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Work-related Asthma

Alessandro Tonacci, Paolina Quattrocchi, Sebastiano Gangemi
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. The IL-33/ST2 axis plays an important role in several acute and chronic inflammatory diseases, including asthma and rheumatoid arthritis...
February 14, 2019: Medicina
Carl Stepnowsky, Kathleen F Sarmiento, Shay Bujanover, Kathleen F Villa, Vicky W Li, Natalia M Flores
STUDY OBJECTIVES: Few population-based studies have explored how excessive sleepiness (ES) contributes to burden of illness among patients with obstructive sleep apnea (OSA). METHODS: This study utilized data from the annual, cross-sectional 2016 US National Health and Wellness Survey. Respondents self-reporting an OSA diagnosis were categorized as having ES (Epworth Sleepiness Scale [ESS] score ≥ 11) or not having ES (ESS score < 11). Comorbidities, health-related quality of life (HRQoL), and productivity were examined in three groups: OSA with ES (n = 731), OSA without ES (n = 1,452), and non-OSA controls (n = 86,961)...
February 4, 2019: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Jessyca P Selman, Fernanda C Lanza, Gustavo F Wandalsen, Dirceu Solé, Denis E O'Donnell, J Alberto Neder, Simone Dal Corso
BACKGROUND: Single-step tests have been proposed as simple and inexpensive challenges to diagnose exercise-induced bronchoconstriction (EIB) in the pediatric population. Work performed and the resulting ventilation, however, might be substantially lower in stepping than running. This might decrease the diagnostic yield of step-based challenges. METHODS: In a cross-sectional study, 53 children with asthma with exercise-related symptoms (34 boys, age 6-18 y) underwent an incremental stepping test, a 6-min constant stepping test, and a treadmill running test on different days...
February 5, 2019: Respiratory Care
Saara Taponen, Jukka Uitti, Kirsi Karvala, Ritva Luukkonen, Lauri Lehtimäki
BACKGROUND: Age at asthma onset is associated with severity and outcomes of the disease. OBJECTIVE: We studied if age at asthma diagnosis is related to employment and outcomes in working career. PATIENTS AND METHODS: A questionnaire was sent to 2613 adults with asthma in Tampere, Finland, and a follow-up questionnaire was sent after six years. Asthmatics were divided into groups based on their employment status: working full-time or work disability...
February 2019: Respiratory Medicine
David A Stupplebeen
INTRODUCTION: Food and housing insecurity are social determinants of health related to chronic disease, including diabetes, cardiovascular disease (CVD), and asthma. How these insecurities affect chronic disease among the 3 largest racial groups in Hawai'i is unknown. The purpose of this study was to examine chronic disease by housing and food insecurity among whites, Asians, and Native Hawaiian/other Pacific Islanders (NHOPIs) in Hawai'i. METHODS: We pooled data on 9,907 respondents from the 2009 and 2012 Behavioral Risk Factor Surveillance System...
January 31, 2019: Preventing Chronic Disease
Claire R LaSee, Carolyn K Reeb-Whitaker
OBJECTIVE: Washington State's work-related asthma (WRA) surveillance program utilizes workers' compensation (WC) data as its primary data source and has spanned a 15-year time period. This study analyses trends for WRA claim incidence rates compared to all WC claim incidence rates. WRA claim incidence rates and WC costs are analyzed by industry. METHODS: Potential WRA cases were identified through the WC system and through direct provider report and classified by industry, age, and year of illness onset...
January 31, 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Shasha Tao, Hong Zhang, Lian Xue, Xiaoyan Jiang, Hongyan Wang, Bingyan Li, Hailin Tian, Zengli Zhang
Fine particulate matter is a well-known air pollutant threatening public health. Studies have confirmed long-term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as increase the incidence and mortality of lung cancer. A clinical study has explored that the prevalence and risks of vitamin D (VD) deficiency in various chronic disease and toxins induced tissue damage. Our current study aimed to explore the mechanism and further therapeutic potential of VD administration to ameliorate fine particles exposure induced pulmonary damage in vivo and in vitro...
January 30, 2019: Environmental Toxicology
Izzuddin M Aris, Abby F Fleisch, Emily Oken
Purpose of review: Many of the diseases and dysfunctions described in the paradigm of the developmental origins of health and disease have been studied in relation to prenatal nutrition or environmental toxicant exposures. Here, we selectively review the current research on four exposures-two nutritional and two environmental-that have recently emerged as prenatal risk factors for long-term health outcomes. Recent findings: Recent studies have provided strong evidence that prenatal exposure to (1) excessive intake of sugar-sweetened beverages, (2) unhealthy dietary patterns, (3) perfluoroalkyl substances, and (4) fine particulate matter, may increase risk of adverse health outcomes, such as obesity, cardiometabolic dysfunction, and allergy/asthma...
September 2018: Current Epidemiology Reports
Ambrose Lau, Susan M Tarlo
Work-related asthma is the most common occupational lung disease encountered in clinical practice. In adult asthmatics, work-relatedness can account for 15%-33% of cases, but delays in diagnosis remain common and lead to worse outcomes. Accurate diagnosis of asthma is the first step to managing occupational asthma, which can be sensitizer-induced or irritant-induced asthma. While latency has traditionally been recognized as a hallmark of sensitizer-induced asthma and rapid-onset a defining feature of irritant-induced asthma (as in Reactive Airway Dysfunction Syndrome), there is epidemiological evidence for irritant-induced asthma with latency from chronic moderate exposure...
March 2019: Allergy, Asthma & Immunology Research
Felix Forster, Tobias Weinmann, Jessica Gerlich, Wolff Schlotz, Gudrun Weinmayr, Jon Genuneit, Doris Windstetter, Christian Vogelberg, Erika von Mutius, Dennis Nowak, Katja Radon
OBJECTIVES: This study analyzes the association of work-related stress with incident asthma and rhinitis in young adults with a special focus on gender-specific differences. METHODS: Incident asthma, wheezing and rhinitis were measured in a cohort of 2051 young German adults (aged 16-18 years at baseline) recruited by the prospective population-based SOLAR study (Study of Occupational Allergy Risks). Work-related stress was measured by the Trier Inventory for the Assessment of Chronic Stress (TICS)...
January 18, 2019: International Archives of Occupational and Environmental Health
Milene Torp Madsen, Lars Rauff Skadhauge, Anders Daldorph Nielsen, Jesper Baelum, David Lee Sherson
INTRODUCTION: Anhydrides are widely used as cross-linking agents in epoxy resins and alkyd production, for example, as coatings and adhesives in plastic products. Sensitisation to several anhydrides is known to cause occupational asthma. There are indications that the lesser known pyromellitic dianhydride (PMDA) can cause irritative respiratory symptoms and possibly asthma. We report three cases of workers from a plastic foil manufacturing plant, who developed asthma when exposed to PMDA during specific inhalation challenge (SIC)...
January 11, 2019: Occupational and Environmental Medicine
John W Downs, Joshua M Renshaw
A 33 year old female healthcare worker with a history of cough variant asthma presented with 2 weeks of dyspnea and cough that she believed to be due to recurring exposure to skunk spray in her work environment. The employee was working in a temporary structure outside the primary hospital campus. During the preceding 2 weeks, at least one striped skunk was observed multiple times by staff members to be crawling under the structure. The employee's symptoms were not initially considered serious by her supervisors who felt that the appreciable "skunk smell" was merely a nuisance odor...
July 2018: U.S. Army Medical Department Journal
Jason E Lang
PURPOSE OF REVIEW: Asthma is one of the most common chronic diseases in children and adults in developed countries around the world. Despite international treatment guidelines, poor asthma control remains a frequent problem leading to missed school and work, and emergency room visits and hospitalizations. Many patients with asthma report exercise as a trigger for their asthma, which likely leads to exercise avoidance as a means to control symptoms. Evolving research has suggested that routine exercise may actually help improve some aspects of asthma control...
December 27, 2018: Current Opinion in Allergy and Clinical Immunology
Jacek M Mazurek, Paul K Henneberger
PURPOSE OF REVIEW: Work-related asthma has been associated with poorer asthma control and frequent unscheduled healthcare visits, and can be fatal. Case reports of work-related asthma deaths are rare, but can initiate efforts to prevent additional cases. We reviewed relevant literature and data sources to evaluate whether analyzing mortality data at the population level can help identify potential sources of exposures that contribute to work-related asthma. RECENT FINDINGS: A limited number of population-based studies have addressed work-related asthma mortality...
December 27, 2018: Current Opinion in Allergy and Clinical Immunology
Abdulaziz M Alrabiah, Tarek Elsaid, Ayla Tourkmani
Background: The level of uncontrolled asthma is still high despite the availability of effective treatments and evidence-based guidelines for controlling asthma. Knowledge and adherence to evidence-based guidelines among care providers are crucial to the treatment. Objective: To investigate the determinants of family physicians' knowledge and application of asthma management guidelines at primary healthcare setting in Saudi Arabia. Methods: This is a cross-sectional study, conducted at 18 primary healthcare centers in Riyadh, Saudi Arabia...
September 2018: Journal of Family Medicine and Primary Care
Scott Klenzak, Igor Danelisen, Grace D Brannan, Melissa A Holland, Miranda Al van Tilburg
Gastroesophageal reflux disease (GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diagnosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor (PPI) class being the preferred and most effective...
December 6, 2018: World Journal of Clinical Cases
Elida Zairina, Gesnita Nugraheni, Gusti Nv Achmad, Arie Sulistyarini, Yunita Nita, Arief Bakhtiar, Muhammad Amin
BACKGROUND: Asthma is a chronic disease that requires indefinite long-term therapy. Many approaches have been developed to enable people with asthma to live as normally as possible. In medication therapy management, pharmacists could play important roles in supporting the everyday life of asthmatic patients, such as by providing education therapy management to ensure that patients achieve optimal therapeutic outcomes. A good collaboration between health care practitioners and patients will produce a better system in terms of therapeutic management, which will lead to health care cost savings related to emergency visits...
December 18, 2018: JMIR Research Protocols
Patricia O'Connell, Benjamin Gaston, Tracey Bonfield, Theresa Grabski, David Fletcher, Steven L Shein
BACKGROUND: Periostin is a protein that serves as a downstream marker of the T-helper type 2 (Th2) cell response. It may serve to identify drug-responsive inflammatory phenotypes, particularly in children with asthma and possibly bronchiolitis. There are no published levels of periostin in healthy children <2 years of age, limiting interpretation of periostin levels in disease. We sought to explore the range of periostin levels of children <2 years without significant confounding illnesses...
February 2019: Pediatric Pulmonology
Jasmin Khateeb, Eyal Fuchs, Mogher Khamaisi
BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and oxidative stress which may target many organs such as the kidney, retina, and the vascular system. The pathophysiology, mechanisms, and consequences of diabetes on these organs have been studied widely. However, no work has been done on the concept of the lung as a target organ for diabetes and its implications for lung diseases. AIM: In this review, we aimed to investigate the effects of diabetes and hypoglycemic agent on lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, and lung cancer...
November 23, 2018: Review of Diabetic Studies: RDS
M Jansà, M J Bertran, J Vilardell, F Garcia, J Escarrabill
BACKGROUND AND OBJECTIVES: The application and monitoring of quality criteria in information and therapeutic patient education can identify areas to improve care. The objectives of this study were: (1) To analyze the characteristics of patient information materials, educational activities, and self-management programs, and (2) to determine health care provider (HCP) proposals on therapeutic patient education. MATERIALS AND METHODS: Using a cross-sectional study, an online questionnaire was sent to hospital departments in a high complexity reference hospital from September to December 2013 to record: (a) information materials, (b) patient educational activities, and self-management program characteristics, (c) HCP proposals...
November 24, 2018: Journal of healthcare quality research
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