Jan Chvojka, Natalie Prochazkova, Monika Rehorova, Jan Kudlacek, Salome Kylarova, Michaela Kralikova, Peter Buran, Romana Weissova, Martin Balastik, John G R Jefferys, Ondrej Novak, Premysl Jiruska
High-frequency oscillations (HFOs) represent an electrographic biomarker of endogenous epileptogenicity and seizure-generating tissue that proved clinically useful in presurgical planning and delineating the resection area. In the neocortex, the clinical observations on HFOs are not sufficiently supported by experimental studies stemming from a lack of realistic neocortical epilepsy models that could provide an explanation of the pathophysiological substrates of neocortical HFOs. In this study, we explored pathological epileptiform network phenomena, particularly HFOs, in a highly realistic murine model of neocortical epilepsy due to focal cortical dysplasia (FCD) type II...
January 2024: Neurobiology of Disease