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Multple sclerosis

Nicole Trager, Jonathan T Butler, Azizul Haque, Swapan K Ray, Craig Beeson, Naren L Banik
The pathogenesis of multiple sclerosis (MS) is mediated by massive infiltration of myelin-specific T cells into the central nervous system (CNS). Self-reactive CD4+ T helper (Th) cells, specifically Th1 and Th17 cells, are hallmarks of active disease in progression, whereas Th2 cells are predominately in remission stages. Calpain has been shown to be upregulated in the CNS of MS patients and inhibition of calpain has been shown previously to decrease disease in experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
June 14, 2013: Journal of Clinical & Cellular Immunology
M Quero Jiménez, M Burgueros Valero, L Herraiz Sarachaga, J A Nieto Curatero, F Acerete Guillén
Clinical and pathological findings are reported in 3 cases of cardiac tumors involving the ventricular septum and free walls. In 2 cases death occurred at ages 4 hours and 3 1/2 years and the pathological study revealed the presence of rhabdomyomas in the heart and tuberous sclerosis in the brain. The cardiac involvement was much more pronounced in the newborn infant than in the 3 1/2-year-old boy. The remaining patient, is a 6-month-old infant who is still alive. An angiocardiographic study performed at age 1 1/2-months revealed the presence of multple filling defects which were localized in the ventricular septum and in the left ventricular free wall...
November 1975: Anales Españoles de Pediatría
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