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Anxiety AND medication

Krystal Khoo, Ryan E K Man, Gwyn Rees, Preeti Gupta, Ecosse L Lamoureux, Eva K Fenwick
IMPORTANCE: Previous work has reported a link between diabetic retinopathy/diabetic macular edema (DR/DME) and psychosocial functioning, although the extent and direction of the association remains uncertain. OBJECTIVE: To determine the relationship between DR/DME and psychosocial functioning, the latter an umbrella term used to capture the emotional and social aspects of functioning which may include, for example, depression; depressive disorder; anxiety; vision-specific distress; diabetes-specific distress and emotional and social well-being...
March 16, 2019: Quality of Life Research
Berber S Laarman, Renée Jr Bouwman, Anke Je de Veer, Michelle Hendriks, Roland D Friele
INTRODUCTION: Disciplinary procedures can have serious consequences for the health, personal life and professional functioning of doctors. Until recently, specific disciplinary measures (reprimands) were publicly disclosed in the Netherlands. The perceived additional impact of disclosing reprimands on the professional and personal life of doctors is unclear. METHODS: All doctors who received a disciplinary measure from the Dutch Disciplinary Board between July 2012 and August 2016 were invited to partake in a 60-item questionnaire concerning the respondents' characteristics, the complaint, experience with the procedure and perceived impact of the procedure on health and professional functioning as reported by doctors themselves...
March 15, 2019: BMJ Open
P Ramírez-Boix, L Giménez-Llort
The increase of prevalence of mental health problems in the elderly due to the aging of the population becomes an outstanding issue since in most individuals it happens in an already complex multimorbid scenario that may include frailty and age-related medical conditions. Depression, soon the major cause of global disease burden, can be found as an age-related comorbidity and frailty, or as part of neurodegenerative diseases and where females are more vulnerable to it. Thought the multifactorial aetiology and heterogeneous nature of depression render it difficult to be modelled in animals, active behaviours elicited in the Forced Swimming Test (FST) are used to screen antidepressant treatments...
March 13, 2019: Experimental Gerontology
Daniel McCabe, Stacey Bangh, Ann Arens, Jon Cole
BACKGROUND: Phenibut is a synthetically produced central nervous system (CNS) depressant that is structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Phenibut has been identified as a drug of abuse with numerous clinical effects in overdose and a withdrawal syndrome with chronic use. The purpose of this study is to report the incidence of exposure calls regarding phenibut to a poison center, describe the reasons for its use and clinical effects. METHODS: Study subjects were identified using Toxicall®, the electronic medical record utilized by the Minnesota Poison Control System...
March 9, 2019: American Journal of Emergency Medicine
Amaryllis Chryssi Malegiannaki, Dimitra Katsarou, Antonios Liolios, Vasiliki Zisi
Individuals with Down Syndrome (DS) are commonly characterized by unique neurocognitive and neurobehavioural profiles that emerge within specific stages in the developmental continuum. A plethora of studies have confirmed DS's relationship to premature aging and subsequent cognitive decline. Due to having three copies of the amyloid precursor protein (APP) gene which results in amyloid-beta plaque deposition, the cognitive decline often resembles the decline observed in Alzheimer's disease. More specifically, as individuals with DS mature in age (>40) they experience a dramatic increase in difficulties in several cognitive domains, such as language, visuo-spatial abilities, executive functions, working memory, etc...
January 2019: Hellenic Journal of Nuclear Medicine
Ali Bidari, Ehsan Moazen-Zadeh, Banafsheh Ghavidel-Parsa, Shahrzad Rahmani, Sajjad Hosseini, Amir Hassankhani
BACKGROUND: Duloxetine and pregabalin are among the most widely used medications in the treatment of patients with fibromyalgia syndrome (FM). OBJECTIVES: To add to the very few lines of evidence that exist on the comparative safety and efficacy of these two medications. METHODS: In this open-label randomized clinical trial, outpatient women, who were diagnosed with FM based on American College of Rheumatology 2010 criteria, and had an age range of 18-65 years old were assigned to either duloxetine 30-60 mg or pregabalin 75-150 mg per day for 4 weeks...
March 14, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Eszter Tisljár-Szabó, Roland Tisljár
Nowadays, the number of bariatric surgery for treating morbid obesity is significant. There is strong evidence about the influence of mental state (depression, anxiety, eating disorder, etc.) on patient's cooperation with the medical team and the outcome, and on the short or long-term effectiveness of surgery. However, no protocol or recommendation exist for screening patients before bariatric procedures in Hungary. Thus, even if the surgeon or the hospital requires psychological expertise, neither doctors are familiar with the expectable results of such an expertise, nor psychologists know exactly what the most important areas are to talk through with patients...
March 2019: Orvosi Hetilap
Hongjin Li, Meihua Ji, Paul Scott, Jacqueline M Dunbar-Jacob
PURPOSE: The purpose of this study was to examine the collective effect of a symptom cluster (depression, anxiety, fatigue, and impaired sleep quality) at baseline on the quality of life (QOL) of patients with type 2 diabetes (T2DM) over time. METHODS: This was a secondary data analysis of 302 patients with T2DM who presented with both hypertension and hyperlipidemia. All of the participants were enrolled in a randomized controlled intervention study testing strategies to improve medication adherence...
March 15, 2019: Diabetes Educator
Manfred E Beutel, Jörg Wiltink, Jasmin Ghaemi Kerahrodi, Ana N Tibubos, Elmar Brähler, Andreas Schulz, Philipp Wild, Thomas Münzel, Karl Lackner, Jochem König, Norbert Pfeiffer, Matthias Michal, Michaela Henning
The purpose of the study was (1) to determine the prevalence of somatic symptoms in men and women in the general population and (2) to identify the contributions of psychosocial factors and somatic disease on symptom reporting. A total of 7,925 participants aged 40 to 80 years underwent medical and psychological assessments, based on the PHQ-15 (Patient Health Questionnaire). We excluded 3 items in order to avoid confounding findings: 2 items overlapping with the depression measure (PHQ-9) and the menstruation complaints item which biases sex comparisons...
March 14, 2019: Scientific Reports
Gianluca Franceschini, Alba Di Leone, Daniela Terribile, Martin Alessandro Sanchez, Riccardo Masetti
Aim of this paper is to allows to analyze a topic of great relevance and media interest such as the role of prophylactic mastectomy in healthy women with BRCA mutation proposing to the surgeons some useful informations for decision-making. Less than 15% of all breast cancers are associated with germline genetic mutations. The majority of hereditary breast tumors are due to mutations in BRCA1 and BRCA2 genes that are responsible for only one third of hereditary cases. The risk estimates are extremely heterogeneous with a mean cumulative lifetime breast cancer risk of approximately 72% in BRCA1 and 69% in BRCA2 by age 80...
2019: Annali Italiani di Chirurgia
Laxmikant S Deshpande, Robert J DeLorenzo
Organophosphate (OP) chemicals include pesticides such as parathion, and nerve gases such as sarin and soman and are considered major chemical threat agents. Acute OP exposure is associated with a cholinergic crisis and status epilepticus (SE). It is also known that the survivors of OP toxicity exhibit neurobehavioral deficits such as mood changes, depression, and memory impairment, and acquired epilepsy. Our research has focused on addressing the need to develop effective therapeutic agents that could be administered even after prolonged seizures and would prevent or lessen the chronic morbidity associated with OP-SE survival...
March 11, 2019: Neurobiology of Disease
Amélie Rochefort, Denise C Jarrin, Lynda Bélanger, Hans Ivers, Charles M Morin
OBJECTIVES: To examine the potential moderating effect of objectively measured sleep duration at baseline on the response to cognitive behavioral therapy for insomnia (CBT-I), administered singly or combined with medication (CBT-I + Med). METHODS: Based on the average PSG-derived sleep duration across two baseline nights and the type of treatment received, 159 adults with insomnia (50.3 ± 10.1 years; 61.0% women) were classified into one of four groups: participants with short sleep duration (ie, ≤ 6 h) treated with CBT-I (n = 26) or CBT-I+Med (n = 25), and participants with normal sleep duration (ie, > 6 h) treated with CBT-I (n = 54) or CBT-I+Med (n = 54)...
January 31, 2019: Sleep Medicine
Marie Pezé
Alert sign of burn out and early diagnosis. The syndrome of mis-adaptation to toxic work organisations and of a frantic acceleration of our neuro-physiological functions, the concept of burn-out is being appropriated by the media and social sphere, rendering nuanced diagnostics impossible. Handling a burn-out requires complex administrative, judicial and medical protocols. This administrative and medical engineering must be mastered, as it's a therapeutic tool that assuages a patient's fear and anxiety better than drugs or therapy...
October 2018: La Revue du Praticien
Alexandra C Battersby, Helen Braggins, Mark S Pearce, Fiona McKendrick, Mari Campbell, Siobhan Burns, Catherine M Cale, David Goldblatt, Andrew R Gennery
X-linked chronic granulomatous disease (XL-CGD), a rare primary immunodeficiency due to a defect in the gp91phox NADPH oxidase subunit, results in recurrent, severe infection, inflammation, and autoimmunity. Patients have an absent, or significantly reduced, neutrophil oxidative burst. Due to lyonization, XL-CGD carriers have a dual population of functional and non-functional phagocytes and experience a range of symptoms including increased risk of autoimmunity, fatigue, and infection. Patients with CGD have poorer quality of life (QoL) than normal controls...
March 13, 2019: Journal of Clinical Immunology
Lynn M Budzak, Waqas Yasin, Jennifer Mulhall
Selective serotonin reuptake inhibitors are a common first choice medication for anxiety and depression treatment, but health care providers should be aware of priapism as a possible adverse effect.
February 2019: Federal Practitioner
Alanna Higgins Joyce, Maya Raman, Jennifer L Beaumont, Heather Heiman, Mark Adler, Suzanne M Schmidt
BACKGROUND: Though pneumatic otoscopy improves accurate diagnosis of ear disease, trainees lack proficiency. We evaluated the effect of three different training techniques on medical students' subsequent reported use of basic and pneumatic otoscopy in patient encounters. METHODS: Pediatric clerkship students participated in an ear exam workshop with randomization to one of three educational interventions: task trainer (Life/form®, Fort Atkinson WI), instructional video, or peer practice...
March 12, 2019: BMC Medical Education
Yvonne Moriarty, Julia Townson, Harriet Quinn-Scoggins, Louise Padgett, Sioned Owen, Stephanie Smits, Rebecca Playle, Polyxeni Dimitropoulou, Bernadette Sewell, Vasiliki Kolovou, Peter Buckle, Ben Carter, Adrian Edwards, Julie Hepburn, Maura Matthews, Caroline Mitchell, Richard D Neal, Michael Robling, Fiona Wood, Kate Brain
BACKGROUND: Cancer survival is lower in socioeconomically deprived communities, partly due to low awareness of symptoms, negative beliefs and delayed help-seeking. We developed an interactive health check questionnaire facilitated by trained lay advisors. It entails 29 questions about background, lifestyle and health with tailored behaviour change advice. Personalised results are printed using a traffic light (red/amber/green) system, highlighting areas where action should be taken. This is an individually randomised control trial to test effectiveness of the health check on symptom recognition...
March 11, 2019: BMC Public Health
Jamie M Jacobs, Molly E Ream, Nicole Pensak, Lauren E Nisotel, Joel N Fishbein, James J MacDonald, Joanne Buzaglo, Inga T Lennes, Steven A Safren, William F Pirl, Jennifer S Temel, Joseph A Greer
BACKGROUND: Oral therapies are increasingly common in oncology care. However, data are lacking regarding the physical and psychologic symptoms patients experience, or how these factors relate to medication adherence and quality of life (QoL). MATERIALS AND METHODS: From December 2014 through August 2016, a total of 181 adult patients who were prescribed oral targeted therapy or chemotherapy enrolled in a randomized study of adherence and symptom management at Massachusetts General Hospital Cancer Center...
March 1, 2019: Journal of the National Comprehensive Cancer Network: JNCCN
Christine Cipra, Brigitte Müller-Hilke
OBJECTIVES: Undergraduate medical students experience a considerable amount of stress and anxiety due to frequent exams. The goal of the present study was to examine the development of exam related anxiety and to test for a correlation between anxiety and learning approaches. METHODS: A whole class of 212 medical students was invited to participate in the study. During their first term, trait anxiety and learning approaches were assessed by use of the state-trait-anxiety inventory (STAI-T) and the approaches-and-study-skills-inventory-for-students (ASSIST), respectively...
2019: PloS One
Vernon M Pais, Brian D Sites
OBJECTIVE: To characterize opioid utilization among those with nephrolithiasis in a national cohort. MATERIALS AND METHODS: We performed cross sectional analysis of participants in the Medical Expenditure Panel Surveys during 2008 - 2014. Sample weights were employed for analysis of complex survey design. Those reporting occurrence of "renal or ureteral calculus" during the survey period represented the cohort of stone formers (SFs). Receipt of opioid prescription as well as total number of opioid prescriptions filled over study period were noted...
March 13, 2019: Clinical Nephrology
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