keyword
https://read.qxmd.com/read/38533577/plasma-neurofilament-light-chain-is-increased-in-niemann-pick-type-c-but-glial-fibrillary-acidic-protein-remains-normal
#1
JOURNAL ARTICLE
Dhamidhu Eratne, Courtney Lewis, Wendy Kelso, Samantha Loi, Wei-Hsuan Michelle Chiu, Kaj Blennow, Henrik Zetterberg, Alexander F Santillo, Dennis Velakoulis, Mark Walterfang
OBJECTIVE: Niemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls. METHODS: Patients with NPC were recruited from a specialist assessment and management service...
March 27, 2024: Acta Neuropsychiatrica
https://read.qxmd.com/read/38502013/-the-self-identity-of-psychiatry-in-the-21st-century
#2
JOURNAL ARTICLE
László Tringer
The relationship of mentally ill patients and the relational society has constantly changed during the course of history. The changes are true reflexions of the given society. In the management of behaviours disturbing community life medical treatment, law enforcement and religious measures change periodically, sometimes one, sometimes the other comes to the fore. One of the most influential spiritual currents of the 20th century has been the dismantling of large institutions, called deinstitutionalisation, which process could be experienced by the currently active professional generations...
2024: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://read.qxmd.com/read/38486046/association-of-semaglutide-with-reduced-incidence-and-relapse-of-cannabis-use-disorder-in-real-world-populations-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
William Wang, Nora D Volkow, Nathan A Berger, Pamela B Davis, David C Kaelber, Rong Xu
Cannabis is the most frequently used illicit drug in the United States with more than 45 million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high prevalence, there are currently no FDA-approved medications for CUD. Patients treated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) approved for treating type 2 diabetes (T2D) and for weight management have reported reduced desire to drink and smoke. Preclinical studies have shown that semaglutide decreased nicotine and alcohol consumption...
March 14, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38480874/painful-physical-symptoms-and-antidepressant-treatment-outcome-in-depression-a-systematic-review-and-meta-analysis
#4
Jia Jia Liu, Xiao Huang, Yan-Ping Bao, Lin Lu, Ping Dong, Owen M Wolkowitz, John R Kelsoe, Jie Shi, Ya Bin Wei
BACKGROUND: Painful physical symptoms (PPS) are highly prevalent in patients with major depressive disorder (MDD). Presence of PPS in depressed patients are potentially associated with poorer antidepressant treatment outcome. We aimed to evaluate the association of baseline pain levels and antidepressant treatment outcomes. METHODS: We searched PubMed, Embase and Cochrane Library databases from inception through February 2023 based on a pre-registered protocol (PROSPERO: CRD42022381349)...
March 13, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38446713/drug-repurposing-and-personalized-treatment-strategies-for-bipolar-disorder-using-transcriptomic
#5
JOURNAL ARTICLE
Paola Rampelotto Ziani, Marco Antônio de Bastiani, Ellen Scotton, Pedro Henrique da Rosa, Tainá Schons, Giovana Mezzomo, Quênia de Carvalho, Flávio Kapczinski, Adriane R Rosa
OBJECTIVE: The present study combined transcriptomic data and computational techniques based on gene expression signatures to identify novel bioactive compounds or FDA-approved drugs for the management of Bipolar Disorder (BD). METHODS: Five transcriptomic datasets, comprising a total of 165 blood samples from BD case-control, were selected from the Gene Expression Omnibus repository (GEO). The number of subjects varied from 6 to 60, with a mean age ranging from 35 to 48, with a gender variation between them...
March 6, 2024: Revista Brasileira de Psiquiatria
https://read.qxmd.com/read/38426610/annual-research-review-neuroimmune-network-model-of-depression-a%C3%A2-developmental-perspective
#6
REVIEW
Robin Nusslock, Lauren B Alloy, Gene H Brody, Gregory E Miller
Depression is a serious public health problem, and adolescence is an 'age of risk' for the onset of Major Depressive Disorder. Recently, we and others have proposed neuroimmune network models that highlight bidirectional communication between the brain and the immune system in both mental and physical health, including depression. These models draw on research indicating that the cellular actors (particularly monocytes) and signaling molecules (particularly cytokines) that orchestrate inflammation in the periphery can directly modulate the structure and function of the brain...
April 2024: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://read.qxmd.com/read/38412941/exploring-the-clinical-potentials-of-zuranolone-in-managing-postpartum-depression-a-new-therapeutic-horizon
#7
JOURNAL ARTICLE
Abdulqadir J Nashwan, Syeda Tayyaba Rehan, Laiba Imran, Samina Ghulam Abbas, Sara Fahim Khan
Postpartum depression (PPD) poses a major threat to maternal mental health and wellbeing while also adversely affecting the mother's relationship with her baby, leading to significant repercussions that may hinder the growth and cognitive development of the child. For decades, antidepressants have been the mainstay of treating PPD; however, recent evidence suggests that antidepressants are not as effective as they are believed to be and there is a dire need to explore new treatment options. In 2023, a breakthrough in treating PPD emerged with the recent FDA approval of zuranolone, a gamma-aminobutyric acid (GABAA ) receptor selective positive allosteric modulator...
February 25, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38387698/expectancy-effects-in-psychedelic-trials
#8
REVIEW
Balázs Szigeti, Boris Heifets
Clinical trials of psychedelic compounds like psilocybin, LSD and DMT have forced a reconsideration of how non-drug factors, like participant expectations, are measured and controlled in mental health research. As doses of these profoundly psychoactive substances increase, so does the difficulty in concealing the treatment condition in the classic double-blind, placebo-controlled trial design. As widespread public enthusiasm for the promise of psychedelic therapy grows, so do questions regarding whether, and how much, trial results are biased by positive expectancy...
February 20, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38369426/french-society-for-biological-psychiatry-and-neuropsychopharmacology-afpbn-guidelines-for-the-management-of-patients-with-partially-responsive-depression-and-treatment-resistant-depression-update-2024
#9
JOURNAL ARTICLE
Antoine Yrondi, Hervé Javelot, Bénédicte Nobile, Ludivine Boudieu, Bruno Aouizerate, Pierre-Michel Llorca, Thomas Charpeaud, Djamila Bennabi, Antoine Lefrere, Ludovic Samalin
INTRODUCTION: The purpose of this update is to add newly approved nomenclatures and treatments as well as treatments yet to be approved in major depressive disorder, thus expanding the discussions on the integration of resistance factors into the clinical approach. METHODS: Unlike the first consensus guidelines based on the RAND/UCLA Appropriateness Method, the French Association for Biological Psychiatry and Neuropsychopharmacology (AFPBN) developed an update of these guidelines for the management of partially responsive depression (PRD) and treatment-resistant depression (TRD)...
February 17, 2024: L'Encéphale
https://read.qxmd.com/read/38367037/french-society-for-biological-psychiatry-and-neuropsychopharmacology-and-french-speaking-marc%C3%A3-society-guidelines-for-the-management-of-mood-disorders-in-women-before-during-and-after-pregnancy
#10
JOURNAL ARTICLE
Raoul Belzeaux, Florence Gressier, Ludivine Boudieu, Adeline Arnould, Elsa Moreau, Julia Pastol, Eleni Tzavara, Anne Laure Sutter-Dallay, Ludovic Samalin
PURPOSE: The French Society for Biological Psychiatry and Neuropsychopharmacology and the French-speaking Marcé Society have joined forces to establish expert recommendations on the prescription of psychotropic drugs before, during, and after pregnancy in women with major depressive disorder (MDD) and bipolar disorder (BD). METHODS: To elaborate recommendations, we used the RAND/UCLA Appropriateness Method, which combines scientific evidence and expert clinicians' opinions...
February 17, 2024: Archives of Women's Mental Health
https://read.qxmd.com/read/38366113/association-of-chronic-pain-with-suicide-attempt-and-death-by-suicide-a-two-sample-mendelian-randomization
#11
JOURNAL ARTICLE
Jude Balit, Annette Erlangsen, Anna Docherty, Gustavo Turecki, Massimiliano Orri
Prior studies have suggested an association between chronic pain and suicidal behavior. However, evidence supporting the causal nature of this association, and the role played by depression, remain difficult to establish due to confounding. We investigated associations of chronic pain with suicide attempt and death by suicide as well as the mediating role of depression in this association using a genetically informed method strengthening causal inference. We conducted a two-sample Mendelian randomization. Independent SNPs (N = 97) from the multisite chronic pain GWAS (NGWAS  = 387,649) were used as instrumental variables to test associations of chronic pain with suicide attempt (measured from hospital records; NGWAS  = 50,264) and death by suicide (measured from official death causes; NGWAS  = 18,085)...
February 16, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38365103/increased-grey-matter-volumes-in-the-temporal-lobe-and-its-relationship-with-cognitive-functioning-in-euthymic-patients-with-bipolar-disorder
#12
JOURNAL ARTICLE
D Porta-Casteràs, M Vicent-Gil, M Serra-Blasco, G Navarra-Ventura, B Solé, L Montejo, C Torrent, A Martinez-Aran, V De la Peña-Arteaga, D Palao, E Vieta, N Cardoner, M Cano
BACKGROUND: Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD patients may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructural alterations are related to the cognitive profile of BD is unclear. METHODS: We aim to explore this relationship in euthymic BD patients with multimodal structural neuroimaging...
February 14, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38363330/corticosteroids-and-mania-a-systematic-review
#13
REVIEW
Mathias DeBock, Pascal Sienaert
Objectives: Corticosteroids are widely prescribed for a variety of medical conditions. Accumulating evidence suggests that their use may be associated with adverse psychiatric effects, including mania. In this systematic review, we aim to critically evaluate the existing literature on the association between corticosteroid use and the emergence of mania. Methods: We conducted a comprehensive search of major electronic databases (PubMed, Embase, Cochrane Library) for relevant studies published up to the date of the search (January 12th , 2023)...
February 16, 2024: World Journal of Biological Psychiatry
https://read.qxmd.com/read/38318421/effort-reward-and-overcommitment-at-work-and-psychiatric-symptoms-in-healthcare-professionals-the-mediation-role-of-allostatic-load
#14
JOURNAL ARTICLE
Daniela Coelho, Siomara Yamaguchi, Alaa Harb, Juliana N Souza-Talarico
BACKGROUND: Despite decades of advancement to support interventions for managing work-related stress, mental health issues have significantly escalated among healthcare professionals. Effort-reward imbalance (ERI) and overcommitment in the workplace are linked to several psychiatric disorders. However, the underlying biological mechanisms remain unclear. This study investigated whether ERI and overcommitment among healthcare professionals were linked to Allostatic Load (AL) and whether AL mediates the relationship between ERI, overcommitment and mental health issues...
February 2024: Comprehensive psychoneuroendocrinology
https://read.qxmd.com/read/38303125/key-psychosocial-issues-in-medical-care
#15
JOURNAL ARTICLE
Giovanni A Fava, Chiara Patierno, Nicoletta Sonino, Fiammetta Cosci
OBJECTIVE: The aim of this review is to illustrate an innovative framework for assessing the psychosocial aspects of medical disorders within the biopsychosocial model. It is based on clinimetrics, the science of clinical measurements. It may overcome the limitations of DSM-5 in identifying highly individualized responses at the experiential, behavioral, and interpersonal levels. METHOD: A critical review of the clinimetric formulations of the biopsychosocial model in the setting of medical disease was performed...
February 1, 2024: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/38256855/therapeutic-drug-monitoring-and-pharmacogenetic-testing-as-guides-to-psychotropic-drug-dose-adjustment-an-observational-study
#16
JOURNAL ARTICLE
Elodie Cuvelier, Houda Khazri, Cloé Lecluse, Benjamin Hennart, Ali Amad, Jean Roche, Michel Tod, Guillaume Vaiva, Olivier Cottencin, Pascal Odou, Delphine Allorge, Bertrand Décaudin, Nicolas Simon
To avoid the failures in therapy with psychotropic drugs, treatments can be personalized by applying the results of therapeutic drug monitoring and pharmacogenetic testing. The objective of the present single-center observational study was to describe the changes in psychotropic drug management prompted by therapeutic drug monitoring and pharmacogenetic testing, and to compare the effective drug concentration based on metabolic status with the dose predicted using an in silico decision tool for drug-drug interactions...
December 22, 2023: Pharmaceuticals
https://read.qxmd.com/read/38238934/understanding-the-pathophysiology-of-mental-diseases-and-early-diagnosis-thanks-to-electrophysiological-tools-some-insights-and-empirical-facts
#17
JOURNAL ARTICLE
Tomiki Sumiyoshi, Salvatore Campanella, Giulia Maria Giordano, Ryouhei Ishii, Oliver Pogarell
Objective . Neurophysiological tools remain indispensable instruments in the assessment of psychiatric disorders. These techniques are widely available, inexpensive and well tolerated, providing access to the assessment of brain functional alterations. In the clinical psychiatric context, electrophysiological techniques are required to provide important information on brain function. While there is an immediate benefit in the clinical application of these techniques in the daily routine (emergency assessments, exclusion of organic brain alterations), these tools are also useful in monitoring the progress of psychiatric disorders or the effects of therapy...
January 18, 2024: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://read.qxmd.com/read/38199800/is-every-psychiatrist-an-oncology-psychiatrist-special-needs-for-special-populations-a-scoping-review
#18
JOURNAL ARTICLE
Timothy Steinhoff, Dana Guyer, Khaldoun Almhanna
BACKGROUND: The evolution of psychiatric care for patients with cancer has played out over the last century. The first collaboration of psychiatry, oncology surgery, and radiation-oncology occurred in the mid-1950s and represented the early seeds of psycho-oncology. The role of a psychiatrist specializing in treating patients with cancer, a psychosocial oncologist or psycho-oncologist, spans the care continuum from prevention to end of life. The specific needs of patients with gastrointestinal (GI) malignancies range from management of anxiety and depression to focused management for adjustment to an ostomy to sexual dysfunction to treatment in the face of a neuroendocrine tumor (NET)...
December 29, 2023: Annals of Palliative Medicine
https://read.qxmd.com/read/38185234/how-real-world-data-can-facilitate-the-development-of-precision-medicine-treatment-in-psychiatry
#19
REVIEW
Elise Koch, Antonio F Pardiñas, Kevin S O'Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F Sullivan, Anders M Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Thomas Werge, Ida Sønderby, Michael C O'Donovan, James T R Walters, Lili Milani, Ole A Andreassen
Precision medicine has the ambition to improve treatment response and clinical outcomes through patient stratification, and holds great potential in mental disorders. However, several important factors are needed to transform current practice into a "precision psychiatry" framework. Most important are (1) the generation of accessible large real-world training and test data including genomic data integrated from multiple sources, (2) the development and validation of advanced analytical tools for stratification and prediction, and (3) the development of clinically useful management platforms for patient monitoring that can be integrated into healthcare systems in real-life settings...
January 5, 2024: Biological Psychiatry
https://read.qxmd.com/read/38177350/psychedelics-for-acquired-brain-injury-a-review-of-molecular-mechanisms-and-therapeutic-potential
#20
REVIEW
Josh Allen, Shannon S Dames, Claire J Foldi, Sandy R Shultz
Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an increased risk of developing neurological and neurodegenerative disorders. These symptoms can stem from various neurophysiological insults, including neuroinflammation, oxidative stress, imbalances in neurotransmission, and impaired neuroplasticity. Despite advancements in medical technology and treatment interventions, managing ABI remains a significant challenge...
January 4, 2024: Molecular Psychiatry
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