 (Diaph1) and the receptor for advanced glycation endproducts (RAGE) drive the negative consequences of RAGE signaling in several disease processes. Reported in this work is how Diaph1 affects the nanoscale clustering and diffusion of RAGE measured using super-resolution stochastic optical reconstruction microscopy (STORM) and single particle tracking (SPT). Altering the Diaph1 binding site has a different impact on RAGE diffusion compared to when Diaph1 expression is reduced in HEK293 cells...
October 26, 2018: Biochimica et Biophysica Acta. Biomembranes
Mitchell Bijnen, Nicky Beelen, Suzan Wetzels, José van de Gaar, Maria Vroomen, Erwin Wijnands, Jean L Scheijen, Marjo P H van de Waarenburg, Marion J Gijbels, Jack P Cleutjens, Erik A L Biessen, Coen D A Stehouwer, Casper G Schalkwijk, Kristiaan Wouters
Non-alcoholic fatty liver disease is a spectrum of liver diseases ranging from steatosis only to non-alcoholic steatohepatitis (NASH). The latter is characterized by hepatic inflammation, which increases the risk of cardiovascular disease. It is poorly understood which factors contribute to the onset of hepatic inflammation characterizing the progression from steatosis to NASH. Previously, we demonstrated increased advanced glycation endproducts (AGEs) in the livers of NASH patients. We hypothesise that AGEs play a key role in NASH development by activating their proinflammatory receptor, RAGE...
October 15, 2018: Scientific Reports
Ali Aljohi, Sabine Matou-Nasri, Donghui Liu, Nadia Al-Khafaji, Mark Slevin, Nessar Ahmed
Diabetes mellitus characterized by hyperglycemia favors formation of advanced glycation endproducts (AGEs) capable of triggering vascular complications by interfering with imbalanced inflammation and angiogenesis to eventually impede wound-healing. Momordica charantia (MC, bitter melon) has been shown to prevent AGE formation and to promote angiogenesis in diabetic wounds in animal models. However, the mechanism underlying its effects on angiogenesis is unclear. We investigated the effects of methanolic extracts of MC pulp (MCP), flesh (MCF) and charantin (active component of MC) using an in vitro model of angiogenesis...
November 14, 2018: Food & Function
Fabrizio Grosjean, Elena M Yubero-Serrano, Feng Zheng, Vittoria Esposito, Shobha Swamy, Sharon J Elliot, Weijing Cai, Helen Vlassara, Fadi Salem, Gary E Striker
Diabetic kidney disease (DKD) is characterized by progressive glomerulosclerosis (GS). ROP mice have a sclerosis-prone phenotype. However, they develop severe, rapidly progressive GS when rendered diabetic. Since GS also develops in aged C57Bl6 mice, and can be reversed using bone marrow from young mice which have lower oxidative stress and inflammation (OS/Infl), we postulated that this might also apply to DKD. Therefore, this pilot study asked whether reducing OS/Infl in young adult sclerosis-prone (ROP) diabetic mice leads to resolution of existing GS in early DKD using safe, FDA-approved drugs...
2018: PloS One
Rabia Nabi, Sahir Sultan Alvi, Mohd Saeed, Saheem Ahmad, M Salman Khan
INTRODUCTION: Diabetes mellitus (DM) acts as an absolute mediator of cardiovascular risk, prompting the prolonged occurrence, size and intricacy of atherosclerotic plaques via enhanced advanced glycation endproducts (AGEs) formation. Moreover, hyperglycemia is associated with enhanced glyco-oxidized and oxidized low-density lipoprotein (LDL) possessing greater atherogenicity and decreased ability to regulate HMG-CoA reductase (HMG-R). Although aminoguanidine (AG) prevents the AGE-induced protein cross-linking due to its anti-glycation potential, it exerts several unusual pharmaco-toxicological effects thus restraining its desirable therapeutic effects...
September 24, 2018: Current Diabetes Reviews
Suzanne May Quinn Tan, Yilynn Chiew, Badariah Ahmad, Khalid Abdul Kadir
Tocotrienol-rich vitamin E from palm oil (Tocovid) has been shown to ameliorate diabetes through its superior antioxidant, antihyperglycemic, and anti-inflammatory properties in diabetic rats. This study aimed to investigate the effects of Tocovid on diabetic nephropathy in patients with type 2 diabetes. Baseline parameters of potential subjects such as HbA1c, blood pressure, Advanced Glycation Endproduct (AGE), soluble receptor for AGE (sRAGE), Nε-Carboxymethyllysine (Nε-CML), and Cystatin C were assessed for possible correlation with diabetic nephropathy...
September 17, 2018: Nutrients
Xiang Fang, Brenda Dorcely, Xi-Ping Ding, Shi Yin, Ni-Huiping Son, Shi-Lian Hu, Ira J Goldberg
OBJECTIVE: Systemic inflammation contributes to cardiovascular disease in patients with type 2 diabetes, and elevated white blood cell (WBC) counts are an established risk factor. Our goal is to describe changes in WBCs and inflammatory markers after glycemic reductions in diabetes. RESEARCH DESIGN AND METHODS: This study enrolled 63 subjects with poorly controlled diabetes, defined as hemoglobin A1c (HbA1c) ≥8% [64 mmol/mol]. Circulating granulocytes and mononuclear cells were separated by histopaque double-density protocol...
November 2018: Journal of Diabetes and its Complications
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