Horia Bumbea, Ana Maria Vladareanu, Ion Dumitru, Viola Maria Popov, Cristina Ciufu, Anca Nicolescu, Minodora Onisai, Cristina Marinescu, Diana Cisleanu, Irina Voican, Sinziana Sarghi
BACKGROUND AND OBJECTIVES: In acute myeloid leukemia (AML), extensive bleeding is one of the most frequent causes of death. Impaired activation and aggregation processes were identified in previous studies on platelet behaviour associated with this disease. This study's aim was to examine platelet function in correlation with other haemorrhage risk factors (fever, sepsis, recent bleeding, uraemia, leucocytosis, haematocrit value, treatment). DESIGN AND METHODS: The analysis of platelet surface proteins (Glycoprotein Ib-IX (CD42b, CD42a), Glycoprotein IIb-IIIa (CD41, CD61), p -selectin (CD62P), granulophysin (CD63)) was conducted by flowcytometry from samples of whole blood in patients with acute myeloid leukaemia in different stages of diagnosis and therapy ( n = 22) in comparison with healthy human controls ( n = 10)...
December 26, 2021: Journal of Clinical Medicine