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Solid Organ Transplantation,Nephrology

Jon Kobashigawa, Darshana Dadhania, Sangeeta Bhorade, Deborah Adey, Joseph Berger, Geetha Bhat, Marie Budev, Andres Duarte-Rojo, Michael Dunn, Shelley Hall, Meera N Harhay, Kirsten L Johansen, Susan Joseph, Cassie C Kennedy, Evan Kransdorf, Krista L Lentine, Raymond J Lynch, Mara McAdams-DeMarco, Shunji Nagai, Michael Olymbios, Jignesh Patel, Sean Pinney, Joanna Schaenman, Dorry L Segev, Palak Shah, Lianne G Singer, Jonathan P Singer, Christopher Sonnenday, Puneeta Tandon, Elliot Tapper, Stefan G Tullius, Michael Wilson, Martin Zamora, Jennifer C Lai
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) and endorsed by the American Society of Nephrology (ASN), the American Society of Transplant Surgeons (ASTS), and the Canadian Society of Transplantation (CST) took place on February 11, 2018 in Phoenix, Arizona. Input from the transplant community through scheduled conference calls enabled wide discussion of current concepts in frailty, exploration of best practices for frailty risk assessment of transplant candidates and for management after transplant, and development of ideas for future research...
December 1, 2018: American Journal of Transplantation
Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi
Mesenchymal stromal cells have emerged as potential candidates for cell-based therapies to modulate the immune response in organ transplantation and repair tissues after acute or chronic injury. Preclinical studies have shown convincingly in rodent models that mesenchymal stromal cells can prolong solid organ graft survival and that they can induce immune tolerance, accelerate recovery from AKI, and promote functional improvement in chronic nephropathies. Multiple complex properties of the cells, including immunomodulatory, anti-inflammatory, and proregenerative effects, seem to contribute...
February 2018: Journal of the American Society of Nephrology: JASN
Armin Rashidi, Daniel C Brennan, Ina E Amarillo, Jason R Wellen, Amanda Cashen
OBJECTIVES: Graft-versus-host disease after solid-organ transplant is exceedingly rare. Although the precise pathogenetic mechanisms are unknown, a progressive increase in donor chimerism is a requirement for its development. The incidence of mixed donor chimerism and its timeline after simultaneous pancreas-kidney transplant is unknown. MATERIALS AND METHODS: After encountering 2 cases of graft-versus-host disease after simultaneous pancreas-kidney transplant at our institution over a period of < 2 years, a collaborative pilot study was conducted by the bone marrow transplant, nephrology, and abdominal transplant surgery teams...
June 2018: Experimental and Clinical Transplantation
Marija Gašpar, Ana Glavina, Kristina Grubišić, Ivan Sabol, Mirela Bušić, Marinka Mravak
AIM: Patients with a solid organ transplant can have many different complications in the mouth, as a result of immunosuppression and side effects of drugs. The aim of this study was to examine the frequency and type of oral lesions in renal transplant patients, dental status, oral hygiene, oral lesions related to drugs which patients take and the time of transplantation as well as the frequency of patient's visits to the dentist in the post-transplant period. MATERIAL AND METHODS: The study was performed in a period of two years and included 100 subjects with a renal transplant during their regular control visits to the Department of Nephrology and Dialysis, Clinical Hospital Centre Zagreb and the Department of Oral Medicine, School of Dental Medicine, University of Zagreb and 100 randomly selected control subjects at the Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb...
September 2015: Acta Stomatologica Croatica
Agata Kujawa-Szewieczek, Marcin Adamczak, Katarzyna Kwiecień, Sylwia Dudzicz, Zofia Prażak, Andrzej Więcek
BACKGROUND: Few studies have evaluated the incidence and risk factors of Clostridium difficile infection (CDI) in the adult Polish population, in particular in solid organ recipients hospitalized at the nephrological ward. AIM: The aim of this study was to analyze Clostridium difficile infections (CDI) among patients hospitalized in the Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice. MATERIAL/METHODS: Thirty-seven patients with Clostridium difficile infection diagnosed between October 2011 and November 2013 (26 months), identified among a total of 3728 patients hospitalized in this department during this period, were included in this retrospective, single-center study...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
Sean M Bagshaw, R T Noel Gibney
The University of Alberta (UofA) in Edmonton, Canada has a rich and productive history supporting the development of critical care medicine, nephrology and the evolving subspecialty of critical care nephrology. The first hemodialysis program for patients with chronic renal failure in Canada was developed at the University of Alberta Hospital. The UofA is also recognized for its early pioneering work on the diagnosis, etiology and outcomes associated with acute kidney injury (AKI), the development of a diagnostic scheme renal allograft rejection (Banff classification), and contributions to the Renal Disaster Relief Task Force...
2016: Blood Purification
G H Struijk, A J J Lammers, R J Brinkman, M J M H Lombarts, M van Vugt, K A M I van der Pant, I J M Ten Berge, F J Bemelman
BACKGROUND: The use of potent immunosuppressive drugs and increased travel by renal transplant recipients (RTR) has augmented the risk for infectious complications. Immunizations and changes in lifestyle are protective. The Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group has developed guidelines on vaccination following solid organ transplantation. The degree of adherence to these guidelines is unknown, as is which barriers must be overcome to improve adherence...
April 2015: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Fatma Al-Raisi, Ghalib Al-Mawali, Hamed Al-Naamani, Umkulthoom Al-Barwani
OBJECTIVES: The main objective of this study is to ensure all patients undergone kidney transplantation receives appropriate standard PCP prophylaxis soon after transplantation, unless contraindicated. METHODS: A prospective study included all kidney transplantation recipients from January 2008 to August 2008. A data collection sheet was designed and reviewed in focus group meetings and modified accordingly. The subjects were followed-up during the admission for transplantation to the date of discharge...
January 2009: Oman Medical Journal
F Sampogna, J N Bouwes Bavinck, M Pawlita, D Abeni, C A Harwood, C M Proby, M C W Feltkamp, S Euvrard, L Naldi, R E Neale, I Nindl, H Pfister, W G V Quint, T Waterboer
Viral skin infections are commonly present in organ transplant recipients (OTR). In this study, we aimed to identify factors associated with human papillomavirus (HPV) infections in OTR. Patients with solid-organ transplants were recruited from the outpatient nephrology and dermatology clinics in five European countries. Only patients with no current or past skin cancer were included in this analysis. Serum samples were analysed for antibodies to the L1 proteins of 26 cutaneous and two genital HPV types from five phylogenetic genera (α, β, γ, μ and ν)...
January 2012: Journal of General Virology
Seyyal Rota, Kibriya Fidan, Gülendam Bozdayı, Aydın Dalgıç, Işıl Fidan, Gülsan Sucak, Tuba Müderris
Human polyomaviruses, namely BK (BKV) and JC (JCV) viruses are small DNA viruses that cause latent infections worldwide. Primary infections are usually acquired in the early periods of life and are generally asymptomatic. However BKV/JCV infections may cause severe clinical conditions in immunosuppressive patients such as bone marrow and solid organ transplantation or cancer patients. The aim of this retrospective study was to investigate the presence of BKV and JCV nucleic acids by real-time polymerase chain reaction (RT-PCR) in the clinical samples of patients with high risk...
April 2011: Mikrobiyoloji Bülteni
G Mosconi, L Panicali, E Persici, D Conte, M L Cappuccilli, V Cuna, I Capelli, P Todeschini, G Liviano D'Arcangelo, S Stefoni
Kidney transplantations combined with other solid organs are progressively increasing in number. There are no guidelines regarding the nephrologic indications for combined transplantations, namely liver-kidney (LKT), or heart-kidney (HKT), in preemptive patients with chronic kidney failure who are not on regular dialysis therapy. The objective of this study was to assess the functional contribution of the native kidneys after preemptive kidney transplantation combined with other solid organs. From 2004, 9 patients (aged 50...
May 2010: Transplantation Proceedings
A Mlynarczyk, W Grzybowska, A Mrowka, S Tyski, T Buczkowska, J Pazik, M Durlik, A Kwiatkowski, L Adadynski, A Chmura, L Paczek, G Mlynarczyk
BACKGROUND: The aim of the investigations was to compare the vancomycin-resistant Enterococcus faecium (VREfm) strains obtained from our patients. MATERIALS AND METHODS: Strains were compared using restriction fragment length polymorphism-pulsed field gel electrophoresis (RFLP-PFGE) of bacterial DNA. RESULTS: VREfm infected 26 liver recipients, 22 kidney recipients, and 9 other surgery or nephrology patients. Only five strains possessed the vanB determinant...
October 2009: Transplantation Proceedings
Gwen E McNatt
Organ transplantation is a complex and highly regulated field. This review focuses on the role of nurses and transplant coordinators in solid organ transplantation, excluding both inpatient staff nursing and procurement activities. The literature describes a robust and autonomous transplant coordinator role; a key member of the multidisciplinary transplant team. Transplant coordinators facilitate patient care throughout all phases of transplantation. However, a lack of consensus on licensure and educational preparation of these important practitioners was evident from the review of literature...
September 2008: Progress in Transplantation
Josh W Joseph, J Richard Thistlethwaite, Michelle A Josephson, Lainie Friedman Ross
BACKGROUND: A United States consensus group on the live donor concluded that minors (<18 years) can ethically serve as live solid organ donors in exceptional circumstances. More recent international guidelines reject this position. Recent United Network of Organ Sharing data show that minors serve as living donors, albeit infrequently. We examined the attitudes of US physicians toward minors as living donors. METHODS: Four hundred members of the American Society of Transplantation and 160 physicians from the American Academy of Pediatrics Section of Nephrology or Bioethics were surveyed...
May 15, 2008: Transplantation
Yolanda Rodríguez-Gil, Sara-Isabel Palencia, Fernando López-Ríos, Pablo L Ortiz, Jose L Rodríguez-Peralto
Long-term survival after solid-organ transplantation is increasing because of recent advances, including new immunosuppressive regimens to avoid graft rejection. However, the resultant modification of the immune system is associated with an increased risk of several cancers. The most common are skin cancers, and lymphomas are second in frequency. Nevertheless, posttransplant primary cutaneous lymphomas (PCLs) are rare, and their incidence is not well known currently. From the files of the Nephrology and Cardiology Departments of University Hospital "12 de Octubre" of Madrid, we obtained clinical data from 1612 transplanted patients and only found 2 cases of posttransplant PCLs, both were T-cell PCL...
April 2008: American Journal of Dermatopathology
Guido Filler, Ajay P Sharma
The aim is to review the tools for early detection of renal dysfunction after pediatric solid organ transplantation. Currently, the most widely used marker for detection of renal dysfunction involves measurement of GFR. Inulin clearance forms the "gold standard" method for measuring GFR; however, nuclear medicine methods ((51)Cr EDTA and (99)Tc DTPA isotope clearance studies) have replaced inulin clearance. The measurement of serum creatinine has a low sensitivity for the early detection of renal damage...
June 2008: Pediatric Transplantation
Joshua N Beilke, Ronald G Gill
Natural killer (NK) cells are recognized for providing an important early innate immune response to viral and bacterial pathogens and for the surveillance of stressed and transformed autologous cells. However, with the exception of a pronounced role in allogeneic hematopoietic stem cell rejection, it has been challenging to ascribe the precise roles for NK cells in reactivity to tissue and solid-organ transplants. In general, NK cells initiate a rapid, proinflammatory environment that is conducive to many forms of effective immune host defense...
August 2007: Journal of the American Society of Nephrology: JASN
Vincent Ws Lee, Jeremy R Chapman
Sirolimus (Rapamycin, Wyeth Pharmaceuticals Australia Pty Ltd, Baulkham Hills, NSW, Australia) (SRL) has received increasing attention as an immunosuppressant in renal and other solid organ transplantation. Sirolimus is the first marketed agent in a new class of drugs with a novel mechanism of action. Sirolimus binds, like tacrolimus, to a member of the FK binding protein (FKBP) family. The SRL/FKBP complex binds to the protein kinase mTOR. Binding to mTOR blocks activation of signal transduction pathways causing arrest of the cell cycle in the G1 phase...
December 2005: Nephrology
Linda Ohler
No abstract text is available yet for this article.
June 2005: Progress in Transplantation
J Horák, S Sulková
The liver and the kidney jointly or in a complementary manner play an important role in maintaining homeostasis of the internal environment, mainly regarding detoxification, excretion and regulation. Hepatorenal syndrome can develop under pathological circumstances due to severe hepatic impairment, when the metabolism of both organs is affected by various xenobiotics, when they are damaged by genetic defects as in renal polycystosis, glycogenoses, alpha-1 antitrypsin deficiency or in hereditary amyloidosis...
2004: Casopís Lékar̆ů C̆eských
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